Articles tagged with Biomarkers
A recent study found that people who restricted their blood flow by wearing inflated blood pressure cuffs on an arm and leg showed signs of more controlled blood flow to their brain. The process, called remote ischemic preconditioning, may be beneficial in preventing neurological diseases such as stroke, Parkinson's disease, and epilepsy.
Researchers at Boston University School of Medicine identified salivary microRNAs that differentiate people with alcohol dependence from healthy controls. The study uses machine learning to predict alcohol dependency with high accuracy, offering potential for early diagnosis and treatment.
Researchers have developed a 3D-printed microchip electrophoresis device that can detect three serum biomarkers of preterm birth with high sensitivity. The device is faster, cheaper, and easier to make than existing methods, which require laborious processes and specialized equipment.
Researchers at the University of Notre Dame have developed a microfluidics platform using extracellular vesicles containing microRNAs for early-stage disease diagnosis, reducing test time by 13 hours.
A study found that metabotropic glutamatergic receptor 5 (mGluR5) availability may serve as a biomarker for suicide risk management in posttraumatic stress disorder (PTSD). Higher mGluR5 levels were associated with suicidal ideation and mood disturbances in individuals with PTSD.
Cognitively normal adults with elevated levels of amyloid-β exhibited mixed attitudes toward physician-assisted death, reflecting complex emotions and values surrounding end-of-life care. The study highlights the need for nuanced discussions about dying wishes and advance care planning in this vulnerable population.
A study suggests that hyperosmotic stress can be used to diagnose ME/CFS, a condition characterized by persistent fatigue and other symptoms. The researchers developed a blood-based assay that measures changes in electrical impedance in response to plasma salt concentrations.
Researchers found that a panel of plasma biomarkers can help identify infants most in need of additional interventions after therapeutic cooling. Cytokines and Tau protein levels changed over time, with peak levels occurring within the first 24 hours and again during rewarmed stages. This study aims to develop a more accurate risk asse...
A risk model has been devised by Dana-Farber Cancer Institute researchers to classify patients with asymptomatic Waldenström macroglobulinemia into low, intermediate, or high risk of developing symptomatic disease. The model uses four biomarkers and was validated on two external cohorts with high accuracy and precision.
The article discusses the potential of liquid biopsy in cancer diagnosis, focusing on targeted disease diagnosis and detection of cancer biomarkers. Researchers have successfully detected specific genetic mutations using digital PCR, identifying promising biomarkers for various cancers, including melanoma and lung squamous cell carcinoma.
The Innovative Medicines Initiative has launched a five-year project to generate exploratory and confirmatory data for novel safety biomarkers. This will improve the diagnosis and management of acute and chronic diseases, as well as reduce safety attrition in drug development.
Researchers have developed a biosynthetic dual-core cell computer using CRISPR-Cas9 components, enabling scalable and flexible computing. This biological system can process up to 100,000 different metabolic molecules per second, far surpassing previous cell computers.
A recent study published in The Gerontologist suggests that the link between caregiving and negative health effects has been overstated. After analyzing data from over three decades of research, Johns Hopkins researchers found a weak association between caregiving and immune system biomarkers.
Researchers are developing a system to test multiple biomarkers at once and a smartphone-based analysis and reporting system for disease monitoring and home care. They aim to identify predictive biomarkers to empower patients to monitor their own disease and prevent serious complications.
Researchers at Cima, Clínica Universidad de Navarra have identified three biomarkers associated with atrial fibrillation risk, including CITP, MMP-1, and PICP. These biomarkers can help optimize treatment and follow-up for patients with this cardiac ailment.
A team of NJIT researchers has created a novel electrochemical biosensing device that can identify tiny signals of biomarkers emitted by diseases, such as cancer and malaria. The device uses gold nanoparticles to enhance signal response and separates plasma from blood to achieve high accuracy.
A collaborative project between C-Path and Japan's PMDA aims to generate critical data for safety decisions in early-stage clinical trials. The study will compare biomarkers in healthy Japanese volunteers with similar Western subjects, informing regulatory submissions.
Researchers found an early atrophy of amygdala and hippocampus in Alzheimer's patients at age 40, differing from normal aging process. Studying biomarkers revealed certain structures shrink before dementia appears.
A new biosensor developed by DGIST's Professor Jae Eun Jang's team can detect biomaterials in real-time without secondary processing or an analyzer. The technology uses plasmonic nanostructures and image signal processing to reveal the colors of colorless biomaterials.
Researchers have identified a new biomarker, ATOEA, that accurately detects cyanide exposure and persists in the body longer than the toxic compound. This breakthrough enables faster diagnosis and treatment of cyanide poisoning.
A multi-center study by MD Anderson Cancer Center reveals that a liquid biopsy test, Guardant360, is comparable to standard tissue biopsies in detecting guideline-recommended biomarkers for advanced NSCLC. The test identified four mutations for which FDA-approved drugs exist and offers faster turn-around time.
A human study published in The FASEB Journal suggests a novel type of biomarker to predict atrial fibrillation progression. Researchers found that patients with persistent atrial fibrillation demonstrated the highest expression of five miRNAs associated with signaling pathways and fibrosis involved in AF.
Research by Thomas Boyce, a CIFAR Fellow, shows that children from lower socio-economic backgrounds have higher levels of cortisol in their saliva and more cavity-causing bacteria around their gums. His study aims to understand why some children struggle and how all can thrive, as explored in his new book The Orchid and the Dandelion.
Researchers at Indiana University School of Medicine have made a breakthrough in developing a blood test that can objectively determine the severity of pain in patients. The test, led by psychiatrist Alexander Niculescu, uses biomarkers found in the blood to match with potential treatment options.
A new study found that people with middle-age chronic inflammation may experience cognitive decline in the decades leading up to old age. Researchers discovered a correlation between high levels of inflammation and steeper declines in thinking and memory skills, particularly in areas of memory.
A new diagnostic technique using infrared imaging and proteomics has identified a protein biomarker called AHNAK2 that can accurately distinguish between bladder cancer and benign inflammation. The technique has been shown to have high sensitivity and specificity in differentiating between various stages of bladder cancer.
A recent study published in Scientific Reports found that smokers demonstrate a higher aging ratio and are predicted to be twice as old as their chronological age compared to nonsmokers. The study used blood biochemistry and artificial intelligence to analyze the impact of smoking on biological age.
Researchers identified racial disparities in Alzheimer's disease diagnosis and progression among African-American participants, who had lower levels of brain protein tau. This may lead to under-recognition of the disease in African-Americans, as they often have lower tau levels than Caucasians, according to a new study.
Researchers found that high ratings for engagement in worthwhile activities are associated with strong personal relationships, healthy lifestyles, sound mental and physical health. High ratings predict healthy lifestyles, increased relationships and socializing, and reduced loneliness, depression, and health issues.
Scientists have found two biomarkers that can be used to identify patients at risk of atrial fibrillation, a heart rhythm disturbance affecting 1.6 million people in the UK. The biomarkers include brain natriuretic peptide and fibroblast growth factor-23.
Researchers analyzed skin cells from over 100 individuals to identify molecular signatures of aging, predicting a person's age with less than eight years error on average. The study's findings provide a foundation for quantitatively addressing unresolved questions in human aging.
Estonian scientists have developed a genetic testing technology called TAC-seq, which enables precise analysis of clinical biomarkers at the single-molecule level. This method raises the precision of biomarker analysis and is poised to make it more affordable.
Researchers tested rats on GM maize MON 810 and NK603 for 6 months, using high-throughput biology techniques. No significant biological markers were found, and anatomic pathology examination revealed no alteration of organs. The study does not detect any harmful effects of the GMOs on rat health or metabolism.
Researchers have identified three biomarkers in saliva samples to detect mild cognitive impairment and Alzheimer's disease. The study uses metabolomics to analyze over 6,000 compounds, showing promising results for a potential clinical test.
A new study found that consuming a Mediterranean-type diet rich in plants and olive oil significantly reduces the risk of cardiovascular disease among American women. The diet's benefits were attributed to changes in inflammation, glucose metabolism, and insulin resistance.
A new study published in Circulation found that running a full marathon significantly raises concentrations of biomarkers indicating heart strain in amateur runners. The study suggests that shorter endurance races may reduce the strain on the heart muscle during competition.
Researchers use big data from medical studies and large biobanks to develop models predicting biological age, aging rate, and potential targets for future anti-aging therapies. The approach also led to the identification of wearable-based biomarkers of aging and frailty.
Researchers from Kanazawa University investigated gut microbiota effects on kidney function and discovered that the gut microbiota produces D-serine, a substance protective for the kidney. Administering D-serine to normal mice mitigated kidney injury, suggesting its potential as a biomarker or medication for acute kidney injury.
Data from Neuroscience 2018 presents genetic deletion of SARM1 protecting axons and reducing biomarkers of neurodegeneration. SARM1 inhibition provides critical insight into developing disease-modifying therapeutics for patients with axonal degeneration.
Researchers found elevated levels of microRNA biomarkers indicating concussions before the season started in college football players. Cognitive tests showed those with balance and memory issues had higher biomarker levels, suggesting past head injuries persisting over time.
A team of researchers has discovered a biomarker, named cBIN1 Score, that measures muscle deterioration and protein regulation in the heart, indicating onset of heart failure. This simple blood test can aid doctors in diagnosing at-risk patients before symptoms appear.
Researchers identified new biomarkers that can detect glaucoma at an early stage, enabling early intervention. The study's findings suggest that these biomarkers may inhibit neurodegeneration in the optic nerve and retina.
Researchers at UCR discovered the oldest clue yet of animal life, found in molecular fossils of sponges that lived on ancient ocean floors. The discovery pushes back the known history of animal life by 100 million years.
A study of over 60,000 adults found that higher biomarker levels for dairy fat consumption are associated with a lower risk of developing type 2 diabetes. The researchers suggest re-examining the metabolic benefits of dairy fat, but note limitations and potential biases in their findings.
The special issue brings together contributions from top academics and industry experts, highlighting the use of generative chemistry and GANs for de-novo molecular design. Experimental validation of generated molecules demonstrates high activity and selectivity in a novel inhibitor of Janus Kinase 3.
A recent symposium will review the current criteria for diagnosing Alzheimer's disease, highlighting the need to rethink diagnostic approaches. The event also explores how brain metabolism changes in women after menopause may increase their risk of developing Alzheimer's.
A world-first electronic capsule measures gaseous biomarkers in the gut to diagnose common and debilitating conditions, offering rapid, non-invasive diagnosis. Phase 2 clinical trials will pursue enhanced technology and target related biomarkers for improved treatment and reduced healthcare costs.
Researchers at the University of Surrey have successfully identified biomarkers in blood that can detect sleep deprivation. A machine learning algorithm detected changes in gene expression levels with 92% accuracy, paving the way for a future test to assess driver fitness.
Resveratrol supplementation significantly reduced pain severity and levels of inflammatory biomarkers, including TNF-α, interleukin IL-1ß, and IL-6, in patients with mild to moderate knee osteoarthritis. The study suggests resveratrol may be an effective add-on to NSAIDs for treating knee osteoarthritis.
Researchers at the University of Würzburg have identified viral microRNA molecules that can serve as ideal biomarkers for detecting human herpesvirus 6 (HHV-6) reactivation. The discovery was made using a novel method that allows for early detection of viral activation, potentially leading to improved clinical interventions.
A new biomarker panel identified in a large metabolomic study could accelerate autism diagnoses, detecting around 17 percent of children with ASD. The panel analyzes amino acid metabolism and shows promise for developing an ASD biomarker test.
A randomized clinical trial found that immediate nicotine reduction resulted in lower toxicant exposure, fewer cigarettes smoked, and greater reduction in dependence compared to gradual reduction. However, this approach also caused higher withdrawal symptoms and study dropout rates.
Researchers developed a three-factor model predicting burn patients at risk for acute respiratory distress syndrome (ARDS). The model includes inhalation injury extent, percentage of body burned, and von Willebrand factor levels. This prediction tool could guide clinical trials to prevent ARDS in high-risk patients.
Researchers developed a novel imaging biomarker to quantify coronary artery inflammation, capturing changes in perivascular fat on CT angiography. This biomarker is associated with increased rates of death from any cause and cardiac causes.
A study has identified six biomarkers of inflammation associated with the risk of polyneuropathy in people with type 2 diabetes. The findings suggest a complex interaction between innate and adaptive immunity in the development of this complication.
A study explores the use of optical coherence tomographic angiography (OCTA) to analyze retinal changes in people with preclinical Alzheimer's disease. Researchers found certain retina alterations were more common among those with preclinical AD, suggesting potential for non-invasive early detection.
Researchers have identified 50 stool proteins that are consistently elevated in patients with inflammatory bowel disease. These biomarkers could help diagnose the condition earlier and more accurately, allowing for quicker treatment. The findings also suggest a potential self-care kit for monitoring the disease.
A novel saliva-based panel is being developed to aid clinicians in the early diagnosis of autism spectrum disorder based on changes in oral microbial communities. The study found altered microbial gene expression patterns associated with energy processing and lysine degradation, indicating potential biomarkers for ASD.
Guidelines for discovering Parkinson's biomarkers aim to develop new treatments, focusing on biomarkers within the disease itself. The research emphasizes collaboration and access to biobanks containing thousands of biological samples.
Researchers at Ohio State University found a strong link between hostility in marriages and the presence of bacteria in the bloodstream, leading to inflammation. Lifestyle changes such as healthy diets and probiotics may help mitigate this effect.