Researchers at the University of Toronto have developed a next-generation RNA therapeutic approach that can treat a wide range of genetic diseases by helping cells read through premature stop signals. The approach, centered on transfer RNA, has shown promise in laboratory and preclinical models of cystic fibrosis, and may be combined w...
Researchers at the University of Toronto have developed a suite of low-cost, portable biotechnology tools to improve access to laboratory research and diagnostics in resource-limited settings. The decentralized biomanufacturing systems enable local production of high-value biological materials, reducing reliance on fragile internationa...
A new AI-driven system, LUMI-lab, has discovered a new class of mRNA-boosting lipids that enhance transfection efficiency. Brominated lipid tails were found to deliver mRNA into human lung cells more efficiently than approved benchmarks.
A new study shows that starting opioid agonist treatment after a hospitalization for toxicity can cut the risk of a repeat event almost in half. The research found that only about 12% of people who experienced a toxicity started OAT within 30 days, but it was highly effective in reducing repeat toxicity.
A new study presents a tumour-customizable mRNA nanomedicine platform that demonstrated efficient mRNA delivery to cancer cells while minimizing harm to healthy tissues. The platform elicited a strong immune response, effectively turning
New research from the University of Toronto warns that applying trade tariffs on Canadian pharmaceuticals could add $750 million in cost to the U.S. market and disrupt drug supply chains. The study highlights the potential for shortages and jeopardizes patient care, particularly for medications with no alternative supplier.
New research shows that routine symptom screening using a validated tool (SSPedi) can reduce symptom burden and support implementing care pathways for improved symptom management. This study found a clinically meaningful decrease in total symptom score, with 12 of 15 symptoms measured showing significant improvement.
Researchers at the University of Toronto have discovered a novel ionizable lipid nanoparticle that enables efficient muscle-focused mRNA delivery while minimizing off-target effects. The study demonstrates potent cellular immune responses and potential as a viable candidate for cancer vaccine development.
Researchers designed a new long-acting injectable drug formulation using machine learning algorithms, achieving a slow-release rate in just one iteration. The study demonstrates the potential for machine learning to accelerate the development of innovative drug delivery technologies.
A novel diagnostic platform has been developed for rapid, low-cost and decentralized patient testing for infectious diseases like Zika. The platform achieved a diagnostic accuracy of 98.5% with 268 patient samples collected in Recife, Brazil.
A new study found that oral bisphosphonates risedronate and alendronate equally protect against hip fractures during a 2-year drug holiday. However, the risk increases slightly for those taking a break from risedronate.
A study by University of Toronto researchers found that using prescription stimulant medications increased the risk of cardiovascular events by 40% in older adults within the first 30 days. The risk was highest during initial use, but decreased over time as patients stopped taking the medication.
Researchers have created a biohybrid system that combines gene circuits with electrodes to detect specific nucleic acid sequences. This approach enables parallel detection of multiple pathogens and has the potential to transform medicine, biotech, academic research, food safety, and other applications.
Researchers at U of T have developed growth factor-mimicking antibodies that can induce tissue repair in the body. The antibodies, called FLAgs, mimic key proteins called Wnt that normally instruct stem cells to form tissue.
Researchers discovered multiple potential targets for glioblastoma by systematically profiling patient-derived brain tumour cells. They found that adult glioblastoma cells rely on genes important for brain development in infancy, highlighting the need for new research to understand the developing human brain.
The CARD System, an evidence-based approach, reduces vaccine-associated pain, fear, and fainting in school-based clinics. Implementing this system in Ontario schools improved student symptoms and increased use of the tools.
Scientists at the University of Toronto are developing a new nanoparticle sensor technology to detect and visually identify pathogens that cause Healthcare-Associated Infections (HAIs). The system, called OptiSolve Insight, will enable rapid detection and effective decontamination of surfaces, potentially reducing illness rates.
The article highlights the need for fundamental changes in pharmacy practice to effectively and safely meet society's healthcare needs. Key findings include repurposing physical layouts, optimizing workflow processes, and integrating pharmacists into patient care plans with eHealth technology and interprofessional teamwork.
Scientists at University of Toronto's Leslie Dan Faculty of Pharmacy have developed a combination approach using nanoparticles to improve chemotherapy response and boost anti-tumor immunity in breast cancer. The treatment resulted in a 60% cure rate and enhanced life expectancy by five-fold compared to treating with chemotherapy alone.