Research on measurable signals of health and disease. Covers ultrasound imaging pipelines, fetal-distress detection, cancer monitoring, and fatigue biology.
UT Southwestern researchers have identified nine serum proteins in blood that strongly predict autism spectrum disorder (ASD) using machine learning tools. These biomarkers could enable earlier diagnosis and prompt therapeutic support, potentially improving quality of life for children with ASD.
A new biomarker has been identified that can determine individual treatment duration for tuberculosis patients, reducing the need for prolonged therapy. The biomarker is based on an RNA signature from 22 genes and was developed using patient cohorts from Germany and Romania.
Researchers identified two distinct pathways leading to septic shock, involving bioactive Adrenomedullin (bio-ADM) and Dipeptidyl peptidase 3 (DPP3). Early diagnosis with biomarker-guided approaches shows promising results in personalized medicine for sepsis treatment. New diagnostics are available for rapid detection of these biomarkers.
A novel gel electrophoresis technique enables rapid biomarker diagnosis via mass spectrometry, overcoming issues with traditional digestion protocols. The method uses dissolvable polyacrylamide gels to recover target proteins, allowing for high-throughput sample preparation and efficient quantification of biomarkers.
Scientists have developed a wearable microfluidic sensor to measure lactate concentration in sweat, offering real-time insights into muscle condition during exercise. The device is designed for comfort and practicality, using a non-irritating material and a microfluidic system for sweat collection.
A University of Oregon scientist has identified myeloid-derived suppressor cells and immunosuppressive cytokine IL-10 as early predictors of treatment response in trauma cases. Abnormal immune suppression may lead to poor bone healing, motivating the need for biomarkers that can predict patient outcomes.
A new study from the University of Eastern Finland has identified two potential biomarkers, miR-9a-3p and miR-136-3p, which could serve as diagnostic biomarkers for mild traumatic brain injury. These microRNAs were found to be elevated in both animal models and human patients, suggesting their potential use in diagnosing the condition....
Researchers have developed a strategy to amplify fluorescence signals using DNA probes and nano-antennas, enabling the detection of biomarkers in low concentrations. This technology has the potential to enable medical screening on patients without laboratory analysis.
A multi-disciplinary team at Harvard's Wyss Institute developed an electrochemical diagnostic sensor platform for multiplexed detection of clinically relevant biomarkers in whole blood. The device accurately detects three different sepsis biomarkers simultaneously and has the potential to revolutionize point-of-care diagnostics.
Researchers identified two highly antigenic epitope markers predicting multiple sclerosis in optic neuritis patients, providing a novel blood biomarker. The study utilizes the Mimotope Variation Analysis technology to analyze over 500 clinical samples from Finnish and Estonian patients.
Researchers used metabolomics and machine learning to identify biomarkers for COVID-19 diagnosis and risk assessment. The study found 26 biomarkers that differed between mild and severe illnesses, potentially revealing new clues on how SARS-CoV-2 affects the body.
NeuroVision Imaging, Inc. has received an investment from the Alzheimer's Drug Discovery Foundation (ADDF) to develop reliable and affordable biomarker tests for Alzheimer's disease and related dementias. The goal is to improve clinical trials and monitor response to treatments.
Researchers at Washington University in St. Louis developed a pain-free microneedle patch that can detect biomarkers in the fluid between cells, revolutionizing diagnostic testing. The technology offers unprecedented sensitivity and could eliminate unnecessary hospital trips and discomfort.
Researchers explore relationship between COVID-19 severity and cardiac injury, finding elevated inflammatory biomarkers associated with higher risk of cardiac damage. High levels of IL-2R and comorbidities predict increased likelihood of cardiac injury in severe COVID-19 patients.
Researchers detected Mexican marigold in ancient Maya ceramic vessels, which they believe were mixed with tobacco to enhance its effects. The discovery sheds light on ancient Maya drug use practices and paves the way for further studies on psychoactive plants.
The study found new biomarkers related to changes in protein function involved in novel regulatory mechanisms of metabolic and immunological pathways in blue mussels, soft-shell clams, Eastern oysters, and Atlantic jackknife clams. Biomarker identification will benefit the aquaculture industry.
Researchers at Washington State University have identified biomarkers in fathers' sperm that are linked to an increased risk of their children developing autism. These epigenetic markers can be detected with high accuracy and may help diagnose the condition, as well as identify environmental factors that contribute to its development.
Researchers developed a blood test that detects misfolded proteins in blood, predicting Alzheimer's disease risk in people with subjective cognitive decline. The test identified those at high and low risk, providing hope for early-stage treatment.
A global research consortium is proposed to collect and share digital speech and language data to detect early signs of Alzheimer's. The consortium aims to create a comprehensive, harmonized repository of samples from diverse cohorts to develop biomarkers that can monitor disease progression.
A large data analysis of over 7,100 U.S. adults found that vaping combined with smoking results in similar levels of inflammation and oxidative stress as smoking cigarettes exclusively. Researchers also found that dual use of both products does not reduce risk.
Researchers developed a gene biomarker identification technique to predict liver toxicity in just 24 hours, reducing lengthy animal studies. The method uses machine learning approaches to identify key genes in messenger RNA, enabling accelerated testing for agrochemical and pharmaceutical companies.
The ADQI consensus statement recommends using a combination of damage and functional biomarkers to manage Acute Kidney Injury (AKI). Proenkephalin penKid is proposed as a marker for assessing AKI progression and kidney recovery, with CE-IVD marked assay available for point-of-care usage.
A study found novel biomarkers associated with incident heart failure, including adiponectin and pyruvate, which were linked to increased risk after 8.8 years of follow-up. Chronic inflammation and metabolic changes were also identified as key factors.
A recent study found that only seven percent of high-risk noncardiac surgery patients underwent preoperative screening for biomarkers, leading to increased mortality and complications. Researchers emphasize the need for improved compliance with guidelines and education among physicians.
A study from the University of East Anglia found that blood biomarkers such as cholesterol, inflammation, and liver function can predict future disability and healthcare demand. The researchers also discovered a pro-rich inequity in health care use, where people with higher incomes are more likely to seek medical attention.
A novel method detects conformational changes in TDP-43 protein in ALS patients' CSF, showing high sensitivity and specificity. The technology has potential for diagnosing and developing clinical therapies for this fatal neurodegenerative disease.
Researchers have identified six biochemical biomarkers linked to COVID-19 infection using a blood test. The test can detect infected patients with high accuracy, allowing for rapid diagnosis and treatment prioritization.
A recent study by MedUni Vienna found that blood biomarkers for systemic inflammation increase with liver cirrhosis stages, predicting complications in asymptomatic patients. The severity of portal hypertension also correlates with levels of inflammatory markers, increasing mortality risk.
A new study finds that tiny malfunctioning compartments in neurons, called endosomes, are commonly defective in Alzheimer's patients. Endosomal trafficking disruption is associated with high levels of tau proteins in spinal fluid and blood, making it a promising target for developing therapies.
Researchers have developed a contact lens that uses tiny channels to collect tears and measure biomarkers like sodium ions and glucose molecules. The lens can detect changes in tear pH and flow rates, offering a potential solution for preventing dry eye disease and monitoring diabetic patients.
A study of over 25,000 female health professionals found that a Mediterranean-style diet was associated with a 30% lower risk of developing type 2 diabetes. The diet's impact on insulin resistance, body mass index, and inflammation were key factors in this reduced risk.
Researchers identify blood biomarkers indicative of brain injury in COVID-19 patients, offering potential for timely diagnosis and cost-effective treatment approaches. The study highlights the increased risks of persistent neurological deficits, psychiatric disorders, and neurodegenerative diseases associated with COVID-19.
Researchers have developed a sensitive optical method to detect formaldehyde in exhaled breath, which could lead to an inexpensive and fast way to screen for lung and breast cancer. The new approach uses multipass spectroscopy with optical fringe quenching technique, allowing detection of formaldehyde at low concentrations.
Researchers found that neurofilament light protein levels in the blood can predict stroke severity and prognosis, as well as anticipate future recovery. Higher NFL levels forecast worse functional outcomes and shorter survival time after a stroke. This discovery establishes NFL as a promising prognostic biomarker for stroke.
Researchers found that antiangiogenic therapy can increase the invasiveness of kidney tumors and induce a poor prognosis. A new biomarker, ALDH1A3, has been identified to predict patient response to treatment.
Researchers found that Trop-2 expression is a predictive biomarker for sacituzumab govitecan efficacy in triple-negative breast cancer. Increasing Trop-2 expression improved SG efficacy in mice with HRR-proficient tumors, suggesting a potential clinical benefit for patients with high Trop-2 levels.
Emanuel Petricoin, Co-Director of CAPMM, is receiving $280,696 in funding to discover protein biomarkers for response prediction in stage II/III breast cancer patients. The project aims to utilize data from the ISPY2 TRIAL to develop novel targeted therapy agents.
Researchers developed a wearable device to monitor stress levels using sweat biomarkers, measuring cortisol, glucose, and vitamin C. The device tracks circadian rhythms and can be controlled via a smartphone, offering noninvasive monitoring of stress levels.
A multi-institutional team led by UCI researchers will expand research on biomarkers of Alzheimer's disease in adults with Down syndrome. The five-year, $109M grant aims to improve the quality of life of aging individuals with Down syndrome through advancing prevention and treatment strategies.
Researchers at Brigham and Women's Hospital identified several biomarkers that can predict the risk of preeclampsia from a blood sample drawn at 12 weeks gestation. The study also found possible subtypes of preeclampsia linked to platelet dysfunction and complement system dysfunction.
Researchers found that consuming flavanol-rich foods and drinks, such as tea and apples, can lead to significant reductions in blood pressure. The study used objective measures of thousands of UK residents' diet and found a comparable effect to Mediterranean and DASH diets.
Researchers identify distinct functional connectivity patterns in brain circuits using EEG, enabling subtyping of patients independent of clinical diagnosis. These patterns can predict treatment outcomes, with some subtypes responding better to psychotherapy or medication while others benefit from non-invasive TMS treatment.
Researchers at UMass Amherst have identified a single-measure biomarker in sperm mitochondrial DNA that may predict male reproductive health and pregnancy success. Higher levels of this biomarker are associated with lower odds of cycle-specific pregnancy and 12-month fertility.
Researchers at Skoltech have identified a novel liver-specific non-coding RNA, named HELIS, which can be used as a biomarker for liver cancer diagnosis. The discovery provides a new panel of potential biomarkers that help distinguish between benign and malignant tumors.
A new Expert Panel Discussion examines the status of blood-based biomarker development and point-of-care testing for concussion diagnosis. The discussion highlights the potential benefits of specific biomarkers in detecting brain trauma masked by other injuries or symptoms, adding value over current clinical methods.
Researchers have developed a wearable device that monitors sweat for key biomarkers associated with inflammatory bowel disease (IBD), which could indicate flare-ups. The device has the potential to empower patients to be actively engaged in monitoring their disease and managing it.
A team of researchers at Case Western Reserve University has identified new biomarkers in the blood that can indicate damage to brain tissue, which could help emergency clinicians quickly recognize minor strokes. The discovery has the potential to reduce delays in treatment and improve patient outcomes.
A new study found that measurements of how pupils react to light can be used as a physiologic biomarker to diagnose sports-related concussions in teens. The researchers tested this method on adolescents and found it to be effective.
Researchers construct a composite measure of physiological dysregulation among human populations and compare it to other primates. Despite differing lifestyles, Tsimane adults show marginally higher rates of increase in physiological dysregulation, but still lower rates compared to urban populations.
Researchers identified Neurofilament light chain in vitreous humor, a potential biomarker for Alzheimer's and Parkinson's diseases. Higher levels were associated with higher levels of other biomarkers known to be linked to neurodegeneration.
Researchers developed a point-of-care GFAP assay that delivers results in minutes, outperforming the current FDA-cleared assay. The assay's diagnostic performance was significantly better than that of the S100B biomarker, validating its utility as a diagnostic marker for CT-detected lesions.
A new biomarker has been identified that reliably predicts the aggressiveness of biliary tract cancer in patients, which could help doctors make informed decisions about chemotherapy. The biomarker, IL-6, has been shown to provide prognostic information not captured by other inflammatory markers already in use.
The NIH has augmented the Health and Aging Brain Among Latino Elders (HABLE) Study to include additional biomarkers, including positron emission tomography (PET) imaging, to better understand Alzheimer's disease in Mexican Americans. The study will help identify health disparities and potential treatments for the condition.
Researchers have identified a potential early biomarker, FABP4, for detecting autism spectrum disorder (ASD) in preschool-aged children. Lower levels of FABP4 were found in the blood of children with ASD compared to typically developing children.
A new study reveals that telomere length in whole blood cells can serve as a reliable proxy for other tissues, with 15 out of 23 tissues showing positive correlation. The findings help clarify conflicting results on relationships between individual traits and telomere length.
Deep Longevity will present research on deep aging clocks at the Kinexum webinar, combining leading researchers and a preeminent expert at the FDA to accelerate the use of aging biomarkers in therapeutic interventions. The company has developed multimodal biomarkers of aging using deep learning techniques.
A team of scientists has identified a collective signature of proteins and metabolites that can predict who is at highest risk of dying from the infection. The biomarkers, including lower levels of glycosylated fetuin A and higher levels of serum protein carbamylation, were associated with death due to Staphylococcus aureus bacteremia.
Researchers at the University of Leeds have developed a new system to detect diseases, including coronavirus and cystic fibrosis, by examining individual molecules in blood. The method can compile a detectable signal from just a few biomarkers in just a few minutes, potentially speeding up testing and providing accurate results.
A new study found that ultra-processed food consumption is associated with shorter telomeres, a marker of biological age. The research suggests that diet may be causing cells to age faster.
Researchers have developed a method to use face masks to collect compounds in exhaled breath aerosols for analysis, enabling large-scale screening for disease biomarkers. The new technique uses a fiber inserted into an N95 face mask to concentrate molecules, allowing for more efficient identification through mass spectrometry.