Research on measurable signals of health and disease. Covers ultrasound imaging pipelines, fetal-distress detection, cancer monitoring, and fatigue biology.
Research shows physically active individuals experience fewer age-related alterations in biomarkers associated with the disease. Regular exercise appears to help prevent physical signs of Alzheimer's in those at risk for the disease.
A new study published in The Journal of Physiology found that an eye-movement test can detect acute sleep loss with high reliability. The researchers used a range of eye-movement measures to distinguish sleep-related impairment from that caused by alcohol or brain injury.
Researchers at KU Leuven have developed a non-invasive biomarker for detecting kidney transplant rejection symptoms after a transplant due to antibody-mediated rejection. The new blood test can identify patients with rejection symptoms earlier and more accurately than current methods, which often rely on invasive biopsies.
Scientists have developed a highly sensitive 'sniff-cam' that can detect low levels of disease biomarkers in breath, including diabetes, lung cancer, and Parkinson's disease. The device uses an ultraviolet ring light, filters, and a camera to measure volatile organic compounds (VOCs) in the breath.
Researchers have developed a miniaturized system that uses low-cost components and smartphones to detect biological viruses. The device is portable, battery-powered and can detect real viruses, holding potential for aid in disease prevention.
Researchers developed a microfluidic concentration method that selectively concentrates proteins and nucleic acids, enabling rapid detection of pathogens and biomarkers. This technique enhanced concentrations by up to a billion-fold within 30 minutes.
A study published in the Journal of Nutrition has linked specific chemical signatures in human hair to a diet of traditional Yup'ik foods. The researchers found that changes in nitrogen isotope ratios along the hair strand correlated with increased consumption of traditional foods like fish and marine mammals.
A novel microfluidics-based system detects clinically significant IL-6 levels for sepsis diagnosis in about 25 minutes using less than a finger prick of blood. This device provides a more sensitive and efficient alternative to traditional assays.
A new study uses amyloid positron emission tomography to track β-amyloid cerebrospinal fluid and monitor Alzheimer's disease progression over six years. The researchers found a significant correlation between β-amyloid levels and cognitive decline, providing valuable insights into the disease's progression.
Researchers investigated the relationship between physical activity, β-amyloid levels, and cognitive decline in clinically normal older adults. Physical activity was found to be associated with reduced cognitive decline and lower β-amyloid levels, suggesting potential neuroprotective effects.
A new AI/ML model developed at UC Davis Health can predict acute kidney injury in burn patients more accurately and quickly than traditional methods. The model achieved 90-100% accuracy for identifying AKI using just routine laboratory results, shortening diagnosis time by nearly a full day.
Research studies using liquid biopsy and ddPCR technology found that mutant BRAF ctDNA levels can predict treatment efficacy in advanced melanoma patients, while ctDNA may not reliably detect brain metastases. Meanwhile, chimeric cell-free DNA tracked tumor recurrence in hepatocellular carcinoma patients.
Scientists at McMaster University have identified biomarkers for Irritable Bowel Syndrome (IBS) in urine, which could lead to better treatments and reduce the need for costly colonoscopy procedures. The study found distinctive metabolic signatures that were elevated in IBS patients, suggesting an impairment of the gut's elastic lining.
Researchers found that two specific biomarkers were elevated in athletes who experienced concussions, indicating potential for longer recovery times. The study suggests these biomarkers could aid in predicting which athletes are more likely to need extended recovery periods after concussion.
Researchers identified a unique biomarker, KLHL11, that targets autoantibodies in men with testicular cancer-associated paraneoplastic encephalitis. The discovery has the potential to diagnose this condition earlier and improve treatment outcomes for patients.
A new biomarker in urine helps detect aggressive prostate cancer, improving detection accuracy and reducing unnecessary treatments. The noninvasive test was found to accurately identify high-risk individuals and achieved similar accuracy as invasive tissue-based tests.
Researchers found that experienced runners showed elevated cardiac biomarkers after ultramarathons, but these levels were below clinical risk thresholds. Novice runners paced themselves below their cardiac limit, using self-selected strategies for safe heart health.
A widely recognized biomarker, CA19-9, is found to promote the development of pancreatic diseases and cancer in genetically engineered mice models. This discovery suggests new treatment strategies for pancreatic cancer and other cancer biomarkers.
Researchers have developed a new method to predict the risk of cardiogenic shock in patients after a heart attack. The tool uses proteomics and biomarkers to identify patients at higher risk, enabling more precise treatment options.
A new biomarker, urinary DKK3, has been identified as a predictor of acute kidney injury (AKI) in patients undergoing cardiac surgery. High preoperative levels of DKK3 are associated with lower kidney function and increased risk of AKI.
Researchers have identified two new biomarkers, ApoB:A1 ratio and metabolomic lipoprotein signatures, to predict cardiovascular risk in juvenile-onset systemic lupus erythematosus (JSLE) patients. These biomarkers can help identify high-risk patients and inform tailored disease treatments.
A recent study published in the Journal of Gerontology: Medical Sciences found that low levels of circulating vitamin K are associated with an increased risk of mobility limitation and disability in older adults. The study, conducted on a sample of 635 men and 688 women aged 70-79 years old, used biomarkers of vitamin K status to evalu...
A new study from Professor Doug VanderLaan's lab found evidence for at least four different subgroups of men, each with distinct biomarkers associated with same-sex attractions. The study suggests that there are multiple and distinct pathways influencing male sexual orientation in men.
Researchers used latent profile analysis to examine biomarkers associated with male sexual orientation in over 800 men. The study identified four subpopulations with differing biomarker profiles, suggesting possible distinct biological mechanisms for nonheterosexual men.
Scientists have created a skin patch with tiny needles to collect interstitial fluid, containing biomarkers of disease. The device uses surface-enhanced Raman scattering to analyze the collected fluid and detect biomarkers more efficiently than traditional methods.
A new meta-analysis of 18 studies found that smoking does not accelerate telomere shortening, challenging the long-held assumption that smoking affects telomere length. Adult telomere length is now considered a static biomarker rather than a dynamic indicator of ageing.
A recent study found that people who restricted their blood flow by wearing inflated blood pressure cuffs on an arm and leg showed signs of more controlled blood flow to their brain. The process, called remote ischemic preconditioning, may be beneficial in preventing neurological diseases such as stroke, Parkinson's disease, and epilepsy.
Researchers at Boston University School of Medicine identified salivary microRNAs that differentiate people with alcohol dependence from healthy controls. The study uses machine learning to predict alcohol dependency with high accuracy, offering potential for early diagnosis and treatment.
Researchers have developed a 3D-printed microchip electrophoresis device that can detect three serum biomarkers of preterm birth with high sensitivity. The device is faster, cheaper, and easier to make than existing methods, which require laborious processes and specialized equipment.
Researchers at the University of Notre Dame have developed a microfluidics platform using extracellular vesicles containing microRNAs for early-stage disease diagnosis, reducing test time by 13 hours.
A study found that metabotropic glutamatergic receptor 5 (mGluR5) availability may serve as a biomarker for suicide risk management in posttraumatic stress disorder (PTSD). Higher mGluR5 levels were associated with suicidal ideation and mood disturbances in individuals with PTSD.
Cognitively normal adults with elevated levels of amyloid-β exhibited mixed attitudes toward physician-assisted death, reflecting complex emotions and values surrounding end-of-life care. The study highlights the need for nuanced discussions about dying wishes and advance care planning in this vulnerable population.
A study suggests that hyperosmotic stress can be used to diagnose ME/CFS, a condition characterized by persistent fatigue and other symptoms. The researchers developed a blood-based assay that measures changes in electrical impedance in response to plasma salt concentrations.
Researchers found that a panel of plasma biomarkers can help identify infants most in need of additional interventions after therapeutic cooling. Cytokines and Tau protein levels changed over time, with peak levels occurring within the first 24 hours and again during rewarmed stages. This study aims to develop a more accurate risk asse...
A risk model has been devised by Dana-Farber Cancer Institute researchers to classify patients with asymptomatic Waldenström macroglobulinemia into low, intermediate, or high risk of developing symptomatic disease. The model uses four biomarkers and was validated on two external cohorts with high accuracy and precision.
The article discusses the potential of liquid biopsy in cancer diagnosis, focusing on targeted disease diagnosis and detection of cancer biomarkers. Researchers have successfully detected specific genetic mutations using digital PCR, identifying promising biomarkers for various cancers, including melanoma and lung squamous cell carcinoma.
The Innovative Medicines Initiative has launched a five-year project to generate exploratory and confirmatory data for novel safety biomarkers. This will improve the diagnosis and management of acute and chronic diseases, as well as reduce safety attrition in drug development.
Researchers have developed a biosynthetic dual-core cell computer using CRISPR-Cas9 components, enabling scalable and flexible computing. This biological system can process up to 100,000 different metabolic molecules per second, far surpassing previous cell computers.
A recent study published in The Gerontologist suggests that the link between caregiving and negative health effects has been overstated. After analyzing data from over three decades of research, Johns Hopkins researchers found a weak association between caregiving and immune system biomarkers.
A team of NJIT researchers has created a novel electrochemical biosensing device that can identify tiny signals of biomarkers emitted by diseases, such as cancer and malaria. The device uses gold nanoparticles to enhance signal response and separates plasma from blood to achieve high accuracy.
Researchers are developing a system to test multiple biomarkers at once and a smartphone-based analysis and reporting system for disease monitoring and home care. They aim to identify predictive biomarkers to empower patients to monitor their own disease and prevent serious complications.
Researchers at Cima, Clínica Universidad de Navarra have identified three biomarkers associated with atrial fibrillation risk, including CITP, MMP-1, and PICP. These biomarkers can help optimize treatment and follow-up for patients with this cardiac ailment.
A collaborative project between C-Path and Japan's PMDA aims to generate critical data for safety decisions in early-stage clinical trials. The study will compare biomarkers in healthy Japanese volunteers with similar Western subjects, informing regulatory submissions.
Researchers found an early atrophy of amygdala and hippocampus in Alzheimer's patients at age 40, differing from normal aging process. Studying biomarkers revealed certain structures shrink before dementia appears.
A new biosensor developed by DGIST's Professor Jae Eun Jang's team can detect biomaterials in real-time without secondary processing or an analyzer. The technology uses plasmonic nanostructures and image signal processing to reveal the colors of colorless biomaterials.
A multi-center study by MD Anderson Cancer Center reveals that a liquid biopsy test, Guardant360, is comparable to standard tissue biopsies in detecting guideline-recommended biomarkers for advanced NSCLC. The test identified four mutations for which FDA-approved drugs exist and offers faster turn-around time.
Researchers have identified a new biomarker, ATOEA, that accurately detects cyanide exposure and persists in the body longer than the toxic compound. This breakthrough enables faster diagnosis and treatment of cyanide poisoning.
A human study published in The FASEB Journal suggests a novel type of biomarker to predict atrial fibrillation progression. Researchers found that patients with persistent atrial fibrillation demonstrated the highest expression of five miRNAs associated with signaling pathways and fibrosis involved in AF.
Research by Thomas Boyce, a CIFAR Fellow, shows that children from lower socio-economic backgrounds have higher levels of cortisol in their saliva and more cavity-causing bacteria around their gums. His study aims to understand why some children struggle and how all can thrive, as explored in his new book The Orchid and the Dandelion.
Researchers at Indiana University School of Medicine have made a breakthrough in developing a blood test that can objectively determine the severity of pain in patients. The test, led by psychiatrist Alexander Niculescu, uses biomarkers found in the blood to match with potential treatment options.
A new study found that people with middle-age chronic inflammation may experience cognitive decline in the decades leading up to old age. Researchers discovered a correlation between high levels of inflammation and steeper declines in thinking and memory skills, particularly in areas of memory.
A new diagnostic technique using infrared imaging and proteomics has identified a protein biomarker called AHNAK2 that can accurately distinguish between bladder cancer and benign inflammation. The technique has been shown to have high sensitivity and specificity in differentiating between various stages of bladder cancer.
A recent study published in Scientific Reports found that smokers demonstrate a higher aging ratio and are predicted to be twice as old as their chronological age compared to nonsmokers. The study used blood biochemistry and artificial intelligence to analyze the impact of smoking on biological age.
Researchers identified racial disparities in Alzheimer's disease diagnosis and progression among African-American participants, who had lower levels of brain protein tau. This may lead to under-recognition of the disease in African-Americans, as they often have lower tau levels than Caucasians, according to a new study.
Researchers found that high ratings for engagement in worthwhile activities are associated with strong personal relationships, healthy lifestyles, sound mental and physical health. High ratings predict healthy lifestyles, increased relationships and socializing, and reduced loneliness, depression, and health issues.
Scientists have found two biomarkers that can be used to identify patients at risk of atrial fibrillation, a heart rhythm disturbance affecting 1.6 million people in the UK. The biomarkers include brain natriuretic peptide and fibroblast growth factor-23.
Researchers analyzed skin cells from over 100 individuals to identify molecular signatures of aging, predicting a person's age with less than eight years error on average. The study's findings provide a foundation for quantitatively addressing unresolved questions in human aging.
Estonian scientists have developed a genetic testing technology called TAC-seq, which enables precise analysis of clinical biomarkers at the single-molecule level. This method raises the precision of biomarker analysis and is poised to make it more affordable.
Researchers tested rats on GM maize MON 810 and NK603 for 6 months, using high-throughput biology techniques. No significant biological markers were found, and anatomic pathology examination revealed no alteration of organs. The study does not detect any harmful effects of the GMOs on rat health or metabolism.
Researchers have identified three biomarkers in saliva samples to detect mild cognitive impairment and Alzheimer's disease. The study uses metabolomics to analyze over 6,000 compounds, showing promising results for a potential clinical test.