Researchers identified NOX-1 as a key molecular target to prolong ketamine's therapeutic benefits. Combining ketamine with NOX-1 inhibitors significantly extended its antidepressant-like effects. K-4, a novel AMPAR modulator, also showed rapid antidepressant effects that persisted for at least 2 weeks.
A new PET imaging study reveals that ketamine relieves treatment-resistant depression by altering AMPAR in brain regions, providing potential biomarker for personalized treatment. The study found that ketamine increased AMPAR density in several cortical regions and decreased it in reward-related areas, strongly correlating with reducti...
Researchers found a significant increase in AMPA receptors across Long COVID patients' brains, correlating with cognitive impairment severity. This discovery provides a direct biological explanation for brain fog symptoms and may lead to novel treatments.
Researchers discover edonerpic maleate enhances neural plasticity, supporting cortical reorganization and improving motor control in non-human primates with SCI. The compound promotes AMPA receptor movement to areas responsible for motor control, strengthening existing neural connections.
Researchers developed a method to visualize AMPA receptors using PET scans, revealing differences in density and distribution between healthy subjects and those with psychiatric disorders. This discovery may lead to new diagnostic and therapeutic approaches for conditions like schizophrenia, bipolar disorder, and autism spectrum disorder.
Volatile organic compounds (VOCs) are a serious cause of concern in wildfire emissions. Researchers found that information on combustion temperatures can help estimate VOC emissions, with over 70% of variability explained by two temperature factors for 22 long-lived VOCs.
Researchers used a radiotracer to investigate AMPAR trafficking in patients with epilepsy, finding a positive correlation between cell surface AMPAR density and gamma activity. The study suggests that Hebbian and homeostatic plasticity differentially regulate brain function in epilepsy.