Articles tagged with Genetic Technology
Researchers identified two highly antigenic epitope markers predicting multiple sclerosis in optic neuritis patients, providing a novel blood biomarker. The study utilizes the Mimotope Variation Analysis technology to analyze over 500 clinical samples from Finnish and Estonian patients.
A new gene panel test developed by researchers allows for highly accurate diagnosis of liposarcoma types, distinguishing them from benign tumors and other cancers, with a success rate of 93% and costs of US$270 per case.
The February edition of SLAS Technology features a special collection on Artificial Intelligence in Process Automation, highlighting its applications in drug discovery, automated gene editing, and machine learning. The issue also celebrates the top 10 most-cited articles within the journal's history.
Researchers have developed a method to detect Cas9 protein, a key component of CRISPR/Cas gene editing technology, in human plasma and mouse models. This breakthrough aims to identify athletes who may be using gene doping to gain an unfair advantage.
A multidisciplinary coalition proposes a framework for field trials of gene drive organisms to ensure safe, transparent, and publicly accountable implementation. The core commitments address fair partnership and transparency, product efficacy and safety, regulatory evaluation and risk/benefit assessment, and monitoring and mitigation.
A new analysis in The Lancet Planetary Health finds that innovations to fix the food system could backfire, leading to increased deforestation and environmental degradation. The study highlights the need to anticipate trade-offs when introducing new technologies to improve human health and the planet.
Researchers at the University of Tsukuba used gene editing to introduce diversity into tomatoes, improving their nutrition and environmental sustainability. The study found that 10 out of 12 resulting tomato lines contained high levels of carotenoids, a precursor to vitamin A with antioxidant properties.
Researchers have developed two new genetic systems, e-CHACR and ERACR, to halt or eliminate the spread of gene drives in the wild. These systems use CRISPR technology to neutralize gene drives, which carry the power to immunize mosquitoes against malarial parasites or act as genetic insecticides.
Researchers developed polymeric carriers that can load multiple types of genetic material, improving efficiency and reducing toxicity compared to existing analogues. The technology has the potential to revolutionize gene therapy by delivering two RNA and DNA molecules through a single carrier.
A research team at Toyohashi University of Technology developed a multiplex genetic diagnostic device for early detection and prevention of crop diseases. The device uses loop-mediated isothermal amplification (LAMP) to diagnose multiple plant viral diseases simultaneously within 1 hour.
Researchers at Mount Sinai Hospital have discovered a novel genetic sequencing technology that identified the cause and treatment of a previously unknown severe auto-inflammatory syndrome. The technology, tailored to the patient's own genetic code, pinpointed an unknown mutation in the JAK1 gene causing permanent immune system activation.
Researchers have developed a new technology called OligoFISSEQ that can visualize hundreds to thousands of genomes simultaneously under the microscope. This breakthrough enables researchers to study genome function and organization in unprecedented detail.
Researchers developed a new genome editing strategy using CRISPR to precisely target genes for desirable traits, such as high beta-carotene levels and disease resistance. This approach reduces the need for marker genes and allows for more complex trait clusters.
A new method for developing genetic markers improves transfer rate to 92% in grapevine species, enabling breeders to quickly identify desirable traits. This breakthrough has far-reaching implications for improving fruit quality and responding to climate threats.
A special issue of Biological Invasions co-edited by Laura Meyerson and Daniel Simberloff offers a comprehensive framework for a national early detection and rapid response program to address the growing threat of invasive species. The papers outline technical guidance for implementation, including technology advancement, risk screenin...
A Japanese survey reveals differing perceptions of gene-edited crops among experts and the general public. Experts see benefits, while the public perceives risks despite acknowledging value. The findings shed light on the deficit model's boundaries in science communication.
Researchers analyzed genome-wide genetic data from Japanese pearl oysters to understand their population structure and adaptability. They found that sea surface temperature and oxygen concentration strongly correlated with genetic variation, leading to the discovery of distinct northern and southern populations. The study provides insi...
Neuroscientists at Lund University have developed a new technology to deliver gene therapy to specific cell types, accelerating evolution from millions of years to weeks. The method combines computer simulations and modeling with gene technology and sequencing to tailor virus shells for precise targeting.
A new study reveals that many people in the US carry Native American DNA, inherited from European and African ancestors who intermarried with indigenous individuals during colonization. The analysis shows regional patterns of Native American ancestry among Spanish descendants, distinguishing between early settlers and later immigrants.
A recent study published in Nature Communications found that assisted reproduction technology has a temporary effect on babies' genes, which are largely corrected by adulthood. The study examined the epigenetic changes caused by fertility treatments and found that they resolve by adulthood.
Researchers developed a new gene editing system that simultaneously suppresses proteins inhibiting the immune system in lymphoma cells and activates cytotoxic T lymphocytes. The technology, based on improved CRISPR gene editing, shows promise for treating various diseases including cancer, autoimmune, and inflammatory conditions.
Researchers at SMART and MIT have developed a technology that significantly accelerates the genetic engineering of microbes used to manufacture chemicals for urban farming. The new technology enables faster, cheaper, and more accurate plasmid construction using standard reusable parts.
Researchers from Berkeley Lab and universities explored human evolution by studying chromosome regions. They discovered massive genetic material in centromere-proximal regions, including unique variation in genes that shape our sense of smell. Meanwhile, scientists created new spiraling crystals made of stacked layers of germanium sulf...
Scientists have developed a new genetic tool called iSuRe-Cre that provides certainty in Cre-inducible genetic modifications. This innovation increases the efficiency and reliability of gene function analysis in mice, allowing for precise investigation of gene role during organ development, physiology, and disease.
Researchers use genomics to unravel a 20-year mystery of two rare disorders: Angelman syndrome and P450scc deficiency. By combining genetic tools, they confirm uniparental disomy and shed light on adrenal insufficiency and sex reversal. The study showcases the power of genomic analysis in solving complex genetic cases.
Researchers have created a new gene expression atlas for ALS, providing unparalleled detail on disease progression. The atlas uncovers early changes in the disease and reveals disease-driven changes in signaling pathways across all cell types in the central nervous system.
Researchers at Shinshu University found that a gene influencing snail shell coil direction also plays a key role in snail evolution, potentially leading to the creation of new species. The study reveals that genetic expression levels can determine handedness in snails, with reduced expression resulting in reversed handedness.
Researchers from the University of Edinburgh's Roslin Institute found thousands of errors in recent human genome sequences generated by long-read technologies, even after using corrective software. The team suggests that these technologies should be interpreted with caution due to potential major implications in clinical studies.
Researchers successfully generated human vascular cells with enhanced function through targeted gene editing of the longevity gene FOXO3. These cells demonstrated improved self-renewal, resistance to oxidative injury and therapeutic efficacy in a mouse model of ischemic injury.
A new report highlights the need for effective communication in addressing 'post-normal' science technologies, such as gene drives, which pose a challenge to science journalists. The technology has the potential to reduce malaria deaths but also raises concerns about safety and regulation.
Scientists at UC San Diego developed a new method to control pest populations using precision-guided genetics, resulting in sterile male progeny with 100% efficiency. The 'precision-guided sterile insect technique' (pgSIT) can be applied to various insects, including disease-spreading mosquitoes.
A team of UD engineers has developed a method to use CRISPR/Cas9 technology for conditional gene regulation, introducing a new functionality to the technology. This allows scientists to precisely target and edit DNA within living cells, which could help correct inherited diseases.
Hal S. Alper's research focuses on creating new molecules for plastics, drugs, and other products using sustainable methods. His work has the potential to significantly reduce pollution in the chemical industry.
A new paper urges creation of a coordinating global body to assure neutral evaluation of gene editing's benefits and risks. The technologies have breathtaking promise but also profound concerns about unintended consequences, requiring careful review and inclusion of local communities.
Researchers developed a novel technology to analyze hundreds of genes at single cell level, revealing critical immune system weakness in cancer. The Pro-Code technique identified disease-causing genes and potential drug targets for cancer immunotherapy.
Researchers at Stanford University have developed a new technique called CRISPR-GO, which allows them to manipulate the genome in three-dimensional space. By reorganizing genetic elements in different locations within the nucleus, scientists can alter their function and study the impact on cell behavior.
A majority of Americans support using gene editing to treat serious diseases in babies, but are less accepting of its use to boost intelligence or develop gene editing technology. The survey also found that people with high science knowledge and lower religious commitment tend to view gene editing more positively.
A new gene-editing technology has been discovered by City of Hope scientist Saswati Chatterjee, which can efficiently correct genetic defects in human blood cells. The platform uses adeno-associated viruses to deliver corrective DNA sequences, offering a promising approach for treating diseases such as sickle cell disease and hemophilia.
Researchers from the University of South Australia have developed a lab-on-a-chip technology that can detect a wide range of fetal genetic abnormalities in early pregnancy. The non-invasive test uses blood samples to isolate fetal cells, providing more information for families and healthcare providers.
A new lab diagnosis guide from IDSA and ASM aims to help healthcare providers accurately diagnose infectious diseases with rapid molecular testing. The guide provides detailed guidance on test selection, specimen collection, and laboratory management to ensure accurate diagnosis and treatment.
Researchers used gene editing and stem cell technologies to predict genetic variants associated with hypertrophic cardiomyopathy, a condition that can lead to sudden cardiac death. The study showed promise for improving the accuracy of gene variant interpretation and diagnostic testing.
A recent clinical study found that most parents-to-be want access to information from preconception carrier screening, including genetic variants associated with common disorders. However, the interpretation of these variants remains a significant challenge due to limited knowledge about their effects on health.
Researchers found that reef fish inherit epigenetic changes from their parents, enabling them to cope with warmer ocean temperatures. This adaptation may provide a buffer against the impacts of climate change and allow for genetic adaptation over time.
Researchers aim to develop an optimized cell-free platform to speed up synthetic biology design-build-test-analyze cycles, enabling faster characterization of novel and improved pathways. The proposed technology leverages advances in DNA synthesis, cell-free biosynthesis capabilities, and genome engineering tools.
The active genetics technology has been used to edit gene regulatory elements in fruit flies, revealing new fundamental mechanisms controlling gene activity. The researchers provided experimental validation for using active genetics as an efficient means for targeted gene insertion and single-step replacement of genetic control elements.
Researchers at Osaka University have developed a novel CRISPR-Cas9 method that can introduce precise modifications to defective genes with fewer safety drawbacks. The new technique, called Single Nicking in the target Gene and Donor (SNGD), reduces unintended genetic mutations by up to 95%.
Researchers from Hong Kong University of Science and Technology discovered a new mechanism of action for DISC1, a protein linked to psychiatric disorders. The study found that DISC1 regulates Ndel1's kinetochore attachment during mitosis, leading to cell-cycle deficits in neuronal stem cells.
Researchers at Salk Institute create a new version of CRISPR/Cas9 that can activate genes without creating DNA breaks, potentially treating diseases such as diabetes and muscular dystrophy. The technology operates epigenetically, influencing gene activity without changing the DNA sequence.
A new drug delivery system uses a synthetic-biological hybrid nanocapsule to target and correct diseased cells at the genetic level, reducing side effects. The platform is programmable, modular, and can integrate diverse peptide sequences for tailored treatment.
The new eMAGE method eliminates DNA breakage errors, enabling efficient genetic modifications with high accuracy. This technology has the potential to revolutionize disease treatment, antibiotic production, and industrial biotechnology applications.
Scientists warn against the accidental spread of self-propagating gene drive systems, which could cause significant ecological harm. However, genetic technologies still hold promise for conservation work, but with strict regulations and international cooperation.
Researchers at Max Planck Florida Institute for Neuroscience have developed a new tool called vSLENDR, which enables precise genome editing in post-mitotic neurons of the brain. This breakthrough technology utilizes CRISPR-Cas9 and an adeno-associated virus to increase the efficiency and flexibility of HDR DNA repair.
The World Health Organization has approved tivanisiran as the international nonproprietary name for SYL1001, a compound developed by Sylentis using RNA interference technology. The drug is administered in ophthalmic drops and aims to improve quality of life for patients with dry eye syndrome, a condition affecting millions worldwide.
Researchers have discovered how Cpf1, a new molecular scissor, can act like a GPS to identify its destination in the genome, enabling precise genome modification and repair. The high precision of Cpf1 will improve the use of this technology in repairing genetic damage and other medical applications.
Scientists at UC Berkeley and UC Riverside have developed a gene editing technique using CRISPR/Cas9 technology to suppress mosquitoes carrying diseases like malaria. The new technique, multiplexing, can target multiple locations in a gene simultaneously, increasing the effectiveness of gene drive systems.
The study provides detailed information about the genetics of crop plants, enabling breeders to identify key genes responsible for cell wall properties. By linking this data to specific changes in genetic information, researchers can make targeted improvements to support agricultural industries and biofuel production.
A recent study from Indiana University challenges the use of CRISPR-Cas9 technology to control disease-carrying insect populations. The research found that naturally occurring genetic variation can render CRISPR-based methods ineffective, complicating efforts to prevent diseases like malaria and crop blights.
A new study by Rice University found that religious individuals are more likely to disapprove of reproductive genetic technologies than non-religious people. Evangelical Christians are the most opposed, with 23% deeming disease technologies morally wrong, while 80% of evangelicals reject enhancement technologies.
Researchers envision AAV as a platform for delivering novel tools for genetic manipulation, including CRISPR-Cas9 and RNA interference. The combination of tailored delivery vectors and new editing techniques will enable unique approaches to therapeutic gene expression.
Regulatory agencies struggle to balance public concerns with their authority, as society demands clearer guidelines for advanced technologies like gene editing. Arizona State University expert Gary Marchant proposes incorporating ethical and social aspects into regulations.