Researchers at the University of Michigan have created a new line of transgenic mice that spontaneously develop skin tumors resembling human basal cell carcinomas. The mice produce abnormally large amounts of Gli2 protein, which plays a key role in the development of these common skin tumors.
The solar system's ultimate fate is predicted to be a collapse of the sun into a white dwarf, incinerating the Earth and inner planets in the process. However, a close encounter with a passing star may rescue life by hurling the Earth out of the solar system.
The study confirms the complex origins of Native Americans by analyzing craniofacial measurements of old and new skulls from around the world. The results separate the native inhabitants of the Western Hemisphere into several different groups, including those descended from Asian groups such as the Jomon people of Japan.
A study of 616 middle-aged men from Finland found that those experiencing high levels of hopelessness were three times more likely to develop hypertension. The link between hopelessness and cardiovascular disease is considered a critical factor in increased risk, independent of other known risk factors.
A new study of borehole temperatures reveals that the 20th century was the warmest of the past five centuries, with Earth's temperature increasing about 1 degree Celsius since 1500. The analysis, which combined data from over 600 sites worldwide, found a greater warming trend in the Northern Hemisphere than previously estimated.
Researchers developed a non-toxic peptide that prevents metastatic prostate cancer from spreading to other organs in laboratory rats. The peptide, PHSRN, was effective even when primary tumors were allowed to grow before treatment began.
University of Michigan physicists have created a database that stores and retrieves data in atomic quantum phase, a new approach to data storage. The study uses cesium atoms and ultrafast lasers to store and retrieve data, confirming theoretical predictions made by L.K. Grover.
A team of astronomers led by University of Michigan professor Douglas Richstone discovered three new supermassive black holes in nearby elliptical galaxies. The formation and evolution of galaxies are linked to the presence of massive black holes, which played a crucial role in shaping galaxy development.
Researchers found that a short distance of 2.53 angstroms between iron atoms in peroxide-bridged ferritin intermediate favors biomineralization process over oxygen activation. The study uses analytical techniques to probe molecular structure and collaboration with experts from different disciplines.
The Monitoring the Future study found that overall illicit drug use among American teens remained steady in 1999, with only modest changes in various drug categories. Inhalant use continued its gradual decline, while crack cocaine use decreased significantly among younger teens. Conversely, MDMA use increased among older teens.
US teen smoking rates have declined gradually from their peak in the late 1990s, with a notable decrease among college-bound eighth- and 10th-graders. However, non-college bound students have shown little improvement, and social class differences in smoking rates are re-emerging.
The University of Michigan Medical School will receive a four-year, $4 million grant from the Howard Hughes Medical Institute to support its new bioinformatics program. The program aims to educate tomorrow's scholars in this emerging scientific field and develop next-generation bioinformatics tools.
Researchers developed a model that relates seismic velocity differences to properties of the mantle, shedding light on mantle evolution and its impact on plate movement, volcanism, and earthquakes. The study suggests temperatures high enough to cause melting in some regions, potentially explaining volcanic activity.
A study led by U-M scientist Lisa Curran found that El Nino triggers the reproduction of tropical forest trees, allowing them to survive and thrive. However, human activity such as logging is destroying the ecosystem, threatening the local economy and global exports.
Using brittle failure theory, University of Michigan researcher Youxue Zhang can calculate the likelihood of fragmentation for a given magma sample based on composition, water content, and temperature. This calculation may help predict when a volcanic eruption will become deadly.
A University of Michigan study found that older Americans with depressive symptoms are at a higher risk of developing new diseases within two years, comparable to those who smoke. Physical limitations and multiple symptoms of depression also significantly increase the likelihood of developing new disease.
Researchers at the University of Michigan have identified a key mechanism by which some viruses, including Kaposi's sarcoma-associated herpesvirus, can hide in human cells for extended periods. The study reveals that a protein called LANA binds to host chromosomes, allowing viral DNA to remain dormant until the immune system is weakened.
Researchers at the University of Michigan have developed a new technique to accelerate ions, using a table-top laser instead of radio-frequency waves. The new technique accelerates ions in almost a million-times shorter distance than a cyclotron, potentially making ion accelerators more affordable and accessible for medical applications.
Researchers find substance use and dependence are significant problems among welfare recipients, but academic skill deficits are a greater barrier to self-sufficiency. Effective services addressing mental health needs and providing support for work barriers are crucial for successful fulfillment of family roles.
A recent study by Reg A. Williams highlights the significant economic impact of depression in the workplace, citing an estimated total cost of up to $44 billion. The study also identifies key risk factors for depression, including stress, negative changes in personal life, and difficulties in interpersonal relationships.
A University of Michigan study found that older adults tend to use the left front side of the brain, specifically the dorsolateral prefrontal cortex, when performing concurrent tasks. This is a difference from younger adults who rely more on visual cortices for task switching.
A study by University of Michigan researchers found that living in segregated cities with high levels of poverty is associated with higher mortality rates, particularly for cancer. The analysis revealed a strong correlation between segregation and increased susceptibility to illness and death among both black and white populations.
A new U-M study examines 11 college campuses' efforts to promote racial harmony and identifies areas for improvement. The study's findings highlight the importance of sustaining programs after grants expire, as communication barriers can persist without continued effort.
A University of Michigan team found that applying repeated strain during tissue development increases the expression of key structural protein genes and improves cell organization, leading to stronger tissues. This approach could improve engineered tissues' strength and potentially be used to investigate disease mechanisms.
A study by University of Michigan researchers found that US teens feel stressed more often than East Asian students, despite performing poorly on math tests. The stress is mainly caused by unclear academic goals and societal expectations, while Japanese students have a clearer focus on academic achievement.
Researchers at the University of Michigan are developing nanomolecular 'smart bombs' that can detect pre-malignant and cancerous changes in living cells. These devices use synthetic polymers called dendrimers to transport anti-cancer drugs and sensing agents into cells.
Researchers are changing treatment methods for gum disease to focus on treating bacterial infections. This approach can save many teeth that were previously considered 'hopeless' and may reduce the risk of heart disease.
Scientists will gather at the University of Michigan to discuss technical problems in measuring global carbon emissions, including identifying 'sinks' for locking up atmospheric carbon. The three-day symposium aims to advance our understanding and verification of carbon credits.
Scientists created a new mouse strain with a genetic deletion that affects stress hormones and behavior. The mice exhibit anxiety-like behavior consistently, not just in response to external stimuli, offering insights into the role of CRH-binding protein in depression and anxiety disorders.
The University of Michigan School of Public Health is leading a $12.5 million project to improve the quality of life for children with asthma. The initiative aims to establish local coalitions that implement programs reducing hospital stays, emergency room visits, and enhancing asthma management. Faculty from U-M's asthma research team...
Researchers found Yersinia pestis uses a protein called YopJ to cut off cellular communication, disrupting immune response and killing the host. Understanding this mechanism could have important implications in medicine, particularly for cancer and immune-related diseases.
The new process uses a terawatt laser to deliver incredible energies in femtoseconds, sorting isotopes by molecular weight. This breakthrough eliminates the need for huge electro-magnets and cross-contaminated byproducts, making it an efficient alternative to gaseous diffusion.
Researchers at the University of Michigan Comprehensive Cancer Center have identified two genes that may control the development of inflammatory breast cancer. The discovery, published in Clinical Cancer Research, could lead to more effective forms of cancer treatment, particularly for newly diagnosed women.
A University of Michigan study found that a low sense of belonging is a stronger predictor of major depression than other factors. The research analyzed data from 31 clients with depression and 379 community college students, concluding that feeling connected to others is crucial in overcoming depression.
Researchers identified two genetic elements, AE5' and AE3', that regulate human Factor IX expression, leading to increased coagulation capacity with age. The study provides insight into the molecular basis of age-related changes in blood clotting.
A new study found nearly half of Internet health pages contain unverified information, with 6% containing wrong data. Doctors and patients can benefit from using trustworthy sources, such as government and nonprofit sites, to access accurate health info.
A mathematical model of H.pylori bacteria and their human hosts reveals the key role played by adherent bacteria in colonization, as well as the dynamic relationship between host response and bacterial persistence. The model sheds light on the complex interactions between the bacteria and human immune system.
Researchers observed a substantial reduction in mortality for heart failure patients who received the Aldactone medication regimen, reducing deaths by 30 percent. The study found that aldosterone blockade played an important role in this reduction and opens the door to developing more effective treatment options.
University of Michigan scientists have found that salicylate can prevent deafness in guinea pigs exposed to aminoglycoside antibiotics. The study suggests that moderate doses of aspirin could be effective in preventing hearing loss and damage caused by these antibiotics.
A new study by University of Michigan professor Dr. Arnold S. Monto found that zanamivir, an antiviral drug, is 67% effective in preventing laboratory-confirmed clinical influenza infection. The drug was also shown to be 84% effective in preventing laboratory-confirmed illnesses with fever.
Researchers at the University of Michigan have found that blocking C5a, a protein that normally activates the immune system, provides significant protection against sepsis in animal studies. In sepsis-induced rats, blocking C5a resulted in more than half surviving compared to just 5% in a control group.
A new study published in the American Journal of Medicine finds that managed care insurance systems can standardize care, eliminate unnecessary tests, and minimize antibiotic resistance by implementing a single guideline for treating uncomplicated urinary tract infections. The study, which included over 3,800 women, showed that using a...
A new treatment approach has been developed to restore normal heart rhythms in patients with atrial fibrillation, a condition affecting over 2 million adults. Ibutilide fumarate injection prior to an electrical shock to the heart was successful in converting abnormal rhythms to normal in all study patients.
Scientists at the University of Michigan used spatial illusion to study how the brain processes sound. By analyzing neural activity in cats and humans, researchers found that the auditory systems use similar spectral characteristics to determine sound locations.
A new study found that cardiac surgery patients with serum potassium levels below 3.5 mmol/L are twice as likely to experience arrhythmias and a doubled need for cardiopulmonary resuscitation. Investigators recommend screening and replenishing potassium on a case-by-case basis.
Researchers at the University of Michigan discovered that folic acid effectively lowers homocysteine levels in blood plasma, reducing the risk of heart attacks and strokes. The study found that folic acid supplementation can also benefit people with normal MTHFR enzymes by protecting them against heat-induced enzyme inactivation.
Researchers discovered that UV radiation blocks the ability of skin cells to recognize retinoic acid, a nutrient made from vitamin A. This triggers a cascade of biochemical changes, causing a functional vitamin A deficiency in human skin. Pretreating skin with retinoic acid before UV exposure can limit the damage.
Astronomers have detected the brightest optical celestial object ever recorded using a low-cost, automated telescope built from recycled lenses and hardware. The ROTSE-1 telescope captured optical emissions from a gamma ray burst while it was still arriving, providing new insights into the phenomenon.
Researchers have developed a new MRI technology that uses xenon gas to generate high-resolution images of the heart and lungs in living laboratory rats. The system detects signals from polarized xenon molecules, allowing for direct measurement of blood flow through organs.
A new study by Peter D. Jacobson examines the role of nurse practitioners (NPs) and physician assistants (PAs) in primary care, finding that their scope of practice and autonomy increase with larger managed care populations. While most physicians view NPs and PAs as peers, some express concerns about quality of care and referrals.