Research on measurable signals of health and disease. Covers ultrasound imaging pipelines, fetal-distress detection, cancer monitoring, and fatigue biology.
A team of researchers has discovered blood biomarkers that can predict patient response to immunotherapy treatment for melanoma. The study found that patients with increased lactate levels and specific lipid and amino acid metabolites were more likely to respond to treatment.
A new study using blood samples from professional soccer players reveals that headers affect brain activity by altering microRNAs, which can serve as biomarkers for brain injury. The research also explores the effects of accidental head impacts and high-intensity exercise on microRNA levels.
Researchers at UC Davis MIND Institute found a novel gene linked to autism spectrum disorder in newborns. The study analyzed DNA methylation signatures in the placenta, which reflected fetal brain development and early autism diagnosis.
The COXEN GC score was a significant predictor of overall survival when looking at both treatment groups combined. The study found no association between COXEN scores and progression-free survival, but the biomarker may serve as a potential tool to improve patient outcomes.
A comprehensive analysis of over 2,200 patients in Europe reveals the complexity of cholangiocarcinoma, a rare cancer often diagnosed at an advanced stage. The study highlights the need for education programs to raise awareness and improve early diagnosis, survival, and quality of life.
A new study has found a potential predictor for perimenopause in the form of IgG glycome composition, which may lead to improved diagnosis and treatment options. The study analyzed nearly 2000 women over 15 years and discovered changes in the IgG glycome that occur rapidly during menopause.
Paczesny will explore biomarkers and a new type of immune cell to identify and regulate acute lung injury after BMT. She aims to improve understanding of signaling mechanisms in lung injury after BMT, particularly as they relate to idiopathic pneumonia syndrome.
Researchers from University of Otago hope to identify Alzheimer's risk in middle age with a simple eye test. Thinner retinal nerve fibre layer and ganglion cell layer are linked to cognitive decline, suggesting optical scans could aid diagnosis.
A novel immune-profiling method can return detailed immune cell type proportions using only DNA from blood, potentially allowing for individualized prediction of outcomes in immunotherapy patients. This approach offers the opportunity to ask and answer questions about the immune system in health and disease.
A University of Houston researcher has identified potential biomarkers for neuropsychiatric symptoms of lupus, which include CSF Lipocalin-2, M-CSF, IgM, and complement C3. Elevated levels of these proteins in cerebrospinal fluid may indicate a diagnosis of NPSLE.
A team of researchers identified clusters of mutations in the genome that contribute to cancer progression in about 10% of human cancers. These clustered somatic mutations can be used to predict patient survival, with specific hotspots linked to better or worse outcomes for certain types of cancer.
Researchers discover that chemotherapy triggers the secretion of mucins in colorectal cancer cells, forming a physical barrier that prevents drugs from reaching their intended target. The study found potential new biomarkers for disease prognosis and a promising treatment strategy using NCX blockers like SN-6.
Researchers developed a new personalized test for monitoring cancer recurrence in acute lymphoblastic leukemia (ALL) patients. The MP PCR uses multiple genomic markers to detect disease recurrence sooner, improving treatment strategies and patient stratification.
A study of 74 healthy individuals found correlations between spleen volume and gender, age, and certain blood parameters such as HGB, HCT, RBC, ALT, but not others like LYM%, PLT. Spleen volume was estimated using the Cavalieri principle and stereological method.
Researchers have identified a germline biomarker signature that can predict serious side effects in up to 3 in 10 patients undergoing anti-PD1/PDL1 therapy. The findings represent an important step toward personalizing checkpoint therapy, potentially improving patient outcomes and reducing harm.
Researchers at the Buck Institute discovered a naturally occurring metabolite, 25-hydroxycholesteral, that significantly reduces senescent cells in multiple cell types and improves muscle mass in aged mice. The molecule targets CRYAB, a small heat shock protein associated with age-related diseases like myopathies.
Researchers found that fuel poverty leads to higher levels of inflammation, affecting physical health, and lower life satisfaction, impacting wellbeing outcomes. The study's findings highlight the need for policies to support low-income households struggling with fuel poverty.
A study led by Clemson University geneticist Allison Hickman has identified 11 high-priority genes associated with uterine cancer. These genes are potential targets for drug therapies, offering new hope for effective treatment options.
Researchers at the University of Illinois have developed a new approach to detect cancer biomarkers in human serum, reducing the detection time from hours to just one minute. This method uses magnetic-plasmonic nanoparticles and photonic resonator absorption microscopy to achieve high selectivity and rapid sample-to-answer analysis.
Scientists have discovered families of proteins that can predict liver transplant rejection, allowing for early detection and modification of immunosuppression. The Blood Proteoform Atlas outlines over 56,000 protein molecules associated with immune cell proteins that change with rejection.
Regular physical activity significantly changes metabolite profiles, associated with a lower risk of type 2 diabetes. The study found improved insulin secretion and reduced fasting glucose levels in physically active men.
Researchers have identified 15 biological markers that can predict severe depression in pregnant women with 83% accuracy. This finding has the potential to improve prenatal care and reduce depressive symptoms in mothers.
The NRG-RTOG 1010 clinical trial found that adding trastuzumab to chemoradiation and surgery did not improve disease-free survival for HER2-positive esophageal adenocarcinoma patients. Despite this, the study highlights future research opportunities to explore combining trastuzumab with other HER2-targeting agents.
The new BD CellView Image Technology enables high-speed sorting of individual cells based on detailed microscopic analysis, accelerating discovery research in immunology, cell biology, and genomics. This technology has the potential to unlock new cell-based therapeutic discoveries and transform various fields of biomedical research.
Sophie Paczesny's research aims to validate biomarker panels that help doctors predict chronic GVHD risk and adjust immune suppression treatments accordingly. The study uses machine learning algorithms to analyze stored plasma and blood cell samples from over 1,300 BMT recipients.
A recent study published in The Journal of Urology found that serum hormone ratios can predict the risk of future infertility in children with cryptorchidism. Researchers discovered that inhibin B levels and anti-Mullerian hormone (AMH) are significant markers of spermatogenesis, helping to identify boys at high risk of infertility.
Researchers found that a third of patients with wet age-related macular degeneration can safely stop eye injection therapy without further vision loss. Patients who stopped treatment showed better visual acuity, gain of vision, and less fluid in their retina compared to those requiring continued injections.
Researchers have discovered two proteins, IGF-1 and IGFBP5, in urine samples that are significantly lower after a concussion. These biomarkers could help diagnose concussion and monitor recovery. The study suggests that urine testing could be an early and inexpensive way to detect concussions.
A new study found that certain brain wave patterns during sleep can be used to diagnose dementia and other cognitive impairments. The study identified parameters for automated detection methods, which were linked to fluid intelligence and declined during early stages of dementia.
A study published in Neuron found that inflammatory markers are elevated even before dementia symptoms appear, suggesting a potential role in neuroprotection. The researchers discovered two proteins linked to a damage control program, which may support the development of new drugs for early detection and treatment.
Researchers found gender-specific brain alterations in people with depression, including altered blood-brain barriers in women. They also identified a potential depression biomarker in women's blood samples.
Researchers have discovered a new biomarker, microstate D, associated with increased sleep disturbance and inattention symptoms in adults with ADHD. The study, published in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, provides evidence for a more precise diagnosis of the disorder.
Researchers have developed a highly sensitive immuno-CRISPR assay to detect acute kidney rejection in urine, potentially allowing for early diagnosis without invasive biopsy. The test uses CRISPR/Cas12a gene editing technology to identify biomarkers of rejection, such as CXCL9, with improved sensitivity compared to existing methods.
Researchers developed a new SERS-based multiplexing technique to detect kidney injury biomarkers SLPI and IL-18, achieving high sensitivity and reliability. The approach shows promise for objectively assessing donor kidney quality, potentially reducing discard rates and recipient complications in clinical practice.
A new study has identified a biomarker for depression and antidepressant response in human platelets. The biomarker can be detected through a blood test and may indicate therapeutic response within one week of treatment.
Researchers at South Ural State University have identified biomarkers for post-traumatic stress disorder (PTSD) in veterans with long-lasting symptoms. Gamma-aminobutyric acid levels were found to be the most sensitive indicator, differing from reference values even years after traumatic events.
Exposure to nitrogen dioxide and fine particles is associated with increased beta-amyloid protein deposition and neurofilament light in cerebrospinal fluid, indicating a potential risk factor for Alzheimer's disease. The study highlights the importance of reducing exposure to air pollution to mitigate this risk.
Researchers have discovered evidence of human habitation in the Faroe Islands dating back to around 500 AD, with signs of domestic sheep arrival at this time. The findings, based on lake sediments and DNA analysis, provide conclusive proof that humans inhabited the islands before the Vikings, who are thought to have arrived around 850 AD.
A new study found that a specific type of carbohydrate called ‘fodmaps’ can aggravate intestinal problems, but its impact is not as significant as previously believed. IBS symptoms were found to be influenced more by psychological factors and individual differences in metabolism and intestinal flora.
A new study has made an Alzheimer's disease biomarker test available to all Canadians, enabling doctors to accurately diagnose the disease even when mild symptoms are present. The test aims to improve care and support for individuals living with Alzheimer's disease and their families.
Researchers found that up to one in five patients experience increased troponin levels after major surgery, indicating potential heart damage. These patients were also more likely to be anaemic before the operation.
Researchers have discovered microRNAs that can detect ovulation and egg quality in fish, and also identify growth signatures. These findings could lead to the development of non-invasive biomarkers for monitoring animal physiological states, enabling cost-effective and accessible information on health.
Researchers identified epimutations in cheek cells that can predict rheumatoid arthritis susceptibility. The discovery could lead to a non-invasive diagnostic test for the disease. Biomarkers were found in both Caucasian and African-American women with rheumatoid arthritis, suggesting a strong signal for the disease.
A team of researchers has recorded electrical signals in the human brain associated with ebbs and flows in OCD symptoms over an extended period. The study could lead to an emerging therapy called deep brain stimulation that adjusts to everyday changes in OCD symptoms, potentially providing more relief and fewer side effects for patients.
A recent study identified several protein biomarkers that protect against the development of inflammatory diseases such as psoriasis and osteoarthritis. The researchers used Mendelian Randomization to determine whether high levels of these proteins are associated with a lower risk of disease.
Researchers used imaging mass cytometry to analyze protein expression and cell location in tumor samples. High density of antigen-presenting cells with high PD-L1 and IDO expression was associated with higher pathological complete response rate in patients treated with atezolizumab plus chemotherapy.
A new study reveals how design bias can affect medical data used in artificial intelligence tools and personalized healthcare. The research highlights the need for more inclusive recruitment strategies to ensure diverse patient populations are represented.
Researchers developed an AI-powered system to model disease progression in patients as they age. The model assesses metabolic and cardiovascular biomarkers to calculate health status and disease risks across a patient's lifespan.
Researchers at Skoltech have created an optoacoustic endoscopic probe that can analyze atherosclerotic plaques by forcing molecules to sound their presence. The device uses laser light to make biomarkers oscillate, producing ultrasound signals that can be detected by a sensitive microphone.
A new study published in the journal Nutrients found that probiotics can reduce nausea and vomiting during pregnancy by up to 33% and improve quality of life symptoms. The study also identified specific gut microbes associated with higher levels of nausea, suggesting potential biomarkers for future research.
A new rapid test developed by Duke University researchers can measure patient immunity against multiple COVID-19 variants like Omicron and Delta. The CoVariant-SCAN test uses a polymer brush coating to detect neutralizing antibodies, allowing for quick and accurate assessment of antibody effectiveness.
Scientists at Virginia Tech have identified a critical modification in the protective molecular bag of the Lyme disease-causing bacterium, allowing it to move effectively and cause disease. The discovery, published in Nature Microbiology, reveals that the bacteria acquires this unique sugar modification from ticks.
A long-term study has revealed that drinking higher amounts of coffee may make you less likely to develop Alzheimer’s disease. The study found an association between coffee and several important markers related to Alzheimer’s disease, including executive function and amyloid protein accumulation in the brain.
Researchers have developed an assay that uses specific immune-biomarkers to monitor patient survival chances and effectiveness of ovarian cancer treatments. The 'sFIS' assay will enable targeted therapy for each patient, improving treatment outcomes.
The Zinc Status Index is a new evaluation method developed by Cornell food scientists that uses biomarkers to calculate the physiological status of a subject. It aims to provide a comprehensive assessment tool for zinc deficiency, which affects over 1 billion people worldwide.
Researchers identified 166 prognostic biomarkers from long non-coding RNAs, with one biomarker, HOXA10-AS, showing high effectiveness in categorizing gliomas as low- or high-risk. The study provides potential therapeutic targets and insights into cancer biology.
Researchers at Peking University developed a non-invasive exhaled breath screening system for COVID-19, identifying key breath-borne VOC biomarkers in just 5-10 minutes. The technology reduces transmission risk by providing quick screenings for false negatives and hospital discharges.
A peer-reviewed study published in Life journal proves Reflex identifies biomarkers for concussions, enabling accurate clinical diagnosis and decision-making. The study, conducted by Purdue University, uses pupillary light reflex to measure concussion patients' recovery and prevent compounding injuries.
A large study published in Nature Communications has identified a protein in the blood, follistatin, which can predict type 2 diabetes up to 19 years before diagnosis. The study found that higher levels of follistatin circulating in the blood are associated with an increased risk of developing the disease.
Researchers have identified new MRI brain imaging biomarkers that can predict the effectiveness of antidepressants with high accuracy. These biomarkers bring a new level of precision to prescribing the most effective treatments, potentially saving patients from months of taking the wrong medication.