Articles tagged with Biomarkers
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers identified IL-8 and IL-33 as key biomarkers for predicting pollen-specific nasal symptoms. These biomarkers also enable the prediction of symptom severity before the start of the pollen season.
Researchers have developed a graphene-based sensor that can detect biomarkers with high sensitivity, allowing for quick and simple disease diagnosis. The sensor uses the deformation of a single atomic sheet to trap biomarkers, which generates force deforming the graphene into a dome shape.
Scientists have identified biomarkers that signal potential heart damage from cancer treatment, allowing for early diagnosis and intervention. The findings could lead to better patient care and outcomes by enabling doctors to adjust chemotherapy types or dosages before cardiac damage occurs.
A new wearable smart patch is being developed to help people personalize their diets and reduce their risk of developing Type 2 diabetes. The device will measure key dietary biomarkers and send the information to an app, enabling users to precisely track how their bodies respond to different foods.
Researchers at CNIC discovered a biomarker, complement component 5 (C5), that detects atherosclerosis in its preclinical phase. Plasma levels of C5 can identify individuals with subclinical atherosclerosis, helping to select those who would benefit from more costly imaging analysis.
A new non-invasive method of monitoring diabetes uses saliva as a more convenient and sustainable alternative to traditional blood glucose testing. The research, published in PLOS ONE, achieved an accuracy rate of 95.2% using infrared platform technology.
Researchers investigated the association between preconception exposure to plastics and the risk of preterm birth. Higher concentrations of phthalates prior to conception were found to be associated with an increased risk of preterm birth in a recent study.
Researchers from Joslin Diabetes Center have identified a potential early biomarker for non-alcoholic fatty liver disease (NAFLD), which is linked to the regulation of liver fat metabolism and fibrosis. The protein NREP was found to decrease in levels as NAFLD progressed, suggesting its role as an early indicator of the disease.
Researchers discovered a biomarker for early detection of Alzheimer's disease in the form of high levels of RNA produced by the PHGDH gene. The study, published in Current Biology, suggests that overproduction of extracellular RNA by the PHGDH gene in elderly individuals may serve as an early warning sign of Alzheimer's disease.
The OncoMX knowledgebase integrates cancer biomarker data with other relevant data types to facilitate efficient research and exploration. The platform combines heterogeneous data using the BioCompute Object framework, enabling users to compare various experimental data.
A recent study examined the association between sleep-disordered breathing and Alzheimer's disease biomarkers in older adults. The research revealed a significant link between the two conditions, with those with sleep-disordered breathing showing higher levels of biomarkers for Alzheimer's disease.
A novel imaging marker has been developed to help diagnose and treat schizophrenia, using abnormal striatal function as a promising biomarker. The study, published in Nature Medicine, shows that this biomarker can distinguish between schizophrenia patients and healthy controls, while also predicting treatment response.
A team of scientists has developed a cancer diagnostics method that amplifies microRNA in live tumor cells using synthetic DNA and nanoparticles. This allows for the detection of tumor cells with high sensitivity, potentially leading to earlier diagnosis and improved treatment outcomes.
Researchers developed a computer program analyzing molecules in blood plasma to identify individuals at risk of becoming overweight and developing obesity-related diseases. The test is 90% accurate in detecting whether the subject will gain weight without intervention, also predicting diabetes and other health risks.
Monitoring lactate and bio-ADM levels helps identify high-risk sepsis patients. Bio-ADM measures blood vessel leakage, which can detect fatal outcomes despite low or decreasing lactate levels.
Researchers found that using AI to analyze CT scans can produce more accurate risk assessment for major cardiovascular events. Automated CT-based body composition biomarkers outperformed established clinical parameters like Framingham risk score and BMI in predicting adverse events.
A new blood test detects abnormal tau protein accumulation, differentiating healthy participants from those with Alzheimer's pathology and predicting disease progression. The test shows promise for early detection and diagnosis of Alzheimer's disease and related neurodegenerative disorders.
Scientists at UCF created functional nanomaterials for highly sensitive biomarker detection. The new method could enable high-performance technologies in various areas, including better diagnostic tools and test strip technology.
A new simple blood test developed by the University of Bristol could help doctors diagnose brain tumors earlier, using fluorescent carbon dots and nanophotonics. The test aims to detect biomarkers such as Glial fibrillary acidic protein (GFAP) in blood samples.
A study published in JAMA found that polygenic risk scores are not a reliable predictor of coronary heart disease (CHD) in patients, contradicting long-held expectations. The researchers analyzed data from over 7,000 adults and concluded that these genetic tests provide limited information about who will develop CHD.
A team of researchers has identified new biomarkers for the diagnosis and prognosis of lung cancer by analyzing repetitive DNA regions. These markers show consistent expression in both healthy cells and cancerous tumors, with potential applications for more accurate diagnoses and treatments.
A recent study by the University of California, Riverside found that e-cigarette users have elevated biomarkers of exposure and potential harm, including zinc excess correlated with oxidative DNA damage. The study highlights the risks of prolonged e-cigarette use and advises physicians to exercise caution when recommending e-cigarettes.
Two studies demonstrate that penKid is the most accurate surrogate for assessing true GFR and predicting AKI in critically ill patients with severe burns. It can complement current diagnostic standard methods to provide timely diagnosis of impaired renal function.
A team of scientists is working on wearable devices that can detect molecules in sweat to monitor patient health status continuously without blood draws. They aim to standardize sample collection methods and develop low-level detection techniques for neuropeptides, allowing for a more holistic understanding of bodily functions.
Higher ratios of very-long-chain to long-chain ceramides were associated with reduced dementia and Alzheimer's disease risks, suggesting a potential role for plasma ceramides as biomarkers. Elevated ceramide ratios may also have protective effects against dementia, while altered lipid metabolism is linked to its development.
A new blood test uses a carbon nanotube-based sensor to detect Alzheimer's disease with high accuracy, measuring key biomarkers in human plasma. The test achieved an average sensitivity of 90.0% and selectivity of 90.0%, outperforming conventional biosensors.
A multicenter study has identified a new biomarker for vascular dementia, lipocalin 2 protein, found in cerebrospinal fluid. The protein's presence can discriminate between vascular dementia and Alzheimer's disease.
Researchers found multiple faults with evidence of over 10 meters of slip during past large earthquakes in the Japan Trench fault zone, revealing a complex history of seismic activity. The technique used to analyze organic molecules in sedimentary rocks provides new insights into the likelihood of future tsunamis and earthquake hazards.
A new portable biosensor developed by researchers at EPFL's School of Engineering can rapidly detect sepsis biomarkers in a patient's bloodstream, slashing diagnosis time from several days to just a few minutes. The device uses plasmonics technology and achieves accuracy on par with gold-standard laboratory methods.
Researchers have identified blood-based biomarkers associated with both delirium duration and severity in critically ill patients. These biomarkers can help identify individuals at risk for longer delirium duration and higher delirium severity, potentially leading to new treatments.
Researchers used imaging mass cytometry to analyze 35 protein biomarkers in breast cancer patients, identifying four subcategories of the disease with varying molecular profiles. This breakthrough has the potential to change clinical practice by enabling precision medicine and personalized treatment approaches.
Researchers have discovered a secreted protein signature of aging cells, which is enriched with biomarkers found in human plasma. This breakthrough could lead to the development of therapeutic approaches to treat age-related diseases by targeting senescent cells.
Scientists have developed a proteomic atlas of senescence-associated secretomes, which can be used to identify senescent cells and their inflammatory factors. This will enable the development of simple, reliable biomarkers to assess the abundance of senescent cells in human tissues.
Researchers at UT Southwestern Medical Center found a significant association between malignant left ventricular hypertrophy and an increased risk of heart failure among black individuals. The study, published in the journal Circulation, suggests that early intervention can be beneficial in preventing future risk.
Researchers used MRI to assess neural activity in preterm infants and adults, finding similar patterns of interindividual variability in brain network activity. The study suggests that age-related increases in brain network variability may be linked to cortical maturation and expansion.
Researchers at Universidad Complutense de Madrid have identified brain biomarkers for detecting Alzheimer's disease. A study found that patients with Mild Cognitive Impairment who develop dementia show increased and then decreased synchronization in brain regions, indicating cortical network dysfunction.
The penKid biomarker accurately predicted acute kidney injury (AKI), multiorgan failure, and mortality in unselected sepsis patients at presentation to the emergency department. Increasing penKid levels indicated worsening kidney function, enabling timely treatment decisions that improve outcomes.
A new study published by sphingotec demonstrates that biomarker bio-ADM identifies high-risk patients for septic shock and those requiring immediate life-saving therapeutic intervention. Elevated bio-ADM levels are associated with prolonged ICU stays, fatal outcomes, and distortions in endothelial function.
A new computational clinical tool predicts osteoporotic vertebral fractures by analyzing patient-specific finite element analysis of functional spinal units from routine clinical scans. The method enables more accurate patient-specific analysis, paving the way for a spinal risk assessment tool and targeted early treatment strategies.
A new study published in the Journal of the American Heart Association finds that heavy drinking can cause subclinical heart damage, increasing levels of blood biomarkers associated with inflammation and cardiac wall stretch. Heavy drinkers are more likely to experience cardiovascular disease than non-problem drinkers.
A new technique uses spectroscopy to identify biomarker patterns in blood samples, allowing for improved diagnosis and tracking of Huntington's disease progression. The breakthrough has the potential to lead to better ways to track treatment effects.
Researchers have developed novel biomarkers to accurately measure dietary intake of key bioactives, including flavanols and procyanidins. This breakthrough enables large-scale studies into the links between these compounds and health benefits, free from limitations inherent to past research approaches.
A study led by Mary Robinson and Jinwen Chen found potential biomarkers of extracorporeal shockwave therapy (ESWT) that could be used to enforce the ban on its use in horses within 10 days of a race. The researchers detected changes in five inflammatory factors, including TNF-? levels, up to three weeks after ESWT treatment.
A new methodology to monitor patients with glioblastoma has been developed at the Universitat Politècnica de València, using Magnetic Resonance Images and biomarkers to track tumor growth and edema. The tool has been validated in a multicenter study involving seven European hospitals.
A new chip-based sensor can detect very low levels of a cancer protein biomarker in urine, paving the way for non-invasive and inexpensive disease diagnosis and monitoring. The sensor's high sensitivity enables detection of minute biomarker concentrations, making it a promising tool for personalized medicine.
A neural circuit in the brains of mice controls the development of compulsive drinking disorders, identified by a biomarker that could become a target for alcohol use disorder therapies. Effective treatments are needed, and this finding offers an extremely promising step forward.
Researchers developed a promising methodology for monitoring postoperative abdominal aortic aneurysm progression using CTA image registration and biomechanical strain analysis. The approach correlates with patient long-term prognosis, offering a new tool for assessing post-EVAR risk of rupture.
Researchers have identified patterns of epigenetic molecules on sperm DNA that can indicate male infertility. A new diagnostic approach could provide doctors with a reliable method to screen men for infertility, saving couples time and effort in finding suitable treatment options.
The Texas Advanced Computing Center will develop a meta-portal to provide access to analytics tools and data sets for researchers studying the biological characteristics underlying acute-to-chronic pain transition. Researchers aim to identify biomarkers that can predict chronic pain for medical and public health use.
A new biomarker, plectin, has been identified in cancer stem cells, which govern cancer survival and spread. Plectin's translocation onto the cell surface is linked to tumor invasion and metastasis, making it a potential target for drug development.
Biomedical researchers at Cincinnati Children's Hospital Medical Center have developed a new rapid blood assay called PERSEVERE to detect and stratify sepsis. The test accurately predicts patient risk of death from sepsis, enabling early medical interventions with greater precision.
A review article highlights traditional and emerging cardiac-specific biomarkers to identify early risk factors for cardiovascular disease in childhood obesity. These biomarkers, such as cardiac troponins and natriuretic peptides, may help target treatment to high-risk individuals, reducing the risk of adult-onset cardiovascular disease.
Researchers found that women with stable heart disease experienced a higher risk of major cardiovascular events after a stressful activity, compared to men. The study measured inflammatory biomarkers in response to stress and tracked participants for three years.
Researchers found ADA2 levels above normal limits strongly indicative of concomitant MAS in children with systemic JIA. The study establishes ADA2 as a valuable diagnostic marker to distinguish MAS from other forms of systemic inflammation.
A diagnostic study found a protein involved in managing bacteria to be a reliable biomarker for the noninvasive detection of NEC. Elevated levels of intestinal alkaline phosphatase (iAP) protein linked to NEC were shed in stool samples, with accuracy rates of 97% and 76% for severe and suspected NEC, respectively.
Researchers developed an AI-powered method to identify biomarkers in MRI data that can help diagnose CM-associated pain in dogs. The study found that certain features in the third ventricle and sphenoid bone are associated with pain, while others are linked to syringomyelia.
A large-scale trial found that vitamin D and omega-3 fatty acid supplements had no effect on reducing markers of systemic inflammation in older US adults. However, participants with low initial fish intake saw a decrease in inflammation biomarkers after taking the omega-3 supplement.
Scientists have identified genes associated with a common depression symptom: lack of motivation. This finding could lead to new diagnostic methods and targeted treatments for depression. The study uses mouse models to understand brain changes related to specific symptoms.
Researchers identified CEUS biomarkers predicting HCC in cirrhotic nodules, stratifying risk within the LI-RADS system. Customized surveillance strategies can be enabled using these biomarkers.
Study reveals substantial changes in metabolic pathways related to energy metabolism, the nervous system, and cell membrane lipid metabolism during methamphetamine self-administration and withdrawal. Biomarkers such as depleted amino acids may help identify early warning signs of methamphetamine dependence.