Articles tagged with Biomarkers
A study found that chronic stress, measured by allostatic load, was associated with a lower likelihood of completing chemotherapy and lower overall survival rate in patients with lymph node-positive or high-risk lymph node-negative HER2-negative breast cancer. Allostatic load may be a better predictor than genetic ancestry for chemothe...
Research investigates m6A regulators in cognitive dysfunctions, identifying potential biomarkers like SNRPG and SNRPD2. The study also highlights the role of APOE ε4 allele and FTO expression in AD development.
Researchers will investigate hidden signs of brain damage in REM behavior disorder, aiming to identify biomarkers that predict impending neurological disease. The goal is to delay the onset or prevent dementia or Parkinsonism through clinical trials.
Scientists at Karolinska Institutet have discovered a carbohydrate called mannose as a biomarker for severe COVID-19 disease severity. The study found that glycolysis and glutaminolysis play a crucial role in SARS-CoV-2's spread and growth, providing potential new therapeutic strategies.
Researchers found that liver transplant recipients who contracted COVID-19 recovered faster and with less severe inflammation compared to heart or kidney recipients. The study suggests testing certain immunosuppressants to treat COVID-19 patients, regardless of their transplant status.
Researchers created a customized device that targets unique brain circuits associated with depression, providing immediate relief. The approach uses neural biomarkers to personalize therapy and has shown long-term efficacy in treatment-resistant patients.
Researchers at JILA have enhanced the sensitivity of their decade-old frequency comb breathalyzer to detect four biomarkers of disease in human breath. The upgraded system can also identify six additional chemicals, with potential implications for COVID-19 testing and real-time health monitoring.
Researchers found that early accumulation of tau proteins in the brain, measured by PET scanner, is more effective at predicting memory impairment than other biomarkers. The study suggests that tau PET should be recommended for clinical prognostic assessment of cognitive decline in Alzheimer's patients.
Researchers developed a non-toxic, small-molecule probe that provides real-time visualization of disease progression, overcoming limitations of MRI and PET imaging. The probe binds copper ions and detects dysregulated levels, accurately identifying Wilson's disease and other maladies.
A team of scientists has identified molecular biomarkers associated with sepsis, which could be used to predict patient outcomes and guide treatment. The study found that changes in CD52 expression were linked to good outcomes, while S100A9 acted as a driver of fatal sepsis.
Studies found distinct patterns in nasal microbiota of individuals infected with SARS-CoV-2, with symptomatic patients showing reduced bacterial counts and increased presence of certain bacteria. The findings suggest that altered microbiota may impact immune response to the virus.
A new study from Karolinska Institutet in Sweden found that COVID-19 disease severity is linked to the characteristics of white blood cells called granulocytes. Combined measurements of granulocyte characteristics and widely used biomarkers can predict key clinical features such as respiratory function and multiorgan failure.
A serum biomarker, polyubiquitinated phosphatase and tensin homolog (PTEN), was associated with a four-fold higher risk of kidney function decline. This modified form of PTEN was linked to severity of lesions in kidney structure, indicating early manifestations of diabetic kidney disease.
Researchers at Buck Institute for Research on Aging provide a framework for precision nutrigeroscience to study the need for individualized dietary interventions. Studies in fruit flies show that lifestyle and genetics impact lifespan and healthspan, leading researchers to challenge the field to adopt a more nuanced approach.
A new study has identified unique genetic codes in the placenta that could detect pregnancy complications earlier than current tests. The researchers found specific biomarkers in maternal blood that indicate placental health and fetal well-being, allowing for real-time assessment throughout pregnancy.
Researchers found that salivary HR-HPV DNA can detect HPV-driven head and neck cancers (HNC) in most patients at the time of diagnosis. The study showed a clear survival advantage for salivary HR-HPV-positive patients, with high-risk strains detected in most cases.
Researchers from FAU and MIT develop a microfluidic assay to study the mechanical performance of red blood cells under hypoxic conditions. The study reveals that cyclic hypoxia can lead to mechanical degradation of the red blood cell membrane, contributing to aging.
Researchers found that pre-treatment circulating tumor DNA (ctDNA) levels can accurately predict long-term survival in non-small cell lung cancer (NSCLC) patients. Patients with low ctDNA levels had significantly improved progression-free survival and overall survival compared to those with high levels.
A study published in PLOS Genetics found that smoking-related DNA methylation patterns explain around 1/5 of the variation in body mass index between individuals. The study analyzed genomic sequence data from over 390,000 participants and found that genetics accounted for 50% of the variation in BMI.
Researchers analyzed large datasets to find biomarkers that could help select immunotherapy treatment for older patients. The analysis suggests that factors such as mutational burden and immune checkpoint protein expression are associated with increased response to immunotherapies in older patients, despite lower general immunity.
Despite its promise, cancer immunotherapy faces several hurdles, including limited efficacy and variable outcomes. Researchers are exploring new therapeutic targets and combination strategies to overcome resistance and improve patient outcomes.
Researchers from the National University of Singapore have identified three new urinary biomarkers that can detect consumption of ADB-BUTINACA, an emerging synthetic cannabinoid. The discovery will help boost global surveillance of synthetic cannabinoid abuse and aid in tackling the increasing abuse of this substance.
Researchers identified specific proteome features in COVID-19 patients' urine to distinguish between mild and severe cases. The study suggests that urine proteomics could be a valuable tool for early detection and prediction of COVID-19 progression.
Georgia State University researcher Vince Calhoun has received a $3.5 million grant to develop new methods for capturing dynamic connectivity in the brain and identifying biomarkers for early detection of Alzheimer's disease. The researchers aim to analyze real-time connectivity patterns to predict future cognitive decline.
The Alzheimer's Drug Discovery Foundation has provided NeuroVision Imaging Inc. with additional funding to accelerate the development of a novel blood-based lab test that can predict dementia before clinical onset. This technology has the potential to make diagnostic testing more practical, less invasive and less costly.
A randomized trial found that a shorter course of rifapentine-isoniazid therapy resulted in significantly higher treatment completion rates compared to a longer daily course. The findings suggest that this regimens can be more effective for preventing tuberculosis disease in individuals with HIV, particularly in high-transmission areas.
Researchers from Tokyo University of Science developed a self-powered diaper sensor that monitors urine sugar levels, providing an alternative biomarker for blood sugar monitoring. The sensor uses a biofuel cell powered by glucose in the urine, detecting sugar levels within 1 second and simplifying caretaking tasks.
A new study finds that female walruses in the Chukchi Sea rely on biomarkers from algae growing within sea ice as a primary food source. The researchers tracked these markers using liver tissues from harvested animals, revealing a difference in foraging behavior between males and females.
A study by the Center for Cell-Based Therapy in São Paulo, Brazil, has discovered a set of biomarkers that can be used to predict which patients with glioblastoma may have tumors resistant to radiation therapy. The genetic signature helps doctors choose the best treatment option for these patients.
Researchers at MUSC identify a type of fat called sphingolipid that could predict the severity of heart disease in African American patients with lupus. Higher levels of Lac-Cer are associated with increased disease activity and may have predictive value for patient progression.
Researchers at Indiana University School of Optometry have identified new biomarkers that can detect early eye changes associated with diabetes-related blindness. The study's findings may lead to earlier identification of people at risk for diabetes or visual impairment.
Researchers discovered that skin fibroblasts from FTD patients exhibit pathological RNA foci, p62 protein-containing vesicles, and defective energy metabolism, which could lead to the development of novel biomarkers and treatments. These findings may also be useful in testing drug effects on FTD patients.
Researchers at Ulsan National Institute of Science and Technology (UNIST) have developed a novel, hemolysis-free method for separating blood cells from plasma using magnetic forces. The new platform achieved 100% plasma purity and high recovery rates, outperforming conventional methods.
A large cross-sectional study in Canada found no association between loud noise exposure and changes in biomarkers for cardiovascular disease or outcomes. However, there were associations found between noise and several biomarkers, but these remained statistically insignificant after adjusting for important variables.
New research published in eNeuro found that premature babies' brain connections at birth can predict their future emotional and social development. The study discovered a link between the strength of the uncinate fasciculus, a white matter tract involved in emotional regulation, and emotion moderation skills in preschoolers.
Researchers review advancements in biosensing technologies for neonatal sepsis diagnosis, highlighting the need for faster and more accurate methods. Biosensors offer a promising solution, detecting multiple parameters simultaneously with high sensitivity and accuracy.
Researchers have discovered that reduced levels of sphingosine are significantly associated with developing COVID-19 symptoms, while elevated sphingosine and acid ceramidase levels are linked to asymptomatic infections. This biomarker has a high degree of accuracy in predicting patient outcomes.
A new biomarker, HBcrAg, has been found to accurately predict viral load in patients with chronic hepatitis B and reflect response to anti-viral treatments. This discovery may lead to improved monitoring methods for CHB, enabling clinical decisions and potentially improving patient outcomes.
Researchers identified predictive molecular biomarkers for non-response to anti-TNF and anti-integrin therapies in UC. Biomarkers in innate and adaptive immune systems, as well as proteolytic degradation, were found to be predictive of therapy non-response.
A recent study by Queen Mary University of London provides new insight into the mechanisms behind uncontrolled inflammation in COVID-19 patients. The research found that treatments increasing specialised pro-resolving mediators (SPM) production, such as dexamethasone, may play a key role in limiting disease severity.
Researchers have developed a new integrative genetic test, LYNX, that analyzes standard and novel molecular markers in common lymphoid neoplasms. The test provides accurate detection of mutations, identification of large genome-wide chromosomal aberrations, and assessment of immunoglobulin and T-cell receptor gene rearrangements.
Researchers predict two nicotine biomarkers, NMR and TNE, in smokers of multiple ethnicities using machine learning approaches. These models can estimate nicotine biomarker levels from DNA data or existing genomic information.
Researchers at the University of Pennsylvania School of Medicine have developed a framework to detect Alzheimer's disease and other forms of neurodegeneration using cerebrospinal fluid biomarkers. The ATN framework, which includes three biomarkers, has been shown to provide accurate diagnoses for patients with frontotemporal degeneration.
Researchers develop low-cost DNA biomarker technique to trace cocoa beans back to specific farms of origin. This approach could help end slavery and child labor in the global cocoa industry by providing consumers with accurate information about the ethics of their chocolate purchases.
Researchers investigated CEA as a blood-based biomarker for anal cancer. Although CEA levels correlated with disease progression, they were not associated with survival outcomes or clinically relevant in managing the disease. Novel approaches with serum biomarkers are necessary for this rare and increasing diagnosed malignancy.
The SCAIFIELD project aims to develop measuring protocols and procedures for maximizing the use of existing MRI technology. This will enable finer details of the human brain to be visualized, leading to better detection of pathological changes in neurodegenerative diseases such as spinocerebellar ataxias.
Researchers at Radboud University have identified new biomarkers for pyridoxine-dependent epilepsy, enabling better and earlier treatment of the disease. The discovery could lead to optimized treatment and improved chances of preventing cognitive disability.
A study has identified a microRNA-like small RNA encoded by SARS-CoV-2 as a reliable biomarker for stratifying severe COVID-19 patients from mild/moderate ones. This biomarker enables early detection of high-risk individuals, allowing for optimized treatment and improved treatment outcomes.
A new study by R&D at British American Tobacco found that switching to exclusive use of glo resulted in significant reductions in exposure to toxicants and indicators of potential harm compared to continuing to smoke. The study showed similar reductions in biomarkers as those who stopped smoking completely.
Researchers have identified stearic acid and ornithine as indicators of coronary microvascular disease (CMD), a condition that damages blood vessels and causes decreased blood flow to the heart muscle. The study suggests that estrogen may also play a role in CMD development, particularly in postmenopausal women.
Researchers have discovered several stool proteins that can detect colorectal cancer and inflammatory bowel disease, potentially replacing invasive endoscopy. These novel biomarkers were identified using aptamer-based screening and showed promise in early diagnosis and predicting disease progression.
Scientists have identified biomarkers that predict HIV remission after antiretroviral therapy (ART) interruption, which could help develop new therapeutic strategies for infection control. These biomarkers provide insights into the biological mechanisms controlling HIV replication and may aid in designing novel cure strategies.
A new study has identified a protein called pentraxin 3 (PTX3) that may be used to aid in the diagnosis of pancreatic cancer. PTX3 levels were found to be significantly higher in patients with pancreatic ductal adenocarcinoma, a type of pancreatic cancer.
The research data provides insights into the biology of Alzheimer's disease among Mexican Americans, highlighting lower levels of beta amyloid protein and earlier onset of cognitive loss compared to non-Latino whites. This comprehensive study is a first-of-its-kind examination of health disparities and diagnostic opportunities for unde...
Researchers detected changes in fractal motor activity regulation (FMAR) patterns in cognitively healthy adults, particularly among women, which were associated with preclinical Alzheimer's disease pathology. FMAR may serve as a non-invasive biomarker for testing and screening AD.
A new AI model can quantify individual deviations from typical aging trajectories in patients with mild cognitive impairment, indicating potential for earlier diagnosis and treatment. The study found that the model's predicted age difference was significantly associated with cognitive decline and progression to Alzheimer's disease.
A recent study by University of Missouri researcher Jennifer Hulett found a link between forgiveness, congregational support, and reduced stress biomarkers in breast cancer survivors. The findings suggest that spiritual practices like prayer, meditation, and yoga may improve physical health outcomes among cancer survivors.
Researchers developed a novel PET tracer to detect abdominal aortic aneurysms (AAAs) and predict rupture risk. The tracer, targeting chemokine receptor type 2 (CCR2), showed safety and effectiveness in diagnosing AAAs and assessing treatment response.
Case Western Reserve University researcher Farren Briggs has been awarded $1.2 million to identify biomarkers for more accurate MS diagnoses. The goal is to monitor disease activity and progression, ultimately improving treatment outcomes.
Researchers employed iTRAQ based quantitative proteomics to characterize protein alterations in fibroepithelial lesions (FELs) of the breast. The study identified three candidate biomarkers: MUCL1, HTRA1, and VEGFD, which were uniquely expressed in FAD, borderline, and malignant PTs, respectively.