Research on measurable signals of health and disease. Covers ultrasound imaging pipelines, fetal-distress detection, cancer monitoring, and fatigue biology.
An international team has identified potential biomarkers for irritable bowel syndrome (IBS), a disease affecting one in six people. The study found that IBS-specific proteins and proteases play a key role in triggering nerve activation, providing new evidence for organic causes of the disease.
Researchers found specific small molecules in blood plasma accurately predict whether someone has sustained a mild traumatic brain injury (mTBI) or not. The discovery could lead to reliable diagnostics for concussions.
A new blood test biomarker has been developed to distinguish between benign and malignant lung tumors with 98% accuracy. This breakthrough technology allows healthcare providers to confidently diagnose and treat patients with low-to-moderate risk nodules, reducing the need for invasive procedures.
A peer-reviewed study published in Oncotarget found that OncoDNA's comprehensive testing and analysis services, combining multiple biomarkers, increased oncologists' ability to make informed treatment decisions. The study showed a significant improvement in overall survival for late-stage patients, from six months to over 12 months.
Researchers at IRB Barcelona have found covalently linked beta-amyloid dimers in the brains of patients with Alzheimer's disease. These dimers are preserved during tissue extraction and could serve as new biomarkers for early detection.
The Critical Path Institute has received a $10 million grant from the Leona M. and Harry B. Helmsley Charitable Trust to identify unmet needs for biomarker development in Crohn's disease. The pre-consortium will focus on laying the groundwork for future regulatory endorsement and accelerate the development of new treatments.
Researchers used Bio-Rad's Droplet Digital PCR technology to identify potential epigenetic biomarkers for lung cancer recurrence and detect HPV cfDNA in cervical cancer patients. The studies found associations between biomarker levels and treatment outcomes, indicating the clinical utility of ddPCR technology.
Researchers have identified seven biomarkers that can predict which glioma patients will progress to a more aggressive form of the disease. A biomarker panel could help physicians decide whether more aggressive treatment is necessary to prevent progression.
Researchers have developed a new technology that can characterize gene expression at the level of individual cells in prostate cancer. The technique uses magnetic nanoparticles to trap and analyze circulating tumor cells, allowing for rapid and accurate detection of biomarkers associated with drug resistance.
Researchers have developed an AI algorithm that can accurately predict biological age and mortality risk using wearable sensor data from a large dataset. The model outperforms previous models and has the potential to refine health risks for life and health insurance programs.
Research from St. Jude Children's Research Hospital found that leukemia itself may increase the risk of long-term neurocognitive problems, even before treatment starts. Elevated biomarkers in cerebrospinal fluid indicate injury to brain cells, suggesting a complex interaction among genetics, treatment intensity, and other factors.
Researchers have identified two biomarkers, KIM-1 and NGAL, that can detect acute and chronic kidney damage in children with cystic fibrosis. The study found that these biomarkers increase during exposure to antibiotics, even before a decline in kidney function is detected by traditional methods.
A study by Tampere University found new prostate cancer mechanisms that are not shown by genomic alterations, including changes in the citric acid cycle. Several potential new biomarkers of prostate cancer were also discovered.
A study found that excessive daytime sleepiness in older adults without dementia is associated with increased β-amyloid levels, a key biomarker for Alzheimer's disease. Disrupted sleep may contribute to β-amyloid accumulation and increase synaptic activity in the brain.
A new liquid biopsy platform uses centrifugal microfluidics to isolate and enrich circulating disease biomarkers from patient blood, promising a less invasive diagnostic procedure. The technique, called μCENSE, separates vesicles containing biomarkers using centrifugal force, reducing extraction time from hours to minutes.
A new study identifies novel molecular biomarkers of preeclampsia, which may be used to develop an early diagnostic blood test. The findings suggest that small non-coding RNAs in a pregnant woman's blood can predict the risk of developing preeclampsia.
Scientists have developed a way to identify biomarkers for a wide range of diseases by assessing the antibodies we are making to the complex sugars coating our cells. The new Luminex Multiplex Glycan Array enables rapid analysis of patient samples and glycans, potentially leading to early disease detection and diagnosis.
Researchers are exploring non-invasive biomarker tests to monitor organ transplant patients and prevent rejection. Current biomarkers fall short, but various teams are hunting for new markers such as RNA levels, exosomes, and proteoforms.
Researchers are struggling to develop a reliable roadside test for marijuana intoxication, as THC levels can vary greatly depending on factors such as consumption method and pairing with alcohol. New biomarkers and tests are being explored to improve safety on the roads and address the complexities of cannabis use.
Researchers found that 500-million-year-old macroorganisms, such as Beltanelliformis, were actually colonies of cyanobacteria. The study used biomarkers to determine the composition of ancient organisms, shedding light on the evolution of life on Earth.
A new study has identified protein biomarkers that can help monitor the progression and treatment of Hutchinson-Gilford progeria syndrome (HGPS) in children. The research found levels of more than 40% of proteins to be significantly different in HGPS samples compared to non-HGPS control samples.
A novel deep-learning based hematological human aging clock predicts the biological age of individual patients with high accuracy. The model outperforms chronological age in predicting all-cause mortality, highlighting population-specific patterns of aging.
Researchers at the University of Luxembourg have discovered a new promising biomarker for colorectal cancer. The biomarker, MYO5B, has been found to decrease in concentration as the disease progresses, indicating lower chances of disease- and metastasis-free survival.
A research team at Rush University Medical Center is working on a simple blood test to detect non-small cell lung cancer with 90% accuracy. The goal is to identify biomarkers that can detect the disease earlier and reduce late-stage diagnoses, improving treatment outcomes.
Researchers identified biomarkers in blood samples that predict response to immunotherapy, allowing for personalized treatment decisions. High-dimensional cell analysis and computer-aided pattern recognition enabled the detection of subtle immune responses and molecular patterns associated with therapy success.
A group of authors from IQWiG has contradicted the American Society of Clinical Oncology's conclusion that MammaPrint can identify patients who do not require chemotherapy. The IQWiG analysis found a statistically significant disadvantage of the test for disease-free survival in certain patient groups.
Researchers from Imperial College London have developed a new detection system that can detect single protein biomarkers directly in human serum, allowing for earlier treatment of diseases. The system uses synthetic DNA molecules to bind to specific target biomarkers and measure changes in electrical current through nanopores.
Researchers have linked changes in brain anatomy to early biomarkers of Alzheimer's disease, suggesting a non-invasive test may detect AD before symptoms appear. The study found that specific regions of the hippocampal circuit shrink in individuals with high levels of tau and amyloid-Beta proteins.
Researchers at the University of Huddersfield have developed a method to quickly detect signs of multiple sclerosis using blood samples. The discovery identifies two natural biomarker compounds, sphingosine and dihydrosphingosine, which are found to be at significantly lower concentrations in patients with MS.
The 2017 WRIB White Papers cover topics such as LCMS small molecules, hybrid LBA/LCMS biotherapeutics, and immunogenicity assays. An interactive Decennial Index of the White Papers provides a decade-long overview of recommendations on bioanalysis and biomarkers.
A novel DNA detector was developed using ultrathin layers, including a nanoporous silicon nitride membrane that serves as a prefilter and a biosensor membrane with a single nanopore. The device creates a nanocavity filled with less than a femtoliter of fluid, improving the precision and reproducibility of DNA detection.
A new study by Children's National Hospital suggests that severely premature children are more susceptible to human rhinovirus infections and may require earlier and more intensive supportive care. The research found a 'dose effect' of prematurity, with children born more prematurely having a higher risk of wheezing and retractions.
Researchers identified an association between a specific SLC6A15 polymorphism and resting-state brain function in multiple brain regions in patients with MDD. The study suggests a potential genetic link to the development of major depressive disorder.
Researchers at Columbia University Irving Medical Center have identified biomarkers that can aid in the development of better treatments for schizophrenia. The biomarkers were successfully tested in over 90% of individuals who received ketamine, and reliably distinguished them from those who had been given a placebo.
Researchers at Purdue University have developed microelectromechanical resonators that can detect biological markers in small amounts of blood, allowing for early disease detection and treatment. The test has potential applications in detecting traumatic brain injury, Alzheimer's disease, Parkinson's disease, and other conditions.
Research suggests that chronic inflammation in mid-life may be an early contributor to brain cell loss and memory decline associated with Alzheimer's disease. The study found people with elevated inflammation biomarkers had smaller brain volumes and lower scores on a memory test compared to those without elevated markers.
Researchers found that 46% of patients experienced mucosal healing after 48 weeks in a tight control protocol compared to 30% in clinical management. The study demonstrated superior outcomes using biomarker monitoring and symptom assessment.
A new study published in PLOS ONE demonstrates that Videssa Breast, a liquid biopsy test, can reliably rule out breast cancer in women with dense and non-dense breast tissue. With an over 99% negative predictive value, clinicians can confidently use the test to detect cancer in women with dense breasts.
A new study published in the American Journal of Respiratory and Critical Care Medicine found that e-cigarettes trigger both unique and familiar immune responses in the lungs. Researchers compared sputum samples from e-cigarette users, cigarette smokers, and non-smokers, revealing significant increases in inflammatory biomarkers, oxida...
Engineers at the University of Arizona have developed a new method to control charge transfer rate from an organic polymer to a biomarker molecule, advancing the field of organic bioelectronics. Their findings show that electron transfer rate depends directly on applied voltage and demonstrate Marcus' theory of inverted charge transfer.
A new NIH-funded study finds that biomarkers for ovarian reserve do not predict fertility in older women attempting to conceive. Hormone levels linked to menopause onset were also found to have no association with conception rates.
A study published in JAMA found that biomarkers indicating diminished ovarian reserve were not associated with reduced fertility in women aged 30-44 attempting natural conception. Low AMH or high FSH levels were not linked to lower fecundability or cumulative probability of conceiving.
Altered MAIT cell concentration and function are linked to T1D pathogenesis, compromising gut mucosa homeostasis and favoring autoimmune responses.
A new biomarker detects Alzheimer's disease in its preclinical phase, identifying individuals with impaired neuropsychological and neurophysiological functions. The discovery has high accuracy and sensitivity, offering a promising approach to early diagnosis and treatment.
Boston University School of Medicine researcher Hugo J. Aparicio is studying the associations between novel vascular biomarkers and cognitive dysfunction in a community-based study. The goal is to identify potential biomarkers for aging-related dementia, which could lead to earlier detection and treatment.
The partnership between genetic testing companies and orphan drug developers has both positive and negative implications. On the one hand, it can lead to faster diagnosis and treatment of rare diseases. However, there are also concerns over patient privacy and potential price-gouging due to rising healthcare costs.
Researchers developed a microfluidics-based approach to detect PD-L1 and other biomarkers in patient blood samples. The novel assay demonstrated a mean detection rate of 22.8% for PD-L1 and PD-L2 expression levels, offering promise for non-invasive cancer diagnosis and treatment monitoring.
Dr. Hankinson aims to improve breast cancer risk prediction by analyzing blood samples from thousands of NHS participants and studying the insulin pathway. She hopes to validate new hormonal biomarkers that can help identify high-risk women who may benefit from risk reduction efforts.
A new biomarker, LRG1, can predict the occurrence of pre-eclampsia in pregnant women with type 1 diabetes, increasing their risk by 4 times. The study found that LRG1 levels were significantly higher in women who developed PE compared to those who did not.
Researchers found that thirdhand smoke exposure causes significant health effects in mice as early as one month after initiation of exposure, including liver damage and insulin resistance. The effects worsen with time, with stress hormones increasing and immune fatigue developing at longer exposure durations.
A new study has demonstrated the potential of using a frequency distribution-based index of brain functional connectivity as a biomarker for detecting Alzheimer's disease and mild cognitive impairment. The findings show good accuracy across databases and test sites, offering promise for widespread clinical usage.
Researchers at Boston Children's Hospital have developed a new DNA nanoswitch platform that can detect biomarkers associated with different diseases, viral strains, and genetic variabilities. The NLISA system uses gel electrophoresis to screen synthesized DNA reagents that change shape in the presence of a specific biomarker.
A new study published in Scientific Reports found that measuring five key biomarkers in blood can quickly identify patients with sepsis, potentially saving lives. The researchers used machine learning models to determine the predictive power of using traditional vital sign data, biomarkers alone, or a combination of both.
A ground-breaking concussion study is underway, involving rugby players, to develop a rapid test for diagnosing concussions. The test, which measures biomarkers present in saliva and urine, has the potential to improve diagnosis and treatment of brain trauma, particularly in sports.
Researchers discuss evolving treatments and future therapies for osteoarthritis pain, highlighting the limitations of existing treatments and introducing new potential treatment targets. Combination therapies and biomarkers are also explored as promising approaches to improve effective pain treatment.
Researchers have developed a rapid portable test for liver cancer that can detect the disease in two minutes and can be administered wherever the patient is. The test uses gold nanoparticles to trap biomarkers from biological fluids, making it a potential game-changer in combating this deadly disease.
Researchers developed self-powered, paper-based devices that detect biomarkers and identify diseases with high accuracy. The devices use electrochemical analyses powered by the user's touch and can be used in remote villages or military bases without requiring electricity or additional equipment.
Researchers have developed a more precise way of diagnosing suicide risk by identifying biomarkers in blood that change in concert with changes in suicidal thoughts. A refined set of biomarkers applies universally to predict risk of suicide among both male and female patients, while others are specific to diagnoses and genders.
Researchers studied health effects of job transition on employed vs unemployed adults, finding that poor quality work was linked to higher chronic stress biomarkers and worse physical health. Good quality work, however, was associated with improved mental health scores.
Researchers have discovered a new biomarker associated with mucopolysaccharidoses (MPS), a group of rare genetic disorders. Elevated CSF spermine levels were linked to CNS symptoms in patients, providing a potential diagnostic tool and target for novel therapeutics.