Articles tagged with Genetic Technology
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers identified a genetic weakness in drug-resistant Mycobacterium tuberculosis, allowing them to develop targeted drugs. This technology has the potential to combat other drug-resistant pathogens and prevent their spread.
The study explores gene fusion technologies, including FISH, PCR, IHC, ECL, and NGS, to detect biomarkers in tumor diagnosis. AI-driven detection and comprehensive genome-wide analysis using NGS and bioinformatic tools enhance diagnostic accuracy.
A new study uses CRISPR-Cas13 to identify nearly 800 noncoding RNAs that are functional and essential for cell function, including in cancer and human development. The researchers found that these RNA molecules modulate key pathways for cell proliferation and can serve as potential biomarkers and therapeutic targets for cancer treatment.
The CRISPR tool was successfully used to correct a genetic defect in cells affected by chronic granulomatous disease. However, the repair process also introduced new genetic defects, highlighting the need for caution when using CRISPR technology in clinical settings.
Researchers at Kumamoto University have developed a cutting-edge diagnostic tool, Intelli-OVI, to rapidly identify emerging SARS-CoV-2 variants. This system combines advanced DNA detection technology with computational algorithms to offer a quicker and more cost-effective method of monitoring viral mutations.
The new biosensor detects symmetric dimethylarginine in urine, providing a more accurate indicator of kidney health than creatinine. It can identify mild kidney impairment and offers a reliable alternative to blood tests, enabling timely interventions and potential long-term outcomes.
Researchers at Tel Aviv University have discovered a new cancer mechanism that prevents the immune system from attacking tumors. The discovery was made by reversing this mechanism, which stimulates the immune system to fight cancer cells, including those resistant to prevailing forms of immunotherapy.
A new co-culture system uses photosynthetic microorganisms to remove waste products and enhance muscle cell growth, resulting in a 30% reduction of lactate and over 90% reduction of ammonia. This innovation provides a low-cost, sustainable alternative to animal serum for cultured meat production.
Researchers have used ancient DNA to corroborate a 800-year-old Norse saga about King Sverre Sigurdsson's military raid. The study reveals details about the 'Well-man,' including his likely blue eyes, blond hair, and ancestral origins in southern Norway.
The new approach utilizes epigenetic principles to encode digital information onto existing DNA strands, significantly increasing storage capacity and reducing costs. The technique enables the storage of vast amounts of data in a minuscule space for long durations, offering a major shift from conventional storage technologies.
A new study found compositional and functional differences in the gut microbiota of Chinese long-living adults (over 90 years) compared to elderly adults (65–74 years). The researchers noted lower relative abundances of bacteria in certain genera, which may regulate biological processes like autophagy and telomere maintenance. These fi...
A new study in mice shows a unique mRNA delivery method can successfully edit faulty genes in fetal brain cells. The technology has the potential to stop progression of genetic-based neurodevelopmental conditions like Angelman syndrome and Rett syndrome before birth.
Understanding plant-to-plant communication through VOCs can lead to innovative strategies for crop protection and yield improvement, potentially revolutionizing sustainable agriculture. This review explores the molecular pathways behind this complex biochemical strategy and its potential applications.
The Colorectal Cancer Alliance's Project Cure CRC has awarded nearly $5 million in research grants to advance urgent science in colorectal cancer. Recent awardees are working on topics such as radioimmunotherapy, CRISPR technology, and the protein drug ProAgio to better understand and treat this disease.
Dr. Fyodor Urnav proposes a set of initiatives to address the crisis, including pooling patients by syndrome and permitting multiple gene editors in a single Investigational New Drug application. This approach aims to accelerate the development of CRISPR therapies for rare genetic diseases.
The ASHG 2024 Annual Meeting will showcase the latest research in human genetics and genomics. The event will feature a Presidential Symposium on Mendelian traits and a Distinguished Speakers Symposium on the promise of human genetics and genomics, among other sessions.
A large-scale study of children with genetic disorders found that thousands benefited from targeted treatments and support after receiving a genetic diagnosis, with over 20% able to start or adjust therapies. Researchers expect this number to grow as new genetic therapies develop.
A research team at IIT has identified a molecular signature in triple-negative breast cancer cells that can predict the formation of metastases and chemotherapy resistance. The study used single-cell sequencing to track the evolution of cancer cells over time, revealing key epigenetic features involved in tumor development.
A new magnetic gene therapy technology allows for precise control of specific brain circuits non-invasively with magnetic fields. The technology has shown promise in reducing abnormal movements in a mouse model of Parkinson's disease, and may have potential applications for treating psychiatric disorders and chronic pain.
Researchers developed a novel single-cell genome approach to analyze microbial diversity and genetic features, recovering 300 missed bacterial species and providing insights into antibiotic resistance genes and gene exchange networks. The study has potential applications in public health, environmental monitoring, and agriculture.
A team of researchers has successfully created the first artificial cell nuclei in living mouse eggs by injecting purified DNA, revealing key mechanisms behind nucleus formation. The study provides crucial insights into nuclear function and structure, with potential applications in reviving extinct animals and creating artificial life.
Researchers at Institute of Science Tokyo create terpene-based chiral capsules that facilitate the easy preparation of well-defined host–guest composites with tunable chiroptical properties. The resulting composites can be used in water without organic solvents, paving the way for advances in cutting-edge optical technologies.
A research team developed an RNA-based sensor platform that can regulate gene expression in bacteria, mimicking natural biological interactions. The START platform enables tunable control over sensor response and detection of various molecules, including drugs and proteins.
The ASAP Global Center at the University of Illinois will integrate international teams and scientific disciplines to tackle global challenges like improving feedstock-crop performance and converting plant matter into fuel. The center aims to generate crucial knowledge, empower communities, and strengthen global cooperation.
A new brain-mapping neurotechnology called Single Transcriptome Assisted Rabies Tracing (START) has been developed to map the brain's intricate neuronal connections. The technique combines two advanced technologies to resolve cortical connectivity at the resolution of transcriptomic cell types, enabling the identification of distinct p...
Ancient DNA analysis reveals the Viking Age trade routes of walrus ivory, confirming early encounters between European Norse and North American Indigenous peoples. Genetic fingerprinting identified specific Arctic hunting grounds as the source of traded ivory.
In this study, researchers from Tokyo Institute of Technology found that hydrogen sulfide-dependent transcription factor YgaV regulates iron uptake dynamics in Escherichia coli. The team observed elevated intracellular H2S levels resulting in increased antibiotic resistance and upregulated genes involved in sulfur metabolism.
Researchers at Tokyo Institute of Technology developed a method to precisely control the timing of DNA droplet division, mimicking biological Liquid-Liquid Phase Separation (LLPS) droplets. This breakthrough enables precise control over synthetic droplet dynamics, key to developing bio-inspired systems.
A new study from Stanford University provides a tool for conservationists and law enforcement to protect captive tigers and prosecute wildlife crimes. The researchers analyzed the genetic diversity of privately held tigers in the US, finding that many are a mix of wild tiger ancestry, but also reflect characteristics of the illegal trade.
A new study has identified key factors to build food resilience in Sub-Saharan Africa, including diversifying suppliers, empowering local farmers, and promoting sustainable practices. The proposed blueprint aims to enhance self-sufficiency and reduce reliance on external sources.
Researchers at Boston University discovered a new method to harness self-amplifying RNA to create more effective vaccines. The modified saRNA vaccine protected mice from severe COVID-19 disease with a lower dose than current mRNA vaccines. Longer duration of protein expression and reduced inflammation were also observed.
Researchers have identified a surprising surge in thyroid and corticoid gene activity during the early larval stage of the Malabar grouper, which could help address disease management challenges in aquaculture. The study provides new insights into the complex hormone-driven processes underlying fish development and metamorphosis.
Researchers have developed an integrated optical sensor capable of detecting dopamine directly from unprocessed blood samples. This breakthrough enables low-cost and efficient screening tools for various neurological conditions and cancers.
Researchers at Gladstone Institutes have developed a streamlined way to engineer bacteriophages, viruses that naturally kill bacteria. The new technique uses retrons to edit phage genomes, allowing for the creation of numerous variants and paving the way for alternative treatments for antibiotic-resistant infections.
Researchers at Tel Aviv University used modern technologies to challenge the long-held myth that the Roman siege of Masada lasted three years. The study found that the siege actually lasted no more than a few weeks, using precise measurements and 3D digital modeling to calculate the time it took to build the siege system.
A McGill-led study found significant shifts in certain gut bacteria corresponding to changes in liver and intestinal genes, suggesting spaceflight may suppress the immune system and alter metabolism. The research could help ensure the success of future space missions and medical advancements on Earth.
The LENN system protects and efficiently releases NA therapies within the cytoplasm of target cells, overcoming low efficiencies and immune system clearance issues. It is biomanufacturable, biodegradable, and highly tunable, targeting a variety of cells depending on their tumor-specific surface markers.
Researchers have demonstrated DNA-based technologies that can store, retrieve, compute, erase, and rewrite data. The technology uses soft polymer materials with unique morphologies to create a structure with high surface area for depositing DNA, enabling the full range of operations found in traditional electronic devices.
The International Space Station National Laboratory is collaborating with NASA to fund up to $4 million in research addressing significant diseases like cancer, cardiovascular disease, and neurodegenerative disease. The joint solicitation aims to leverage microgravity to improve existing or develop new technologies for health problems ...
A Chinese Medical Journal study developed an AI-based system to automate embryo selection and eliminate subjectivity in IVF. The system improved human embryo assessment and selection, achieving higher accuracy in embryo aneuploidy screening than experienced embryologists.
Protein misfolding is a critical factor in neurodegenerative diseases. CRISPR/Cas9 technology allows precise modifications of genes associated with these disorders, potentially halting or reversing disease progression.
The CRISPR/Cas9 system has been adapted for genome visualization, enabling the study of chromatin dynamics and genome organization in living cells. Recent advancements have expanded its applications to live cell imaging, providing a robust tool for visualizing genomic loci.
Researchers from POSTECH and KRICT created a 3D artificial lung using bioprinting technology, closely mimicking the human respiratory tract. This model allows for accurate testing of COVID-19 drugs and development of therapeutic treatments, potentially shortening the drug development process to under 5 years.
The Rice University lab has developed a new noninvasive technique, called REMIS, that can measure gene expression and gene therapy delivery in specific brain regions using ultrasound. This technology could revolutionize brain-based gene therapy for neurodegenerative diseases.
A study published in Future Foods found that German consumers are willing to try and buy cheese produced through precision fermentation. Emphasizing high product quality and environmental benefits increases acceptance, while concerns about traditional agriculture reduce willingness to purchase.
Researchers investigated the effects of initial microbiota on microbial succession during eggplant fermentation, finding two distinct patterns of LAB dominance. They also identified Lactiplantibacillus plantarum as a primary contributor to lactic acid production and nutrient content.
Scientists successfully mapped transcriptomes from 1.3 million brain cortex cells to gain molecular insights into Alzheimer's vulnerability and resilience. The resulting atlas holds promise for gene and molecular discovery across pathways affecting brain health.
Scientists improve stability and bioavailability of mRNA nanocarriers using triphenylphosphonium, leading to increased protein production in tumor tissues. The TPP-based system also shows higher mRNA levels in blood after 30 minutes compared to amine-based micelles.
Researchers have developed a smart RNA capable of regulating gene expression in response to various signals, enabling the precise design of gene therapies and advanced personalized treatments for diseases.
Researchers have developed ENGRAM, a method that records cell signals and biological states as they occur inside living cells. This approach offers a novel way to capture biological information in living systems, potentially helping answer questions about cellular pasts and futures.
Historical DNA barcodes from over a century old butterfly specimens help classify a group of rare Calinaginae butterflies. The classification sheds new light on the taxonomy of this insect group.
Researchers have developed a new method called PUMA that uses CRISPR-Cas12 nucleases to detect RNA biomarkers. This technology overcomes limitations of existing methods by reprogramming tracrRNAs to recognize specific RNA targets, enabling precise detection without requiring a specific recognition sequence.
Researchers developed an innovative gene-writing technology based on R2 retrotransposons, enabling efficient and precise targeted gene integration in human cells. The en-R2Tg system achieves high gene integration specificity at the 28S rDNA safe harbor site, reducing mutagenesis risks.
Researchers have designed a novel Co-STAR receptor that combines genetic components of four types of immune cells to recognize and fight cancer cells. In laboratory studies, the Co-STAR receptor induced a sustained anti-tumor response against human cancer cells, leading to long-lasting remissions in mouse models.
A CHARMed collaboration has created a set of molecular tools called CHARMs that can turn off disease-causing genes, including those coding for the prion protein. The tools have shown promise in silencing the prion protein gene and improving or eliminating disease symptoms in animals.
The special issue explores challenges and opportunities in managing synthetic genomics risks, introducing a common global baseline for nucleic acid synthesis screening. Review articles provide insights into enhancing gene synthesis security and biosecurity practices of synthetic DNA providers.
The RENEW system, launched in 2022, uses new research discoveries to pinpoint genetic variants causing rare diseases. Researchers successfully diagnosed 63 patients out of 1,066 undiagnosed cases with an average diagnosis time of 20 seconds.
Researchers at U of T have harnessed CRISPR to efficiently and precisely control RNA splicing, enabling the systematic interrogation of gene functions and correction of splicing deficiencies in diseases. This new tool allows for targeted activation or repression of alternative exons with high specificity.
Scientists have discovered that ADGRF5 helps maintain the integrity of the glomerular filtration barrier, which is critical for filtering waste from the blood. The study found that disrupting ADGRF5 expression led to abnormalities in the glomerular basement membrane and increased albuminuria.
Researchers at EPFL have published an open-source project Tabulae Paralytica, providing a comprehensive understanding of spinal cord injury biology. The study identifies specific neurons and genes involved in recovery and proposes a successful gene therapy derived from its discoveries.