Articles tagged with Biomarkers
A new methodology to monitor patients with glioblastoma has been developed at the Universitat Politècnica de València, using Magnetic Resonance Images and biomarkers to track tumor growth and edema. The tool has been validated in a multicenter study involving seven European hospitals.
A neural circuit in the brains of mice controls the development of compulsive drinking disorders, identified by a biomarker that could become a target for alcohol use disorder therapies. Effective treatments are needed, and this finding offers an extremely promising step forward.
Researchers have identified patterns of epigenetic molecules on sperm DNA that can indicate male infertility. A new diagnostic approach could provide doctors with a reliable method to screen men for infertility, saving couples time and effort in finding suitable treatment options.
The Texas Advanced Computing Center will develop a meta-portal to provide access to analytics tools and data sets for researchers studying the biological characteristics underlying acute-to-chronic pain transition. Researchers aim to identify biomarkers that can predict chronic pain for medical and public health use.
Researchers developed a promising methodology for monitoring postoperative abdominal aortic aneurysm progression using CTA image registration and biomechanical strain analysis. The approach correlates with patient long-term prognosis, offering a new tool for assessing post-EVAR risk of rupture.
A new biomarker, plectin, has been identified in cancer stem cells, which govern cancer survival and spread. Plectin's translocation onto the cell surface is linked to tumor invasion and metastasis, making it a potential target for drug development.
Biomedical researchers at Cincinnati Children's Hospital Medical Center have developed a new rapid blood assay called PERSEVERE to detect and stratify sepsis. The test accurately predicts patient risk of death from sepsis, enabling early medical interventions with greater precision.
A review article highlights traditional and emerging cardiac-specific biomarkers to identify early risk factors for cardiovascular disease in childhood obesity. These biomarkers, such as cardiac troponins and natriuretic peptides, may help target treatment to high-risk individuals, reducing the risk of adult-onset cardiovascular disease.
Researchers found that women with stable heart disease experienced a higher risk of major cardiovascular events after a stressful activity, compared to men. The study measured inflammatory biomarkers in response to stress and tracked participants for three years.
Researchers found ADA2 levels above normal limits strongly indicative of concomitant MAS in children with systemic JIA. The study establishes ADA2 as a valuable diagnostic marker to distinguish MAS from other forms of systemic inflammation.
A diagnostic study found a protein involved in managing bacteria to be a reliable biomarker for the noninvasive detection of NEC. Elevated levels of intestinal alkaline phosphatase (iAP) protein linked to NEC were shed in stool samples, with accuracy rates of 97% and 76% for severe and suspected NEC, respectively.
Researchers developed an AI-powered method to identify biomarkers in MRI data that can help diagnose CM-associated pain in dogs. The study found that certain features in the third ventricle and sphenoid bone are associated with pain, while others are linked to syringomyelia.
A large-scale trial found that vitamin D and omega-3 fatty acid supplements had no effect on reducing markers of systemic inflammation in older US adults. However, participants with low initial fish intake saw a decrease in inflammation biomarkers after taking the omega-3 supplement.
Scientists have identified genes associated with a common depression symptom: lack of motivation. This finding could lead to new diagnostic methods and targeted treatments for depression. The study uses mouse models to understand brain changes related to specific symptoms.
Researchers identified CEUS biomarkers predicting HCC in cirrhotic nodules, stratifying risk within the LI-RADS system. Customized surveillance strategies can be enabled using these biomarkers.
Study reveals substantial changes in metabolic pathways related to energy metabolism, the nervous system, and cell membrane lipid metabolism during methamphetamine self-administration and withdrawal. Biomarkers such as depleted amino acids may help identify early warning signs of methamphetamine dependence.
A new rapid assay for Lyme disease uses several biomarkers to detect infection and is more sensitive than current tests when diagnosing early after suspected infection. The research could lead to a practical test for healthcare providers.
Researchers have created a platinum nanoreactor that enables visual detection and mass spectrometry fingerprinting of metabolic biomarkers, allowing for biopsy-free diagnosis of pancreatic cancer patients. The platform has shown sensitivity and specificity of 84% and 92%, respectively.
Researchers have discovered that certain molecules in semen, known as miRNAs, may serve as non-invasive biomarkers for prostate cancer. The study found that these molecules can provide reliable information to help diagnose and predict the progression of the disease.
A urine test that measures specific proteins found in urine can detect early-stage pancreatic cancer with nearly 95% accuracy. The UroPanc clinical study aims to validate this biomarker in a clinical setting, with the potential to develop a standardized urine test for clinicians to use as a diagnostic aid.
A new test measures protein albumin proportions in blood plasma and serum samples to establish their integrity, addressing concerns about degraded samples producing spurious results. The study highlights the importance of proper sample handling and storage conditions to maintain reliability in medical research.
Researchers have identified a novel biomarker for dementia, IGFBP-2, which is associated with an increased risk of all-cause dementia and Alzheimer's disease. Elevated circulating levels of IGFBP-2 significantly improved dementia risk classification when added to traditional risk factors.
Researchers have identified microRNA-204 as a biomarker for early beta cell death in Type 1 diabetes, which can identify disease onset in children and adults with recent-onset Type 1 diabetes. Serum miR-204 levels were found to be elevated in individuals with Type 1 diabetes and inversely correlated with remaining beta-cell function.
A novel disease mechanism links circulating DPP3 to cardiac and renal dysfunction, with sustained high DPP3 levels associated with reduced cardiac function, impaired kidney function, and increased mortality. The DPP3 biomarker has high potential utility in diagnosing organ dysfunction and predicting outcomes in cardiogenic shock patients.
Procizumab shows high therapeutic potential in treating acute heart failure and cardiogenic shock by targeting the DPP3 enzyme. The company is setting up GMP process for Procizumab manufacturing and expects to enter regulatory non-clinical safety studies next year.
University of Alberta researchers have identified a unique biological marker that can predict the course of myasthenia gravis and develop personalized treatment plans. The biomarker, composed of 12 metabolites exclusive to patients with myasthenia gravis, enables early diagnosis and more effective management of the disease.
Researchers found that all three healthy diets emphasized different macronutrients reduced heart cell damage and inflammation. The findings suggest that flexibility in food selection is key to improving cardiovascular health.
Researchers at Arizona State University describe an innovative diagnostic technique that pinpoints molecular signatures of Lyme disease with high accuracy. The method, using a multi-platform approach, uncovers six potential biomarkers for early identification of the disease.
A new blood test has been developed to detect concussions and subconcussive injuries in children and adults, which can cause wear and tear on the brain over time. The study included over 700 patients with varying injury mechanisms, revealing elevated levels of two biomarkers GFAP and UCH-L1 in patients with non-concussive head trauma.
Researchers at Uppsala University and Vesicode AB have developed a novel proximity-dependent barcoding assay (PBA) to map surface protein complements on individual exosomes. The method enables large-scale screens for biomarkers in disease, providing a new tool for early detection and prognosis.
Researchers discovered a group of genes whose activity was associated with longevity in response to various interventions. The study used mice as a model organism and identified biomarkers that could facilitate the search for new longevity interventions.
Researchers found that heavy alcohol consumption is associated with altered immune function among people living with HIV, leading to higher levels of biomarkers linked to mortality. The study highlights the potential harms of heavy drinking on people with HIV and emphasizes the need for further research.
Researchers at the University of Sussex have identified novel biomarkers in bodily fluids that could signal the presence of glioblastoma. These biomarkers are associated with extracellular vesicles and may enable a simpler way to test for the tumor, rather than a biopsy.
A study published in Acta Neuropathologica Communications found that interregional differences in the somatic genetic landscape of glioblastoma affect prognosis. The research analyzed Japanese patients with IDH-wildtype GBM and discovered a biomarker, triple CNA, associated with survival duration.
Research shows physically active individuals experience fewer age-related alterations in biomarkers associated with the disease. Regular exercise appears to help prevent physical signs of Alzheimer's in those at risk for the disease.
A new study published in The Journal of Physiology found that an eye-movement test can detect acute sleep loss with high reliability. The researchers used a range of eye-movement measures to distinguish sleep-related impairment from that caused by alcohol or brain injury.
Researchers at KU Leuven have developed a non-invasive biomarker for detecting kidney transplant rejection symptoms after a transplant due to antibody-mediated rejection. The new blood test can identify patients with rejection symptoms earlier and more accurately than current methods, which often rely on invasive biopsies.
Scientists have developed a highly sensitive 'sniff-cam' that can detect low levels of disease biomarkers in breath, including diabetes, lung cancer, and Parkinson's disease. The device uses an ultraviolet ring light, filters, and a camera to measure volatile organic compounds (VOCs) in the breath.
Researchers have developed a miniaturized system that uses low-cost components and smartphones to detect biological viruses. The device is portable, battery-powered and can detect real viruses, holding potential for aid in disease prevention.
Researchers developed a microfluidic concentration method that selectively concentrates proteins and nucleic acids, enabling rapid detection of pathogens and biomarkers. This technique enhanced concentrations by up to a billion-fold within 30 minutes.
A study published in the Journal of Nutrition has linked specific chemical signatures in human hair to a diet of traditional Yup'ik foods. The researchers found that changes in nitrogen isotope ratios along the hair strand correlated with increased consumption of traditional foods like fish and marine mammals.
A novel microfluidics-based system detects clinically significant IL-6 levels for sepsis diagnosis in about 25 minutes using less than a finger prick of blood. This device provides a more sensitive and efficient alternative to traditional assays.
A new study uses amyloid positron emission tomography to track β-amyloid cerebrospinal fluid and monitor Alzheimer's disease progression over six years. The researchers found a significant correlation between β-amyloid levels and cognitive decline, providing valuable insights into the disease's progression.
Researchers investigated the relationship between physical activity, β-amyloid levels, and cognitive decline in clinically normal older adults. Physical activity was found to be associated with reduced cognitive decline and lower β-amyloid levels, suggesting potential neuroprotective effects.
A new AI/ML model developed at UC Davis Health can predict acute kidney injury in burn patients more accurately and quickly than traditional methods. The model achieved 90-100% accuracy for identifying AKI using just routine laboratory results, shortening diagnosis time by nearly a full day.
Research studies using liquid biopsy and ddPCR technology found that mutant BRAF ctDNA levels can predict treatment efficacy in advanced melanoma patients, while ctDNA may not reliably detect brain metastases. Meanwhile, chimeric cell-free DNA tracked tumor recurrence in hepatocellular carcinoma patients.
Scientists at McMaster University have identified biomarkers for Irritable Bowel Syndrome (IBS) in urine, which could lead to better treatments and reduce the need for costly colonoscopy procedures. The study found distinctive metabolic signatures that were elevated in IBS patients, suggesting an impairment of the gut's elastic lining.
Researchers found that two specific biomarkers were elevated in athletes who experienced concussions, indicating potential for longer recovery times. The study suggests these biomarkers could aid in predicting which athletes are more likely to need extended recovery periods after concussion.
Researchers identified a unique biomarker, KLHL11, that targets autoantibodies in men with testicular cancer-associated paraneoplastic encephalitis. The discovery has the potential to diagnose this condition earlier and improve treatment outcomes for patients.
A new biomarker in urine helps detect aggressive prostate cancer, improving detection accuracy and reducing unnecessary treatments. The noninvasive test was found to accurately identify high-risk individuals and achieved similar accuracy as invasive tissue-based tests.
Researchers found that experienced runners showed elevated cardiac biomarkers after ultramarathons, but these levels were below clinical risk thresholds. Novice runners paced themselves below their cardiac limit, using self-selected strategies for safe heart health.
A widely recognized biomarker, CA19-9, is found to promote the development of pancreatic diseases and cancer in genetically engineered mice models. This discovery suggests new treatment strategies for pancreatic cancer and other cancer biomarkers.
Researchers have developed a new method to predict the risk of cardiogenic shock in patients after a heart attack. The tool uses proteomics and biomarkers to identify patients at higher risk, enabling more precise treatment options.
A new biomarker, urinary DKK3, has been identified as a predictor of acute kidney injury (AKI) in patients undergoing cardiac surgery. High preoperative levels of DKK3 are associated with lower kidney function and increased risk of AKI.
Researchers have identified two new biomarkers, ApoB:A1 ratio and metabolomic lipoprotein signatures, to predict cardiovascular risk in juvenile-onset systemic lupus erythematosus (JSLE) patients. These biomarkers can help identify high-risk patients and inform tailored disease treatments.
A recent study published in the Journal of Gerontology: Medical Sciences found that low levels of circulating vitamin K are associated with an increased risk of mobility limitation and disability in older adults. The study, conducted on a sample of 635 men and 688 women aged 70-79 years old, used biomarkers of vitamin K status to evalu...
A new study from Professor Doug VanderLaan's lab found evidence for at least four different subgroups of men, each with distinct biomarkers associated with same-sex attractions. The study suggests that there are multiple and distinct pathways influencing male sexual orientation in men.
Researchers used latent profile analysis to examine biomarkers associated with male sexual orientation in over 800 men. The study identified four subpopulations with differing biomarker profiles, suggesting possible distinct biological mechanisms for nonheterosexual men.
Scientists have created a skin patch with tiny needles to collect interstitial fluid, containing biomarkers of disease. The device uses surface-enhanced Raman scattering to analyze the collected fluid and detect biomarkers more efficiently than traditional methods.
A new meta-analysis of 18 studies found that smoking does not accelerate telomere shortening, challenging the long-held assumption that smoking affects telomere length. Adult telomere length is now considered a static biomarker rather than a dynamic indicator of ageing.