Articles tagged with Biomarkers
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
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Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers have created a pioneering nanobiodevice that can isolate cancer biomarkers quickly with high resolution. The device separates microRNA from DNA/RNA mixtures in under 100ms, promising faster and more reliable isolation of microRNA for cancer detection.
A new biomarker called methylthioadenosine (MTA) has been identified as a predictor of death in sepsis patients. Measuring MTA levels can be approximately 80% accurate in predicting patient outcomes, similar to the APACHE II score.
A team of researchers has developed a new technique to identify cancer-causing substances in the urine or blood using an integrated centrifugal microfluidic platform. The device, called Exodisc, can isolate extracellular vesicles from urine within 30 minutes and detect biomarkers for bladder cancer.
Researchers will measure circulating biomarkers in over 17,000 persons enrolled in the Framingham Heart Study to identify new biomarkers for cerebral small vessel disease. The goal is to develop a gold standard for early detection and intervention with treatment.
Adding two blood-borne proteins, TFPI and tenascin C, to the current biomarker CA-19-9 improves the detection of early-stage pancreatic cancer in three cohorts. The combination shows higher predictive value than the individual biomarkers.
Researchers found that an initial diagnosis of acute kidney injury may have been inaccurate for many patients, as the current method of assessing kidney function may be misleading during the initial evaluation. The study identified sets of biomarkers in mouse models that could potentially detect kidney damage more reliably.
Researchers have identified early biomarkers of Huntington's disease in a five-year-old HD sheep, revealing metabolic changes prior to physical symptoms. These findings suggest that the disease affects important bodily processes before they become apparent, and could lead to the development of new treatments.
A new study finds that high levels of a biomarker called nuclear KIFC1 are linked to poor prognosis in African-American patients with triple-negative breast cancer. In contrast, the same biomarker does not affect disease outcomes in white patients, highlighting racial disparities in breast cancer treatment.
A Saint Louis University researcher is using a $363,000 grant to test two molecules as potential biomarkers for four debilitating health conditions: chemotherapy-induced peripheral neuropathy, endometriosis, interstitial cystitis, and vulvodynia. The goal is to develop new painkillers that target these pathways.
Scientists analyzed microRNAs from Ötzi's skin, stomach, and stomach contents to determine their stability over time. They found some molecules were present predominantly in ancient tissues, while others were not detectable.
A Harvard study found that heavy lifting and non-daytime work schedules can decrease fertility in women, especially those who are overweight or over 37. The researchers measured biomarkers of fecundity in nearly 500 women seeking infertility treatment, revealing an inverse association between physical demands and egg yields.
Researchers found that elevated levels of GFAP and UCH-L1 in patients with acute orthopedic injuries did not distinguish between those with and without mild traumatic brain injury. This study highlights the need for caution when using these biomarkers, as false-positive diagnoses could lead to unnecessary imaging.
Researchers at Kumamoto University have developed highly sensitive gas sensors for detecting volatile organic compounds, with the ability to detect biomarkers in the parts-per-billion range. The sensors use anisotropically shaped SnO2 nanocrystals with precise control over particle size and pore distribution.
Perena Gouma's invention uses semiconductor sensors to detect the flu virus in a patient's breath, potentially leading to earlier diagnosis and treatment. The handheld device has far-reaching implications for public health and may help prevent flu epidemics from spreading.
Researchers found that even modest levels of physical activity decreased insulin resistance and biomarkers of inflammation, while sedentary time increased levels of satiety-related chemicals in the blood. The study suggests that physical activity and inactivity may operate through different pathways to modulate disease risk.
Researchers developed an acoustofluidic chip to concentrate fluorescently labeled biomarkers using ultrasound, enabling the detection of smaller particles and boost their signal. The technique shows promise for point-of-care diagnostic applications, including the potential analysis via smartphone apps.
A new study found that serum microRNAs are associated with MRI measures of multiple sclerosis severity, suggesting they could serve as biomarkers. The research identified distinct microRNA sets linked to lesions and atrophy, which may help identify underlying disease processes and guide therapeutic decisions.
Research from Ohio State University Wexner Medical Center finds depression in pregnancy associated with lower BDNF levels, which also predict low birth weight. The study suggests that increasing BDNF through exercise may be a beneficial way to address the issue.
Researchers at Boston University have discovered patterns of biomarkers that predict how well people age and their risk for future age-related diseases. The study, led by Paola Sebastiani and Thomas Perls, used data from over 5,000 participants to identify 26 different predictive biomarker signatures.
Researchers at Northwestern University's Auditory Neuroscience Laboratory have discovered a biological marker in the auditory system that can reliably diagnose concussions. The study found that children who suffered concussions had a distinct pattern in their brain activity when exposed to sound, which could be used to identify them.
A new study found that urinary epidermal growth factor levels provided improved ability to distinguish between patients with kidney involvement and those without. The biomarker was also associated with overall lupus damage, suggesting its potential role in monitoring disease progression.
A team of scientists has developed a miniaturized lab-on-chip approach for detecting cancer DNA biomarkers in blood, promising early diagnosis and treatment. The method uses optofluidic chips to analyze multiple targets on a silicon-based molecular detection platform.
The Special Focus Issue covers multi-analyte measurement of endogenous metabolites using various technologies and statistical techniques. It provides new tools for discovering novel biomarkers in precision medicine.
A new biomarker associated with an overactive stress system has been found in suicidal individuals, according to a study published in Translational Psychiatry. The biomarker, linked to higher cortisol levels, was discovered in cell-free blood plasma of patients who had attempted suicide.
Researchers identified four unique depression subtypes based on brain connectivity patterns, providing potential biomarkers for diagnosis and treatment. These subtypes differ in clinical symptoms and response to transcranial magnetic stimulation therapy.
A DNA methylation biomarker called PITX2 has been identified as a reliable predictor of prostate cancer recurrence. The study found that patients with high PITX2 methylation levels were at significantly increased risk for recurrence. This breakthrough could lead to more personalized treatment strategies for prostate cancer patients.
A study published in ACS Central Science reveals that MAO activity increases with Aβ plaque formation in patients with Alzheimer's, suggesting it could serve as a biomarker for diagnosis and monitoring. The research also identified three distinct phases of MAO activity that change along with disease progression.
A new study finds that inflammatory marker AGP better predicts mortality than IL-6, offering insights for personalized medicine. Researchers used data from 1997 to 2015 on 6545 adults aged 45-69, revealing the potential for inflammation markers to predict disease risk and death.
A wearable device measures key biomarkers in sweat to monitor health during exercise and detect diseases like cystic fibrosis. The low-cost, flexible device analyzes biomarker concentrations using colorimetric analysis and provides real-time results.
A new sweat-sensing skin patch can track biomarkers like electrolytes, glucose, and pH to monitor health and fitness. The device was tested in healthy volunteers and showed reliable results with minimal discomfort.
The Biogerontology Research Foundation and collaborators announce the development of a novel approach to analyzing transcriptomic data sets, titled iPANDA. The system applies deep learning algorithms to identify patient-specific pathway signatures associated with breast cancer patients.
Insilico Medicine developed a novel tool, iPANDA, to derive new insights from gene expression repositories. The method combines precalculated gene coexpression data with gene importance factors for obtaining pathway activation scores, producing highly consistent sets of biologically relevant biomarkers.
The Origami Diagnostics project aims to detect individuals carrying malaria parasites without symptoms, using a paper microfluidics-based test. The test is 100 times more sensitive and retains low cost and simplicity.
Researchers from Mayo Clinic identified a new biomarker for brain and spinal cord inflammation, allowing for faster diagnosis and treatment of patients with autoimmune meningoencephalomyelitis. The biomarker, an antibody targeting glial fibrillary acidic protein, helps diagnose the disease earlier and promotes more effective therapy.
Researchers at Stanford University have identified several biological markers that can measure the progression of Huntington's disease in non-neural tissues. The team found that levels of mitochondrial DNA were elevated in plasma samples from patients with the disease, and P110 treatment corrected these levels.
Researchers have developed a new metabolomics-based screening approach that can identify multiple different inborn errors of metabolism (IEMs) in a single urine sample. This method has the potential to detect numerous IEMs, which were previously detected in various bodily fluids such as blood and cerebrospinal fluid.
The US FDA has awarded Critical Path Institute three grants to develop data standards for HIV treatment, Clostridium difficile-associated diarrhea, and improved animal efficacy studies. C-Path will collaborate with CDISC to create therapeutic area data standards to accelerate clinical research and medical product development.
Researchers at Kumamoto University have developed a new method to detect pancreatic cancer using blood biomarkers, enabling early-stage diagnosis and improving prognosis. The discovery of insulin-like growth factor binding protein 2 (IGFBP2) and IGFBP3 as promising biomarkers shows promise for screening various types of cancer.
The Innovative Medicines Initiative (IMI) SAFE-T and C-Path PSTC have obtained regulatory support from the US FDA and EMA for four new liver safety biomarkers. These biomarkers, including cytokeratin 18, HMGB1, osteopontin, and MCSFR1, show promise in predicting drug-induced liver injury and may improve early prediction of liver toxici...
Researchers aim to create personalized brain signatures for effective PTSD treatment using biomarkers and functional MRI scans. The study will track 160 veterans receiving psychotherapy to evaluate the predictive value of cognitive biomarkers.
A systematic review and meta-analysis of 19 randomized controlled trials found potential beneficial effects of flavanol-rich cocoa on cardiometabolic health. Flavanol intake may reduce dyslipidemia, insulin resistance, and systemic inflammation, which are major subclinical risk factors for cardiometabolic diseases.
Researchers developed an MRI-based method to track the state and progression of genetically mutated brain cancer using a new biomarker 2HG. This non-invasive method provides a diagnosis when neurological risk from surgery is too high, and allows for rapid assessment of treatment response.
Researchers at MUSC discovered novel biomarkers that significantly improve the prediction of therapeutic efficacy in lupus nephritis. A targeted panel of urinary biomarkers, combined with machine learning modeling, provides an early decision-support tool for predicting outcomes.
Scientists have long assumed chimeric RNA indicates cancer, but new research reveals these fusions can also be a normal part of human genetics. Researchers are working to develop more accurate biomarkers and therapeutic targets by understanding the complexities of normal genetic programming.
Researchers at the University of Manchester developed a universally applicable method to assess senescence across biomedicine. The new biomarker provides unprecedented advantages over existing products, being sensitive, specific, and easy-to-use.
Ghedin aims to identify key drivers of disease severity and biomarkers predictive of neurological problems. The grant supplements an existing research program focusing on influenza infections.
Italian researchers identified a biomarker bio-Adrenomedullin that correlates with good microcirculation and longevity in centenarians. The study found that low levels of this peptide hormone are associated with efficient blood perfusion, similar to that in younger individuals.
A study by Helmholtz Zentrum München found that myeloid-derived suppressor cells (MDSC) are increased in the blood of patients with idiopathic pulmonary fibrosis (IPF), correlating with lung function decline. MDSC may serve as a biomarker for IPF diagnosis and disease progression.
Researchers at UAB found that the biomarker detected 14 of 15 bacterial infections in cerebrospinal fluid, outperforming the current diagnostic gold standard. The test showed excellent diagnostic capability with a sensitivity of 93% and specificity of 86%. This breakthrough could improve patient care and reduce healthcare expenses by d...
A recent study has found that four biomarkers in the blood are associated with an increased risk of stroke. These biomarkers include homocysteine, vascular endothelial growth factor, C-reactive protein, and tumor necrosis factor receptor 2. Adding these biomarkers to existing methods of predicting stroke risk improved accuracy.
Six individuals, including Becca Levy and Luigi Ferrucci, have been recognized by the Gerontological Society of America for their groundbreaking research on aging and Alzheimer's disease. Their study found that negative age stereotypes can predict Alzheimer's disease biomarkers, highlighting the importance of cultural factors in aging.
A new gene expression analysis method, GlobinLockTM, overcomes technical bias in blood sample analysis caused by erythrocytes, allowing for more effective biomarker identification. The patented assay minimizes reagent and sample material needs, making it a robust tool for biotechnology companies.
A study published in Neurology tracks neural changes in patients with Parkinson's disease and two similar conditions over time. Researchers found decreased activity in specific brain regions, which could provide a new tool for testing experimental medications.
Researchers developed a non-invasive way to track Parkinson's disease progression using functional magnetic resonance imaging, revealing areas of progressive brain decline. This biomarker could help evaluate experimental treatments and measure neurological changes behind symptoms.
A research team at the Krembil Research Institute has discovered two tissue biomarkers that directly contribute to harmful joint degeneration associated with spine osteoarthritis. Elevated levels of these biomarkers cause inflammation, cartilage destruction, and collagen depletion.
A new study published in Genetic Testing and Molecular Biomarkers found that analyzing cell-free DNA using next-generation sequencing is more accurate than the current standard approach of Sanger sequencing. This method can detect genetic abnormalities responsible for myelodysplastic syndrome (MDS) with greater sensitivity.
A team of researchers from the University of Sheffield has identified 788 biomarkers in blood that could be used to develop an early stage cancer screening test. The comprehensive list of relevant cancer blood biomarkers has been compiled through a systematic review of 4,000 studies published over the last five years.
Researchers found that consuming five or more servings of nuts per week lowered biomarkers of inflammation, such as C-reactive protein and interleukin 6. Substituting nuts for red meat also reduced inflammatory biomarkers. The study suggests a possible mechanism by which nuts may benefit cardiometabolic health.
A new study published in the American Journal of Clinical Nutrition found a positive association between tree nut intake and lower levels of inflammatory biomarkers. Higher nut consumption was associated with reduced C-reactive protein and Interleukin 6, which increase during inflammation.
Researchers propose combining multiple methods to identify cheating athletes, including hemoglobin mass, gene expression changes, ironomics, and blood storage-related biomarkers. These new tools offer a potential solution to detecting autologous blood transfusions.