Articles tagged with Biomarkers
Researchers have identified 15 biological markers that can predict severe depression in pregnant women with 83% accuracy. This finding has the potential to improve prenatal care and reduce depressive symptoms in mothers.
The NRG-RTOG 1010 clinical trial found that adding trastuzumab to chemoradiation and surgery did not improve disease-free survival for HER2-positive esophageal adenocarcinoma patients. Despite this, the study highlights future research opportunities to explore combining trastuzumab with other HER2-targeting agents.
The new BD CellView Image Technology enables high-speed sorting of individual cells based on detailed microscopic analysis, accelerating discovery research in immunology, cell biology, and genomics. This technology has the potential to unlock new cell-based therapeutic discoveries and transform various fields of biomedical research.
Sophie Paczesny's research aims to validate biomarker panels that help doctors predict chronic GVHD risk and adjust immune suppression treatments accordingly. The study uses machine learning algorithms to analyze stored plasma and blood cell samples from over 1,300 BMT recipients.
A recent study published in The Journal of Urology found that serum hormone ratios can predict the risk of future infertility in children with cryptorchidism. Researchers discovered that inhibin B levels and anti-Mullerian hormone (AMH) are significant markers of spermatogenesis, helping to identify boys at high risk of infertility.
Researchers found that a third of patients with wet age-related macular degeneration can safely stop eye injection therapy without further vision loss. Patients who stopped treatment showed better visual acuity, gain of vision, and less fluid in their retina compared to those requiring continued injections.
Researchers have discovered two proteins, IGF-1 and IGFBP5, in urine samples that are significantly lower after a concussion. These biomarkers could help diagnose concussion and monitor recovery. The study suggests that urine testing could be an early and inexpensive way to detect concussions.
A new study found that certain brain wave patterns during sleep can be used to diagnose dementia and other cognitive impairments. The study identified parameters for automated detection methods, which were linked to fluid intelligence and declined during early stages of dementia.
A study published in Neuron found that inflammatory markers are elevated even before dementia symptoms appear, suggesting a potential role in neuroprotection. The researchers discovered two proteins linked to a damage control program, which may support the development of new drugs for early detection and treatment.
Researchers found gender-specific brain alterations in people with depression, including altered blood-brain barriers in women. They also identified a potential depression biomarker in women's blood samples.
Researchers have discovered a new biomarker, microstate D, associated with increased sleep disturbance and inattention symptoms in adults with ADHD. The study, published in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, provides evidence for a more precise diagnosis of the disorder.
Researchers developed a new SERS-based multiplexing technique to detect kidney injury biomarkers SLPI and IL-18, achieving high sensitivity and reliability. The approach shows promise for objectively assessing donor kidney quality, potentially reducing discard rates and recipient complications in clinical practice.
Researchers have developed a highly sensitive immuno-CRISPR assay to detect acute kidney rejection in urine, potentially allowing for early diagnosis without invasive biopsy. The test uses CRISPR/Cas12a gene editing technology to identify biomarkers of rejection, such as CXCL9, with improved sensitivity compared to existing methods.
A new study has identified a biomarker for depression and antidepressant response in human platelets. The biomarker can be detected through a blood test and may indicate therapeutic response within one week of treatment.
Researchers at South Ural State University have identified biomarkers for post-traumatic stress disorder (PTSD) in veterans with long-lasting symptoms. Gamma-aminobutyric acid levels were found to be the most sensitive indicator, differing from reference values even years after traumatic events.
A new study found that a specific type of carbohydrate called ‘fodmaps’ can aggravate intestinal problems, but its impact is not as significant as previously believed. IBS symptoms were found to be influenced more by psychological factors and individual differences in metabolism and intestinal flora.
Exposure to nitrogen dioxide and fine particles is associated with increased beta-amyloid protein deposition and neurofilament light in cerebrospinal fluid, indicating a potential risk factor for Alzheimer's disease. The study highlights the importance of reducing exposure to air pollution to mitigate this risk.
Researchers have discovered evidence of human habitation in the Faroe Islands dating back to around 500 AD, with signs of domestic sheep arrival at this time. The findings, based on lake sediments and DNA analysis, provide conclusive proof that humans inhabited the islands before the Vikings, who are thought to have arrived around 850 AD.
A new study has made an Alzheimer's disease biomarker test available to all Canadians, enabling doctors to accurately diagnose the disease even when mild symptoms are present. The test aims to improve care and support for individuals living with Alzheimer's disease and their families.
Researchers found that up to one in five patients experience increased troponin levels after major surgery, indicating potential heart damage. These patients were also more likely to be anaemic before the operation.
Researchers have discovered microRNAs that can detect ovulation and egg quality in fish, and also identify growth signatures. These findings could lead to the development of non-invasive biomarkers for monitoring animal physiological states, enabling cost-effective and accessible information on health.
Researchers identified epimutations in cheek cells that can predict rheumatoid arthritis susceptibility. The discovery could lead to a non-invasive diagnostic test for the disease. Biomarkers were found in both Caucasian and African-American women with rheumatoid arthritis, suggesting a strong signal for the disease.
A team of researchers has recorded electrical signals in the human brain associated with ebbs and flows in OCD symptoms over an extended period. The study could lead to an emerging therapy called deep brain stimulation that adjusts to everyday changes in OCD symptoms, potentially providing more relief and fewer side effects for patients.
A recent study identified several protein biomarkers that protect against the development of inflammatory diseases such as psoriasis and osteoarthritis. The researchers used Mendelian Randomization to determine whether high levels of these proteins are associated with a lower risk of disease.
Researchers used imaging mass cytometry to analyze protein expression and cell location in tumor samples. High density of antigen-presenting cells with high PD-L1 and IDO expression was associated with higher pathological complete response rate in patients treated with atezolizumab plus chemotherapy.
A new study reveals how design bias can affect medical data used in artificial intelligence tools and personalized healthcare. The research highlights the need for more inclusive recruitment strategies to ensure diverse patient populations are represented.
Researchers developed an AI-powered system to model disease progression in patients as they age. The model assesses metabolic and cardiovascular biomarkers to calculate health status and disease risks across a patient's lifespan.
Researchers at Skoltech have created an optoacoustic endoscopic probe that can analyze atherosclerotic plaques by forcing molecules to sound their presence. The device uses laser light to make biomarkers oscillate, producing ultrasound signals that can be detected by a sensitive microphone.
A new study published in the journal Nutrients found that probiotics can reduce nausea and vomiting during pregnancy by up to 33% and improve quality of life symptoms. The study also identified specific gut microbes associated with higher levels of nausea, suggesting potential biomarkers for future research.
A new rapid test developed by Duke University researchers can measure patient immunity against multiple COVID-19 variants like Omicron and Delta. The CoVariant-SCAN test uses a polymer brush coating to detect neutralizing antibodies, allowing for quick and accurate assessment of antibody effectiveness.
Scientists at Virginia Tech have identified a critical modification in the protective molecular bag of the Lyme disease-causing bacterium, allowing it to move effectively and cause disease. The discovery, published in Nature Microbiology, reveals that the bacteria acquires this unique sugar modification from ticks.
A long-term study has revealed that drinking higher amounts of coffee may make you less likely to develop Alzheimer’s disease. The study found an association between coffee and several important markers related to Alzheimer’s disease, including executive function and amyloid protein accumulation in the brain.
Researchers have developed an assay that uses specific immune-biomarkers to monitor patient survival chances and effectiveness of ovarian cancer treatments. The 'sFIS' assay will enable targeted therapy for each patient, improving treatment outcomes.
The Zinc Status Index is a new evaluation method developed by Cornell food scientists that uses biomarkers to calculate the physiological status of a subject. It aims to provide a comprehensive assessment tool for zinc deficiency, which affects over 1 billion people worldwide.
Researchers identified 166 prognostic biomarkers from long non-coding RNAs, with one biomarker, HOXA10-AS, showing high effectiveness in categorizing gliomas as low- or high-risk. The study provides potential therapeutic targets and insights into cancer biology.
Researchers at Peking University developed a non-invasive exhaled breath screening system for COVID-19, identifying key breath-borne VOC biomarkers in just 5-10 minutes. The technology reduces transmission risk by providing quick screenings for false negatives and hospital discharges.
A peer-reviewed study published in Life journal proves Reflex identifies biomarkers for concussions, enabling accurate clinical diagnosis and decision-making. The study, conducted by Purdue University, uses pupillary light reflex to measure concussion patients' recovery and prevent compounding injuries.
A large study published in Nature Communications has identified a protein in the blood, follistatin, which can predict type 2 diabetes up to 19 years before diagnosis. The study found that higher levels of follistatin circulating in the blood are associated with an increased risk of developing the disease.
Researchers developed a blood test that can detect prostate cancer patients who are resistant to chemotherapy drug docetaxel, enabling early detection and personalized treatment. The test analyzes circulating tumor cells in the bloodstream, revealing patterns that predict disease progression and survival.
Researchers have identified new MRI brain imaging biomarkers that can predict the effectiveness of antidepressants with high accuracy. These biomarkers bring a new level of precision to prescribing the most effective treatments, potentially saving patients from months of taking the wrong medication.
Researchers at West Virginia University have received FDA approval for a new drug to treat uveal melanoma, a rare form of eye cancer. The drug, MTI-201, targets specific biomarkers in diseased cells, allowing for more precise treatment with minimal damage to healthy cells.
A study at the University of São Paulo found that Torquetenovirus (TTV) titer is higher in people infected by SARS-CoV-2, suggesting it could be a biomarker for COVID-19 severity. TTV load correlates with disease progression and outcome, and its measurement may support diagnosis.
Researchers discovered a new biomarker, inactive AMPK (lo-P-AMPK), that may predict immune evasion in lung cancer. The finding could enable better personalized care for lung cancer patients by identifying those most likely to benefit from immunotherapies.
Research reveals brief DBS exposure triggers significant brain state changes and sustained antidepressant response. A decrease in beta power is identified as a novel biomarker for DBS treatment optimization.
A new pilot study reveals a prostate cancer urine test can identify men with intermediate-risk disease, allowing them to opt for active surveillance instead of immediate treatment. The test assesses the amount of aggressive cancer in the prostate without needing a biopsy.
Researchers from MUSC Hollings Cancer Center, UCLA Jonsson Comprehensive Cancer Center, and Winship Cancer Institute discovered that pre-surgical anti-PD-1 immunotherapy is safe and effective for OCSCC patients. The studies identified potential molecular biomarkers in blood and tumors to predict treatment response.
Researchers found diet-associated molecules in the gut are associated with aggressive prostate cancer, linking them to higher levels of metabolites like phenylacetylglutamine and nutrients choline and betaine. The study's findings may have clinical implications for diagnosing and preventing lethal prostate cancer.
Researchers at the University of Waterloo have created a deep neural network that detects disease biomarkers with high accuracy, achieving 98 per cent detection of peptide features. This breakthrough could enable earlier and more accurate disease detection through tissue sample analysis.
Scientists at the University of Colorado School of Medicine have identified specific genetic biomarkers in blood samples that can indicate the severity of COVID-19. The study's findings suggest that these signals can be used to monitor SARS-CoV-2 status and predict clinical outcomes.
Researchers developed two model systems to study peritoneal metastases from colorectal cancer patients. Biomarkers were identified, including severe mutations of the BRCA2 gene, which predict therapy response. These findings offer new hope for treating advanced cases.
The NRG-RTOG 0815 trial found that adding androgen suppression to dose-escalated radiotherapy did not improve overall survival, but reduced rates of biochemical failure and distant metastases. Future studies are needed to identify subsets of patients who may benefit from this intervention.
Researchers found that certain urinary biomarkers, including neutrophil gelatinase-associated lipocalin and kidney injury molecule-1, were associated with increased risk of severe acute kidney injury or death in patients hospitalized with COVID-19. These biomarkers may help identify patients at high risk for adverse kidney outcomes.
Researchers identified a protein leakage related to chronic airway diseases, which restricts breathing. Decreasing this leakage could improve asthma and COPD management by relaxing airways.
A pilot study examines graph-theoretical properties of brain networks in traumatic brain injury and controls, showing association with balance impairment and structural damage. The study uses EEG-based functional connectivity measures during a balance perturbation task to explore underlying neural mechanisms.
Concordia researchers develop a new liquid biopsy method that uses lab-on-a-chip technology to identify biomarkers of concern before a tumor even forms. The technique attracts and captures particles containing cancer-causing biomarkers, allowing for early diagnosis and targeted treatment.
Researchers from University of Copenhagen discover a protein analysis that can predict COVID-19 patient death or hospitalization with high accuracy, predicting 78.7% of hospitalizations and 93.9% of non-serious infections. This discovery has the potential to save lives by identifying high-risk individuals.
Researchers at Georgia Institute of Technology have developed a flow control technology to overcome limitations of traditional dipstick tests. This technology enables complex biomedical assays and can detect multiple pathogens, including SARS-CoV-2 and influenza viruses.
A woman-owned spinout company, Chosen Diagnostics Inc, has received a $2.1M NIH grant to develop and commercialize a noninvasive diagnostic biomarker test for necrotizing enterocolitis. The test, called NECDetect, identifies 93% true positives and 95% true negatives in diagnosing the disease.
New research reveals that microglia in the brain take up more glucose than previously thought, leading to altered PET scan images. This finding has significant implications for understanding neurodegenerative diseases and developing new diagnostic tools.
A plasma biomarker panel identified a combination of sTNFR1, sTNFR2, cystatin C, and eGFR that discriminated between patients with worsening or low risk of chronic kidney disease after three years. This combination was particularly effective at identifying those with very low risk of subsequent kidney dysfunction.