Articles tagged with Genetic Technology
The T2T consortium's completed human genome has shown significant improvements in DNA sequencing accuracy, correcting tens of thousands of errors and revealing millions of genetic variations. This new reference genome can support the analysis of over 200 genes of medical relevance, potentially propelling research into genetic disorders.
Researchers fill in gaps in Human Reference Genome, discovering repetitive sections are a major source of human variation and genetic diversity. The Telomere-2-Telomere project reveals complex architectural features with significant consequences for understanding human evolution and biological function.
A new study introduces a commercially available test that enables laboratories with real-time PCR capabilities to detect known SARS-CoV-2 variants. The assay is faster and more cost-effective than traditional sequencing methods, allowing for more widespread tracking of circulating variants.
Scientists at UC San Diego are working on next-generation gene drive systems based on CRISPR technology to combat malaria and reduce mosquito populations. The $1.4 million grant will support the development of new technologies, including a neutralizing system called ERACR, to mitigate risks associated with gene editing in mosquitoes.
Scientists have developed a new approach to expand the target range of CRISPR/Cas systems, allowing for slight variations in target DNA while maintaining local specificity. This technology could help realize the potential of CRISPR/Cas-based gene therapy and pathogen diagnosis, particularly for diagnostics.
A research team has discovered a genetic sensor of blue light that regulates oil synthesis in industrial microalga, leading to double the microalgal productivity of oils. This finding has major implications for microalgae-based conversion of carbon dioxide to biofuels.
A team of researchers identified a stem rust resistance gene from wild goat grass species Aegilops sharonensis, which can be cross-bred into wheat for immunity against deadly crop pathogens. The genetic potential of this hardy relative has been largely unexplored and holds promise for reducing the threat of the stem rust disease.
Researchers at Northwestern University developed an AI-assisted Nanofountain Probe Electroporation system to engineer stem cells. The new method reduces cell loss and increases throughput, enabling selective manipulation of individual cells in micro-arrays.
A POSTECH research team has developed a technology to select genes from animal models that accurately mimic human diseases. This allows for the prediction of success or failure of animal disease models before making them, leading to more effective new drugs.
Researchers at Toyohashi University of Technology have developed DNA stamper injections using nanoscale-tipped wire arrays to deliver biomolecules into live neuronal cells within brain tissues ex vivo and in vivo. This technique allows for the efficient genetic modification of brain cells, making it a powerful tool for neuronal research.
Researchers developed a novel genetic barcode system to mark cancer cells with different gene modifications and image their characteristics. The Perturb-map platform identified specific genes controlling lung tumor growth, immune composition, and response to immunotherapy, offering new approaches for targeting anti-cancer drugs.
Researchers at Colorado State University are developing an RNA-based method for controlling herbicide-resistant weeds using gene-silencing technology. The goal is to create a non-genetically modified, shelf-stable spray that targets specific strands of RNA in weed cells, leaving crops untouched.
A new DNA test has been developed to identify a range of hard-to-diagnose neurological and neuromuscular genetic diseases quicker and more accurately than existing tests. The test uses Nanopore sequencing technology to scan for abnormally long repeats within patients' genes, which are the hallmarks of disease.
Researchers at the University of Washington developed an AI-designed protein that can awaken individual dormant genes by disabling chemical 'off switches'. This approach allows for safe upregulation of specific genes to affect cell activity without permanently changing the genome.
Researchers have discovered that bioprosthetic heart valve patients develop an immune response against foreign sugars in the valves, leading to calcification and deterioration. By genetically engineering these sugars out of the valves, durability can be increased, offering a potential solution for patients.
CROPSR, an open-source software tool, accelerates CRISPR experiment design and evaluation by addressing challenges in complex crop genomes. The genome-wide approach significantly shortens the time required to design a CRISPR experiment, reducing failed experiments.
Researchers used identical twins to exclude genetic influences and track immune system changes responsible for triggering multiple sclerosis. The study found that an error in the communication of immune cells leads to greater activation of T cells, causing damage in the central nervous system.
Researchers have discovered a spray-induced gene silencing technique that effectively controls late blight, a devastating disease affecting potatoes and tomatoes. This environmentally friendly method has potential to reduce the usage of chemical pesticides and can be quickly adapted for new targets.
Researchers developed a new RNA editing technology that makes efficient use of native ADAR enzymes to correct disease-causing mutations in RNA. The technology holds promise as a gene therapy for treating genetic diseases like Hurler syndrome and cystic fibrosis, with promising results in mouse models.
Researchers develop a new wheat mutant with broad-spectrum powdery mildew resistance, without growth or yield defects. They achieve this through multiplex genome editing, identifying the role of TaTMT3B in alleviating growth penalties associated with MLO disruption.
A recent study published in Developmental Cell reveals that Kras mutation causes chromatin rearrangement, leading to stem-like cell regeneration and tumor onset. The team discovered a protein complex called AP-1 as the mediator of this process, which can be targeted with small-molecule drugs.
Researchers have successfully developed CRISPR-Cas9 inheritance control in male mice by shifting the gene editing window to match the timing of meiosis. This achievement expands the potential for human disease research and environmental applications, offering benefits such as laboratory efficiency improvements and cost savings.
Researchers have developed a highly sensitive immuno-CRISPR assay to detect acute kidney rejection in urine, potentially allowing for early diagnosis without invasive biopsy. The test uses CRISPR/Cas12a gene editing technology to identify biomarkers of rejection, such as CXCL9, with improved sensitivity compared to existing methods.
Researchers developed a microfluidic chip for rapid and simultaneous diagnosis of COVID-19 and influenza diseases, achieving results within 30 minutes. The device uses the LAMP method for genetic amplification and has potential applications in various fields beyond human infectious diseases.
Researchers have created a new approach to edit genes within specific bacteria in a community using CRISPR-Cas9, enabling targeted genetic modifications. This technology could be used to track edited microbes and potentially treat diseases like digestive issues or create more resilient crops.
The inaugural WHO classification of childhood tumors presents a single, updated compendium of all tumor entities in childhood or adolescence, divided by organ sites. This classification incorporates traditional morphology, immunohistochemistry, and molecular characteristics to provide essential criteria for definition of tumor types.
Scientists at Oak Ridge National Laboratory developed a self-detect solution to monitor CRISPR gene editing tools in organisms. The system uses a biosensor guide RNA and reporter protein to trigger the technology's reveal itself, enabling real-time detection of CRISPR activity.
A recent study by NTU Singapore and Singapore General Hospital found that mutations in the DDX3X gene are responsible for chemotherapy resistance in some blood cancer patients. The study also discovered that STAT inhibitors can effectively kill lymphoma cells with DDX3X mutations, providing hope for new treatment options.
Researchers at UC Berkeley have developed a new CRISPR editing technology that enables simultaneous editing of genes in multiple cell types and species within a microbial community. This approach, called community editing, has the potential to track edited microbes and understand their functions within complex ecosystems.
Researchers have developed a powerful new tool that can determine the diversity of hard corals on a reef by analyzing DNA in seawater samples. This method is faster, easier, and less expensive than traditional visual identification, allowing for more accurate coral reef conservation and restoration.
Researchers genetically mapped the cell types of the mouse iris, revealing four new cell types and mapping genetic changes that occur when the iris dilates. This research may help connect genetic similarities between mice and humans, offering clues for developing new diagnostic tests and treatments for eye diseases.
A team of researchers from Lund University has developed a virtual reality tool called CellexalVR to help scientists better understand the complex relationships between genes and cell types. By using VR technology, researchers can visually explore large amounts of genomic data in a more intuitive and collaborative way.
A new study by USC researchers uses a genetic technology to analyze gene expression signatures of individual cancer cells from patients with leukemia. The findings show that cancer cells with distinct gene expression profiles tend to grow in different organs, while those with specific genes are more resistant to chemotherapy.
A new study published in Science Advances has shed light on the genetic basis of human appearance features by investigating the role of Hox genes. The researchers replaced the proboscipedia gene in a common laboratory fruit fly with its counterpart from a rarer Hawaiian cousin, revealing that Hox genes function as scaffolds for downstr...
Researchers at McGill University developed a new technique to manipulate DNA methylation levels at specific genes using CRISPR/Cas9 technology. This approach enables targeted demethylation of genes associated with diseases, such as insulin gene dysregulation in diabetes.
Researchers at UC San Diego have created a CRISPR-based rapid diagnostic technology that detects SARS-CoV-2, the coronavirus causing COVID-19. The new SENSR system is designed to simplify SARS-CoV-2 detection with a goal of eventual adaptation for in-home use.
Researchers at Rutgers University have linked Fragile X and SHANK3 deletion syndrome, both associated with autism and health problems, to walking patterns. The study used motion-sensored sneakers to detect gait problems 15-20 years before clinical diagnosis, offering a potential framework for early intervention.
Researchers found that as icebergs melted, vegetation became scarce, making it difficult for the giant animals to survive. The team analyzed ancient environmental DNA and sequenced plant remains to draw globally significant conclusions.
A novel computational platform called scAAVengr uses single-cell RNA sequencing to quickly evaluate viral vectors for delivering gene therapies to the retina with maximum efficiency and precision. This approach saves time and resources by identifying suitable candidates that can deliver therapy to affected parts of the retina accurately.
A new AI-powered algorithm, GEM, has been developed to quickly identify genetic causes of serious disease in newborns. The technology leverages machine learning and natural language processing to analyze vast amounts of genomic data and clinical records, achieving an accuracy rate of 92% compared to existing tools.
The University of Maryland Center for Environmental Science has sequenced the genome of the blue crab, revealing approximately 24,000 genes and a genome length that is one third of the human genome. This breakthrough will aid in fisheries policies, aquaculture, and potentially track food source origins.
A team of Harvard researchers created an integrated pipeline, STAMPScreen, to help genetic engineers identify target genes and perform screening studies. The protocol combines computational tools with lab experiments to quickly and efficiently test gene function in living cells.
GIST scientists utilized latest advances in single molecule detection to observe the enzymatic activity of gene repair. The study revealed that ExoIII has an affinity for damaged DNA sites, creating a gap that Pol I fills. Understanding this mechanism may lead to technologies for targeted gene repair and drug development.
Researchers at UC San Diego develop precision-guided sterile insect technique (pgSIT) to control mosquito populations. The system uses CRISPR to alter genes linked to male fertility and female flight in Aedes aegypti, reducing disease transmission.
Researchers at UMD are developing CRISPR-Combo systems to improve genome editing and crop regeneration. The technology aims to reduce the time and cost of breeding new crop varieties with enhanced nutritional and agronomic traits.
Scientists are still unraveling how pathogens adapt to changing conditions, including climate change and global trade. Genome sequencing and big data technologies have revealed that dramatic events like hybridization between pathogen species can lead to rapid evolution of virulence on new host plants.
Researchers found that human antibiotic use increased resistance to antibiotics in bears' bacteria, affecting even those far from civilization. The study suggests that reducing antibiotic use can help decline resistance rates.
The new MIC-Drop technology enables rapid evaluation of hundreds of genes in a single experiment, improving large-scale genetic studies. Researchers can identify essential genes for healthy heart development and function.
Researchers identified a genetic mutation in nonhuman primates that closely resembles Pelizaeus-Merzbacher disease, a rare and progressive disorder affecting the central nervous system. The discovery was made possible by a massive genomic database built at OHSU's Oregon National Primate Research Center.
Researchers have mapped the structure of CRISPR-Cas12j3 from bacteriophages, a discovery that reveals how it works and solves packaging problems for genome editing. The new system has vast potential for precise genome editing with improved efficiencies and alternative targeting mechanisms.
Yiping Qi's team will test new delivery technologies for CRISPR-Cas12a to develop a pipeline for genome editing in carrots. They aim to create more nutritious and hypoallergenic carrot varieties with improved nutritional value and reduced allergenicity.
Researchers identified a novel lncRNA, Teshl, which plays a crucial role in the development of Y-bearing sperm and regulates sex chromosome gene expression. The study provides new insights into sex ratio variations and suggests that genetics may be a key factor in human male infertility.
Researchers have developed a new integrative genetic test, LYNX, that analyzes standard and novel molecular markers in common lymphoid neoplasms. The test provides accurate detection of mutations, identification of large genome-wide chromosomal aberrations, and assessment of immunoglobulin and T-cell receptor gene rearrangements.
Researchers successfully tested gene drive technology to control malaria-carrying mosquitoes in large cages mimicking natural environments. The technology, which spreads a genetic modification blocking female reproduction, worked as expected and showed significant population decline within one year.
Researchers created a CRISPR-Cas9-based gene drive that cuts and copies genetic elements in Arabidopsis plants, transmitting specific traits from a single parent. This technology could help plants defend against diseases and grow more productive crops, addressing global food security concerns.
Researchers at UC San Diego have developed a novel genetic sensor called CopyCatcher to detect precise CRISPR editing in cells throughout the body. The study shows promise for treating genetic disorders such as blood diseases, vision and hearing problems, and muscular dystrophy.
Nanoscope Technologies is featuring groundbreaking research on optical gene delivery and functional characterization platform technologies for treating retinal diseases. The company's lead product, vMCO-010, delivers light-sensitive Multi-Characteristics Opsin into retinal cells to restore vision in patients with degeneration.
CRISPR/Cas technology has advanced diagnostics and gene therapy, enabling fast and accurate disease diagnosis and treating untreatable diseases like cancer and blood disorders. Recent advances in CRISPR-Cas technologies are highlighted, with a discussion of the strength and challenges for its future clinical usage.
Scientists report that prime editing successfully shuts down a gene involved in smooth muscle cell differentiation, correcting genetic problems and disease models. Prime editing is less complicated and more precise than traditional CRISPR, with fewer components and no collateral damage.
A combination of three gene drive technologies could effectively suppress a targeted grey squirrel population while limiting the risk to native species. The combined technology introduces genes that induce infertility in females, allowing for population control.