Articles tagged with Biomarkers
The ADQI consensus statement recommends using a combination of damage and functional biomarkers to manage Acute Kidney Injury (AKI). Proenkephalin penKid is proposed as a marker for assessing AKI progression and kidney recovery, with CE-IVD marked assay available for point-of-care usage.
A study found novel biomarkers associated with incident heart failure, including adiponectin and pyruvate, which were linked to increased risk after 8.8 years of follow-up. Chronic inflammation and metabolic changes were also identified as key factors.
A recent study found that only seven percent of high-risk noncardiac surgery patients underwent preoperative screening for biomarkers, leading to increased mortality and complications. Researchers emphasize the need for improved compliance with guidelines and education among physicians.
A study from the University of East Anglia found that blood biomarkers such as cholesterol, inflammation, and liver function can predict future disability and healthcare demand. The researchers also discovered a pro-rich inequity in health care use, where people with higher incomes are more likely to seek medical attention.
A novel method detects conformational changes in TDP-43 protein in ALS patients' CSF, showing high sensitivity and specificity. The technology has potential for diagnosing and developing clinical therapies for this fatal neurodegenerative disease.
Researchers have identified six biochemical biomarkers linked to COVID-19 infection using a blood test. The test can detect infected patients with high accuracy, allowing for rapid diagnosis and treatment prioritization.
A recent study by MedUni Vienna found that blood biomarkers for systemic inflammation increase with liver cirrhosis stages, predicting complications in asymptomatic patients. The severity of portal hypertension also correlates with levels of inflammatory markers, increasing mortality risk.
A new study finds that tiny malfunctioning compartments in neurons, called endosomes, are commonly defective in Alzheimer's patients. Endosomal trafficking disruption is associated with high levels of tau proteins in spinal fluid and blood, making it a promising target for developing therapies.
Researchers have developed a contact lens that uses tiny channels to collect tears and measure biomarkers like sodium ions and glucose molecules. The lens can detect changes in tear pH and flow rates, offering a potential solution for preventing dry eye disease and monitoring diabetic patients.
A study of over 25,000 female health professionals found that a Mediterranean-style diet was associated with a 30% lower risk of developing type 2 diabetes. The diet's impact on insulin resistance, body mass index, and inflammation were key factors in this reduced risk.
Researchers identify blood biomarkers indicative of brain injury in COVID-19 patients, offering potential for timely diagnosis and cost-effective treatment approaches. The study highlights the increased risks of persistent neurological deficits, psychiatric disorders, and neurodegenerative diseases associated with COVID-19.
Researchers have developed a sensitive optical method to detect formaldehyde in exhaled breath, which could lead to an inexpensive and fast way to screen for lung and breast cancer. The new approach uses multipass spectroscopy with optical fringe quenching technique, allowing detection of formaldehyde at low concentrations.
Researchers found that neurofilament light protein levels in the blood can predict stroke severity and prognosis, as well as anticipate future recovery. Higher NFL levels forecast worse functional outcomes and shorter survival time after a stroke. This discovery establishes NFL as a promising prognostic biomarker for stroke.
Researchers found that antiangiogenic therapy can increase the invasiveness of kidney tumors and induce a poor prognosis. A new biomarker, ALDH1A3, has been identified to predict patient response to treatment.
Researchers found that Trop-2 expression is a predictive biomarker for sacituzumab govitecan efficacy in triple-negative breast cancer. Increasing Trop-2 expression improved SG efficacy in mice with HRR-proficient tumors, suggesting a potential clinical benefit for patients with high Trop-2 levels.
Emanuel Petricoin, Co-Director of CAPMM, is receiving $280,696 in funding to discover protein biomarkers for response prediction in stage II/III breast cancer patients. The project aims to utilize data from the ISPY2 TRIAL to develop novel targeted therapy agents.
Researchers developed a wearable device to monitor stress levels using sweat biomarkers, measuring cortisol, glucose, and vitamin C. The device tracks circadian rhythms and can be controlled via a smartphone, offering noninvasive monitoring of stress levels.
A multi-institutional team led by UCI researchers will expand research on biomarkers of Alzheimer's disease in adults with Down syndrome. The five-year, $109M grant aims to improve the quality of life of aging individuals with Down syndrome through advancing prevention and treatment strategies.
Researchers at Brigham and Women's Hospital identified several biomarkers that can predict the risk of preeclampsia from a blood sample drawn at 12 weeks gestation. The study also found possible subtypes of preeclampsia linked to platelet dysfunction and complement system dysfunction.
Researchers found that consuming flavanol-rich foods and drinks, such as tea and apples, can lead to significant reductions in blood pressure. The study used objective measures of thousands of UK residents' diet and found a comparable effect to Mediterranean and DASH diets.
Researchers identify distinct functional connectivity patterns in brain circuits using EEG, enabling subtyping of patients independent of clinical diagnosis. These patterns can predict treatment outcomes, with some subtypes responding better to psychotherapy or medication while others benefit from non-invasive TMS treatment.
Researchers at UMass Amherst have identified a single-measure biomarker in sperm mitochondrial DNA that may predict male reproductive health and pregnancy success. Higher levels of this biomarker are associated with lower odds of cycle-specific pregnancy and 12-month fertility.
Researchers at Skoltech have identified a novel liver-specific non-coding RNA, named HELIS, which can be used as a biomarker for liver cancer diagnosis. The discovery provides a new panel of potential biomarkers that help distinguish between benign and malignant tumors.
A new Expert Panel Discussion examines the status of blood-based biomarker development and point-of-care testing for concussion diagnosis. The discussion highlights the potential benefits of specific biomarkers in detecting brain trauma masked by other injuries or symptoms, adding value over current clinical methods.
Researchers have developed a wearable device that monitors sweat for key biomarkers associated with inflammatory bowel disease (IBD), which could indicate flare-ups. The device has the potential to empower patients to be actively engaged in monitoring their disease and managing it.
A new study found that measurements of how pupils react to light can be used as a physiologic biomarker to diagnose sports-related concussions in teens. The researchers tested this method on adolescents and found it to be effective.
A team of researchers at Case Western Reserve University has identified new biomarkers in the blood that can indicate damage to brain tissue, which could help emergency clinicians quickly recognize minor strokes. The discovery has the potential to reduce delays in treatment and improve patient outcomes.
Researchers construct a composite measure of physiological dysregulation among human populations and compare it to other primates. Despite differing lifestyles, Tsimane adults show marginally higher rates of increase in physiological dysregulation, but still lower rates compared to urban populations.
Researchers identified Neurofilament light chain in vitreous humor, a potential biomarker for Alzheimer's and Parkinson's diseases. Higher levels were associated with higher levels of other biomarkers known to be linked to neurodegeneration.
Researchers developed a point-of-care GFAP assay that delivers results in minutes, outperforming the current FDA-cleared assay. The assay's diagnostic performance was significantly better than that of the S100B biomarker, validating its utility as a diagnostic marker for CT-detected lesions.
A new biomarker has been identified that reliably predicts the aggressiveness of biliary tract cancer in patients, which could help doctors make informed decisions about chemotherapy. The biomarker, IL-6, has been shown to provide prognostic information not captured by other inflammatory markers already in use.
The NIH has augmented the Health and Aging Brain Among Latino Elders (HABLE) Study to include additional biomarkers, including positron emission tomography (PET) imaging, to better understand Alzheimer's disease in Mexican Americans. The study will help identify health disparities and potential treatments for the condition.
Researchers have identified a potential early biomarker, FABP4, for detecting autism spectrum disorder (ASD) in preschool-aged children. Lower levels of FABP4 were found in the blood of children with ASD compared to typically developing children.
A new study reveals that telomere length in whole blood cells can serve as a reliable proxy for other tissues, with 15 out of 23 tissues showing positive correlation. The findings help clarify conflicting results on relationships between individual traits and telomere length.
Deep Longevity will present research on deep aging clocks at the Kinexum webinar, combining leading researchers and a preeminent expert at the FDA to accelerate the use of aging biomarkers in therapeutic interventions. The company has developed multimodal biomarkers of aging using deep learning techniques.
A team of scientists has identified a collective signature of proteins and metabolites that can predict who is at highest risk of dying from the infection. The biomarkers, including lower levels of glycosylated fetuin A and higher levels of serum protein carbamylation, were associated with death due to Staphylococcus aureus bacteremia.
Researchers at the University of Leeds have developed a new system to detect diseases, including coronavirus and cystic fibrosis, by examining individual molecules in blood. The method can compile a detectable signal from just a few biomarkers in just a few minutes, potentially speeding up testing and providing accurate results.
A new study found that ultra-processed food consumption is associated with shorter telomeres, a marker of biological age. The research suggests that diet may be causing cells to age faster.
Researchers have developed a method to use face masks to collect compounds in exhaled breath aerosols for analysis, enabling large-scale screening for disease biomarkers. The new technique uses a fiber inserted into an N95 face mask to concentrate molecules, allowing for more efficient identification through mass spectrometry.
A new study finds that endurance exercise induces changes in sweat biomolecule levels, potentially creating a non-invasive exercise monitoring system. Sweat extracellular vesicles contain microRNA molecules, which regulate biological processes and are essential mediators in exercise adaptations.
Researchers identified an enzyme that breaks down mucus in the gut, providing a potential biomarker for intestinal diseases. The discovery could lead to earlier diagnosis and treatment of conditions such as ulcerative colitis and colorectal cancer.
A study analyzing dolphin blood biomarkers reveals age-related declines in hemoglobin, alkaline phosphatase, platelets, and lymphocytes. This variation in aging rates suggests potential strategies for slowing disease progression and preventing chronic conditions in humans.
Researchers identified five blood biomarkers associated with increased odds of clinical deterioration and death in COVID-19 patients. Elevated levels of these biomarkers were linked to inflammation and bleeding disorders, increasing the risk of ICU admission, ventilatory support, and mortality.
Researchers identified reduced functional connectivity between the cerebellum and extrastriate cortex in FMR1 premutation carriers, which may serve as an early emerging indicator of FXTAS. This biomarker could help predict who among FMR1 carriers will develop characteristic symptoms before they appear.
Scientists at UCL have discovered new biomarkers that can identify people with Type 1 diabetes who are likely to respond to the immunotherapy drug Abatacept. The study found that certain immune cells, known as 'follicular helper T cells', play a key role in the disease.
A UArizona-TGen led team identified robust biomarkers through proteomics and metabolomic analysis that could help guide treatment for tens of millions of patients who sustain traumatic brain injuries. The study found that RIC (Remote Ischemic Conditioning) can be an effective intervention in preventing severe long-term disabilities.
A study compared the diagnostic accuracy of a blood biomarker tau phosphorylated at threonine 217 (P-tau217) with other biomarkers for distinguishing Alzheimer's from neurodegenerative diseases. The results showed that P-tau217 had high sensitivity and specificity, making it a promising tool for early diagnosis.
Researchers identified phosphoprotein biomarkers to guide cancer therapy, demonstrating a novel approach for identifying and detecting tumor drivers. The study's findings suggest that precision medicine is a realizable goal for rare and recalcitrant cancers.
A team of researchers has developed a multi-analyte test strip to monitor various biomarkers continuously, enabling personalized medicine. The technology combines big-data analysis with wearable sensors and minimally invasive methods.
Researchers at UConn Health have developed a non-invasive biomarker panel for diagnosing and monitoring infant urinary tract obstruction. The panel of five proteins can detect UPJO in infants and toddlers, reducing the need for expensive and invasive tests.
The FDA has issued a positive response to C-Path's biomarker panel for detecting acute drug-induced skeletal muscle injury in phase 1 clinical trials. The panel, developed by C-Path's Predictive Safety Testing Consortium and Duchenne Regulatory Science Consortium, uses four molecular biomarkers to aid in the detection of this condition.
The Predictive Safety Testing Consortium and Duchenne Regulatory Science Consortium have developed a glutamate dehydrogenase (GLDH) biomarker to detect drug-induced liver injury in patients with inherited muscle disorders. The FDA has agreed to accept the Qualification Plan for GLDH as an important and accurate measurement of DILI.
Researchers at Duke University have developed a new optical sensing platform that can detect genomic cancer biomarkers in tissue samples using silver-plated gold nanostars. This technique has the potential to provide fast and reliable diagnostic results for cancer and other diseases, simplifying testing processes.
A study of 9,029 adults found that cystatin C-based kidney function was associated with lower odds of frailty, falls, and cardiovascular disease events. The difference between cystatin C- and creatinine-based kidney function could be used to predict adverse outcomes in older adults.
Scientists at Flinders University recommend AIEgen technology for accurate clinical biomarkers and rapid disease screening through bioprobe tests. The technique can detect disease biomarkers in very low concentrations using low-cost, portable devices.
Researchers at Walter Reed Army Institute of Research have found that cathepsin B levels are increased in areas of injured brain relevant to critical executive functions. The study suggests that cathepsin B could be used as a blood-based biomarker to identify TBI severity within different brain regions and cerebral spinal fluid.
A nine-year longitudinal study found that family caregivers did not experience significantly greater inflammation levels compared to non-caregivers, challenging past research findings. The study suggests that caregiving may have minimal effects on physical health for most caregivers.
A new study found that a simple blood test can accurately predict concussion severity and duration, similar to expensive and invasive spinal taps. The test measures neurofilament light chain levels in the blood, which correlate strongly with the severity of concussions.
Two studies by European and US researchers found that higher consumption of these foods is associated with a lower risk of developing type 2 diabetes. Increasing fruit and vegetable intake by 66 grams per day was linked to a 25% lower risk, while whole grain consumption was also significantly related to reduced disease risk.
Researchers have discovered two novel biomarkers, FKBPL and CD44, that can predict key underlying causes of preeclampsia. The biomarkers show potential for early diagnosis in both early and late pregnancy, as well as targeted treatments.