Articles tagged with Genetic Technology
Researchers developed a novel technology to engineer proteins targeting specific DNA sequences, offering a new approach to gene therapies. The system generates engineered zinc fingers that bind to any given sequence of DNA, potentially treating diseases caused by genetic mutations.
Scientists recreated ancient human and Denisovan noses to compare their olfactory receptor genes, finding differences in sensitivity to various odors. This research sheds light on how our closest genetic relatives perceived and interacted with their environment.
A study by Tokyo Institute of Technology mapped how singlet oxygen molecules travel along DNA strands, shedding light on their propagation and oxidation patterns. The research could lead to more efficient and selective photosensitizer agents for targeted photodynamic therapy, a promising cancer treatment.
Researchers at Children's Hospital of Philadelphia developed ESPRESSO, a new computational tool that can accurately discover and quantify RNA molecules from error-prone long-read RNA sequencing data. This will enable better diagnosis of rare genetic diseases and discovery of potential therapeutic targets in cancer.
Researchers have identified the genetic secrets behind skullcap's anti-cancer activity, enabling the production of synthetic compounds. The discovery is expected to lead to more sustainable and rapid synthesis of cancer-fighting molecules.
Research from Brigham and Women's Hospital found that genetic analysis can identify up to 65% more A2 donors, increasing potential kidney transplants for recipient candidates with blood type B. This could improve availability and equity in kidney transplantation.
A new study standardizes the use of optical genome mapping (OGM) for patients with blood cancers, demonstrating its potential as a frontline test for diagnosing hematologic malignancies. OGM outperforms existing tests in detecting cancer-causing gene variants and identifying additional information that can improve patient outcomes.
Researchers developed a flexible genetic hacking system to convert split gene drives into full gene drives, enabling safe testing and potential real-world applications. The new system revealed surprising fitness costs of full drive systems, with slower-than-predicted spread rates in cage experiments.
A WSU-led survey found that US consumers value grape taste more than gene editing, with appearance and pesticide concerns ranking second and third respectively. Most participants were indifferent to the use of CRISPR technology in table grapes.
A new AI algorithm, STORK-A, can predict IVF embryo viability with 70% accuracy, reducing the need for invasive genetic testing. The algorithm analyzes microscope images of embryos and incorporates information about maternal age and IVF clinic scoring to detect aneuploidy.
A global registry for gene-drive modified organisms could facilitate transparent communication, monitor ecological impacts, and inform local decision-making. Experts agree that a registry is necessary for the fair development, testing, and use of gene-drive technologies.
Scientists have identified two-million-year-old DNA fragments in northern Greenland's Ice Age sediment, providing insights into the past ecosystem and its potential to predict climate change. The discovery has sparked hopes that it could help academics build a picture of the DNA evolution of species still in existence today.
Researchers at Cornell University discover how to modulate the affinity of Cas proteins, enabling precise gene editing and reducing off-target effects. By modifying guide RNAs, they can tune Cas removal, contributing to future CRISPR applications.
Researchers found that longer chromosomal arms are always thicker throughout eukaryotic species, providing insights into mitotic chromosomal structure. This study challenges current perspectives on mitotic chromosome formation and may lead to new ways to prevent chromosome miscarriage and cancer cell formation.
Using an AI, researchers successfully designed synthetic DNA that controls protein production in cells. The technology can speed up the development of vaccines, drugs for severe diseases, and alternative food proteins.
Researchers have developed a new approach to stopping viral infections using a live-attenuated DNA virus vaccine. The method employs centanamycin to generate an altered virus that can't reproduce inside cells, stimulating the host's immune system to recognize and eliminate the invading virus particles.
A new statistical method called CLIMB provides a more efficient way to analyze genomic data across multiple conditions. The method combines principles from two traditional techniques, reducing computational intensity and producing biologically interpretable results.
A new CRISPR genome editing treatment has shown promising results in alleviating swelling and reducing the frequency of attacks in hereditary angioedema patients. The treatment, NTLA-2002, targets the KLKB1 gene and reduces kallikrein production, a protein responsible for debilitating swelling attacks.
Researchers developed a world-first proof of concept for t-CRISPR technology to control invasive mice. The technology induces female infertility in the target population, eradicating an island population of 200,000 mice in around 20 years.
Scientists at NTU Singapore have successfully modified a plant protein to increase vegetable oil yield. By improving the binding affinity of WRI1, the team was able to enhance oil accumulation in seeds by 15-18% under laboratory conditions.
A new study by UCL researchers found that tailoring whole genome sequencing analysis to individual patients can double the diagnostic rates of rare diseases. The personalised approach increased the diagnostic rate from 16.7% to 31.4%, detecting potential disease-causing variants in a further 3.9% of patients.
A new technology called RADARS allows scientists to detect and target specific cell types and states, opening up potential applications in diagnostics and therapeutics. The platform detects a particular RNA sequence in live cells and produces a protein of interest in response.
Researchers at the University of Alabama at Birmingham have identified TBX20 as a vital regulator of direct human cardiac reprogramming. Adding TBX20 to existing cocktails improves contractility and mitochondrial function in reprogrammed heart muscle cells, suggesting a therapeutic potential for TBX20.
A collaborative team at IGB discovered 30 new compounds, including three with antibacterial properties, using the Illinois Biological Foundry for Advanced Biomanufacturing. The platform allowed for rapid screening of hundreds of genes and pathways, enabling the researchers to identify potential anti-microbial compounds.
Genetic and genomic technologies can protect marine life by identifying illegally harvested seafood products and monitoring disease outbreaks. Assisted evolution and synthetic biology could also benefit ocean ecosystems by introducing beneficial species or manufacturing products in the lab.
A new CRISPR-Cas approach, SpRYgests, allows for precise DNA cleavage at any sequence, expanding the utility of molecular cloning approaches. This innovation simplifies and expedites DNA editing and has potential clinical implications.
Researchers at Northwestern University developed a new CRISPR-based therapy platform that can deliver cargo to a broader range of tissue and cell types, increasing its potential for treating various diseases. The platform achieves this by transforming the Cas-9 protein into a spherical nucleic acid and loading it with critical components.
Researchers have identified a single mutation in the MDS3 gene that improves yeast's tolerance to carbon dioxide pressure, resulting in full-flavored beer. This breakthrough could lead to improved quality beer production worldwide.
Scientists from NTU Singapore have discovered that telomeres are stacked in columns like a spring, leaving DNA exposed to damage. This finding could improve understanding of how humans age and develop cancer, with potential treatments for diseases caused by dysfunctional telomeres.
Researchers at the University of South Australia are using new technologies to speed up blood cancer diagnosis and treatment. The project aims to identify genetic variants that cause cancer, enabling clinicians to provide targeted treatments and improve patient management.
Researchers engineered mosquitoes to produce compounds that stunt malaria parasite growth, reducing the risk of disease transmission. The technique could be combined with gene drive technology to drastically cut malaria transmission in real-world settings.
Researchers at Gladstone Institutes and UCSF have developed a new approach to introduce long DNA sequences into cells with remarkable efficiency. The technology, which uses single-stranded DNA templates, overcomes the limitations of traditional viral vectors and has the potential to make cell therapies faster, better, and less expensive.
Researchers at UVA have discovered the mechanism behind gene regulation during organ development, shedding light on how genetic material interacts with transcription factors to create different cell types. The study's findings could offer insights into the initiation of certain cancers and inspire new therapeutic development.
Scientists at Kyoto University developed two methods to identify RNA modifications impacting gene regulation and disease. Their approach uses probability algorithms with high-throughput sequencing technology, distinguishing pseudouridine substitutions from other base changes.
Researchers at the University of California San Diego have developed a precision-guided sterile insect technique (pgSIT) to control invasive fruit fly populations. The technology uses CRISPR editing to target key genes in female viability and male fertility, resulting in a fertility dead end for the species.
The study reveals that environmental conditions cause RNA structures to change, affecting plant flowering times and potentially leading to more desirable traits. This technology can also be applied to human cells, enabling the design of RNA-based therapies for diseases like SARS-COV-2.
Researchers have mapped RNA diversity in human tissues at unprecedented depth, discovering tens of thousands of novel transcripts. The study used long read sequencing to catalog the genetic code's transcripts, shedding light on how genetic and environmental differences affect gene regulation.
The American College of Physicians (ACP) has issued a position paper on the ethical use of genetic testing and precision medicine in internal medicine. The guidelines address key issues such as incidental findings, education for physicians and patients, and counseling needs. ACP emphasizes the need for ongoing surveillance and anticoag...
A new study from Tel Aviv University found that CRISPR therapeutics can lead to a significant loss of genetic material in treated cells, potentially destabilizing the genome and promoting cancer. The researchers detected up to 10% of cells with lost chromosomes, highlighting the need for extra care when using this technology.
Researchers at Indiana University School of Medicine used tissue nanotransfection (TNT) technology to edit genes in chronic wound tissue, rescuing wound healing. The study found that gene silencing due to DNA methylation was a critical barrier to wound closure.
Researchers track changes in fitness landscapes as viruses and hosts undergo ongoing survival competition. The study reveals that coevolution propels adaptations, with viruses innovating to overcome host resistance. This new understanding provides a quantitative framework for predicting evolution in coevolving ecological communities.
Researchers created a detailed map of how immune genes function together, shedding light on the basic drivers of immune cell function and immune diseases. The study found interconnected regulatory networks that can help explain why mutations in different genes lead to the same disease or how drugs impact multiple immune proteins.
A team of researchers developed a mathematical model to simulate the impact of gene drives on mammal populations at a landscape scale. The X-shredder drive has been shown to potentially eradicate mice, rats, and rabbits, but with varying probabilities of success and eradication times ranging from 18 to 48 years.
A new CRISPR strategy, employing natural DNA repair machinery, provides a foundation for novel gene therapy strategies to cure genetic diseases. The technique, known as homologous chromosome-templated repair, uses "nicks" of single DNA strands to correct genetic defects.
The Emu project effectively identifies bacterial species by leveraging long DNA sequences spanning the entire length of the gene under study. This approach facilitates the analysis of key genes in microbiome researchers' efforts to sort out harmful and helpful bacteria.
Researchers at New York University have created artificial Hox genes using synthetic DNA technology and genomic engineering in stem cells. The findings confirm that clusters of Hox genes help cells learn and remember where they are in the body, with no other genes needed to be present.
A Danish research study has made significant discoveries about the CRISPR/Cas9 protein and its gRNA component, enabling more accurate gene modification. The findings aim to optimize the effectiveness of gene editing, addressing concerns over 'off-target effects'.
Delft University of Technology researchers successfully added human muscle genes to yeast cells, governed by a group of ten vital genes. The modified yeast model will aid medical scientists in studying diseases like cancer and testing new treatments.
A collaborative team of scientists has discovered 15 additional genetic mutations in the KCNK9 gene that cause a neurodevelopmental syndrome. The study provides definitive diagnoses to 21 families worldwide, offering new insights into the disorder's symptoms and treatment options.
Researchers used nanopore sequencing to detect specific genomic disorders in a fraction of the time it takes traditional testing. The study showed that diagnosis of larger chromosomal alterations could be made in one day, while smaller CNVs took two days.
Researchers have created a new electrical test to screen hundreds of gene mutations, pinpointing harmful mutations that cause inherited heart disorders and sudden death. The breakthrough can identify genetic variants associated with neurological conditions, muscle and kidney diseases.
Researchers developed a genetic test that diagnoses primary immunodeficiency disorders (PID), revealing inherited genetic defects in nearly half of patients. The test uses next-generation sequencing technology to identify specific gene variants associated with PID, enabling targeted treatment and earlier intervention for family members.
A new genome-editing strategy called DAP array can correct dozens of errors at the same time with high precision and efficiency, avoiding off-target edits. The technique leverages tRNA to drive multiple guide RNAs on a single array, then released individually by cells to direct genome editors for edits at multiple human genomic sites.
Researchers developed a droplet-based microfluidic technology to produce micro-organospheres from cancer patient biopsies within an hour. These miniature tumors retain the original microenvironment and can be used for testing many drug conditions, showing almost perfect correlation with actual clinical treatment outcomes.
Researchers developed a deep learning-based model to predict drug-drug interactions using gene expression data. The DeSIDE-DDI model can identify potentially dangerous pairs and act as a drug safety monitoring system, helping establish the correct usage of drugs in the development phase.
Researchers at WFIRM have developed a novel method to refine CRISPR/Cas9 gene editing, increasing efficiency and decreasing large DNA deletions. The technique, which fuses DNA polymerase I or the Klenow fragment to Cas9, improves safety and functional editing outcomes.
Scientists have successfully developed a gene-editing platform called TALED that can perform A-to-G base conversion in mitochondria, the final missing piece of the puzzle in gene-editing technology. This breakthrough has significant implications for treating previously incurable genetic diseases caused by mutations in mitochondrial DNA.
A recent study published in Genome Biology and Evolution found that ancient human remains from Bulgaria are more closely related to contemporary East Asians than Europeans. The researchers propose a scenario where an African population hub expanded into Europe and East Asia around 45,000 years ago, with the European representatives dec...
A new study introduces a commercially available test that enables laboratories with real-time PCR capabilities to detect known SARS-CoV-2 variants. The assay is faster and more cost-effective than traditional sequencing methods, allowing for more widespread tracking of circulating variants.
The T2T consortium's completed human genome has shown significant improvements in DNA sequencing accuracy, correcting tens of thousands of errors and revealing millions of genetic variations. This new reference genome can support the analysis of over 200 genes of medical relevance, potentially propelling research into genetic disorders.