Articles tagged with Biomarkers
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
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Study reveals substantial changes in metabolic pathways related to energy metabolism, the nervous system, and cell membrane lipid metabolism during methamphetamine self-administration and withdrawal. Biomarkers such as depleted amino acids may help identify early warning signs of methamphetamine dependence.
Researchers have created a platinum nanoreactor that enables visual detection and mass spectrometry fingerprinting of metabolic biomarkers, allowing for biopsy-free diagnosis of pancreatic cancer patients. The platform has shown sensitivity and specificity of 84% and 92%, respectively.
Researchers have discovered that certain molecules in semen, known as miRNAs, may serve as non-invasive biomarkers for prostate cancer. The study found that these molecules can provide reliable information to help diagnose and predict the progression of the disease.
A urine test that measures specific proteins found in urine can detect early-stage pancreatic cancer with nearly 95% accuracy. The UroPanc clinical study aims to validate this biomarker in a clinical setting, with the potential to develop a standardized urine test for clinicians to use as a diagnostic aid.
A new test measures protein albumin proportions in blood plasma and serum samples to establish their integrity, addressing concerns about degraded samples producing spurious results. The study highlights the importance of proper sample handling and storage conditions to maintain reliability in medical research.
Researchers have identified a novel biomarker for dementia, IGFBP-2, which is associated with an increased risk of all-cause dementia and Alzheimer's disease. Elevated circulating levels of IGFBP-2 significantly improved dementia risk classification when added to traditional risk factors.
Researchers have identified microRNA-204 as a biomarker for early beta cell death in Type 1 diabetes, which can identify disease onset in children and adults with recent-onset Type 1 diabetes. Serum miR-204 levels were found to be elevated in individuals with Type 1 diabetes and inversely correlated with remaining beta-cell function.
A novel disease mechanism links circulating DPP3 to cardiac and renal dysfunction, with sustained high DPP3 levels associated with reduced cardiac function, impaired kidney function, and increased mortality. The DPP3 biomarker has high potential utility in diagnosing organ dysfunction and predicting outcomes in cardiogenic shock patients.
Procizumab shows high therapeutic potential in treating acute heart failure and cardiogenic shock by targeting the DPP3 enzyme. The company is setting up GMP process for Procizumab manufacturing and expects to enter regulatory non-clinical safety studies next year.
University of Alberta researchers have identified a unique biological marker that can predict the course of myasthenia gravis and develop personalized treatment plans. The biomarker, composed of 12 metabolites exclusive to patients with myasthenia gravis, enables early diagnosis and more effective management of the disease.
Researchers found that all three healthy diets emphasized different macronutrients reduced heart cell damage and inflammation. The findings suggest that flexibility in food selection is key to improving cardiovascular health.
Researchers at Arizona State University describe an innovative diagnostic technique that pinpoints molecular signatures of Lyme disease with high accuracy. The method, using a multi-platform approach, uncovers six potential biomarkers for early identification of the disease.
A new blood test has been developed to detect concussions and subconcussive injuries in children and adults, which can cause wear and tear on the brain over time. The study included over 700 patients with varying injury mechanisms, revealing elevated levels of two biomarkers GFAP and UCH-L1 in patients with non-concussive head trauma.
Researchers at Uppsala University and Vesicode AB have developed a novel proximity-dependent barcoding assay (PBA) to map surface protein complements on individual exosomes. The method enables large-scale screens for biomarkers in disease, providing a new tool for early detection and prognosis.
Researchers discovered a group of genes whose activity was associated with longevity in response to various interventions. The study used mice as a model organism and identified biomarkers that could facilitate the search for new longevity interventions.
Researchers found that heavy alcohol consumption is associated with altered immune function among people living with HIV, leading to higher levels of biomarkers linked to mortality. The study highlights the potential harms of heavy drinking on people with HIV and emphasizes the need for further research.
Researchers at the University of Sussex have identified novel biomarkers in bodily fluids that could signal the presence of glioblastoma. These biomarkers are associated with extracellular vesicles and may enable a simpler way to test for the tumor, rather than a biopsy.
A study published in Acta Neuropathologica Communications found that interregional differences in the somatic genetic landscape of glioblastoma affect prognosis. The research analyzed Japanese patients with IDH-wildtype GBM and discovered a biomarker, triple CNA, associated with survival duration.
Research shows physically active individuals experience fewer age-related alterations in biomarkers associated with the disease. Regular exercise appears to help prevent physical signs of Alzheimer's in those at risk for the disease.
A new study published in The Journal of Physiology found that an eye-movement test can detect acute sleep loss with high reliability. The researchers used a range of eye-movement measures to distinguish sleep-related impairment from that caused by alcohol or brain injury.
Researchers at KU Leuven have developed a non-invasive biomarker for detecting kidney transplant rejection symptoms after a transplant due to antibody-mediated rejection. The new blood test can identify patients with rejection symptoms earlier and more accurately than current methods, which often rely on invasive biopsies.
Scientists have developed a highly sensitive 'sniff-cam' that can detect low levels of disease biomarkers in breath, including diabetes, lung cancer, and Parkinson's disease. The device uses an ultraviolet ring light, filters, and a camera to measure volatile organic compounds (VOCs) in the breath.
Researchers have developed a miniaturized system that uses low-cost components and smartphones to detect biological viruses. The device is portable, battery-powered and can detect real viruses, holding potential for aid in disease prevention.
Researchers developed a microfluidic concentration method that selectively concentrates proteins and nucleic acids, enabling rapid detection of pathogens and biomarkers. This technique enhanced concentrations by up to a billion-fold within 30 minutes.
A study published in the Journal of Nutrition has linked specific chemical signatures in human hair to a diet of traditional Yup'ik foods. The researchers found that changes in nitrogen isotope ratios along the hair strand correlated with increased consumption of traditional foods like fish and marine mammals.
A novel microfluidics-based system detects clinically significant IL-6 levels for sepsis diagnosis in about 25 minutes using less than a finger prick of blood. This device provides a more sensitive and efficient alternative to traditional assays.
A new study uses amyloid positron emission tomography to track β-amyloid cerebrospinal fluid and monitor Alzheimer's disease progression over six years. The researchers found a significant correlation between β-amyloid levels and cognitive decline, providing valuable insights into the disease's progression.
Researchers investigated the relationship between physical activity, β-amyloid levels, and cognitive decline in clinically normal older adults. Physical activity was found to be associated with reduced cognitive decline and lower β-amyloid levels, suggesting potential neuroprotective effects.
A new AI/ML model developed at UC Davis Health can predict acute kidney injury in burn patients more accurately and quickly than traditional methods. The model achieved 90-100% accuracy for identifying AKI using just routine laboratory results, shortening diagnosis time by nearly a full day.
Research studies using liquid biopsy and ddPCR technology found that mutant BRAF ctDNA levels can predict treatment efficacy in advanced melanoma patients, while ctDNA may not reliably detect brain metastases. Meanwhile, chimeric cell-free DNA tracked tumor recurrence in hepatocellular carcinoma patients.
Scientists at McMaster University have identified biomarkers for Irritable Bowel Syndrome (IBS) in urine, which could lead to better treatments and reduce the need for costly colonoscopy procedures. The study found distinctive metabolic signatures that were elevated in IBS patients, suggesting an impairment of the gut's elastic lining.
Researchers identified a unique biomarker, KLHL11, that targets autoantibodies in men with testicular cancer-associated paraneoplastic encephalitis. The discovery has the potential to diagnose this condition earlier and improve treatment outcomes for patients.
Researchers found that two specific biomarkers were elevated in athletes who experienced concussions, indicating potential for longer recovery times. The study suggests these biomarkers could aid in predicting which athletes are more likely to need extended recovery periods after concussion.
A new biomarker in urine helps detect aggressive prostate cancer, improving detection accuracy and reducing unnecessary treatments. The noninvasive test was found to accurately identify high-risk individuals and achieved similar accuracy as invasive tissue-based tests.
Researchers found that experienced runners showed elevated cardiac biomarkers after ultramarathons, but these levels were below clinical risk thresholds. Novice runners paced themselves below their cardiac limit, using self-selected strategies for safe heart health.
A widely recognized biomarker, CA19-9, is found to promote the development of pancreatic diseases and cancer in genetically engineered mice models. This discovery suggests new treatment strategies for pancreatic cancer and other cancer biomarkers.
Researchers have developed a new method to predict the risk of cardiogenic shock in patients after a heart attack. The tool uses proteomics and biomarkers to identify patients at higher risk, enabling more precise treatment options.
A new biomarker, urinary DKK3, has been identified as a predictor of acute kidney injury (AKI) in patients undergoing cardiac surgery. High preoperative levels of DKK3 are associated with lower kidney function and increased risk of AKI.
Researchers have identified two new biomarkers, ApoB:A1 ratio and metabolomic lipoprotein signatures, to predict cardiovascular risk in juvenile-onset systemic lupus erythematosus (JSLE) patients. These biomarkers can help identify high-risk patients and inform tailored disease treatments.
A recent study published in the Journal of Gerontology: Medical Sciences found that low levels of circulating vitamin K are associated with an increased risk of mobility limitation and disability in older adults. The study, conducted on a sample of 635 men and 688 women aged 70-79 years old, used biomarkers of vitamin K status to evalu...
A new study from Professor Doug VanderLaan's lab found evidence for at least four different subgroups of men, each with distinct biomarkers associated with same-sex attractions. The study suggests that there are multiple and distinct pathways influencing male sexual orientation in men.
Researchers used latent profile analysis to examine biomarkers associated with male sexual orientation in over 800 men. The study identified four subpopulations with differing biomarker profiles, suggesting possible distinct biological mechanisms for nonheterosexual men.
Scientists have created a skin patch with tiny needles to collect interstitial fluid, containing biomarkers of disease. The device uses surface-enhanced Raman scattering to analyze the collected fluid and detect biomarkers more efficiently than traditional methods.
A new meta-analysis of 18 studies found that smoking does not accelerate telomere shortening, challenging the long-held assumption that smoking affects telomere length. Adult telomere length is now considered a static biomarker rather than a dynamic indicator of ageing.
A recent study found that people who restricted their blood flow by wearing inflated blood pressure cuffs on an arm and leg showed signs of more controlled blood flow to their brain. The process, called remote ischemic preconditioning, may be beneficial in preventing neurological diseases such as stroke, Parkinson's disease, and epilepsy.
Researchers at Boston University School of Medicine identified salivary microRNAs that differentiate people with alcohol dependence from healthy controls. The study uses machine learning to predict alcohol dependency with high accuracy, offering potential for early diagnosis and treatment.
Researchers have developed a 3D-printed microchip electrophoresis device that can detect three serum biomarkers of preterm birth with high sensitivity. The device is faster, cheaper, and easier to make than existing methods, which require laborious processes and specialized equipment.
Researchers at the University of Notre Dame have developed a microfluidics platform using extracellular vesicles containing microRNAs for early-stage disease diagnosis, reducing test time by 13 hours.
A study found that metabotropic glutamatergic receptor 5 (mGluR5) availability may serve as a biomarker for suicide risk management in posttraumatic stress disorder (PTSD). Higher mGluR5 levels were associated with suicidal ideation and mood disturbances in individuals with PTSD.
Cognitively normal adults with elevated levels of amyloid-β exhibited mixed attitudes toward physician-assisted death, reflecting complex emotions and values surrounding end-of-life care. The study highlights the need for nuanced discussions about dying wishes and advance care planning in this vulnerable population.
A study suggests that hyperosmotic stress can be used to diagnose ME/CFS, a condition characterized by persistent fatigue and other symptoms. The researchers developed a blood-based assay that measures changes in electrical impedance in response to plasma salt concentrations.
Researchers found that a panel of plasma biomarkers can help identify infants most in need of additional interventions after therapeutic cooling. Cytokines and Tau protein levels changed over time, with peak levels occurring within the first 24 hours and again during rewarmed stages. This study aims to develop a more accurate risk asse...
A risk model has been devised by Dana-Farber Cancer Institute researchers to classify patients with asymptomatic Waldenström macroglobulinemia into low, intermediate, or high risk of developing symptomatic disease. The model uses four biomarkers and was validated on two external cohorts with high accuracy and precision.
The article discusses the potential of liquid biopsy in cancer diagnosis, focusing on targeted disease diagnosis and detection of cancer biomarkers. Researchers have successfully detected specific genetic mutations using digital PCR, identifying promising biomarkers for various cancers, including melanoma and lung squamous cell carcinoma.
The Innovative Medicines Initiative has launched a five-year project to generate exploratory and confirmatory data for novel safety biomarkers. This will improve the diagnosis and management of acute and chronic diseases, as well as reduce safety attrition in drug development.
Researchers have developed a biosynthetic dual-core cell computer using CRISPR-Cas9 components, enabling scalable and flexible computing. This biological system can process up to 100,000 different metabolic molecules per second, far surpassing previous cell computers.
A recent study published in The Gerontologist suggests that the link between caregiving and negative health effects has been overstated. After analyzing data from over three decades of research, Johns Hopkins researchers found a weak association between caregiving and immune system biomarkers.
Researchers are developing a system to test multiple biomarkers at once and a smartphone-based analysis and reporting system for disease monitoring and home care. They aim to identify predictive biomarkers to empower patients to monitor their own disease and prevent serious complications.
Researchers at Cima, Clínica Universidad de Navarra have identified three biomarkers associated with atrial fibrillation risk, including CITP, MMP-1, and PICP. These biomarkers can help optimize treatment and follow-up for patients with this cardiac ailment.
A team of NJIT researchers has created a novel electrochemical biosensing device that can identify tiny signals of biomarkers emitted by diseases, such as cancer and malaria. The device uses gold nanoparticles to enhance signal response and separates plasma from blood to achieve high accuracy.