Research on measurable signals of health and disease. Covers ultrasound imaging pipelines, fetal-distress detection, cancer monitoring, and fatigue biology.
A new simple blood test developed by the University of Bristol could help doctors diagnose brain tumors earlier, using fluorescent carbon dots and nanophotonics. The test aims to detect biomarkers such as Glial fibrillary acidic protein (GFAP) in blood samples.
A study published in JAMA found that polygenic risk scores are not a reliable predictor of coronary heart disease (CHD) in patients, contradicting long-held expectations. The researchers analyzed data from over 7,000 adults and concluded that these genetic tests provide limited information about who will develop CHD.
A recent study by the University of California, Riverside found that e-cigarette users have elevated biomarkers of exposure and potential harm, including zinc excess correlated with oxidative DNA damage. The study highlights the risks of prolonged e-cigarette use and advises physicians to exercise caution when recommending e-cigarettes.
A team of researchers has identified new biomarkers for the diagnosis and prognosis of lung cancer by analyzing repetitive DNA regions. These markers show consistent expression in both healthy cells and cancerous tumors, with potential applications for more accurate diagnoses and treatments.
Two studies demonstrate that penKid is the most accurate surrogate for assessing true GFR and predicting AKI in critically ill patients with severe burns. It can complement current diagnostic standard methods to provide timely diagnosis of impaired renal function.
Higher ratios of very-long-chain to long-chain ceramides were associated with reduced dementia and Alzheimer's disease risks, suggesting a potential role for plasma ceramides as biomarkers. Elevated ceramide ratios may also have protective effects against dementia, while altered lipid metabolism is linked to its development.
A team of scientists is working on wearable devices that can detect molecules in sweat to monitor patient health status continuously without blood draws. They aim to standardize sample collection methods and develop low-level detection techniques for neuropeptides, allowing for a more holistic understanding of bodily functions.
A new blood test uses a carbon nanotube-based sensor to detect Alzheimer's disease with high accuracy, measuring key biomarkers in human plasma. The test achieved an average sensitivity of 90.0% and selectivity of 90.0%, outperforming conventional biosensors.
A multicenter study has identified a new biomarker for vascular dementia, lipocalin 2 protein, found in cerebrospinal fluid. The protein's presence can discriminate between vascular dementia and Alzheimer's disease.
Researchers found multiple faults with evidence of over 10 meters of slip during past large earthquakes in the Japan Trench fault zone, revealing a complex history of seismic activity. The technique used to analyze organic molecules in sedimentary rocks provides new insights into the likelihood of future tsunamis and earthquake hazards.
A new portable biosensor developed by researchers at EPFL's School of Engineering can rapidly detect sepsis biomarkers in a patient's bloodstream, slashing diagnosis time from several days to just a few minutes. The device uses plasmonics technology and achieves accuracy on par with gold-standard laboratory methods.
Researchers have identified blood-based biomarkers associated with both delirium duration and severity in critically ill patients. These biomarkers can help identify individuals at risk for longer delirium duration and higher delirium severity, potentially leading to new treatments.
Researchers used imaging mass cytometry to analyze 35 protein biomarkers in breast cancer patients, identifying four subcategories of the disease with varying molecular profiles. This breakthrough has the potential to change clinical practice by enabling precision medicine and personalized treatment approaches.
Researchers have discovered a secreted protein signature of aging cells, which is enriched with biomarkers found in human plasma. This breakthrough could lead to the development of therapeutic approaches to treat age-related diseases by targeting senescent cells.
Scientists have developed a proteomic atlas of senescence-associated secretomes, which can be used to identify senescent cells and their inflammatory factors. This will enable the development of simple, reliable biomarkers to assess the abundance of senescent cells in human tissues.
Researchers at UT Southwestern Medical Center found a significant association between malignant left ventricular hypertrophy and an increased risk of heart failure among black individuals. The study, published in the journal Circulation, suggests that early intervention can be beneficial in preventing future risk.
Researchers used MRI to assess neural activity in preterm infants and adults, finding similar patterns of interindividual variability in brain network activity. The study suggests that age-related increases in brain network variability may be linked to cortical maturation and expansion.
The penKid biomarker accurately predicted acute kidney injury (AKI), multiorgan failure, and mortality in unselected sepsis patients at presentation to the emergency department. Increasing penKid levels indicated worsening kidney function, enabling timely treatment decisions that improve outcomes.
A new study published by sphingotec demonstrates that biomarker bio-ADM identifies high-risk patients for septic shock and those requiring immediate life-saving therapeutic intervention. Elevated bio-ADM levels are associated with prolonged ICU stays, fatal outcomes, and distortions in endothelial function.
Researchers at Universidad Complutense de Madrid have identified brain biomarkers for detecting Alzheimer's disease. A study found that patients with Mild Cognitive Impairment who develop dementia show increased and then decreased synchronization in brain regions, indicating cortical network dysfunction.
A new computational clinical tool predicts osteoporotic vertebral fractures by analyzing patient-specific finite element analysis of functional spinal units from routine clinical scans. The method enables more accurate patient-specific analysis, paving the way for a spinal risk assessment tool and targeted early treatment strategies.
A new study published in the Journal of the American Heart Association finds that heavy drinking can cause subclinical heart damage, increasing levels of blood biomarkers associated with inflammation and cardiac wall stretch. Heavy drinkers are more likely to experience cardiovascular disease than non-problem drinkers.
A new technique uses spectroscopy to identify biomarker patterns in blood samples, allowing for improved diagnosis and tracking of Huntington's disease progression. The breakthrough has the potential to lead to better ways to track treatment effects.
Researchers have developed novel biomarkers to accurately measure dietary intake of key bioactives, including flavanols and procyanidins. This breakthrough enables large-scale studies into the links between these compounds and health benefits, free from limitations inherent to past research approaches.
A study led by Mary Robinson and Jinwen Chen found potential biomarkers of extracorporeal shockwave therapy (ESWT) that could be used to enforce the ban on its use in horses within 10 days of a race. The researchers detected changes in five inflammatory factors, including TNF-? levels, up to three weeks after ESWT treatment.
A new chip-based sensor can detect very low levels of a cancer protein biomarker in urine, paving the way for non-invasive and inexpensive disease diagnosis and monitoring. The sensor's high sensitivity enables detection of minute biomarker concentrations, making it a promising tool for personalized medicine.
A new methodology to monitor patients with glioblastoma has been developed at the Universitat Politècnica de València, using Magnetic Resonance Images and biomarkers to track tumor growth and edema. The tool has been validated in a multicenter study involving seven European hospitals.
A neural circuit in the brains of mice controls the development of compulsive drinking disorders, identified by a biomarker that could become a target for alcohol use disorder therapies. Effective treatments are needed, and this finding offers an extremely promising step forward.
The Texas Advanced Computing Center will develop a meta-portal to provide access to analytics tools and data sets for researchers studying the biological characteristics underlying acute-to-chronic pain transition. Researchers aim to identify biomarkers that can predict chronic pain for medical and public health use.
Researchers developed a promising methodology for monitoring postoperative abdominal aortic aneurysm progression using CTA image registration and biomechanical strain analysis. The approach correlates with patient long-term prognosis, offering a new tool for assessing post-EVAR risk of rupture.
Researchers have identified patterns of epigenetic molecules on sperm DNA that can indicate male infertility. A new diagnostic approach could provide doctors with a reliable method to screen men for infertility, saving couples time and effort in finding suitable treatment options.
Biomedical researchers at Cincinnati Children's Hospital Medical Center have developed a new rapid blood assay called PERSEVERE to detect and stratify sepsis. The test accurately predicts patient risk of death from sepsis, enabling early medical interventions with greater precision.
A new biomarker, plectin, has been identified in cancer stem cells, which govern cancer survival and spread. Plectin's translocation onto the cell surface is linked to tumor invasion and metastasis, making it a potential target for drug development.
A review article highlights traditional and emerging cardiac-specific biomarkers to identify early risk factors for cardiovascular disease in childhood obesity. These biomarkers, such as cardiac troponins and natriuretic peptides, may help target treatment to high-risk individuals, reducing the risk of adult-onset cardiovascular disease.
Researchers found that women with stable heart disease experienced a higher risk of major cardiovascular events after a stressful activity, compared to men. The study measured inflammatory biomarkers in response to stress and tracked participants for three years.
Researchers found ADA2 levels above normal limits strongly indicative of concomitant MAS in children with systemic JIA. The study establishes ADA2 as a valuable diagnostic marker to distinguish MAS from other forms of systemic inflammation.
A diagnostic study found a protein involved in managing bacteria to be a reliable biomarker for the noninvasive detection of NEC. Elevated levels of intestinal alkaline phosphatase (iAP) protein linked to NEC were shed in stool samples, with accuracy rates of 97% and 76% for severe and suspected NEC, respectively.
A large-scale trial found that vitamin D and omega-3 fatty acid supplements had no effect on reducing markers of systemic inflammation in older US adults. However, participants with low initial fish intake saw a decrease in inflammation biomarkers after taking the omega-3 supplement.
Researchers developed an AI-powered method to identify biomarkers in MRI data that can help diagnose CM-associated pain in dogs. The study found that certain features in the third ventricle and sphenoid bone are associated with pain, while others are linked to syringomyelia.
Scientists have identified genes associated with a common depression symptom: lack of motivation. This finding could lead to new diagnostic methods and targeted treatments for depression. The study uses mouse models to understand brain changes related to specific symptoms.
Researchers identified CEUS biomarkers predicting HCC in cirrhotic nodules, stratifying risk within the LI-RADS system. Customized surveillance strategies can be enabled using these biomarkers.
A new rapid assay for Lyme disease uses several biomarkers to detect infection and is more sensitive than current tests when diagnosing early after suspected infection. The research could lead to a practical test for healthcare providers.
Study reveals substantial changes in metabolic pathways related to energy metabolism, the nervous system, and cell membrane lipid metabolism during methamphetamine self-administration and withdrawal. Biomarkers such as depleted amino acids may help identify early warning signs of methamphetamine dependence.
Researchers have created a platinum nanoreactor that enables visual detection and mass spectrometry fingerprinting of metabolic biomarkers, allowing for biopsy-free diagnosis of pancreatic cancer patients. The platform has shown sensitivity and specificity of 84% and 92%, respectively.
Researchers have discovered that certain molecules in semen, known as miRNAs, may serve as non-invasive biomarkers for prostate cancer. The study found that these molecules can provide reliable information to help diagnose and predict the progression of the disease.
A urine test that measures specific proteins found in urine can detect early-stage pancreatic cancer with nearly 95% accuracy. The UroPanc clinical study aims to validate this biomarker in a clinical setting, with the potential to develop a standardized urine test for clinicians to use as a diagnostic aid.
A new test measures protein albumin proportions in blood plasma and serum samples to establish their integrity, addressing concerns about degraded samples producing spurious results. The study highlights the importance of proper sample handling and storage conditions to maintain reliability in medical research.
Researchers have identified a novel biomarker for dementia, IGFBP-2, which is associated with an increased risk of all-cause dementia and Alzheimer's disease. Elevated circulating levels of IGFBP-2 significantly improved dementia risk classification when added to traditional risk factors.
Researchers have identified microRNA-204 as a biomarker for early beta cell death in Type 1 diabetes, which can identify disease onset in children and adults with recent-onset Type 1 diabetes. Serum miR-204 levels were found to be elevated in individuals with Type 1 diabetes and inversely correlated with remaining beta-cell function.
Procizumab shows high therapeutic potential in treating acute heart failure and cardiogenic shock by targeting the DPP3 enzyme. The company is setting up GMP process for Procizumab manufacturing and expects to enter regulatory non-clinical safety studies next year.
A novel disease mechanism links circulating DPP3 to cardiac and renal dysfunction, with sustained high DPP3 levels associated with reduced cardiac function, impaired kidney function, and increased mortality. The DPP3 biomarker has high potential utility in diagnosing organ dysfunction and predicting outcomes in cardiogenic shock patients.
University of Alberta researchers have identified a unique biological marker that can predict the course of myasthenia gravis and develop personalized treatment plans. The biomarker, composed of 12 metabolites exclusive to patients with myasthenia gravis, enables early diagnosis and more effective management of the disease.
Researchers found that all three healthy diets emphasized different macronutrients reduced heart cell damage and inflammation. The findings suggest that flexibility in food selection is key to improving cardiovascular health.
A new blood test has been developed to detect concussions and subconcussive injuries in children and adults, which can cause wear and tear on the brain over time. The study included over 700 patients with varying injury mechanisms, revealing elevated levels of two biomarkers GFAP and UCH-L1 in patients with non-concussive head trauma.
Researchers at Uppsala University and Vesicode AB have developed a novel proximity-dependent barcoding assay (PBA) to map surface protein complements on individual exosomes. The method enables large-scale screens for biomarkers in disease, providing a new tool for early detection and prognosis.
Researchers at Arizona State University describe an innovative diagnostic technique that pinpoints molecular signatures of Lyme disease with high accuracy. The method, using a multi-platform approach, uncovers six potential biomarkers for early identification of the disease.
Researchers discovered a group of genes whose activity was associated with longevity in response to various interventions. The study used mice as a model organism and identified biomarkers that could facilitate the search for new longevity interventions.
Researchers found that heavy alcohol consumption is associated with altered immune function among people living with HIV, leading to higher levels of biomarkers linked to mortality. The study highlights the potential harms of heavy drinking on people with HIV and emphasizes the need for further research.
A study published in Acta Neuropathologica Communications found that interregional differences in the somatic genetic landscape of glioblastoma affect prognosis. The research analyzed Japanese patients with IDH-wildtype GBM and discovered a biomarker, triple CNA, associated with survival duration.
Researchers at the University of Sussex have identified novel biomarkers in bodily fluids that could signal the presence of glioblastoma. These biomarkers are associated with extracellular vesicles and may enable a simpler way to test for the tumor, rather than a biopsy.