Articles tagged with Biomarkers
A novel Ebola virus-encoded microRNA-like fragment serves as a biomarker for early diagnosis of Ebola virus disease (EVD). This fragment was found to be detectable in the blood of patients before the development of viremia, suggesting its potential to advance the diagnosable window for EVD.
A new method using proton nuclear magnetic resonance (H-NMR) of blood plasma identifies unique metabolic biomarkers for early and late-stage lung cancer. The technique correctly classifies 78% of patients and 92% of controls, showing promise as a complementary tool to improve lung cancer screening.
EPFL researchers have developed a low-cost, portable microfluidic diagnostic device that can detect various diseases with high accuracy. The device operates on battery power, uses inexpensive microscopes, and requires no pre-treatment of blood samples.
Research has made significant progress in understanding mood and psychotic disorders, enabling individualized treatment approaches. Key findings highlight the potential of biomarkers such as neuroanatomy, neuro-circuitry, and genetic markers to stratify patients into clinically distinct subgroups.
Researchers developed a new technology to detect disease biomarkers in nucleic acids, which can be used as indicators of what's going on inside cells and tissue. The approach uses nanotechnology to identify specific target sequences and quantify them through electronic signatures.
A new DNA-based digital PCR assay has been developed to detect persistent disease in CML patients who appear to be in remission. The assay was found to be more sensitive than current methods, detecting disease in 81% of samples, and may lead to improved treatment decisions for individual patients.
A study published in Neurology found that people taking natalizumab for multiple sclerosis have a higher risk of developing JC virus-related infections, which can lead to fatal brain disease. Researchers monitored levels of anti-JC virus antibodies in patients treated with natalizumab and found a significant increase in risk.
Researchers at Georgia State University discovered gene-targets that may enable alternative treatments or new drugs targeting metastasis-promoting tumor genes. Biomarkers like enhanced neuropilin-1 and NEDD9 positively correlated with metastasis in endometrial and lung cancer.
A new study by King's College London found that measuring fetal fibronectin at 18-21 weeks of gestation offers a similar predictive value to measurements at 22-27 weeks for spontaneous preterm birth. Combining cervical length with the biomarker test improves diagnostic accuracy.
Patients undergoing major vascular surgery experienced high rates of acute kidney injury and chronic kidney disease, increasing long-term cardiovascular-specific death. Preoperative risk stratification through estimated glomerular filtration rate and albuminuria can help prevent or mitigate further decline in kidney function.
Researchers at Columbia University Irving Medical Center found stronger DMN connectivity in individuals at high familial risk for depression. The study suggests that this increased connectivity may be a precursor, or biomarker, indicating a risk of developing major depressive disorder.
A new study finds that biomarkers outperform symptoms in identifying distinct psychosis subgroups, suggesting a more precise diagnosis may lead to improved treatments. The research used 1,872 participants and identified three biotypes, each with unique patterns of brain function and structure.
Researchers at UC San Diego are investigating DNA methylation in the blood as a potential signature for Parkinson's disease. The study, funded by the Michael J. Fox Foundation, aims to improve early diagnosis and treatment of the chronic movement disorder.
Scientists at Cornell University's Baker Institute have developed a device that diagnoses stroke in under 10 minutes using a drop of blood. The technology detects biomarkers in the blood to measure the concentration of neuron-specific enolase (NSE), a substance found in higher concentrations in stroke victims.
A recent study published in Cancer Epidemiology, Biomarkers & Prevention found that U.S. adults who used only smokeless tobacco products had higher levels of biomarkers for nicotine and cancer-causing toxins. This increased exposure puts smokeless tobacco users at risk for adverse health effects, including cancer.
The special issue of Biomarkers in Medicine focuses on advances in biomarker research for regulatory science. Biomarkers are used to predict response to therapies, disease prognosis, and establish baseline risk. The journal aims to facilitate translation of research knowledge into clinical practice.
Researchers at Michigan Technological University found that thyroid cancer detection assays may not accurately measure two major biomarkers. The proteins tend to clump together, making it difficult to detect the true levels of thyroglobulin and galectin-3. By adding a step to break up these clumps, the tests could be made more accurate.
Researchers have discovered a large number of genes that are upregulated in various types of cancer, which could be used to develop early detection tests and targeted therapies. The study, published in Cancer Research, utilized two different technologies to identify 128 markers that were consistently perturbed in both datasets.
A phase III trial showed that sorafenib modestly increased progression-free survival (PFS) and disease control rate in NSCLC patients, but did not impact overall survival. The study also found that EGFR mutation positive patients receiving sorafenib had significantly longer OS and PFS.
Researchers have developed a blood test that can detect subtle signs of concussion in children with 94% accuracy, identifying the presence of traumatic brain injuries and severity levels. This simple yet effective test uses biomarkers found in glial cells surrounding neurons in the brain.
Researchers have discovered that autism-relevant biomarkers can be measured in adult saliva, providing a promising avenue for non-invasive diagnosis and treatment. The study, which analyzed levels of 10 biomarkers in saliva from neurotypical adults, brings us closer to effectively diagnosing and treating autism.
The article reviews lessons learned from Alzheimer's disease research to advance the development of screening and diagnostic algorithms for Parkinson's disease. It explores MCI-AD research, clinical trials incorporating biomarkers and genetics, and emerging therapeutic strategies targeting specific biological mechanisms.
Researchers have developed a technique that uses volatile organic compounds (VOCs) in exhaled breath to identify biomarkers of hypoxia. The study replicated a standard 'hypoxic' event and found that VOC analysis could detect the condition, which can be life-threatening if left untreated.
Researchers at Rice University have developed a new tool to identify DNA and RNA sequences, which will help detect diseases and design therapies. The method allows for the simultaneous observation of multiple biomarkers by adjusting the brightness of fluorescent probes.
Researchers have identified a small RNA molecule, SNORA42, that enables aggressive colorectal cancers to progress and resist treatment. Detecting high levels of this biomarker in patient tissues may help clinicians determine which patients benefit from more aggressive therapy.
Researchers at Barrow Neurological Institute and TGen will analyze blood and CSF samples from 60 participants to identify peptide, protein, and RNA biomarkers indicative of ALS progression. The goal is to develop effective treatments for patients in clinical trials.
A University of Chicago team aims to establish a new system of diagnosis for psychotic diseases using biomarkers, which may guide the development of novel therapies. The Bipolar-Schizophrenia Network on Intermediate Phenotypes will recruit additional study participants over five years.
Researchers analyzed Eocene rocks found in the Green River Formation and identified features that visually indicate the presence of life. They used chemical analysis to confirm the presence of lipid biomarkers, which are preserved remnants of lipids synthesized by organisms.
A new study found that monitoring specific angiogenic biomarkers in maternal blood during early pregnancy can predict patients who will have normal pregnancies and those at high risk for complications. This allows physicians to identify, counsel, and manage high-risk patients earlier.
Cancer patients with high cardiovascular hormone/peptide levels have a shorter survival rate, even without clinical signs of heart disease or infection. These biomarkers indicate heart tissue damage directly linked to cancer progression.
Researchers at UCI have found a biomarker for diagnosing certain forms of autism, which involves a cellular calcium signaling process. The study also points to potential new drug discovery advances by targeting the inositol trisphosphate receptor, a key player in this process.
Researchers at NC State University isolated possible ovarian cancer biomarkers using a highly sensitive mass spectrometry analysis. The study found that the level of biomarkers associated with ovarian cancer does not simply increase or decrease over the course of the disease, but can rise and fall during different stages.
Researchers at Nanjing University have discovered new epigenetic markers for colorectal cancer, which may offer a new approach for treatment. The study found that heterochromatin protein HP1γ was critical for CRC cell proliferation and could be specially regulated by miR-30a.
Research suggests oxygen in atmospheres of habitable extrasolar planets might not necessarily come from biological processes, potentially expanding the search for life. Scientists have proposed alternative explanations for oxygen formation, including abiotic reactions on planetary surfaces.
A study found that obese individuals' brains show different connectivity patterns when craving food compared to normal-weight individuals. The researchers discovered a link between increased brain activity and weight gain in obese subjects.
IU School of Medicine researchers have developed biomarkers and apps that can predict the risk of suicide in individuals with bipolar disorder and other psychiatric illnesses. The tests, which use RNA biomarkers from blood samples along with questionnaire instruments, were able to predict suicidal ideation with over 90% accuracy.
Researchers at UT Southwestern Medical Center found that exercise can help alleviate excessive daytime sleepiness in depressed individuals by reducing two biological markers associated with hypersomnia. The study identified the biomarkers and showed that exercise reduced their levels, resulting in improved symptoms.
A study at the University of Texas MD Anderson Cancer Center found that CSN6 is overexpressed in colorectal cancer tissue samples, leading to poor survival rates. The biomarker's deregulation can lead to cancer development through cellular signaling pathways.
Researchers at Cedars-Sinai Medical Center have identified a novel genetic biomarker responsible for the progression of breast and prostate cancers. This discovery may aid clinicians in identifying patients who will respond better to common chemotherapy drugs that target aggressive forms of cancer.
A study has identified a novel microRNA, miR-181a-5p, as a potential diagnostic breast cancer biomarker in the blood. The use of Droplet Digital PCR technology enabled the accurate quantification of this miRNA, which showed significant downregulation in the serum of patients with breast cancer.
A new study has found that biomarkers, specifically phosphatidylethanol (PEth), are significantly higher in binge drinkers than moderate drinkers. PEth levels were positively correlated with the number of drinks consumed and self-assessment survey scores.
The University of Montana research team, led by Sarj Patel and Tom Rau, will conduct expanded testing on biomarkers for traumatic brain injury. They aim to clinically validate their research and explore chronic traumatic encephalopathy.
Researchers have identified two proteins in blood and cerebrospinal fluid that increase significantly after traumatic brain injury, suggesting they could be used to detect trauma-related brain damage. These biomarkers, UCH-L1 and GFAP, correlate with direct evidence of brain damage and may aid in assessing brain injury following TBI.
Researchers are collecting data from children with Autism Spectrum Disorders (ASD) to identify non-invasive biological markers for diagnosis, tracking, and assessment. The study aims to advance treatment research in autism by creating methods to measure social function and develop indicators of long-term clinical outcome.
The NIH is supporting a multi-year project to develop and improve clinical research tools for studying social impairment in children with autism. The project aims to create reliable tools for assessing potential treatments, which will aid in precision medicine approaches.
Researchers found evidence of Alzheimer's-like pathologies in individuals with the APOE ε4 variant, including increased amyloid plaque and tau levels. This study provides a foundation for further research among patients at risk of Alzheimer's earlier than usual.
Children of depressed mothers who show increased pupil dilation to sad faces are at higher risk of developing depressive symptoms and diagnoses over two years. The study suggests pupillometry could be used as a low-cost tool for pediatricians to identify children at highest risk.
Changes in key biomarkers of Alzheimer's disease during midlife may help identify those who will develop dementia years later. The study found that drops in amyloid beta 42 levels among cognitively normal participants are linked to the appearance of plaques in brain scans years later.
The study provides a comprehensive review of folate biomarkers, which can be used to assess an individual's or population group's folate status. Adequate folate intake is critical during fetal development to prevent birth defects such as spina bifida.
Researchers at University of California, San Diego School of Medicine found that early indicators of Alzheimer's disease are not fixed in a specific sequence, complicating diagnosis efforts. The study suggests that different neurobiological pathways lead to the expression of the disease.
Researchers at Hiroshima University found a correlation between telomere G-tail length and endothelial dysfunction, as well as stroke and dementia, in patients with chronic cerebrovascular disease. The study suggests that telomere G-tail length may be a useful biomarker for predicting cardiovascular risk.
Researchers at University of California, San Diego School of Medicine have identified a biological marker for mental illness in female patients. The study found that specific genes, including XIST, are over-produced in women with mental illnesses like bipolar disorder, major depression, and schizophrenia.
A special issue of Future Oncology explores the role of biomarkers and next-generation sequencing in advancing cancer research and treatment. The issue highlights the potential of these technologies to provide a more precise picture of cancer and identify effective treatments.
Researchers used social network analysis to identify cancer biomarkers in patient genomic microarray data, dramatically decreasing the number of features to analyze. The approach has been successfully demonstrated for three types of cancer: lymphoma, colon cancer, and leukemia.
The discovery of microfossils in rocks dating back 1.5 billion years has confirmed the existence of eukaryotes, shedding light on their evolution and origins. The analysis of steroid molecules revealed no signs of contamination, contradicting previous findings.
Researchers at the University of Pittsburgh School of Medicine have identified two new classes of RNAs associated with breast cancer biomarker YB-1, which may play a role in prostate cancer progression. The discovery could lead to the development of new cancer treatments and provide insights into human biology.
Researchers have discovered a novel biomarker that tracks Parkinson's progression in the brain, providing a new tool for diagnosis and treatment. The study uses MRI-based diffusion imaging to measure changes in brain tissue fluid levels, which can inform treatment decisions and identify promising new therapies.
Researchers found that patients with anti-TP53 autoantibodies can detect ovarian cancer up to 13 months before rising CA125 levels. The study suggests a novel assay method for earlier detection of the disease.
Researchers have discovered a protein biomarker that may indicate the presence of more aggressive prostate cancer. The biomarker, Runx2 phosphorylation, is closely associated with aggressive disease and has the potential to be a new drug target.
Researchers developed a new approach to identify reliable blood biomarkers for Parkinson's disease, which may lead to early diagnosis and targeted treatments. The study found RNA signatures that correlate with the disease-causing mutations in the LRRK2 gene.