Articles tagged with Biomarkers
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
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Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers at UMass Amherst have identified a single-measure biomarker in sperm mitochondrial DNA that may predict male reproductive health and pregnancy success. Higher levels of this biomarker are associated with lower odds of cycle-specific pregnancy and 12-month fertility.
Researchers at Skoltech have identified a novel liver-specific non-coding RNA, named HELIS, which can be used as a biomarker for liver cancer diagnosis. The discovery provides a new panel of potential biomarkers that help distinguish between benign and malignant tumors.
A new Expert Panel Discussion examines the status of blood-based biomarker development and point-of-care testing for concussion diagnosis. The discussion highlights the potential benefits of specific biomarkers in detecting brain trauma masked by other injuries or symptoms, adding value over current clinical methods.
Researchers have developed a wearable device that monitors sweat for key biomarkers associated with inflammatory bowel disease (IBD), which could indicate flare-ups. The device has the potential to empower patients to be actively engaged in monitoring their disease and managing it.
A team of researchers at Case Western Reserve University has identified new biomarkers in the blood that can indicate damage to brain tissue, which could help emergency clinicians quickly recognize minor strokes. The discovery has the potential to reduce delays in treatment and improve patient outcomes.
A new study found that measurements of how pupils react to light can be used as a physiologic biomarker to diagnose sports-related concussions in teens. The researchers tested this method on adolescents and found it to be effective.
Researchers construct a composite measure of physiological dysregulation among human populations and compare it to other primates. Despite differing lifestyles, Tsimane adults show marginally higher rates of increase in physiological dysregulation, but still lower rates compared to urban populations.
Researchers identified Neurofilament light chain in vitreous humor, a potential biomarker for Alzheimer's and Parkinson's diseases. Higher levels were associated with higher levels of other biomarkers known to be linked to neurodegeneration.
Researchers developed a point-of-care GFAP assay that delivers results in minutes, outperforming the current FDA-cleared assay. The assay's diagnostic performance was significantly better than that of the S100B biomarker, validating its utility as a diagnostic marker for CT-detected lesions.
A new biomarker has been identified that reliably predicts the aggressiveness of biliary tract cancer in patients, which could help doctors make informed decisions about chemotherapy. The biomarker, IL-6, has been shown to provide prognostic information not captured by other inflammatory markers already in use.
The NIH has augmented the Health and Aging Brain Among Latino Elders (HABLE) Study to include additional biomarkers, including positron emission tomography (PET) imaging, to better understand Alzheimer's disease in Mexican Americans. The study will help identify health disparities and potential treatments for the condition.
A new study reveals that telomere length in whole blood cells can serve as a reliable proxy for other tissues, with 15 out of 23 tissues showing positive correlation. The findings help clarify conflicting results on relationships between individual traits and telomere length.
Researchers have identified a potential early biomarker, FABP4, for detecting autism spectrum disorder (ASD) in preschool-aged children. Lower levels of FABP4 were found in the blood of children with ASD compared to typically developing children.
Deep Longevity will present research on deep aging clocks at the Kinexum webinar, combining leading researchers and a preeminent expert at the FDA to accelerate the use of aging biomarkers in therapeutic interventions. The company has developed multimodal biomarkers of aging using deep learning techniques.
A team of scientists has identified a collective signature of proteins and metabolites that can predict who is at highest risk of dying from the infection. The biomarkers, including lower levels of glycosylated fetuin A and higher levels of serum protein carbamylation, were associated with death due to Staphylococcus aureus bacteremia.
Researchers at the University of Leeds have developed a new system to detect diseases, including coronavirus and cystic fibrosis, by examining individual molecules in blood. The method can compile a detectable signal from just a few biomarkers in just a few minutes, potentially speeding up testing and providing accurate results.
A new study found that ultra-processed food consumption is associated with shorter telomeres, a marker of biological age. The research suggests that diet may be causing cells to age faster.
A new study finds that endurance exercise induces changes in sweat biomolecule levels, potentially creating a non-invasive exercise monitoring system. Sweat extracellular vesicles contain microRNA molecules, which regulate biological processes and are essential mediators in exercise adaptations.
Researchers have developed a method to use face masks to collect compounds in exhaled breath aerosols for analysis, enabling large-scale screening for disease biomarkers. The new technique uses a fiber inserted into an N95 face mask to concentrate molecules, allowing for more efficient identification through mass spectrometry.
Researchers identified an enzyme that breaks down mucus in the gut, providing a potential biomarker for intestinal diseases. The discovery could lead to earlier diagnosis and treatment of conditions such as ulcerative colitis and colorectal cancer.
A study analyzing dolphin blood biomarkers reveals age-related declines in hemoglobin, alkaline phosphatase, platelets, and lymphocytes. This variation in aging rates suggests potential strategies for slowing disease progression and preventing chronic conditions in humans.
Researchers identified five blood biomarkers associated with increased odds of clinical deterioration and death in COVID-19 patients. Elevated levels of these biomarkers were linked to inflammation and bleeding disorders, increasing the risk of ICU admission, ventilatory support, and mortality.
Researchers identified reduced functional connectivity between the cerebellum and extrastriate cortex in FMR1 premutation carriers, which may serve as an early emerging indicator of FXTAS. This biomarker could help predict who among FMR1 carriers will develop characteristic symptoms before they appear.
Scientists at UCL have discovered new biomarkers that can identify people with Type 1 diabetes who are likely to respond to the immunotherapy drug Abatacept. The study found that certain immune cells, known as 'follicular helper T cells', play a key role in the disease.
A UArizona-TGen led team identified robust biomarkers through proteomics and metabolomic analysis that could help guide treatment for tens of millions of patients who sustain traumatic brain injuries. The study found that RIC (Remote Ischemic Conditioning) can be an effective intervention in preventing severe long-term disabilities.
Researchers identified phosphoprotein biomarkers to guide cancer therapy, demonstrating a novel approach for identifying and detecting tumor drivers. The study's findings suggest that precision medicine is a realizable goal for rare and recalcitrant cancers.
A team of researchers has developed a multi-analyte test strip to monitor various biomarkers continuously, enabling personalized medicine. The technology combines big-data analysis with wearable sensors and minimally invasive methods.
A study compared the diagnostic accuracy of a blood biomarker tau phosphorylated at threonine 217 (P-tau217) with other biomarkers for distinguishing Alzheimer's from neurodegenerative diseases. The results showed that P-tau217 had high sensitivity and specificity, making it a promising tool for early diagnosis.
Researchers at UConn Health have developed a non-invasive biomarker panel for diagnosing and monitoring infant urinary tract obstruction. The panel of five proteins can detect UPJO in infants and toddlers, reducing the need for expensive and invasive tests.
The FDA has issued a positive response to C-Path's biomarker panel for detecting acute drug-induced skeletal muscle injury in phase 1 clinical trials. The panel, developed by C-Path's Predictive Safety Testing Consortium and Duchenne Regulatory Science Consortium, uses four molecular biomarkers to aid in the detection of this condition.
Researchers at Duke University have developed a new optical sensing platform that can detect genomic cancer biomarkers in tissue samples using silver-plated gold nanostars. This technique has the potential to provide fast and reliable diagnostic results for cancer and other diseases, simplifying testing processes.
The Predictive Safety Testing Consortium and Duchenne Regulatory Science Consortium have developed a glutamate dehydrogenase (GLDH) biomarker to detect drug-induced liver injury in patients with inherited muscle disorders. The FDA has agreed to accept the Qualification Plan for GLDH as an important and accurate measurement of DILI.
A study of 9,029 adults found that cystatin C-based kidney function was associated with lower odds of frailty, falls, and cardiovascular disease events. The difference between cystatin C- and creatinine-based kidney function could be used to predict adverse outcomes in older adults.
Scientists at Flinders University recommend AIEgen technology for accurate clinical biomarkers and rapid disease screening through bioprobe tests. The technique can detect disease biomarkers in very low concentrations using low-cost, portable devices.
Researchers at Walter Reed Army Institute of Research have found that cathepsin B levels are increased in areas of injured brain relevant to critical executive functions. The study suggests that cathepsin B could be used as a blood-based biomarker to identify TBI severity within different brain regions and cerebral spinal fluid.
A nine-year longitudinal study found that family caregivers did not experience significantly greater inflammation levels compared to non-caregivers, challenging past research findings. The study suggests that caregiving may have minimal effects on physical health for most caregivers.
Two studies by European and US researchers found that higher consumption of these foods is associated with a lower risk of developing type 2 diabetes. Increasing fruit and vegetable intake by 66 grams per day was linked to a 25% lower risk, while whole grain consumption was also significantly related to reduced disease risk.
A new study found that a simple blood test can accurately predict concussion severity and duration, similar to expensive and invasive spinal taps. The test measures neurofilament light chain levels in the blood, which correlate strongly with the severity of concussions.
Researchers have discovered two novel biomarkers, FKBPL and CD44, that can predict key underlying causes of preeclampsia. The biomarkers show potential for early diagnosis in both early and late pregnancy, as well as targeted treatments.
Repeated blood tests measuring liver damage biomarker FIB-4 identify people at high risk of severe liver disease. The study found that increased FIB-4 scores between testing occasions can predict future liver cirrhosis, with almost half of affected individuals identifiable.
The study found that colchicine treatment was associated with reduced levels of inflammatory biomarkers and improved clinical outcomes in patients hospitalized with COVID-19. Colchicine's effectiveness in managing cardiac-related complications was also observed, suggesting potential benefits for these patients.
A study from University of Gothenburg found that COVID-19 patients with moderate to severe symptoms exhibited brain injury signs, including elevated GFAP and NfL biomarkers. These biomarkers were also associated with disease severity and ventilator treatment.
Researchers have identified unique metabolic signatures, called metabotypes, in over 50% of children with autism spectrum disorder. These biomarkers, detected through metabolomics tests, show promise in detecting early risk and potentially personalized therapies for ASD.
Researchers discovered a novel combination of biomarkers from baseline tumor tissues that predict improved clinical responses and prolonged survival in patients with advanced bladder cancer. ARID1A mutations and CXCL13 expression were associated with better overall survival, suggesting potential patient selection improvements.
Scientists at the University of Sussex have identified a potential pattern within blood that signals the presence of motor neuron disease. The discovery could significantly improve diagnosis with a future development of a blood test that identifies the unique biomarker, simplifying and speeding up diagnosis.
Researchers have developed a blood test that can accurately diagnose frontotemporal lobar degeneration (FTLD) and predict disease severity. The test measures neurofilament light chain levels in the blood, which are associated with FTLD progression, clinical phenotype, and prognosis.
Scientists at the University of Southampton are developing a rapid bedside test to diagnose neonatal Respiratory Distress Syndrome in premature babies. The test uses photonic technology and fingerprint spectroscopies, offering compact and versatile diagnostic capabilities.
A Cleveland Clinic-led research team will study the central vein sign as a reliable diagnostic marker for MS, aiming to improve accuracy and simplify clinical decision-making. The prospective study will enroll 400 patients at 11 centers in North America.
Researchers at A*STAR in Singapore have identified a potential biomarker, GSTT1, to screen the quality of donor's stem cells before harvesting. This biomarker can help determine the growth capacity and potency of MSCs, which is crucial for effective stem cell therapies.
Researchers identified 27 protein biomarkers in COVID-19 patients' blood plasma linked to disease severity. These molecular signatures can precisely classify patients according to World Health Organization's coding criteria, enabling early diagnosis and treatment.
A new mobile app assesses risk factors and key biomarkers from blood tests to produce a COVID-19 severity score. The tool has been validated using data from over 1,000 New York City patients, confirming its ability to identify those at high risk for severe cases.
A new study has found that neurofilament light chain (NfL) levels in the blood can distinguish individuals at high risk of Alzheimer's disease at age 22, on average 22 years before their estimated age of cognitive impairment.
A blood test using neurofilament light chain may predict recovery time after concussion, especially for those with multiple concussions. High levels of the biomarker are associated with severe symptoms like post-traumatic stress disorder and depression years later.
Two plasma and 10 cerebrospinal fluid biomarkers were identified to aid in early detection of MS with high sensitivity and specificity. These biomarkers may help monitor treatment response and disease progression.
Researchers found two single-miRNA and 29 two-miRNA biomarkers in serum plasma that can predict later onset of preeclampsia in asymptomatic pregnant women. Early identification could lead to prevention and better maternal and newborn outcomes.
Researchers at Duke University have developed a new imaging device that can measure the thickness and texture of the retina, potentially providing an early warning system for Alzheimer's disease. The device combines two technologies to spot structural changes in the retina, which could be indicative of the disease.
High DPP3 blood concentrations are linked to circulatory failure, cardiac depression, and acute kidney injury in burn patients. Decreasing DPP3 levels indicate a reduced risk of mortality.
Researchers at Duke University use plasmonics to boost fluorescence in diagnostics, increasing test brightness by over 150 times. The approach could make point-of-care diagnostics more widespread and affordable.
A study published in Brain found that a lag in blood drainage from the deep region of the brain is associated with ventriculomegaly and can be detected with MRI. The researchers identified this biomarker as a potential predictor for dementia and ventriculomegaly, which can be reversed by removing excess fluid.
A study published in Nature Communications reveals distinct urinary biomarker proteins for lupus nephritis in African American patients. The findings suggest that the ALCAM protein may be a promising therapeutic target. Researchers plan to conduct a longitudinal study to predict disease flares and improve treatment options.