Articles tagged with Genetic Technology
A new gene-editing system successfully cured a genetic blood disorder in living mice, offering a minimally invasive treatment for beta thalassemia and sickle cell disease. The technology significantly decreases unwanted gene mutations and uses FDA-approved nanoparticles to deliver PNA molecules.
UCLA scientists used a new technology to analyze DNA and found dozens of genes involved in the development of schizophrenia. The study provides important information on how the disorder originates and may lead to better treatments.
Researchers developed a detailed model system to study the Barr body's highly organized structure, revealing two distinct lobes with smaller active DNA domains. Topologically associating domains play a significant role in gene expression within the otherwise inactive lobes.
A new hybridization-induced aggregation technology detects KRAS mutations in lung and colorectal cancers, enabling targeted therapies. The technique is simple, rapid, and inexpensive, with 100% agreement with sequencing results.
Researchers have improved upon previous assemblies of the gorilla genome using long-read sequencing technology and algorithms, reducing sequence gaps by 96% and closing 94% of previously identified gaps. The new assembly provides a better understanding of genetic variation between humans and non-human primates.
Scientists have developed a process to improve the efficiency of CRISPR, allowing for greater consistency in deleting unwanted genes. By tweaking the sequence of single guide RNA, researchers achieved knockout efficiency of over 50% and hope to increase adoption of this technology.
Researchers suggest using CRISPR-Cas9 technology to introduce a male sex determining gene into female mosquito embryos, potentially reducing disease transmission. The goal is to create sterile or fertile males that outcompete females in the wild.
GW University's Paul Brindley and MIT's Kevin Esvelt are working on a gene drive project to eliminate schistosomiasis using CRISPR technology. The goal is to 'supercharge' evolution, sterilizing and eliminating the disease-causing parasites.
Researchers developed soft robotic grippers to interact with deep sea coral reef organisms without harming them. The grippers' compliant materials matched natural environments, allowing for non-destructive manipulation and sampling of fragile organisms.
McGill University researchers suggest a model for guiding policy on germline gene editing, based on pre-implantation genetic diagnosis after in vitro fertilization. The PGD model provides a robust approach to regulation, outlining medically determined requirements and substantial risk of occurrence for genetic testing.
A team of researchers from Lehigh University and partners studied self-assembled complexes of DNA wrapped around single-wall carbon nanotubes using two-color photoluminescence spectroscopy. They confirmed a fast DNA autoionization rate and demonstrated that DNA holds the nanotube in water without changing its properties.
The partnership aims to improve genomic research efficiency, increase output, and reduce costs. Gene technology will be utilized to create a better life for humanity, with the goal of advancing life sciences research.
Scientists from HKUST and Tsinghua University solved the structure of the MCM2-7 Complex using Cryo Electron Microscopy. The complex plays a key role in destabilizing and unwinding duplex DNA during DNA replication. The team's findings provide new insights into the mechanism and function of the MCM2-7 complex.
A unanimous international consensus reached by 26 scientists recommends specific measures for the responsible conduct of gene drive research. The group calls for all researchers to use multiple confinement strategies to prevent accidental alteration of wild populations.
A new technique has been developed to create tens of thousands of precisely guided probes covering an organism's entire genome for less than $100 in supplies. This enables genetic screening potentially accessible to organisms less well studied, facilitating targeted gene therapy and disease discovery.
The National Academies have launched an international initiative to address the technical, social, and ethical issues surrounding human genome editing. The initiative aims to provide a comprehensive understanding of human genome editing and its implications for improving human health and boosting food production.
Researchers argue that adding genes from wild cousins can strengthen crops without losing natural traits, benefiting organic farmers. Precise genetic engineering could make 'rewilded' crops compatible with organic agriculture values.
Researchers at Yale University successfully corrected the F508del mutation in the cystic fibrosis gene, a lethal genetic disorder. The novel approach uses synthetic molecules to edit the genetic defect, with minimal off-target effects.
The CRISPR-Cas9 technology enables the rapid creation of transgenic mouse models in just three weeks, compared to six months, revolutionizing the study of diseases such as Huntington's and autism. Dr. Feng Zhang's groundbreaking research has made significant progress in deploying and refining this technique for therapeutic applications.
A new single-cell gene expression technology allows for the study of large numbers of genes in tens of thousands to hundreds of thousands of cells at once. The technology uses cell- and molecule-specific barcodes to enable the analysis of gene activity with absolute quantification.
A*STAR scientists identified a genetic pathway responsible for the size of the human brain, which accounts for superior cognitive abilities. The KATNB1 gene is essential for central nervous system development in humans and other animals.
A new technology, known as FISH investigation protocol, optimizes flow cytometry to reveal RNA transcription in cells. This breakthrough enables researchers to study the mechanisms causing diseases and establish drug efficacy.
New clinical data show Vectra DA is a strong predictor of radiographic progression over two years compared to other tests used to assess risk of joint damage. The study found that among patients with low CRP, high Vectra DA scores were associated with increased risk of radiographic progression.
Crescendo Bioscience will showcase new clinical data on Vectra DA at the 2014 ACR Annual Meeting, highlighting its value in assessing RA disease activity and predicting patient risk of joint damage. The company will present two oral presentations and four poster presentations.
Researchers create genetic profile of grape crown gall tumor disease, identifying core microbiome common to 52 sampled tumors. The study aims to improve disease management and crop production of all grape varieties.
Researchers have made significant breakthroughs in understanding the relationship between genetic changes and disease causation using next-generation sequencing technology. Subtle gene changes are now being associated with unique disease presentations, even in previously undiagnosed forms of disease.
A cross-disciplinary team proposes using gene drives to manage ecosystems, potentially combating malaria and other diseases. Gene drives can spread specified genetic alterations through targeted wild populations over many generations.
Researchers have found a unique genetic pattern in leukemia cells of 22 patients diagnosed with cytogenetically normal acute myelogenous leukemia, which may lead to more targeted therapy and definitive prognosis.
The Hastings Center President Emeritus Thomas H. Murray calls for a national conversation about the discretion parents should have in choosing their child's traits. The FDA is considering human testing of mitochondrial manipulation, which could prevent rare diseases and address female infertility, raising concerns about safety and ethics.
The MRC Integrative Epidemiology Unit will conduct cutting-edge research to improve understanding of biological mechanisms and environmental factors underlying common diseases. Researchers will develop novel approaches to analyze data from 'omics' technologies and identify true causes of disease.
Scientists at UC Riverside are using DNA marker-assisted breeding to accelerate the development of new cowpea varieties with desirable traits such as drought tolerance, pest resistance, and high yield. The research aims to improve crop yields in several African countries, supporting USAID's Feed the Future initiative.
Researchers at UNC will sequence the genome of 400 infants to determine useful clinical data from genomic tests. The study aims to build a model for informed choices about newborn testing, including educational tools and parental consent protocols.
Researchers from RIKEN have developed a highly efficient molecular probe, Eprobe, for real-time PCR monitoring and genetic testing. The new technology enables advanced assays for DNA-based genetic testing and helps bring genome-wide sequencing studies to patients in the clinic.
Researchers used single-cell RNA sequencing to track the genetic development of a human and mouse embryo at an unprecedented level of accuracy. The technique could lead to earlier and more accurate diagnoses of genetic diseases, even when the embryo consists of only eight cells.
Seven graduate students and one undergraduate received prestigious poster awards for their research on Caenorhabditis elegans, a model organism used to study human biology and disease. The winners will receive cash prizes, certificates, and a complimentary one-year extension to their GSA membership.
A team from UNIGE developed a biotechnology that enables the direct observation of 'clock genes' in mice for several months. This allows researchers to study molecular mechanisms that regulate internal clocks and their impact on various biological functions.
A new US patent application allows for methods of restoring visual responses using optogenetic compounds, covering channelrhodopsin and halorhodopsin variants. The approved patent will substantively expand RetroSense's IP estate, providing broad protection for their gene therapies.
Researchers discover that defective viruses, once thought useless, increase the spread of disease by 'hitchhiking' with functional viruses. The presence of a defective DENV-1 virus may have led to large increases in dengue fever cases in Myanmar in 2001 and 2002.
Researchers at Northwestern University develop spherical nucleic acids (SNAs) for biomedical applications, offering improved delivery and targeting of therapeutics. SNAs show promise in treating genetic diseases and neurological disorders, including glioblastoma and Alzheimer's disease.
Researchers at the University of Exeter have developed a new genetic sequencing technology to identify novel mutations causing congenital hyperinsulinism. This breakthrough will enable clinicians to make more informed decisions about treatment, reducing the need for invasive procedures.
A study used next-generation sequencing to identify tuberculosis genes in a 19th-century skeleton, revealing a historic strain of the disease. The technology saved time and accurately identified DNA, paving the way for further research into the disease's evolution.
Gene therapy is poised to disrupt traditional treatment methods with its effectiveness in treating diseases such as hemophilia B. The technology has demonstrated feasibility and is expected to bring significant changes to the healthcare marketplace.
The American Chemical Society honors Keith H. Gibson, Andrew J. Barker, and George L. Trainor for their contributions to personalized medicine and genetic sequencing. The trio developed a new drug that helped pioneer the era of 'personalized medicine' for cancer patients.
The Amniochip technology uses microarray technology to detect genetic syndromes with a diagnostic resolution 100 times greater than conventional techniques. This reduces the waiting time for results to 48 hours, compared to three weeks with traditional methods.
A new report highlights concerns about home genetic tests making exaggerated claims to consumers. Medical professionals argue that individuals should be protected from misinterpretation of complex genomic data. Experts call for a balance between public access and responsible marketing practices.
Scientists have identified two genetic mutations that cause metachondromatosis, a rare heritable disorder leading to bony growths, by sequencing the entire genome of one individual. The study uses whole-genome sequencing technology and classic genetic approaches to provide faster identification of Mendelian genes.
Researchers have discovered two mutations in the PTPN11 gene that cause metachondromatosis, a rare heritable disease. The study's findings suggest that next-gen sequencing may rapidly resolve familial diseases and provide insights into other related syndromes.
Researchers identified a gene in the yeast Saccharomyces cerevisiae that enables it to convert five-carbon sugars like xylose into ethanol. This discovery may lead to the development of new, industrially-applicable strains for large-scale bioethanol production.
The study supports the utility of Chronix's serum DNA tests to predict clinical status and monitor disease activity in multiple sclerosis. The findings show that the approach can differentiate periods of active disease attacks from stable periods, providing a real-time measure of disease activity.
Advances in DNA sequencing technology make it possible for consumers to access their 'personal genome' for disease prevention and treatment strategies. The cost of sequencing is expected to drop sharply, raising ethical and legal concerns about genetic information use.
Researchers have successfully created the first transgenic prairie voles, allowing them to investigate the genetic mechanisms of social bonding and its impact on psychiatric disorders. This advancement may lead to new treatments for impairments in social behavior.
A Yale team used whole exome sequencing to identify a mutation in a Turkish baby's genome, leading to a surprise diagnosis and treatment of congenital chloride diarrhea. The approach has potential for dramatic insights into human diseases and could become commonly used in clinical settings.
German researchers have uncovered new details about the heredity of Vitis varieties in cultivation today, potentially breaking a bottleneck in the progress of the wine industry. They discovered a double mutation that could lead to more accurate classification tools and effective marker-assisted breeding methods.
Two studies found that the DISC1 gene regulates neuronal development by interacting with Girdin, an actin-binding protein. Disrupted interactions lead to abnormal neurogenesis and a disorganized hippocampus. Pharmacological inhibition of mTOR rescues defects in neuronal development.
Idaho researchers have been awarded a three-year grant to explore novel approaches to gene therapies by targeting specific sections of chromosomes with locked nucleic acids. The team aims to improve targeting and show its impact on genes, potentially leading to new treatments for genetic diseases.
Researchers have generated the first partial genomic sequence of waterhemp, a Midwestern weed resistant to herbicides. The data will help identify resistance mechanisms and inform strategies to combat it.
A systematic review methodology is proposed to collate and synthesize high-quality research evidence on gene-disease associations. The approach emphasizes identifying true genetic associations amidst a large volume of false positives.
Genetic testing has significantly improved the detection of individuals at risk for sudden cardiac death in athletes. This technology enables informed decision-making regarding care and training continuation among athletes. However, its use in asymptomatic genetic carriers with normal phenotypes is a topic of controversy.
Scientists have pinpointed the FCER1A gene as a major factor in allergic diseases, influencing IgE antibody production and leading to conditions like hay fever and asthma. The discovery has potential for guiding new drug development.
Researchers at Mount Sinai School of Medicine have developed a new gene silencing technology that can effectively suppress transcriptional expression of targeted genes in human cells, including those linked to various diseases. This breakthrough could pave the way for preventing diseases where gene dysfunction plays a role.