Research on measurable signals of health and disease. Covers ultrasound imaging pipelines, fetal-distress detection, cancer monitoring, and fatigue biology.
Researchers developed a blood test that can detect prostate cancer patients who are resistant to chemotherapy drug docetaxel, enabling early detection and personalized treatment. The test analyzes circulating tumor cells in the bloodstream, revealing patterns that predict disease progression and survival.
Researchers at West Virginia University have received FDA approval for a new drug to treat uveal melanoma, a rare form of eye cancer. The drug, MTI-201, targets specific biomarkers in diseased cells, allowing for more precise treatment with minimal damage to healthy cells.
A study at the University of São Paulo found that Torquetenovirus (TTV) titer is higher in people infected by SARS-CoV-2, suggesting it could be a biomarker for COVID-19 severity. TTV load correlates with disease progression and outcome, and its measurement may support diagnosis.
Researchers discovered a new biomarker, inactive AMPK (lo-P-AMPK), that may predict immune evasion in lung cancer. The finding could enable better personalized care for lung cancer patients by identifying those most likely to benefit from immunotherapies.
A new pilot study reveals a prostate cancer urine test can identify men with intermediate-risk disease, allowing them to opt for active surveillance instead of immediate treatment. The test assesses the amount of aggressive cancer in the prostate without needing a biopsy.
Research reveals brief DBS exposure triggers significant brain state changes and sustained antidepressant response. A decrease in beta power is identified as a novel biomarker for DBS treatment optimization.
Researchers from MUSC Hollings Cancer Center, UCLA Jonsson Comprehensive Cancer Center, and Winship Cancer Institute discovered that pre-surgical anti-PD-1 immunotherapy is safe and effective for OCSCC patients. The studies identified potential molecular biomarkers in blood and tumors to predict treatment response.
Researchers at the University of Waterloo have created a deep neural network that detects disease biomarkers with high accuracy, achieving 98 per cent detection of peptide features. This breakthrough could enable earlier and more accurate disease detection through tissue sample analysis.
Researchers found diet-associated molecules in the gut are associated with aggressive prostate cancer, linking them to higher levels of metabolites like phenylacetylglutamine and nutrients choline and betaine. The study's findings may have clinical implications for diagnosing and preventing lethal prostate cancer.
Scientists at the University of Colorado School of Medicine have identified specific genetic biomarkers in blood samples that can indicate the severity of COVID-19. The study's findings suggest that these signals can be used to monitor SARS-CoV-2 status and predict clinical outcomes.
Researchers developed two model systems to study peritoneal metastases from colorectal cancer patients. Biomarkers were identified, including severe mutations of the BRCA2 gene, which predict therapy response. These findings offer new hope for treating advanced cases.
The NRG-RTOG 0815 trial found that adding androgen suppression to dose-escalated radiotherapy did not improve overall survival, but reduced rates of biochemical failure and distant metastases. Future studies are needed to identify subsets of patients who may benefit from this intervention.
Researchers found that certain urinary biomarkers, including neutrophil gelatinase-associated lipocalin and kidney injury molecule-1, were associated with increased risk of severe acute kidney injury or death in patients hospitalized with COVID-19. These biomarkers may help identify patients at high risk for adverse kidney outcomes.
Researchers identified a protein leakage related to chronic airway diseases, which restricts breathing. Decreasing this leakage could improve asthma and COPD management by relaxing airways.
A pilot study examines graph-theoretical properties of brain networks in traumatic brain injury and controls, showing association with balance impairment and structural damage. The study uses EEG-based functional connectivity measures during a balance perturbation task to explore underlying neural mechanisms.
Concordia researchers develop a new liquid biopsy method that uses lab-on-a-chip technology to identify biomarkers of concern before a tumor even forms. The technique attracts and captures particles containing cancer-causing biomarkers, allowing for early diagnosis and targeted treatment.
Researchers from University of Copenhagen discover a protein analysis that can predict COVID-19 patient death or hospitalization with high accuracy, predicting 78.7% of hospitalizations and 93.9% of non-serious infections. This discovery has the potential to save lives by identifying high-risk individuals.
Researchers at Georgia Institute of Technology have developed a flow control technology to overcome limitations of traditional dipstick tests. This technology enables complex biomedical assays and can detect multiple pathogens, including SARS-CoV-2 and influenza viruses.
A woman-owned spinout company, Chosen Diagnostics Inc, has received a $2.1M NIH grant to develop and commercialize a noninvasive diagnostic biomarker test for necrotizing enterocolitis. The test, called NECDetect, identifies 93% true positives and 95% true negatives in diagnosing the disease.
New research reveals that microglia in the brain take up more glucose than previously thought, leading to altered PET scan images. This finding has significant implications for understanding neurodegenerative diseases and developing new diagnostic tools.
A plasma biomarker panel identified a combination of sTNFR1, sTNFR2, cystatin C, and eGFR that discriminated between patients with worsening or low risk of chronic kidney disease after three years. This combination was particularly effective at identifying those with very low risk of subsequent kidney dysfunction.
A study published in JAMA Neurology found that long-term exposure to space can cause brain damage in cosmonauts. The research analyzed five Russian male cosmonauts who spent an average of 169 days in space, showing significant increases in biomarkers for brain cell damage upon their return to Earth.
A recent study published in the American Journal of Clinical Nutrition found that consuming whole fat milk has no negative impact on children's health. The research, which involved 49 healthy children aged four to six, showed that both groups consumed similar amounts of calories and fat.
Researchers at Keck School of Medicine will collect and analyze imaging data from over 1,300 children nationwide to identify biological markers predicting recovery or persistent symptoms after concussion. The study aims to develop a diagnostic protocol for clinicians caring for pediatric patients with concussion.
Scientists at DZNE and UMG identified three microRNAs in the blood that correlate with mental fitness and cognitive decline. The biomarker is associated with an increased risk of Alzheimer's disease within two years, offering potential targets for therapy and early warning signs.
Researchers at the University of Houston have developed a new, label-free biosensing platform for detecting cancer biomarkers in exosomes. The technology uses gold nanodisks to capture and analyze surface proteins on exosomes with high sensitivity.
A study found that chronic stress, measured by allostatic load, was associated with a lower likelihood of completing chemotherapy and lower overall survival rate in patients with lymph node-positive or high-risk lymph node-negative HER2-negative breast cancer. Allostatic load may be a better predictor than genetic ancestry for chemothe...
Research investigates m6A regulators in cognitive dysfunctions, identifying potential biomarkers like SNRPG and SNRPD2. The study also highlights the role of APOE ε4 allele and FTO expression in AD development.
Researchers will investigate hidden signs of brain damage in REM behavior disorder, aiming to identify biomarkers that predict impending neurological disease. The goal is to delay the onset or prevent dementia or Parkinsonism through clinical trials.
Scientists at Karolinska Institutet have discovered a carbohydrate called mannose as a biomarker for severe COVID-19 disease severity. The study found that glycolysis and glutaminolysis play a crucial role in SARS-CoV-2's spread and growth, providing potential new therapeutic strategies.
Researchers found that liver transplant recipients who contracted COVID-19 recovered faster and with less severe inflammation compared to heart or kidney recipients. The study suggests testing certain immunosuppressants to treat COVID-19 patients, regardless of their transplant status.
Researchers created a customized device that targets unique brain circuits associated with depression, providing immediate relief. The approach uses neural biomarkers to personalize therapy and has shown long-term efficacy in treatment-resistant patients.
Researchers at JILA have enhanced the sensitivity of their decade-old frequency comb breathalyzer to detect four biomarkers of disease in human breath. The upgraded system can also identify six additional chemicals, with potential implications for COVID-19 testing and real-time health monitoring.
Researchers found that early accumulation of tau proteins in the brain, measured by PET scanner, is more effective at predicting memory impairment than other biomarkers. The study suggests that tau PET should be recommended for clinical prognostic assessment of cognitive decline in Alzheimer's patients.
Researchers developed a non-toxic, small-molecule probe that provides real-time visualization of disease progression, overcoming limitations of MRI and PET imaging. The probe binds copper ions and detects dysregulated levels, accurately identifying Wilson's disease and other maladies.
A team of scientists has identified molecular biomarkers associated with sepsis, which could be used to predict patient outcomes and guide treatment. The study found that changes in CD52 expression were linked to good outcomes, while S100A9 acted as a driver of fatal sepsis.
Studies found distinct patterns in nasal microbiota of individuals infected with SARS-CoV-2, with symptomatic patients showing reduced bacterial counts and increased presence of certain bacteria. The findings suggest that altered microbiota may impact immune response to the virus.
A new study from Karolinska Institutet in Sweden found that COVID-19 disease severity is linked to the characteristics of white blood cells called granulocytes. Combined measurements of granulocyte characteristics and widely used biomarkers can predict key clinical features such as respiratory function and multiorgan failure.
A serum biomarker, polyubiquitinated phosphatase and tensin homolog (PTEN), was associated with a four-fold higher risk of kidney function decline. This modified form of PTEN was linked to severity of lesions in kidney structure, indicating early manifestations of diabetic kidney disease.
Researchers at Buck Institute for Research on Aging provide a framework for precision nutrigeroscience to study the need for individualized dietary interventions. Studies in fruit flies show that lifestyle and genetics impact lifespan and healthspan, leading researchers to challenge the field to adopt a more nuanced approach.
A new study has identified unique genetic codes in the placenta that could detect pregnancy complications earlier than current tests. The researchers found specific biomarkers in maternal blood that indicate placental health and fetal well-being, allowing for real-time assessment throughout pregnancy.
Researchers found that salivary HR-HPV DNA can detect HPV-driven head and neck cancers (HNC) in most patients at the time of diagnosis. The study showed a clear survival advantage for salivary HR-HPV-positive patients, with high-risk strains detected in most cases.
Researchers from FAU and MIT develop a microfluidic assay to study the mechanical performance of red blood cells under hypoxic conditions. The study reveals that cyclic hypoxia can lead to mechanical degradation of the red blood cell membrane, contributing to aging.
Researchers found that pre-treatment circulating tumor DNA (ctDNA) levels can accurately predict long-term survival in non-small cell lung cancer (NSCLC) patients. Patients with low ctDNA levels had significantly improved progression-free survival and overall survival compared to those with high levels.
A study published in PLOS Genetics found that smoking-related DNA methylation patterns explain around 1/5 of the variation in body mass index between individuals. The study analyzed genomic sequence data from over 390,000 participants and found that genetics accounted for 50% of the variation in BMI.
Researchers analyzed large datasets to find biomarkers that could help select immunotherapy treatment for older patients. The analysis suggests that factors such as mutational burden and immune checkpoint protein expression are associated with increased response to immunotherapies in older patients, despite lower general immunity.
Despite its promise, cancer immunotherapy faces several hurdles, including limited efficacy and variable outcomes. Researchers are exploring new therapeutic targets and combination strategies to overcome resistance and improve patient outcomes.
Researchers from the National University of Singapore have identified three new urinary biomarkers that can detect consumption of ADB-BUTINACA, an emerging synthetic cannabinoid. The discovery will help boost global surveillance of synthetic cannabinoid abuse and aid in tackling the increasing abuse of this substance.
Researchers identified specific proteome features in COVID-19 patients' urine to distinguish between mild and severe cases. The study suggests that urine proteomics could be a valuable tool for early detection and prediction of COVID-19 progression.
Georgia State University researcher Vince Calhoun has received a $3.5 million grant to develop new methods for capturing dynamic connectivity in the brain and identifying biomarkers for early detection of Alzheimer's disease. The researchers aim to analyze real-time connectivity patterns to predict future cognitive decline.
The Alzheimer's Drug Discovery Foundation has provided NeuroVision Imaging Inc. with additional funding to accelerate the development of a novel blood-based lab test that can predict dementia before clinical onset. This technology has the potential to make diagnostic testing more practical, less invasive and less costly.
A randomized trial found that a shorter course of rifapentine-isoniazid therapy resulted in significantly higher treatment completion rates compared to a longer daily course. The findings suggest that this regimens can be more effective for preventing tuberculosis disease in individuals with HIV, particularly in high-transmission areas.
Researchers from Tokyo University of Science developed a self-powered diaper sensor that monitors urine sugar levels, providing an alternative biomarker for blood sugar monitoring. The sensor uses a biofuel cell powered by glucose in the urine, detecting sugar levels within 1 second and simplifying caretaking tasks.
A new study finds that female walruses in the Chukchi Sea rely on biomarkers from algae growing within sea ice as a primary food source. The researchers tracked these markers using liver tissues from harvested animals, revealing a difference in foraging behavior between males and females.
A study by the Center for Cell-Based Therapy in São Paulo, Brazil, has discovered a set of biomarkers that can be used to predict which patients with glioblastoma may have tumors resistant to radiation therapy. The genetic signature helps doctors choose the best treatment option for these patients.
Researchers at MUSC identify a type of fat called sphingolipid that could predict the severity of heart disease in African American patients with lupus. Higher levels of Lac-Cer are associated with increased disease activity and may have predictive value for patient progression.
Researchers at Indiana University School of Optometry have identified new biomarkers that can detect early eye changes associated with diabetes-related blindness. The study's findings may lead to earlier identification of people at risk for diabetes or visual impairment.
Researchers discovered that skin fibroblasts from FTD patients exhibit pathological RNA foci, p62 protein-containing vesicles, and defective energy metabolism, which could lead to the development of novel biomarkers and treatments. These findings may also be useful in testing drug effects on FTD patients.
Researchers at Ulsan National Institute of Science and Technology (UNIST) have developed a novel, hemolysis-free method for separating blood cells from plasma using magnetic forces. The new platform achieved 100% plasma purity and high recovery rates, outperforming conventional methods.
A large cross-sectional study in Canada found no association between loud noise exposure and changes in biomarkers for cardiovascular disease or outcomes. However, there were associations found between noise and several biomarkers, but these remained statistically insignificant after adjusting for important variables.