Articles tagged with Tissue Engineering
A pioneering study has successfully implanted autologous tissue-engineered vascular grafts in dialysis patients, with a majority of the grafts functioning for six to 20 months after implantation. The novel approach uses cells harvested from the patient's own skin to create the grafts without synthetic scaffolds or biomaterials.
Researchers at Brown University have successfully grown and assembled living microtissues into complex three-dimensional structures, advancing tissue engineering. The breakthrough could eventually reduce the need for certain kinds of animal research, with implications for basic cell biology, drug discovery, and tissue research.
Eben Alsberg, a biomedical engineering professor at Case Western Reserve University, has received the Ellison Medical Foundation New Scholar in Aging award. The award provides funding for his project to develop novel microenvironmental technology to rescue chondrogenic potential of mesenchymal stem cells from aged individuals.
Researchers at Rice and UT-Houston will lead a $2 million DOD-funded project to develop new tissue engineering technologies and novel reconstructive surgical techniques for facial reconstruction. The goal is to quickly grow large volumes of bone tissue to aid wounded soldiers.
The study outlines strategic directions in tissue engineering, focusing on angiogenic control, stem cell science, and molecular/systems biology to provide engineered tissues with adequate blood supply and integrate knowledge at the cellular and molecular level.
Researchers at MIT have developed a method to create three-dimensional microparticles using ultraviolet light, offering unprecedented control over size, shape, and texture. The particles can be designed with specific chemical properties, such as porosity, making them suitable for use in medical diagnostics and tissue engineering.
Cornell engineers develop gel scaffold that can nourish growing tissues, supplying oxygen and nutrients. The system mimics a vascular system at the cellular scale, allowing for fine-tuning of biochemical environments and desired tissue outcomes.
Xinqiao Jia is awarded a National Science Foundation Faculty Early Career Development Award for her work on developing strong, yet soft and flexible biomaterials for engineering damaged tissues. Her goal is to create hybrid materials that can respond rapidly and reversibly to mechanical forces.
Researchers successfully engineered human cartilage using tissue engineering methods, demonstrating potential for therapeutic applications. The study also found that osteogenic protein-1 enhances cartilage production when added to chondrocytes on scaffolds.
Dr. David Mooney is recognized for his groundbreaking work on tissue engineering and tissue regeneration, including blood vessel and bone regeneration. He will receive the IADR Isaac Schour Memorial Award, a prestigious honor acknowledging outstanding scientific contributions in the field.
Researchers at the University of Bristol successfully regenerated cartilage in injured knees using bioengineered tissue implants. The study showed that engineered cartilage tissue can grow and mature even in knees affected by osteoarthritis, offering a promising approach to treating joint damage.
Dental stem cells have been characterized for their potential to differentiate into various tooth tissue types. The study aims to define the molecular and differentiation profiles of these cells, enabling ongoing tooth tissue engineering efforts.
Researchers developed engineered tissue that can conduct electricity, potentially replacing pacemakers in children with heart block. The tissue was tested in rats and shown to integrate with surrounding heart tissue, establishing an electrical conduction pathway.
Researchers have made significant breakthroughs in developing biohybrid lung devices, regenerative potential of stem cells, biomechanical training of tissue constructs, and artificial esophagus using extracellular matrix scaffolds. These advancements aim to restore function of damaged or diseased tissues and organs.
Researchers at Rice University have developed a self-assembly method to grow dime-sized disks of cartilage with properties approaching native tissue. The technique uses only donor cells, eliminating rejection risks, and has been refined to produce virtually identical cartilage in terms of mechanical and biochemical makeup.
Researchers successfully produced blood vessels within heart muscle tissue, showing significant improvement in heart function. The tissue-engineered construct remained viable even after three weeks of implantation, maintaining cardiac specific function.
Researchers created a simplified version of cardiac tissue using cells from neonatal rats, mimicking normal heart tissue. The study found that pace-setting pulses successfully halted the abnormal rhythm 80% of the time, but in 20% of cases, it worsened the condition.
Researchers at Virginia Tech have developed a new bone tissue engineering material using amorphous calcium phosphates, which they believe could lead to faster and higher quality bone formation. The team's work, in collaboration with the American Dental Association, is currently in press for several scientific journals.
Researchers have developed a new tissue-engineered vessel made from the patient's own cells, which can replace synthetic grafts used in coronary bypass surgeries. The first human trial showed promising results, with no failures noted during the first five months of use.
The University of Liverpool is leading a major €17 million European tissue engineering project, funded by the European Commission. The project aims to develop cost-effective methods for generating precise tissue types specific to individual patients.
Researchers have developed a bank of fetal skin cells that can provide burned patients with high-quality skin substitutes, closing wounds in just over two weeks. The technique has great potential for tissue engineering and could simplify the surgical process.
Researchers at Vanderbilt University have created a new approach to tissue engineering that allows for the growth of predictable volumes of bone on demand. This method involves creating a 'bioreactor' space under the periosteum, a thin outer layer covering long bones, and filling it with a gel containing calcium to stimulate bone growth.
Researchers are exploring new technologies to regenerate bone, enhance ligament healing, produce tissue-engineered cartilage and improve bone healing with stem cells derived from muscle. These advances hold promise for treating devastating congenital or traumatic problems and preventing degenerative processes in the aging population.
Tissue engineering aims to regenerate human tissue through artificial means, mimicking the body's natural processes. Researchers at U-M School of Dentistry are working on combining therapies to improve tissue engineering outcomes, such as using parathyroid hormone and bone morphogenetic proteins.
Jeffrey A. Hubbell will receive the Elmer Gaden Award, a $1000 prize, and an acknowledgement in an upcoming journal issue. The award lecture will be held on March 15, 2005, at the American Chemical Society's National Meeting in San Diego.
Mikos has developed extensive expertise in fabricating synthetic materials with tailored chemistries for specific tissue-engineered repair of orthopaedic injuries. His laboratory has created novel materials based on fumaric acid, non-toxic to surrounding cells and tissues.
The Center will focus on designing biodegradable tissue engineering scaffolds and novel bioreactors to optimize stem cell responses toward new tissue formation. It will also host collaborations with other laboratories to enhance core projects, such as tissue engineering of human ligaments using transfected adult stem cells.
Dr. Anseth's team has developed an injectable scaffold to regenerate cartilaginous tissue using light-activated chemistries, with potential applications in treating Parkinson's disease by injecting stem cells into human brains.
Researchers at UMHS have developed re-engineered blood vessels that can be used in heart bypass surgery, lower extremity bypasses, and tissue transfers. The new method reduces the risk of rejection by using the host's own cells, increasing the likelihood of success.
Researchers at Rice University are working on growing replacement cartilage for the meniscus, a kidney-shaped wedge of cartilage that cushions stress in the knee joint. By developing methods to simulate mechanical conditions and grow tissue in precise shapes, they aim to create more effective treatments for osteoarthritis.
Researchers developed a new tissue-engineering technique using fibroblast and endothelial cells to create functional blood vessels. The engineered vessels demonstrated durability and resistance to blood clots in laboratory tests and short-term animal experiments.
Researchers at MIT have created a biodegradable polymer called biorubber that can stretch and snap back into shape, mimicking the elasticity of human organs. This breakthrough material has potential applications in tissue engineering, including heart tissue, blood vessels, and whole organs for transplantation.
Researchers have successfully engineered cardiac tissue, a crucial step towards repairing damaged heart tissue and testing new drugs. The team characterized the tissues' structural and electrical properties, identifying key parameters for growth and development.