Articles tagged with Biomarkers
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A team of scientists has identified serum cytokine concentrations as a quick and affordable means of classifying the severity of spinal cord injury in patients. The study aims to provide personalized healthcare decisions and accelerate research into spinal cord injury, with potential applications in developing countries.
A study by Zhang et al. has uncovered evidence of ancient marine algae in fossilized remains from 1400 million-year-old rocks, 600 million years earlier than previously known. The findings suggest that both green and red algal groups were present in marine ecosystems at this time.
Researchers have identified five novel diabetes subgroups with distinct biomarker profiles, highlighting the importance of inflammation in diabetes-related complications. These differences may enable early detection and therapy in individual subgroups, particularly those with severe insulin resistance.
Osaka University researchers used a photostabilizer to modulate fluorescence blinking in biochemical assays, allowing for the detection of a cancer RNA biomarker at ultralow concentrations. The technique increases fluorescence and eliminates blinking, providing a clear means to diagnose diseases in early stages.
New research suggests that HDL particles' anti-inflammatory properties may predict future cardiovascular events, improving risk assessment and prediction. The study found that individuals with lower anti-inflammatory activity in their HDL particles were more likely to experience cardiovascular events.
IU School of Medicine researchers have developed a blood test that can distinguish between severe depression and bipolar disorder, as well as predict future episodes. The test uses RNA biomarkers to inform tailored medication choices, offering a promising precision medicine approach to treatment.
Researchers at Buck Institute discover non-invasive biomarker test to measure and track performance of senolytic drugs, which target multiple age-related diseases. The biomarker detects a unique lipid metabolite released when senescent cells die.
The IASLC Molecular Database Project seeks to accelerate understanding of lung cancer biology, clinical care, and global scale. It aims to provide a platform for deeper, broader understanding of molecular testing and targeted therapy.
A team of researchers identified a novel biomarker, membrane-bound BASP-1 protein, to visualize adult human neural stem cells in the live mammalian brain. This discovery enables better understanding of neurogenesis and its relevance to neurological disorders, potentially leading to new therapeutic approaches.
A new diagnostic tool uses DPP3 to predict sepsis outcomes and guide early management. High DPP3 levels indicate severe sepsis and predict organ failure.
Researchers used quantitative proteomics to stratify fibroepithelial breast lesions, identifying three candidate biomarkers: MUCL1, HTRA1, and VEGFD. These markers show promise in augmenting existing diagnosis and monitoring disease progression.
Researchers at the University of Plymouth have discovered a biomarker, Fibulin-2 (FBLN2), that can distinguish between grade I and II meningioma tumours. This breakthrough could spare surgery for up to 85% of patients with lower-grade tumours, reducing the need for high-risk treatments.
A comprehensive analysis of biomarker testing reveals substantial variation in test utilization and treatment outcomes for stage IV NSCLC patients. Whole-genome sequencing may streamline diagnostic workflows and reduce complexity, but its cost-effectiveness remains uncertain.
Researchers at University of Montreal Hospital Research Centre have identified biomarkers associated with the severity of COVID-19. The study found specific immune alterations linked to SARS-CoV-2 infection and disease progression, which could help stratify patients by risk and identify new therapeutic targets.
Researchers found that conventional diagnostic methods for liver fibrosis do not accurately track the disease in patients who underwent Fontan surgery. The study revealed a unique regional development of fibrosis, which was not observed with hepatitis C and B, highlighting the need for new biomarkers and imaging techniques.
A study found associations between urinary miRNAs and cardiorenal outcomes, including blood pressure and eGFR levels, in Mexican children. The researchers identified several miRNAs associated with kidney function, blood pressure, and electrolyte biomarkers.
Researchers discovered five proteins associated with neutrophil activation that can predict severe COVID-19 outcomes. These biomarkers are elevated in patients who later require ICU admission or die from the virus.
UT Southwestern researchers have identified nine serum proteins in blood that strongly predict autism spectrum disorder (ASD) using machine learning tools. These biomarkers could enable earlier diagnosis and prompt therapeutic support, potentially improving quality of life for children with ASD.
Researchers discovered a blood biomarker that predicts kidney transplant rejection with a lead time of about eight months. The biomarker suggests using an existing medication to right the course of long-term recovery and prevent permanent damage.
A new biomarker has been identified that can determine individual treatment duration for tuberculosis patients, reducing the need for prolonged therapy. The biomarker is based on an RNA signature from 22 genes and was developed using patient cohorts from Germany and Romania.
A novel gel electrophoresis technique enables rapid biomarker diagnosis via mass spectrometry, overcoming issues with traditional digestion protocols. The method uses dissolvable polyacrylamide gels to recover target proteins, allowing for high-throughput sample preparation and efficient quantification of biomarkers.
Researchers identified two distinct pathways leading to septic shock, involving bioactive Adrenomedullin (bio-ADM) and Dipeptidyl peptidase 3 (DPP3). Early diagnosis with biomarker-guided approaches shows promising results in personalized medicine for sepsis treatment. New diagnostics are available for rapid detection of these biomarkers.
Scientists have developed a wearable microfluidic sensor to measure lactate concentration in sweat, offering real-time insights into muscle condition during exercise. The device is designed for comfort and practicality, using a non-irritating material and a microfluidic system for sweat collection.
A University of Oregon scientist has identified myeloid-derived suppressor cells and immunosuppressive cytokine IL-10 as early predictors of treatment response in trauma cases. Abnormal immune suppression may lead to poor bone healing, motivating the need for biomarkers that can predict patient outcomes.
A new study from the University of Eastern Finland has identified two potential biomarkers, miR-9a-3p and miR-136-3p, which could serve as diagnostic biomarkers for mild traumatic brain injury. These microRNAs were found to be elevated in both animal models and human patients, suggesting their potential use in diagnosing the condition....
Researchers have developed a strategy to amplify fluorescence signals using DNA probes and nano-antennas, enabling the detection of biomarkers in low concentrations. This technology has the potential to enable medical screening on patients without laboratory analysis.
A multi-disciplinary team at Harvard's Wyss Institute developed an electrochemical diagnostic sensor platform for multiplexed detection of clinically relevant biomarkers in whole blood. The device accurately detects three different sepsis biomarkers simultaneously and has the potential to revolutionize point-of-care diagnostics.
Researchers identified two highly antigenic epitope markers predicting multiple sclerosis in optic neuritis patients, providing a novel blood biomarker. The study utilizes the Mimotope Variation Analysis technology to analyze over 500 clinical samples from Finnish and Estonian patients.
Researchers used metabolomics and machine learning to identify biomarkers for COVID-19 diagnosis and risk assessment. The study found 26 biomarkers that differed between mild and severe illnesses, potentially revealing new clues on how SARS-CoV-2 affects the body.
NeuroVision Imaging, Inc. has received an investment from the Alzheimer's Drug Discovery Foundation (ADDF) to develop reliable and affordable biomarker tests for Alzheimer's disease and related dementias. The goal is to improve clinical trials and monitor response to treatments.
Researchers at Washington University in St. Louis developed a pain-free microneedle patch that can detect biomarkers in the fluid between cells, revolutionizing diagnostic testing. The technology offers unprecedented sensitivity and could eliminate unnecessary hospital trips and discomfort.
Researchers explore relationship between COVID-19 severity and cardiac injury, finding elevated inflammatory biomarkers associated with higher risk of cardiac damage. High levels of IL-2R and comorbidities predict increased likelihood of cardiac injury in severe COVID-19 patients.
Researchers detected Mexican marigold in ancient Maya ceramic vessels, which they believe were mixed with tobacco to enhance its effects. The discovery sheds light on ancient Maya drug use practices and paves the way for further studies on psychoactive plants.
The study found new biomarkers related to changes in protein function involved in novel regulatory mechanisms of metabolic and immunological pathways in blue mussels, soft-shell clams, Eastern oysters, and Atlantic jackknife clams. Biomarker identification will benefit the aquaculture industry.
Researchers at Washington State University have identified biomarkers in fathers' sperm that are linked to an increased risk of their children developing autism. These epigenetic markers can be detected with high accuracy and may help diagnose the condition, as well as identify environmental factors that contribute to its development.
Researchers developed a blood test that detects misfolded proteins in blood, predicting Alzheimer's disease risk in people with subjective cognitive decline. The test identified those at high and low risk, providing hope for early-stage treatment.
A global research consortium is proposed to collect and share digital speech and language data to detect early signs of Alzheimer's. The consortium aims to create a comprehensive, harmonized repository of samples from diverse cohorts to develop biomarkers that can monitor disease progression.
A large data analysis of over 7,100 U.S. adults found that vaping combined with smoking results in similar levels of inflammation and oxidative stress as smoking cigarettes exclusively. Researchers also found that dual use of both products does not reduce risk.
Researchers developed a gene biomarker identification technique to predict liver toxicity in just 24 hours, reducing lengthy animal studies. The method uses machine learning approaches to identify key genes in messenger RNA, enabling accelerated testing for agrochemical and pharmaceutical companies.
The ADQI consensus statement recommends using a combination of damage and functional biomarkers to manage Acute Kidney Injury (AKI). Proenkephalin penKid is proposed as a marker for assessing AKI progression and kidney recovery, with CE-IVD marked assay available for point-of-care usage.
A study found novel biomarkers associated with incident heart failure, including adiponectin and pyruvate, which were linked to increased risk after 8.8 years of follow-up. Chronic inflammation and metabolic changes were also identified as key factors.
A recent study found that only seven percent of high-risk noncardiac surgery patients underwent preoperative screening for biomarkers, leading to increased mortality and complications. Researchers emphasize the need for improved compliance with guidelines and education among physicians.
A study from the University of East Anglia found that blood biomarkers such as cholesterol, inflammation, and liver function can predict future disability and healthcare demand. The researchers also discovered a pro-rich inequity in health care use, where people with higher incomes are more likely to seek medical attention.
A novel method detects conformational changes in TDP-43 protein in ALS patients' CSF, showing high sensitivity and specificity. The technology has potential for diagnosing and developing clinical therapies for this fatal neurodegenerative disease.
Researchers have identified six biochemical biomarkers linked to COVID-19 infection using a blood test. The test can detect infected patients with high accuracy, allowing for rapid diagnosis and treatment prioritization.
A recent study by MedUni Vienna found that blood biomarkers for systemic inflammation increase with liver cirrhosis stages, predicting complications in asymptomatic patients. The severity of portal hypertension also correlates with levels of inflammatory markers, increasing mortality risk.
A new study finds that tiny malfunctioning compartments in neurons, called endosomes, are commonly defective in Alzheimer's patients. Endosomal trafficking disruption is associated with high levels of tau proteins in spinal fluid and blood, making it a promising target for developing therapies.
Researchers have developed a contact lens that uses tiny channels to collect tears and measure biomarkers like sodium ions and glucose molecules. The lens can detect changes in tear pH and flow rates, offering a potential solution for preventing dry eye disease and monitoring diabetic patients.
A study of over 25,000 female health professionals found that a Mediterranean-style diet was associated with a 30% lower risk of developing type 2 diabetes. The diet's impact on insulin resistance, body mass index, and inflammation were key factors in this reduced risk.
Researchers identify blood biomarkers indicative of brain injury in COVID-19 patients, offering potential for timely diagnosis and cost-effective treatment approaches. The study highlights the increased risks of persistent neurological deficits, psychiatric disorders, and neurodegenerative diseases associated with COVID-19.
Researchers have developed a sensitive optical method to detect formaldehyde in exhaled breath, which could lead to an inexpensive and fast way to screen for lung and breast cancer. The new approach uses multipass spectroscopy with optical fringe quenching technique, allowing detection of formaldehyde at low concentrations.
Researchers found that neurofilament light protein levels in the blood can predict stroke severity and prognosis, as well as anticipate future recovery. Higher NFL levels forecast worse functional outcomes and shorter survival time after a stroke. This discovery establishes NFL as a promising prognostic biomarker for stroke.
Researchers found that antiangiogenic therapy can increase the invasiveness of kidney tumors and induce a poor prognosis. A new biomarker, ALDH1A3, has been identified to predict patient response to treatment.
Researchers found that Trop-2 expression is a predictive biomarker for sacituzumab govitecan efficacy in triple-negative breast cancer. Increasing Trop-2 expression improved SG efficacy in mice with HRR-proficient tumors, suggesting a potential clinical benefit for patients with high Trop-2 levels.
Emanuel Petricoin, Co-Director of CAPMM, is receiving $280,696 in funding to discover protein biomarkers for response prediction in stage II/III breast cancer patients. The project aims to utilize data from the ISPY2 TRIAL to develop novel targeted therapy agents.
Researchers developed a wearable device to monitor stress levels using sweat biomarkers, measuring cortisol, glucose, and vitamin C. The device tracks circadian rhythms and can be controlled via a smartphone, offering noninvasive monitoring of stress levels.
A multi-institutional team led by UCI researchers will expand research on biomarkers of Alzheimer's disease in adults with Down syndrome. The five-year, $109M grant aims to improve the quality of life of aging individuals with Down syndrome through advancing prevention and treatment strategies.
Researchers at Brigham and Women's Hospital identified several biomarkers that can predict the risk of preeclampsia from a blood sample drawn at 12 weeks gestation. The study also found possible subtypes of preeclampsia linked to platelet dysfunction and complement system dysfunction.
Researchers found that consuming flavanol-rich foods and drinks, such as tea and apples, can lead to significant reductions in blood pressure. The study used objective measures of thousands of UK residents' diet and found a comparable effect to Mediterranean and DASH diets.
Researchers identify distinct functional connectivity patterns in brain circuits using EEG, enabling subtyping of patients independent of clinical diagnosis. These patterns can predict treatment outcomes, with some subtypes responding better to psychotherapy or medication while others benefit from non-invasive TMS treatment.