Articles tagged with Biomarkers
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers have discovered microRNAs that can detect ovulation and egg quality in fish, and also identify growth signatures. These findings could lead to the development of non-invasive biomarkers for monitoring animal physiological states, enabling cost-effective and accessible information on health.
A team of researchers has recorded electrical signals in the human brain associated with ebbs and flows in OCD symptoms over an extended period. The study could lead to an emerging therapy called deep brain stimulation that adjusts to everyday changes in OCD symptoms, potentially providing more relief and fewer side effects for patients.
A recent study identified several protein biomarkers that protect against the development of inflammatory diseases such as psoriasis and osteoarthritis. The researchers used Mendelian Randomization to determine whether high levels of these proteins are associated with a lower risk of disease.
A new study reveals how design bias can affect medical data used in artificial intelligence tools and personalized healthcare. The research highlights the need for more inclusive recruitment strategies to ensure diverse patient populations are represented.
Researchers developed an AI-powered system to model disease progression in patients as they age. The model assesses metabolic and cardiovascular biomarkers to calculate health status and disease risks across a patient's lifespan.
Researchers used imaging mass cytometry to analyze protein expression and cell location in tumor samples. High density of antigen-presenting cells with high PD-L1 and IDO expression was associated with higher pathological complete response rate in patients treated with atezolizumab plus chemotherapy.
A new study published in the journal Nutrients found that probiotics can reduce nausea and vomiting during pregnancy by up to 33% and improve quality of life symptoms. The study also identified specific gut microbes associated with higher levels of nausea, suggesting potential biomarkers for future research.
A new rapid test developed by Duke University researchers can measure patient immunity against multiple COVID-19 variants like Omicron and Delta. The CoVariant-SCAN test uses a polymer brush coating to detect neutralizing antibodies, allowing for quick and accurate assessment of antibody effectiveness.
Researchers at Skoltech have created an optoacoustic endoscopic probe that can analyze atherosclerotic plaques by forcing molecules to sound their presence. The device uses laser light to make biomarkers oscillate, producing ultrasound signals that can be detected by a sensitive microphone.
Scientists at Virginia Tech have identified a critical modification in the protective molecular bag of the Lyme disease-causing bacterium, allowing it to move effectively and cause disease. The discovery, published in Nature Microbiology, reveals that the bacteria acquires this unique sugar modification from ticks.
A long-term study has revealed that drinking higher amounts of coffee may make you less likely to develop Alzheimer’s disease. The study found an association between coffee and several important markers related to Alzheimer’s disease, including executive function and amyloid protein accumulation in the brain.
Researchers have developed an assay that uses specific immune-biomarkers to monitor patient survival chances and effectiveness of ovarian cancer treatments. The 'sFIS' assay will enable targeted therapy for each patient, improving treatment outcomes.
The Zinc Status Index is a new evaluation method developed by Cornell food scientists that uses biomarkers to calculate the physiological status of a subject. It aims to provide a comprehensive assessment tool for zinc deficiency, which affects over 1 billion people worldwide.
Researchers identified 166 prognostic biomarkers from long non-coding RNAs, with one biomarker, HOXA10-AS, showing high effectiveness in categorizing gliomas as low- or high-risk. The study provides potential therapeutic targets and insights into cancer biology.
Researchers at Peking University developed a non-invasive exhaled breath screening system for COVID-19, identifying key breath-borne VOC biomarkers in just 5-10 minutes. The technology reduces transmission risk by providing quick screenings for false negatives and hospital discharges.
A peer-reviewed study published in Life journal proves Reflex identifies biomarkers for concussions, enabling accurate clinical diagnosis and decision-making. The study, conducted by Purdue University, uses pupillary light reflex to measure concussion patients' recovery and prevent compounding injuries.
A large study published in Nature Communications has identified a protein in the blood, follistatin, which can predict type 2 diabetes up to 19 years before diagnosis. The study found that higher levels of follistatin circulating in the blood are associated with an increased risk of developing the disease.
Researchers have identified new MRI brain imaging biomarkers that can predict the effectiveness of antidepressants with high accuracy. These biomarkers bring a new level of precision to prescribing the most effective treatments, potentially saving patients from months of taking the wrong medication.
Researchers developed a blood test that can detect prostate cancer patients who are resistant to chemotherapy drug docetaxel, enabling early detection and personalized treatment. The test analyzes circulating tumor cells in the bloodstream, revealing patterns that predict disease progression and survival.
Researchers at West Virginia University have received FDA approval for a new drug to treat uveal melanoma, a rare form of eye cancer. The drug, MTI-201, targets specific biomarkers in diseased cells, allowing for more precise treatment with minimal damage to healthy cells.
A study at the University of São Paulo found that Torquetenovirus (TTV) titer is higher in people infected by SARS-CoV-2, suggesting it could be a biomarker for COVID-19 severity. TTV load correlates with disease progression and outcome, and its measurement may support diagnosis.
Researchers discovered a new biomarker, inactive AMPK (lo-P-AMPK), that may predict immune evasion in lung cancer. The finding could enable better personalized care for lung cancer patients by identifying those most likely to benefit from immunotherapies.
A new pilot study reveals a prostate cancer urine test can identify men with intermediate-risk disease, allowing them to opt for active surveillance instead of immediate treatment. The test assesses the amount of aggressive cancer in the prostate without needing a biopsy.
Research reveals brief DBS exposure triggers significant brain state changes and sustained antidepressant response. A decrease in beta power is identified as a novel biomarker for DBS treatment optimization.
Researchers from MUSC Hollings Cancer Center, UCLA Jonsson Comprehensive Cancer Center, and Winship Cancer Institute discovered that pre-surgical anti-PD-1 immunotherapy is safe and effective for OCSCC patients. The studies identified potential molecular biomarkers in blood and tumors to predict treatment response.
Researchers at the University of Waterloo have created a deep neural network that detects disease biomarkers with high accuracy, achieving 98 per cent detection of peptide features. This breakthrough could enable earlier and more accurate disease detection through tissue sample analysis.
Researchers found diet-associated molecules in the gut are associated with aggressive prostate cancer, linking them to higher levels of metabolites like phenylacetylglutamine and nutrients choline and betaine. The study's findings may have clinical implications for diagnosing and preventing lethal prostate cancer.
Researchers developed two model systems to study peritoneal metastases from colorectal cancer patients. Biomarkers were identified, including severe mutations of the BRCA2 gene, which predict therapy response. These findings offer new hope for treating advanced cases.
The NRG-RTOG 0815 trial found that adding androgen suppression to dose-escalated radiotherapy did not improve overall survival, but reduced rates of biochemical failure and distant metastases. Future studies are needed to identify subsets of patients who may benefit from this intervention.
Scientists at the University of Colorado School of Medicine have identified specific genetic biomarkers in blood samples that can indicate the severity of COVID-19. The study's findings suggest that these signals can be used to monitor SARS-CoV-2 status and predict clinical outcomes.
Researchers found that certain urinary biomarkers, including neutrophil gelatinase-associated lipocalin and kidney injury molecule-1, were associated with increased risk of severe acute kidney injury or death in patients hospitalized with COVID-19. These biomarkers may help identify patients at high risk for adverse kidney outcomes.
A pilot study examines graph-theoretical properties of brain networks in traumatic brain injury and controls, showing association with balance impairment and structural damage. The study uses EEG-based functional connectivity measures during a balance perturbation task to explore underlying neural mechanisms.
Researchers identified a protein leakage related to chronic airway diseases, which restricts breathing. Decreasing this leakage could improve asthma and COPD management by relaxing airways.
Concordia researchers develop a new liquid biopsy method that uses lab-on-a-chip technology to identify biomarkers of concern before a tumor even forms. The technique attracts and captures particles containing cancer-causing biomarkers, allowing for early diagnosis and targeted treatment.
Researchers at Georgia Institute of Technology have developed a flow control technology to overcome limitations of traditional dipstick tests. This technology enables complex biomedical assays and can detect multiple pathogens, including SARS-CoV-2 and influenza viruses.
Researchers from University of Copenhagen discover a protein analysis that can predict COVID-19 patient death or hospitalization with high accuracy, predicting 78.7% of hospitalizations and 93.9% of non-serious infections. This discovery has the potential to save lives by identifying high-risk individuals.
A woman-owned spinout company, Chosen Diagnostics Inc, has received a $2.1M NIH grant to develop and commercialize a noninvasive diagnostic biomarker test for necrotizing enterocolitis. The test, called NECDetect, identifies 93% true positives and 95% true negatives in diagnosing the disease.
New research reveals that microglia in the brain take up more glucose than previously thought, leading to altered PET scan images. This finding has significant implications for understanding neurodegenerative diseases and developing new diagnostic tools.
A study published in JAMA Neurology found that long-term exposure to space can cause brain damage in cosmonauts. The research analyzed five Russian male cosmonauts who spent an average of 169 days in space, showing significant increases in biomarkers for brain cell damage upon their return to Earth.
A plasma biomarker panel identified a combination of sTNFR1, sTNFR2, cystatin C, and eGFR that discriminated between patients with worsening or low risk of chronic kidney disease after three years. This combination was particularly effective at identifying those with very low risk of subsequent kidney dysfunction.
Researchers at Keck School of Medicine will collect and analyze imaging data from over 1,300 children nationwide to identify biological markers predicting recovery or persistent symptoms after concussion. The study aims to develop a diagnostic protocol for clinicians caring for pediatric patients with concussion.
Scientists at DZNE and UMG identified three microRNAs in the blood that correlate with mental fitness and cognitive decline. The biomarker is associated with an increased risk of Alzheimer's disease within two years, offering potential targets for therapy and early warning signs.
Researchers at the University of Houston have developed a new, label-free biosensing platform for detecting cancer biomarkers in exosomes. The technology uses gold nanodisks to capture and analyze surface proteins on exosomes with high sensitivity.
A recent study published in the American Journal of Clinical Nutrition found that consuming whole fat milk has no negative impact on children's health. The research, which involved 49 healthy children aged four to six, showed that both groups consumed similar amounts of calories and fat.
Research investigates m6A regulators in cognitive dysfunctions, identifying potential biomarkers like SNRPG and SNRPD2. The study also highlights the role of APOE ε4 allele and FTO expression in AD development.
A study found that chronic stress, measured by allostatic load, was associated with a lower likelihood of completing chemotherapy and lower overall survival rate in patients with lymph node-positive or high-risk lymph node-negative HER2-negative breast cancer. Allostatic load may be a better predictor than genetic ancestry for chemothe...
Researchers will investigate hidden signs of brain damage in REM behavior disorder, aiming to identify biomarkers that predict impending neurological disease. The goal is to delay the onset or prevent dementia or Parkinsonism through clinical trials.
Scientists at Karolinska Institutet have discovered a carbohydrate called mannose as a biomarker for severe COVID-19 disease severity. The study found that glycolysis and glutaminolysis play a crucial role in SARS-CoV-2's spread and growth, providing potential new therapeutic strategies.
Researchers found that liver transplant recipients who contracted COVID-19 recovered faster and with less severe inflammation compared to heart or kidney recipients. The study suggests testing certain immunosuppressants to treat COVID-19 patients, regardless of their transplant status.
Researchers created a customized device that targets unique brain circuits associated with depression, providing immediate relief. The approach uses neural biomarkers to personalize therapy and has shown long-term efficacy in treatment-resistant patients.
Researchers at JILA have enhanced the sensitivity of their decade-old frequency comb breathalyzer to detect four biomarkers of disease in human breath. The upgraded system can also identify six additional chemicals, with potential implications for COVID-19 testing and real-time health monitoring.
Researchers found that early accumulation of tau proteins in the brain, measured by PET scanner, is more effective at predicting memory impairment than other biomarkers. The study suggests that tau PET should be recommended for clinical prognostic assessment of cognitive decline in Alzheimer's patients.
Researchers developed a non-toxic, small-molecule probe that provides real-time visualization of disease progression, overcoming limitations of MRI and PET imaging. The probe binds copper ions and detects dysregulated levels, accurately identifying Wilson's disease and other maladies.
A team of scientists has identified molecular biomarkers associated with sepsis, which could be used to predict patient outcomes and guide treatment. The study found that changes in CD52 expression were linked to good outcomes, while S100A9 acted as a driver of fatal sepsis.
Studies found distinct patterns in nasal microbiota of individuals infected with SARS-CoV-2, with symptomatic patients showing reduced bacterial counts and increased presence of certain bacteria. The findings suggest that altered microbiota may impact immune response to the virus.
A new study from Karolinska Institutet in Sweden found that COVID-19 disease severity is linked to the characteristics of white blood cells called granulocytes. Combined measurements of granulocyte characteristics and widely used biomarkers can predict key clinical features such as respiratory function and multiorgan failure.
A serum biomarker, polyubiquitinated phosphatase and tensin homolog (PTEN), was associated with a four-fold higher risk of kidney function decline. This modified form of PTEN was linked to severity of lesions in kidney structure, indicating early manifestations of diabetic kidney disease.
Researchers at Buck Institute for Research on Aging provide a framework for precision nutrigeroscience to study the need for individualized dietary interventions. Studies in fruit flies show that lifestyle and genetics impact lifespan and healthspan, leading researchers to challenge the field to adopt a more nuanced approach.
A new study has identified unique genetic codes in the placenta that could detect pregnancy complications earlier than current tests. The researchers found specific biomarkers in maternal blood that indicate placental health and fetal well-being, allowing for real-time assessment throughout pregnancy.
Researchers found that salivary HR-HPV DNA can detect HPV-driven head and neck cancers (HNC) in most patients at the time of diagnosis. The study showed a clear survival advantage for salivary HR-HPV-positive patients, with high-risk strains detected in most cases.