A recent study found that circulating stem cells contribute less than 1% to lung repair, while most contributions come from lung-resident stem cells. The study also suggests a link between the number of Y-chromosome containing pneumocytes and acute cellular rejection in lung tissue.
Researchers have identified gene mutations that cause life-threatening aortic aneurysms and dissections, providing a new molecular pathway for therapy development and early warning signs. The study found four families with variations in the TGFBR2 gene, which alters protein structure and sends incorrect signals.
Researchers have discovered that phospholipids, a crucial component of cell membranes, directly influence the folding of membrane proteins. The absence of phosphatidylethanolamine (PE) led to misfolding and reduced protein activity in E. coli bacteria.
A clinical trial found rifaximin effective in preventing travelers' diarrhea, with only 14.74% of participants experiencing symptoms after two weeks of daily dosing. The antibiotic lacks side effects and does not stimulate resistance in bacteria, making it a promising preventive measure.
The ALLHAT study confirms diuretics are superior to newer drugs in lowering blood pressure and preventing complications. Diuretics were also found to be more effective in reducing high blood pressure and preventing stroke in black patients.
A recent study found that removing a specific protein from mice with chronic lung disease led to increased inflammation and damage. The discovery contradicts previous theories suggesting the protein's potential benefits in treating asthma.
Researchers found that ultrasound therapy increased clot clearance by 26% compared to tPA alone, with 70% of patients experiencing complete or partial clearance. The study used a hand-held extracranial ultrasound device to deliver heavy doses of the clot-busting drug tPA directly to blood clots.
Researchers will pinpoint the genetic cause of Thiel-Behnke, a rare corneal dystrophy, using a $1.1 million NEI grant. The study aims to improve diagnosis and treatment options for other types of corneal dystrophies.
Researchers have found that fat buildup in the heart muscle, called lipotoxicity, is associated with metabolic irregularities and insulin resistance in obese and diabetic patients. Gene expression and protein findings provide potential long-term targets for treating heart failure, which affects 5 million US patients annually.
The study reveals how botulism-causing Clostridium botulinum detects nitric oxide, shedding light on its role in human cardiovascular, neurological, and immunological systems. The research also provides insights into the structural details of soluble guanylyl cyclase, a protein difficult to crystallize for analysis.
The UT Prevention Research Center will continue its work in translating research into practice, with a focus on Texas youth and communities. The center's programs, including Coordinated Approach to Child Health and Familias, aim to prevent health-related problems such as diabetes and asthma.
Researchers found a novel rhodopsin protein in bacteria that can distinguish between blue and orange light, enabling more efficient harvesting of light for photosynthesis. This discovery sheds light on the role of cell membranes in biological functions and has potential applications in nano-machinery as a color-sensor.
The University of Texas-Houston has established a Specialized Center of Research (SCOR) in scleroderma, a chronic disease with no known effective treatment or prevention. The center will conduct investigations into the genetic and environmental factors that affect susceptibility to the disease.
Researchers have identified key features of cardiac troponin C, a protein that regulates muscle contraction. The study's findings may lead to the development of new therapies for patients with congestive heart failure, by targeting calcium binding to regulatory proteins.
Researchers at UT-Houston Medical School discovered that growth factor TGF-Beta plays a key role in forming long-term memories. The study found that TGF-Beta produces stronger electrical nerve cell connections, similar to those observed in animals with enhanced withdrawal response triggered by behavioral training.
Researchers at UT-Houston Institute of Molecular Medicine have discovered sentrin, a protein that protects cells from apoptosis by blocking Fas/APO-1 and TNFR receptors. This finding has significant implications for the diagnosis and treatment of cardiovascular diseases, cancer, and degenerative diseases such as arthritis and Alzheimer's.