Articles tagged with Genetic Technology
A genomic study reveals koalas experienced a severe population decline around 100,000 years ago due to climate change and habitat loss. This finding overturns earlier studies that suggest human arrival led to the decline.
Scientists have successfully developed wheat with dramatically reduced levels of asparagine, without affecting yield, using CRISPR genome editing. The study resulted in a significant reduction in free asparagine concentrations, up to 93%, without impacting yield, and lower acrylamide formation in food products.
Researchers have discovered a sophisticated 3D scaffold of DNA being built before the genome fully awakens, controlling gene expression and preventing developmental defects. The breakthrough technology, Pico-C, enables high-resolution mapping of the genome's shape, shedding light on its role in human health.
A new Immunology Center will accelerate discoveries in muscle immunology and immune responses to gene therapies. Klaudia Kuranda brings expertise in immunology, onco-immunology, and leadership experience to the center.
The journal explores the convergence of computational biology, artificial intelligence, and healthcare innovation, with a focus on precision medicine and enhanced patient care. Submissions are accepted from researchers, clinicians, and technologists on topics such as AI in medicine, computational genomics, and drug discovery.
The John Innes Centre has been awarded £21.5m in funding to support four precision breeding projects, aiming to reduce emissions and strengthen crop resilience. These projects will help protect two major agricultural crops from diseases, enhance the nutritional content of tomatoes, and develop sustainable sources of rubber.
A major U.S. clinical trial has uncovered a genetic factor that may inform how to optimize the dosing of abiraterone, a widely used hormone treatment for advanced prostate cancer. Researchers found that men who carry a specific version of the gene SULT2A1 clear abiraterone from their bodies more slowly, which could affect how well it w...
Researchers identified specific microbial patterns associated with tumor location, genetic features, and patient outcomes. A new Microbial Risk Score (MRS) offers a practical way to translate complex microbiome data into prognostic insight.
A team of plant biotechnologists at Texas Tech University has developed a groundbreaking method to accelerate crop creation, bypassing the time-consuming process of tissue culture. The new technique enables plants to grow new shoots directly from wounded tissue, eliminating the need for traditional lab-based regeneration steps.
A new method called GenomePAM enables targeted modification of genomes using CRISPR technology. This breakthrough accelerates the development of precision gene editing tools and advances clinical drug development.
The ASHG 2025 Annual Meeting will highlight advancements in rare disease research through long-read sequencing and collaboration. Genetic mechanisms of cancer risk and the clinical impact of latest epilepsy neurogenetics advances will also be showcased, along with decoding human aging and AI-powered genomics.
Researchers at the University of Sydney developed a biological 'artificial intelligence' system called PROTEUS, which can accelerate cycles of evolution and natural selection to create molecules with new functions in weeks. The system has potential applications in finding new medicines and improving gene editing technology like CRISPR.
Researchers demonstrated CycloneSEQ's ability to sequence complete bacterial genomes with long-read data and hybrid assembly methods. This work has improved our understanding of microbial functions by closing gaps in genomic assemblies, particularly for complex bacterial communities.
A Kobe University team developed a DNA base editing technology that enables precise control over microorganism genetic content without using template DNA from other organisms. They successfully applied this technique to industrially important Lactobacillus strains, creating safer probiotics for people with type 2 diabetes.
Researchers analyzed DNA from four generations of a large family to understand genetic mutations and their transmission. They found that the rate of de novo mutations varied by over twenty-fold depending on genome location.
The study reveals that centromeric R-loops play a critical role in ensuring chromosome alignment during oocyte meiotic divisions. Disruption of R-loop homeostasis leads to spindle assembly defects and chromosomal misalignment, highlighting the importance of R-loops in maintaining genomic stability.
The Extant Life Volumetric Imaging System (ELVIS) will test a new holographic microscope on the International Space Station to analyze the adaptability and resilience of microorganisms. The system aims to reveal how life might persist on distant moons and planets, significantly enhancing our search for life outside Earth.
A comprehensive review highlights growing concerns over cyber-biosecurity threats to next-generation DNA sequencing, which could be exploited for data breaches and biothreats. The study recommends practical solutions, including secure protocols, encrypted storage, and AI-powered anomaly detection.
Researchers developed fluorescent polyionic nanoclays that can be customized for medical imaging, sensor technology, and environmental protection. These tiny clay-based materials exhibit high brightness and versatility, enabling precise tuning of optical properties.
Researchers have developed an innovative optical genome mapping technique that can identify structural variants and copy number variations across the entire genome in a single test. The method has been shown to reduce material requirements and improve prognostic stratification for patients with multiple myeloma.
Researchers at MIT engineered bacteria to produce unique wavelengths of light that can be detected using hyperspectral cameras. This technology could enable the development of bacterial sensors for agricultural applications, such as monitoring crop health and detecting pollutants.
Researchers used CRISPR interference to examine every gene in the human genome and discovered a new set of genes contributing to Parkinson's disease risk. The study identified the Commander complex, which regulates lysosomal function and is implicated in PD risk, offering opportunities for new treatments.
The CombPlex technology developed at Weizmann Institute allows for the simultaneous imaging and quantification of nearly two dozen proteins within individual cells. This breakthrough enables researchers to measure lots of proteins at the same time, crucial for understanding tissue function and disease processes.
A new point-of-care technology developed by Northwestern University scientists can detect multiple HIV antigens at high sensitivity in a matter of minutes. The technology uses a nanomechanical platform and tiny cantilevers to measure the binding of p24 antigens to surface antibodies, demonstrating high specificity.
Researchers developed a new viscoelastic model of enzymes, elucidating the intertwined effects of elastic forces and friction forces on enzyme function. This breakthrough allows proteins to be perceived as soft robots or programmable active matter, revolutionizing our understanding of enzymatic catalysis.
Dr. Brian Brown is recognized for his groundbreaking work in gene therapy and functional genomics, which has helped transform the fields and contributed to key advancements in medicine and biotechnology. His innovations have been broadly used across biomedical fields, including cancer, immunology, and genetic disease research.
A team of scientists has created a new method to selectively modify specific proteins in complex biological environments. They achieved this using aptamers and deoxyoxanosine, allowing precise conjugation of desired sites on target proteins. This breakthrough technology has the potential to revolutionize cancer diagnosis and treatment.
Researchers have developed a way to activate adult stem cells from human bone marrow, enabling their expansion outside the body for use in bone marrow regeneration. The new method significantly improves transplant success rates for patients with genetic disorders or those who require a bone marrow transplant.
Yale scientists have developed a new CRISPR-Cas12a tool that allows simultaneous assessment of genetic interactions on various immunological responses to multiple diseases, including cancer. This enables researchers to study complex genetic interactions and their effects involved in many disorders.
A team of scientists has successfully developed a novel platform for diabetes treatment utilizing bioink derived from pancreatic tissue and 3D bioprinting technology. The HICA-V platform replicates the structure and function of the human endocrine pancreas, supporting islet maturation and functional enhancement.
Researchers developed gene-edited lettuce with significantly higher levels of β-carotene, zeaxanthin, and ascorbic acid without compromising plant growth. This breakthrough highlights the potential of gene editing to combat micronutrient deficiencies and improve dietary quality.
The University of Texas at Arlington (UTA) has earned the prestigious R1 designation, recognizing its highest level of research activity. UTA has maintained this classification since 2015 and continues to demonstrate its commitment to innovation and academic excellence.
A new study reveals that overusing genetically engineered corn resistant to rootworm pests has reduced farmers' profits in the Midwest. The research found that pest pressure has shifted towards other areas, making the technology less effective, and its use has become increasingly costly.
Researchers developed a first-of-its-kind nanosensor capable of detecting Fe(II) and Fe(III) in living plants with high spatial and temporal resolution. This innovation enables real-time non-destructive iron tracking, optimizing plant nutrient management and improving crop health.
The Asilomar conference set the groundwork for evidence-based safety guidelines, but regulations hinder scientific innovation. A new focus issue in Trends in Biotechnology explores how genetic modification is regulated.
UTA research projects contributed $59 million to the national economy in 2024, supporting student development and collaboration with other research organizations. The university's research infrastructure, including cutting-edge equipment, helped drive economic impact in North Texas and beyond.
BGI Genomics' Indonesian joint venture signed a partnership agreement to advance prenatal genetic screening technology in Indonesia. The collaboration focuses on extended Non-Invasive Prenatal Test (NIPT-Pro) and Copy Number Variation Sequencing (CNVseq) for early detection of fetal genetic disorders.
The Grubhub Community Fund has awarded the American Heart Association a $2 million grant to support food security, technology innovation, and economic resiliency in New York City and Chicago. The funds will be allocated to up to 12 organizations and entrepreneurs focused on improving health equity and expanding access to capital.
A new method combines traditional histopathology with spatial transcriptomics data to improve understanding of chronic kidney disease lesions at the cellular and molecular levels. This approach has the potential to identify new biomarkers and therapeutic strategies for patients.
University of Queensland researchers have successfully introduced genetic material into plants via their roots using nanoparticle technology, enabling rapid crop improvement. This innovative approach could lead to the development of new crop varieties with improved yield and quality without traditional breeding methods.
Recent advancements in materials science have led to the creation of flexible and lightweight energy storage solutions, overcoming traditional battery limitations. These integrated systems facilitate continuous operation of sensors and processors vital for real-time health monitoring, minimizing reliance on external power sources.
Researchers found a biomarker, RNA Polymerase II (RNAPII), associated with tumor aggressiveness and recurrence in meningioma and breast cancers. The study developed a novel profiling technology, Cleavage Under Targeted Accessible Chromatin (CUTAC), to measure gene transcription activity from DNA, which predicted cancer outcomes.
Researchers use CRISPR/Cas9 and CRISPR/Cpf1 genome editing to precisely edit the promoter region of key high-temperature-responsive gene GhCKI, leading to improved anther development and heat tolerance in cotton. The breakthrough provides novel genetic resources for breeding heat-tolerant cotton varieties.
A new 3D bioprinted gastric cancer model successfully replicates the unique characteristics of individual patients' tissues, predicting drug responses and prognosis with high accuracy. This innovative platform enables rapid evaluation within two weeks, contributing to personalized cancer treatment development.
Researchers at KAIST have discovered a molecular switch that can induce cancer reversal by capturing the moment of critical transition before normal cells become irreversibly cancerous. The technology uses single-cell RNA sequencing data and computer simulation analysis to identify the molecular switch.
Researchers at Kyungpook National University have developed a new approach to map and engineer enzymes for enhanced plastic recycling. They employ landscape profiling to identify efficient biocatalysts for recycling polyethylene terephthalate (PET), producing high-purity monomers under mild conditions.
A new study reveals that long-read sequencing can diagnose rare genetic diseases more accurately, quickly, and affordably. By analyzing longer stretches of DNA, this technology eliminates gaps and provides direct phasing data, improving the diagnostic yield of genetic sequencing.
Genetic testing using high-throughput sequencing (HTS) technology has significantly improved detection rates for thalassemia, offering a valuable model for high-prevalence regions. HTS-based genetic testing offers greater sensitivity and specificity without adding significant costs.
Researchers at La Jolla Institute for Immunology discovered that tissue-resident memory CD8 T cells rise up to fight infections in the small intestine, using spatial transcriptomics technology. These immune cells are split between villi and crypts, with progenitor-like cells replenishing effector T cells.
A novel diagnostic system called TwinDemic Detection offers simultaneous and rapid detection of SARS-CoV-2 and influenza A virus. The system has a detection limit of 0.46 picomolar for CoV and 0.39 pM for IAV, correctly predicting positive and negative samples in high percentages.
Lehigh University bioengineering researcher Tomas Gonzalez-Fernandez is exploring how combining CRISPR with biomaterials can improve gene editing's safety and efficacy for therapeutic use. His NSF CAREER award-funded research aims to develop more targeted and controlled therapies for genetic diseases.
Researchers have developed a new genetic engineering tool, mvGPT, that can precisely edit genes, activate gene expression, and repress genes all at the same time. The technology has shown promise in treating genetic diseases such as Wilson's disease and type I diabetes by targeting multiple genetic conditions simultaneously.
Researchers developed biodegradable polymeric nanoparticles that selectively target cancer cells with two approved drug pairs for skin and breast cancers. The treatment showed significantly enhanced therapeutic effects, reduced tumor size, and prolonged median survival in mice.
Researchers at KAIST have developed a technology that can treat colon cancer by converting cancer cells into normal-like cells. The breakthrough involves creating a digital twin of the gene network associated with normal cell differentiation, leading to significant promise for reversible cancer therapies.
The team developed a Synthetic Translational Coupling Element (SynTCE) that enhances the precision and integration density of genetic circuits in synthetic biology. This allows for more efficient gene circuit integration, minimizing interference between biological parts and enabling precise control over multiple genes.
Researchers discovered a novel platinum complex that targets androgen receptor signaling, inhibiting cell growth and survival in prostate cancer cells. The complex, 5-H-Y, showed stronger cytotoxic effects than cisplatin with minimal toxicity, offering a promising approach to treating advanced prostate cancer.
The partnership aims to improve disease screening and prevention, as well as talent training and medical infrastructure development in Punjab Province. BGI Genomics will focus on localized innovation and genetic technology applications to support precision medicine services in Pakistan.
Researchers at Tokyo University of Science found that kaempferol increases RALDH2 levels in dendritic cells, promoting regulatory T-cell development and reducing inflammation. The study suggests that flavonoids like kaempferol may serve as natural remedies to alleviate allergic symptoms.
Scientists emphasize the need for gene editing and plant domestication to protect food supplies due to the climate crisis. Researchers propose two strategies: introducing genes that support resistance to environmental stress into existing crops or domesticate wild plants with lower yields but higher resilience.
A systematic review and meta-analysis found a slightly higher likelihood of androgenetic alopecia among individuals who consume alcohol, but the association is not statistically significant. The study suggests that further research is needed to clarify whether alcohol impacts AGA risk.