Articles tagged with Genetic Technology
Researchers have identified a new mechanism by which phages evade CRISPR-Cas immune systems in bacteria, revealing a potential approach to make gene editing safer and more efficient. This discovery could lead to the development of bespoke anti-CRISPRs to neutralize CRISPR-Cas systems and provide an alternative to antibiotics.
A new specimen collection system has been developed to enhance assisted reproductive technologies by providing a simple one-step method for selecting high-quality sperm for ICSI. The system, known as NovaSort, uses a barrier mesh to isolate mobile sperm without damaging their DNA.
Researchers have discovered a novel enzyme family related to bacterial pathogenicity in Gram-negative bacteria. The study revealed that enzymes involved in OPG synthesis and regulation play crucial roles in bacterial infection capability.
The team created a glycoengineering platform that simplifies the production of customized sugar carbohydrates, known as glycans, which play a crucial role in various therapeutic applications. This innovation enables the engineering of new glycans with unprecedented flexibility, addressing limitations in existing approaches.
Researchers found a quantitative difference in B cell response following vaccination between young and older adults, with younger adults mounting a stronger clonal response and older adults having more activated B cells. This study provides insights into the age-related differences in B cell vaccine response and may lead to the develop...
The Keck School of Medicine of USC has received a $2 million grant from the California Institute of Regenerative Medicine to further enhance its cutting-edge cGMP Laboratory. The funding will support the adoption of advanced technologies, including an electronic quality management system and optimized cell therapy manufacturing processes.
A new CRISPR-based gene therapy platform will be developed to target genetic brain diseases like Angelman syndrome and H1-4 syndrome. The platform utilizes a novel delivery technology called STEP (Stimuli-responsive Traceless Engineering Platform), which has the capacity to revolutionize genome-editing therapy.
A new study published in Exp. Mol. Med. has identified Thrap3 as a key player in exacerbating non-alcoholic fatty liver disease (NAFLD) by inhibiting AMPK, a crucial regulator of fat metabolism. Inhibiting Thrap3 expression presents a promising avenue for treating NAFLD.
Researchers discovered protein p53's role in regulating sociability, repetitive behavior, and hippocampus-related learning and memory in mice. Lowering p53 levels led to changes in gene expressions related to behavior, while elevated p53 levels were linked to positive learning outcomes.
A UMass Amherst neuroscientist is mapping the brain of a sea slug to study how neurons are added to functional neural circuits, shedding light on how this process contributes to neurological conditions. The project aims to provide an unprecedented look at brain development and potentially inform human brain development.
Researchers developed a technology to rapidly screen genetic edits in immune cells, identifying a new combination that improves their effectiveness against cancers. By combining multiple genes into long DNA stretches and testing thousands of combinations, scientists discovered that different CARs can be optimized by different factors.
A Pittsburgh-based surveillance system detected a drug-resistant Pseudomonas aeruginosa infection linked to artificial tears months before the national public health alert. The findings demonstrate the effectiveness of whole genome sequencing-based surveillance in detecting outbreaks and preventing nationwide cases.
Researchers identified distinct genomic characteristics that impact prognosis for patients with triple negative apocrine carcinoma. The study confirmed a five-year disease-free survival rate of 92.2% for these patients, significantly higher than those diagnosed with other types of TNBC.
Researchers discovered NSMF protein's role in alleviating DNA replication stress by displacing weakly bound RPA proteins and promoting phosphorylation. This mechanism accelerates relief of replication stress, offering a new direction for treating various diseases, including cancer and age-related conditions.
A new technology has identified a genetic abnormality causing xeroderma pigmentosum (XP)-F, a skin disorder. The technique effectively reversed many cellular phenotypes associated with XP and may be effective for genetic treatments of other diseases.
Researchers unveil a groundbreaking MRI technology that non-invasively assesses brain iron homeostasis, shedding light on its role in normal brain function, aging, and disease. The technology offers sensitivity to changes in iron mobilization capacity and can differentiate between tumor tissue and healthy tissue.
A recent study has successfully predicted potential drug outcomes and side effects by analyzing the discrepancy in gene perturbation effects between cells and humans. Researchers used machine learning to forecast drug approvals, improving reliability over conventional methods that only consider chemical properties.
The study presents a pioneering detection tool that combines molecular biology and electronics to identify various pathogenic agents. The technology has demonstrated remarkable sensitivity detecting as few as 10 target molecules and rapid results under one hour.
A new genotyping method called Single Primer Enrichment Technology (SPET) was used to investigate the genetic diversity of lettuce and identify genomic regions underlying important agronomic traits. The study revealed over 80,000 high-quality SNPs, allowing researchers to group accessions by type and geographic origin.
Scientists engineer bacteria to target cancer cells, utilizing NIR fluorescence and photothermal conversion to selectively eliminate malignant cells. The study demonstrates effective optical and immunological functions in a mouse model of colon cancer.
A new gene-editing technique combines peptide nucleic acids and prokaryotic Argonautes to introduce targeted breaks in the genome. The approach, called PNP editing, offers advantages over CRISPR-based methods, including improved specificity and targeting.
The 3D-BRICKS project aims to develop a new family of 3D nanotransistors using DNA technologies, reducing production costs and increasing computing power. By leveraging carbon nanotubes and self-assembling materials, researchers hope to create compact and efficient nano-transistors.
A global team of experts outlines a roadmap for creating a comprehensive and inclusive reference work on human skin cell composition. The proposed Human Skin Cell Atlas will provide a standardized framework for semi-automated mapping of patient-specific changes in skin diseases, supporting personalized medicine.
A novel CRISPR-based gene-editing treatment, EBT-001, effectively removes SIV from the genomes of non-human primates without off-target effects. The study's findings support the development of a cure for HIV/AIDS in humans and pave the way for ongoing clinical trials.
Researchers at Children's Hospital of Philadelphia developed TEQUILA-seq, a cost-effective technology for targeted long-read RNA sequencing. This innovation enables accurate accounting of all RNA molecules emanating from a single gene, crucial for understanding diseases like cancer.
A research group at Kyoto University has successfully developed a self-fertile buckwheat variety and a new type of the crop with a sticky texture. This breakthrough could contribute to the efficient breeding of less-common orphan crops, addressing the world's growing food demands.
A new machine-learning method, BigMHC, can accurately predict cancer-related protein fragments that may trigger an immune system response. By leveraging massive data through transfer learning, BigMHC enables scientists to develop personalized immunotherapies and vaccines by identifying the most likely to provoke an immune response.
Biologists argue that building on genomic sequencing momentum is critical in society's response to future pandemics. The technology improved during the COVID-19 pandemic, but gaps remain in global infrastructure and data sharing.
Researchers have identified a genetic cause for virgin birth in female flies, allowing them to reproduce without males. The ability is passed down through generations of females and can be induced in an animal that usually reproduces sexually.
Researchers found that mutations in the Pro1 protein enable the rice blast fungus to thrive through increased conidia release. This finding suggests an adaptive advantage for the pathogen, potentially linked to its loss of female fertility.
Researchers at WVU have developed a way to view synthetic DNA at the atomic level, enabling them to understand how to change its structure for enhanced scissor-like function. This breakthrough could lead to new technology for medical diagnoses and treatments, including potential therapies for diseases like retinal degeneration and cancer.
Researchers found significant relationships between the cows' genetic merit and their calves' performance. The genomic prediction tool allowed farmers to make informed decisions that enhance sustainable profitability.
A novel stress signalling system has been discovered by SMART researchers, enabling bacteria cells to adapt and survive against the immune system and certain antibiotics. The breakthrough discovery of RlmN as a stress sensor may lead to the development of new therapies to combat antimicrobial resistance.
A new study has created the largest single-cell atlas of the human kidney, mapping healthy and diseased cell states across over 90 patients. The atlas reveals that certain cell types in the kidney get stuck in a 'maladaptive repair state,' leading to disease progression and irreversible reduction of kidney functions.
Scientists have developed a new genetic technology called Ifegenia that suppresses populations of Anopheles gambiae mosquitoes, which primarily spread malaria in Africa. The system targets females, which are the primary disease carriers, and kills them, halting parasite transmission.
Researchers use base editing technology to restart fetal hemoglobin expression in SCD patient cells, achieving higher and more stable levels than other genome editing technologies. The approach has potential as a 'one-size-fits-all' treatment for all mutations that cause SCD and beta-thalassemia.
Researchers have isolated and analyzed individual immune cells targeting the hepatitis C virus, providing valuable data for vaccine development. The study found that antiviral treatment reduces cytotoxicity in HCV-specific immune cells, offering a potential pathway to an effective vaccine.
Researchers discovered a TIR1/AFB-independent auxin signaling mechanism in Klebsormidium nitens, a primitive alga. They identified KnRAV as a key transcription factor that activates auxin-inducible genes and binds to promoter sequences.
Researchers have developed a new method to control the movement of individual DNA molecules through a nanopore, allowing for higher accuracy in sequencing and analysis. This breakthrough has the potential to improve diagnostic and sequencing applications, including peptide sequencing.
Researchers at UCL have developed base-edited T-cells that can fight leukemia, showing promise in a NHS clinical trial. Three patients with relapsed T-cell leukaemia were treated with the cells, with one patient experiencing complete remission after just four weeks.
Researchers found that L1 jumping genes can be widely activated in normal cells, leading to the accumulation of genomic mutations over time. The study highlights the critical role of epigenetic changes in regulating L1 jumping gene activity.
Scientists at Temple University have developed a novel gene-editing strategy that disrupts the ability of HIV-1 virus to enter host cells by targeting a rare genetic disorder. This approach may offer another target for developing next-generation CRISPR technology for HIV elimination, while avoiding adverse effects on cell mortality.
Researchers discovered that MSH2-MSH3 plays a crucial role in selecting the right DNA repair process by interacting with other proteins during DSB repair. This interaction facilitates error-free homologous recombination and blocks error-prone polymerase theta-mediated end-joining.
Researchers used machine learning to identify 'synthetic extreme' DNA sequences that are active in humans but not fruit flies. These rare sequences have potential practical applications in biotechnology and biomedical research.
A new University of Florida study reveals high-quality human DNA in various environments, including beaches, rivers, and air samples. The findings raise significant ethical concerns about consent and privacy, highlighting the need for policymakers to develop regulations.
Researchers have engineered a new CRISPR-based drug candidate targeting E. coli directly while preserving the microbiome. The innovative treatment has shown promise in reducing E. coli burden in mice and is now in phase 1 clinical trials to treat blood cancer patients and prevent deadly infections.
Scientists have developed a new method to deliver genetic information to stem cells using nanoparticles coated with a specific polymer, enabling more efficient control over cellular differentiation. This innovation has the potential to improve the efficiency and effectiveness of regenerative medicine treatments.
Researchers at Temple University and the University of Nebraska Medical Center developed a novel dual gene-editing approach that can effectively eliminate HIV infection. The therapy targets both HIV-1, the virus responsible for AIDS, and CCR5, a co-receptor that facilitates viral entry into cells.
Researchers develop PrimeRoot, a tool for efficient and precise targeted insertion of large DNA segments in plants, achieving efficiencies up to 6% and inserting segments up to 11.1 kb.
A new review paper highlights the potential of fungal biotechnology to advance various industries. By manipulating fungal genomes, researchers can develop bioinformatic tools and create sustainable biomaterials, such as machine learning algorithms for predicting mycological patterns or fungal batteries.
Researchers used prime editing to correct the mutation that causes sickle cell disease, restoring normal blood parameters in mice. The approach showed promising results with up to 41% conversion of mutated cells to healthy ones.
Researchers have developed a new technology to sequence individual mitochondria in single cells, allowing for unbiased analysis of full-length mtDNA. This has revealed complex patterns of pathogenic mtDNA mutations and the potential risks of off-target mutations in genetic editing strategies.
Researchers developed an optimized genome-editing method that vastly reduces mutations, enabling more effective treatment of genetic diseases. The new technique uses a 'safeguard gRNA' to control DNA cleavage, reducing off-target effects and cytotoxicity.
Genetic welding proposes using CRISPR-Cas9 technology to rapidly change evolutionary courses in animals or plants. Cutting argues that this method requires scientific and ethical scrutiny before its application.
James Chappell, a Rice University bioscientist, has won a National Science Foundation CAREER Award to create RNA programming methods for microbial communities in natural habitats. His research aims to improve human health and the environment by genetically manipulating microbial communities.
Researchers used long-read sequencing to identify novel mutational patterns and complex genomic rearrangements in cancer genomes, including those associated with liposarcoma. This approach offers a more comprehensive understanding of DNA mutations and their impact on cell function.
Researchers used C-trap technology to investigate how different DNA repair proteins identify and bind to their respective forms of damage. They found that some proteins arrived at the damage site together and departed together, while others showed surprising variability in their association and dissociation patterns. The study provides...
Researchers at Duke-NUS Medical School have devised a way to rapidly and precisely measure the length of a single telomere, opening doors to developing lifestyle interventions that slow ageing and prevent disease. The novel approach uses DNA sequences called 'telobaits' to latch onto the ends of telomeres in large pools of DNA fragments.
A new nonhuman primate model of Usher syndrome has been confirmed, providing hope for the development of a treatment for this leading cause of blindness-deafness. The model, created using CRISPR/Cas9 technology, exhibits symptoms similar to those experienced by humans with the condition.
A survey found that a substantial portion of Americans are willing to use polygenic embryo screening and gene editing to increase the chances of having a baby admitted to a top-100 ranked college. The study suggests growing interest in using genetic technologies to influence offspring traits, including educational attainment.