Research on measurable signals of health and disease. Covers ultrasound imaging pipelines, fetal-distress detection, cancer monitoring, and fatigue biology.
A new study found that consuming a Mediterranean-type diet rich in plants and olive oil significantly reduces the risk of cardiovascular disease among American women. The diet's benefits were attributed to changes in inflammation, glucose metabolism, and insulin resistance.
A new study published in Circulation found that running a full marathon significantly raises concentrations of biomarkers indicating heart strain in amateur runners. The study suggests that shorter endurance races may reduce the strain on the heart muscle during competition.
Researchers use big data from medical studies and large biobanks to develop models predicting biological age, aging rate, and potential targets for future anti-aging therapies. The approach also led to the identification of wearable-based biomarkers of aging and frailty.
Researchers from Kanazawa University investigated gut microbiota effects on kidney function and discovered that the gut microbiota produces D-serine, a substance protective for the kidney. Administering D-serine to normal mice mitigated kidney injury, suggesting its potential as a biomarker or medication for acute kidney injury.
Data from Neuroscience 2018 presents genetic deletion of SARM1 protecting axons and reducing biomarkers of neurodegeneration. SARM1 inhibition provides critical insight into developing disease-modifying therapeutics for patients with axonal degeneration.
Researchers found elevated levels of microRNA biomarkers indicating concussions before the season started in college football players. Cognitive tests showed those with balance and memory issues had higher biomarker levels, suggesting past head injuries persisting over time.
A team of researchers has discovered a biomarker, named cBIN1 Score, that measures muscle deterioration and protein regulation in the heart, indicating onset of heart failure. This simple blood test can aid doctors in diagnosing at-risk patients before symptoms appear.
Researchers identified new biomarkers that can detect glaucoma at an early stage, enabling early intervention. The study's findings suggest that these biomarkers may inhibit neurodegeneration in the optic nerve and retina.
Researchers at UCR discovered the oldest clue yet of animal life, found in molecular fossils of sponges that lived on ancient ocean floors. The discovery pushes back the known history of animal life by 100 million years.
A study of over 60,000 adults found that higher biomarker levels for dairy fat consumption are associated with a lower risk of developing type 2 diabetes. The researchers suggest re-examining the metabolic benefits of dairy fat, but note limitations and potential biases in their findings.
The special issue brings together contributions from top academics and industry experts, highlighting the use of generative chemistry and GANs for de-novo molecular design. Experimental validation of generated molecules demonstrates high activity and selectivity in a novel inhibitor of Janus Kinase 3.
A recent symposium will review the current criteria for diagnosing Alzheimer's disease, highlighting the need to rethink diagnostic approaches. The event also explores how brain metabolism changes in women after menopause may increase their risk of developing Alzheimer's.
A world-first electronic capsule measures gaseous biomarkers in the gut to diagnose common and debilitating conditions, offering rapid, non-invasive diagnosis. Phase 2 clinical trials will pursue enhanced technology and target related biomarkers for improved treatment and reduced healthcare costs.
Researchers at the University of Surrey have successfully identified biomarkers in blood that can detect sleep deprivation. A machine learning algorithm detected changes in gene expression levels with 92% accuracy, paving the way for a future test to assess driver fitness.
Resveratrol supplementation significantly reduced pain severity and levels of inflammatory biomarkers, including TNF-α, interleukin IL-1ß, and IL-6, in patients with mild to moderate knee osteoarthritis. The study suggests resveratrol may be an effective add-on to NSAIDs for treating knee osteoarthritis.
Researchers at the University of Würzburg have identified viral microRNA molecules that can serve as ideal biomarkers for detecting human herpesvirus 6 (HHV-6) reactivation. The discovery was made using a novel method that allows for early detection of viral activation, potentially leading to improved clinical interventions.
A new biomarker panel identified in a large metabolomic study could accelerate autism diagnoses, detecting around 17 percent of children with ASD. The panel analyzes amino acid metabolism and shows promise for developing an ASD biomarker test.
A randomized clinical trial found that immediate nicotine reduction resulted in lower toxicant exposure, fewer cigarettes smoked, and greater reduction in dependence compared to gradual reduction. However, this approach also caused higher withdrawal symptoms and study dropout rates.
Researchers developed a three-factor model predicting burn patients at risk for acute respiratory distress syndrome (ARDS). The model includes inhalation injury extent, percentage of body burned, and von Willebrand factor levels. This prediction tool could guide clinical trials to prevent ARDS in high-risk patients.
Researchers developed a novel imaging biomarker to quantify coronary artery inflammation, capturing changes in perivascular fat on CT angiography. This biomarker is associated with increased rates of death from any cause and cardiac causes.
A study has identified six biomarkers of inflammation associated with the risk of polyneuropathy in people with type 2 diabetes. The findings suggest a complex interaction between innate and adaptive immunity in the development of this complication.
A study explores the use of optical coherence tomographic angiography (OCTA) to analyze retinal changes in people with preclinical Alzheimer's disease. Researchers found certain retina alterations were more common among those with preclinical AD, suggesting potential for non-invasive early detection.
Researchers have identified 50 stool proteins that are consistently elevated in patients with inflammatory bowel disease. These biomarkers could help diagnose the condition earlier and more accurately, allowing for quicker treatment. The findings also suggest a potential self-care kit for monitoring the disease.
A novel saliva-based panel is being developed to aid clinicians in the early diagnosis of autism spectrum disorder based on changes in oral microbial communities. The study found altered microbial gene expression patterns associated with energy processing and lysine degradation, indicating potential biomarkers for ASD.
Guidelines for discovering Parkinson's biomarkers aim to develop new treatments, focusing on biomarkers within the disease itself. The research emphasizes collaboration and access to biobanks containing thousands of biological samples.
Researchers at Ohio State University found a strong link between hostility in marriages and the presence of bacteria in the bloodstream, leading to inflammation. Lifestyle changes such as healthy diets and probiotics may help mitigate this effect.
Researchers analyzed animal fat residues to link a 8,200-year-old climate shift in Greenland with changes in a human settlement. The study found correlations between the climate event and shifts from cattle herding to goat herding and changes in dwelling structures, ultimately leading to settlement abandonment.
Researchers explore novel concepts and approaches to stroke rehabilitation, highlighting the potential of biomarkers to predict motor recovery and outcomes. Brain-machine interfaces are also shown to promote recovery in patients with severe paralysis.
The myfood24 online diet monitoring tool has been shown to be as effective as traditional methods in providing detailed nutrient data. The study compared its performance with a gold standard measure, finding it to be comparable across various measures.
A recent study published in the Journal of the American Heart Association found that older adults who spend less time sitting and more time engaged in light to vigorous physical activity benefit from healthier levels of heart and vessel disease markers. The results showed that increased physical activity was particularly beneficial for...
Researchers have identified four biomarkers, including a new chemical called verruculotoxin, that may predict signs of first-trimester stillbirth. By analyzing maternal blood, scientists can develop tools to screen for preventable illnesses affecting both women and children.
A new diagnostic blood test developed by Banyan Biomarkers Inc. has been validated to correctly identify 99.6% of patients without traumatic brain injury (TBI) on head CT scans. The test reduces unnecessary head CT scans, radiation exposure and healthcare costs associated with TBI treatment.
A blood test has been shown to accurately identify patients without traumatic intracranial injuries, reducing the need for CT scans. The test uses biomarker proteins released into the bloodstream after a brain injury and showed a high sensitivity rate of 99.6%.
A Stanford University team has created a stretchy patch that measures cortisol levels in sweat, offering non-invasive and continuous monitoring of physiological conditions. The device, which uses a membrane bound to cortisol, detects charged ions in sweat and provides results in seconds.
A new study found that measuring blood telomeres can predict future risk of worsening COPD or death. Azithromycin treatment was shown to help patients with short telomeres stave off negative clinical outcomes, suggesting its potential as a biomarker for patient risk-stratification.
A new biomarker blood test improves lung cancer risk assessment over existing guidelines, capturing risk for people who have ever smoked. The test achieved superior sensitivity and accuracy compared to guidelines for screening approved by the USPSTF for heavy smokers.
Researchers at the University at Buffalo have discovered biomarkers that can accurately identify hypervirulent Klebsiella pneumoniae, a rare but increasingly common strain of the bacterium. The discovery provides a clear roadmap for developing a diagnostic test to optimize patient care and epidemiologic surveillance.
Researchers found elevated levels of tau and ubiquitin C-terminal hydrolase L1 biomarkers after high-acceleration head impacts, even without clinical concussion. The study suggests a potential new avenue for reducing risk to young athletes through technological improvements and game rule refinements.
Researchers at Eindhoven University of Technology have developed a new sensing technology that enables the super-sensitive measurement of biomarker concentrations over time. The technique, called BPM, is based on the mobility of tiny particles in liquid and can detect biomarkers in pico- or nanomolar concentrations.
A multidisciplinary team from UGR has developed software that can analyze heterogeneous genetic expression data to identify potential pancreatic cancer biomarkers. The new integrative system has identified 5 commonly expressed potential biomarkers and 28 novel genes that are differentially expressed in the meta-analysis.
The journal Bioanalysis has released a Special Focus Issue on biomarker assay validation (BAV), highlighting the evolution of regulatory activities and recent developments. The issue features expert opinions and scientific insights into BAV, including parallelism assessments and clinical biomarker validation.
The initiative aims to enrich the world's largest health database with comprehensive metabolic biomarker profiles from 500,000 blood samples. Nightingale Health's technology will measure over 200 metabolic biomarkers in a single blood test.
Researchers developed a computational method called Multi-Omics Factor Analysis (MOFA) to jointly analyze multiple molecular data types from patients, identifying molecular signatures that distinguish individuals. MOFA can help understand cancer development and inform personalized treatment.
Research from the Global Forum on Nicotine highlights reduced cravings for cigarettes after vaping or using iQOS. Smokers who switch to vapour alternatives experience improved health measures, comparable to quitting entirely. Vaping is banned in Thailand, but permitted in the UK.
Researchers have found a blood-based genetic biomarker, KLRD1, which determines an individual's susceptibility to the flu. Those with higher levels of this gene have better immune defenses and are less likely to fall ill.
A possible biomarker for long-term learning has been discovered, which may lead to different educational techniques to improve retention of information. The researchers used EEG to measure students' brain responses to anatomical terms before and after an introductory anatomy class.
Researchers at Rockefeller University have devised an improved method for isolating and identifying tiny fragments of RNA in human blood products, establishing extracellular RNA as a potentially reliable class of biomarkers. The new approach has been successfully tested on 312 blood samples from healthy subjects, confirming the stabili...
A Phase II trial found that adding PARP inhibitor veliparib to standard chemotherapy improved overall response rates and progression-free survival in patients with small cell lung cancer. Researchers identified SLFN11 as a biomarker for patient selection, which may lead to new treatment options.
A new diagnostic test that uses a simple nasal brush to identify mild to moderate asthma has been developed by Mount Sinai researchers. The test, which uses machine learning algorithms and RNA sequencing, can differentiate asthma from other respiratory conditions and is less expensive than traditional pulmonary function testing.
Researchers at Rush University Medical Center identified two biomarkers that indicate patients likely to develop osteolysis, a condition causing joint loosening and potential revision surgery. These biomarkers can be detected up to six years before diagnosis.
A study found that serum NF-L concentrations showed promise as a biomarker for brain injury due to repetitive subconcussive head impacts, but further research is needed. The researchers also observed fluctuations in tau protein concentrations, which did not show significant differences between starters and nonstarters.
The VTC Research Institute is developing a test to diagnose mild traumatic brain injury (mTBI), which can have long-term damage despite subtle or no physical signs. The test combines analysis of multiple biomarkers with imaging and cognitive tests.
Researchers at ETH Zurich have identified volatile biomarkers that can detect malaria in people with no external symptoms. The study found that changes in human odours are characteristic of both acute and asymptomatic malaria infections, allowing for nearly 100% detection rate even at low pathogen quantities.
Distinct profiles of volatile skin emissions were found in malaria-infected individuals compared to uninfected ones. Machine learning models successfully identified asymptomatic infections based on skin volatile profiles, even at low parasite loads undetectable by microscopy.
A recent study found that yogurt consumption can improve the integrity of the intestinal lining and reduce pro-inflammatory molecules, thereby reducing chronic inflammation. The study enrolled 120 premenopausal women who consumed either low-fat yogurt or non-dairy pudding for nine weeks, showing significant improvements in certain key ...
A team of University of Tsukuba-centered researchers discovered a novel biomarker, citrullinated ITIH4 protein, that is highly specific to patients with rheumatoid arthritis. The levels of this protein decreased in correlation with the reduction of disease activity score after effective treatment.
Researchers found that the Ediacara Biota, soft-bodied ocean dwellers, lived off bacterial primary production and organic matter. This suggests they inhabited oligotrophic regions with sufficient nutrients for feeding.
Researchers have developed a groundbreaking technique to detect tumor biomarkers in brain tumors through a simple blood test, potentially eliminating the need for surgical biopsies. The method uses focused ultrasound and tiny bubbles to release tumor-specific biomarkers into the bloodstream.
A new study by University of Gothenburg researchers identifies a superior blood-based biomarker for assessing subtle brain injury after sports-related concussions. The protein neurofilament light (NfL) levels were found to correlate with the severity of concussion and the duration of post-concussive symptoms.
Researchers discovered a gene linked to high fatality rates in P. aeruginosa BSI, which could be used as a novel prognostic biomarker. The helP gene was identified through genetic characteristics and gene expression data of P. aeruginosa strains from patients with a bloodstream infection.