Articles tagged with Biomarkers
A systematic review and meta-analysis of 19 randomized controlled trials found potential beneficial effects of flavanol-rich cocoa on cardiometabolic health. Flavanol intake may reduce dyslipidemia, insulin resistance, and systemic inflammation, which are major subclinical risk factors for cardiometabolic diseases.
Researchers developed an MRI-based method to track the state and progression of genetically mutated brain cancer using a new biomarker 2HG. This non-invasive method provides a diagnosis when neurological risk from surgery is too high, and allows for rapid assessment of treatment response.
Researchers at MUSC discovered novel biomarkers that significantly improve the prediction of therapeutic efficacy in lupus nephritis. A targeted panel of urinary biomarkers, combined with machine learning modeling, provides an early decision-support tool for predicting outcomes.
Scientists have long assumed chimeric RNA indicates cancer, but new research reveals these fusions can also be a normal part of human genetics. Researchers are working to develop more accurate biomarkers and therapeutic targets by understanding the complexities of normal genetic programming.
Researchers at the University of Manchester developed a universally applicable method to assess senescence across biomedicine. The new biomarker provides unprecedented advantages over existing products, being sensitive, specific, and easy-to-use.
Ghedin aims to identify key drivers of disease severity and biomarkers predictive of neurological problems. The grant supplements an existing research program focusing on influenza infections.
Italian researchers identified a biomarker bio-Adrenomedullin that correlates with good microcirculation and longevity in centenarians. The study found that low levels of this peptide hormone are associated with efficient blood perfusion, similar to that in younger individuals.
A study by Helmholtz Zentrum München found that myeloid-derived suppressor cells (MDSC) are increased in the blood of patients with idiopathic pulmonary fibrosis (IPF), correlating with lung function decline. MDSC may serve as a biomarker for IPF diagnosis and disease progression.
Researchers at UAB found that the biomarker detected 14 of 15 bacterial infections in cerebrospinal fluid, outperforming the current diagnostic gold standard. The test showed excellent diagnostic capability with a sensitivity of 93% and specificity of 86%. This breakthrough could improve patient care and reduce healthcare expenses by d...
A recent study has found that four biomarkers in the blood are associated with an increased risk of stroke. These biomarkers include homocysteine, vascular endothelial growth factor, C-reactive protein, and tumor necrosis factor receptor 2. Adding these biomarkers to existing methods of predicting stroke risk improved accuracy.
Six individuals, including Becca Levy and Luigi Ferrucci, have been recognized by the Gerontological Society of America for their groundbreaking research on aging and Alzheimer's disease. Their study found that negative age stereotypes can predict Alzheimer's disease biomarkers, highlighting the importance of cultural factors in aging.
A new gene expression analysis method, GlobinLockTM, overcomes technical bias in blood sample analysis caused by erythrocytes, allowing for more effective biomarker identification. The patented assay minimizes reagent and sample material needs, making it a robust tool for biotechnology companies.
A study published in Neurology tracks neural changes in patients with Parkinson's disease and two similar conditions over time. Researchers found decreased activity in specific brain regions, which could provide a new tool for testing experimental medications.
Researchers developed a non-invasive way to track Parkinson's disease progression using functional magnetic resonance imaging, revealing areas of progressive brain decline. This biomarker could help evaluate experimental treatments and measure neurological changes behind symptoms.
A research team at the Krembil Research Institute has discovered two tissue biomarkers that directly contribute to harmful joint degeneration associated with spine osteoarthritis. Elevated levels of these biomarkers cause inflammation, cartilage destruction, and collagen depletion.
A new study published in Genetic Testing and Molecular Biomarkers found that analyzing cell-free DNA using next-generation sequencing is more accurate than the current standard approach of Sanger sequencing. This method can detect genetic abnormalities responsible for myelodysplastic syndrome (MDS) with greater sensitivity.
A team of researchers from the University of Sheffield has identified 788 biomarkers in blood that could be used to develop an early stage cancer screening test. The comprehensive list of relevant cancer blood biomarkers has been compiled through a systematic review of 4,000 studies published over the last five years.
Researchers found that consuming five or more servings of nuts per week lowered biomarkers of inflammation, such as C-reactive protein and interleukin 6. Substituting nuts for red meat also reduced inflammatory biomarkers. The study suggests a possible mechanism by which nuts may benefit cardiometabolic health.
A new study published in the American Journal of Clinical Nutrition found a positive association between tree nut intake and lower levels of inflammatory biomarkers. Higher nut consumption was associated with reduced C-reactive protein and Interleukin 6, which increase during inflammation.
Researchers propose combining multiple methods to identify cheating athletes, including hemoglobin mass, gene expression changes, ironomics, and blood storage-related biomarkers. These new tools offer a potential solution to detecting autologous blood transfusions.
The Moffitt Imaging Biomarker Validation Center will discover, develop and validate biomarkers for risk assessment, detection and molecular diagnosis of early cancer. The center is part of the National Cancer Institute's Early Detection Research Network.
A new clinical study found that exclusive e-cigarette use significantly reduces exposure to harmful chemicals similar to complete smoking cessation. The study measured biomarkers in urine, blood, and exhaled breath, revealing reductions of over 75% in carbon monoxide levels and over 80% in volatile organic compounds.
A study of 85 Gulf War veterans identified three types of white blood cells and six proteins in the blood that can help diagnose Gulf War Illness with 90% accuracy. The research found chronic inflammation as a key component of the illness, supporting the hypothesis that it is a well-defined chronic inflammatory disease.
Researchers have identified various miRNAs that can predict the response of metastatic renal cancer patients to anti-angiogenic agents. These biomarkers have been shown to be stable and detectable, allowing for personalized treatment. The study provides a promising tool for improving patient outcomes.
A recent study reveals that nearly 60 percent of people have preclinical heart failure stages A and B, with stage B individuals at increased risk for death. The findings highlight the importance of targeting prevention efforts at the earliest HF stages to avoid death, particularly among men and older adults.
A new biomarker, phosphorylated protein kinase LRRK2, has been found in patient urine samples and correlates with the presence and severity of Parkinson's disease. Elevated levels of this biomarker predict the risk for onset of Parkinson's disease and may be a promising guide for future clinical treatments.
Researchers discovered that tiny micro-vesicle structures in blood carry tell-tale proteins associated with Alzheimer's disease, enabling the prediction of mild cognitive impairment (MCI) progression. The findings represent a quicker and less invasive way to identify impending cognitive decline.
Researchers developed biomarker ratio imaging microscopy (BRIM) to differentiate between aggressive and non-aggressive ductal carcinoma in situ (DCIS). The technique combines traditional pathology and mathematical analysis, identifying biomarkers that can indicate the potential for cancer to become invasive.
Researchers at University of Birmingham develop test to predict sepsis in burn victims using biomarkers of neutrophil function. The test shows promise in identifying patients at risk of developing sepsis, a life-threatening condition that can be fatal if left untreated.
Researchers have discovered biomarkers using non-invasive liquid biopsies to identify aggressive disease in prostate cancer patients before surgery. The study uses urine samples from 210 patients and identifies a range of proteins that can help predict which patients have slow-growing versus aggressive cancer.
A meta-analysis of phase I clinical trials involving thousands of patients found that precision medicine treatment arms showed a higher response rate (30%) compared to non-personalized arms (4.9%), leading to improved outcomes and longer disease remission.
The Wilke Cohen Lyme Disease Project has received a $3 million pledge from the Steven & Alexandra Cohen Foundation to support its research into potential biomarkers for Lyme disease. The project aims to develop more effective diagnostics and treatments, building on initial discoveries made by ISB researchers.
Insilico Medicine presents research on applying deep learning to biomarker development and cosmetics applications at INNOCOS World Beauty Innovation Summit. The company's app RYNKL evaluates anti-aging interventions using machine learning methods, minimizing animal testing.
Researchers discover USP14 as a promising biomarker for predicting endometrial cancer recurrence. Women with high levels of USP14 are seven times more likely to recur than those with low levels, highlighting the potential for tailored treatment approaches.
The IsoPSA test detects prostate cancer by identifying molecular changes in the prostate specific antigen (PSA) protein. It also differentiates between high-risk and low-risk disease, as well as benign conditions.
Researchers at Tufts University have developed a method to stabilize blood samples for long periods without refrigeration, using air-dried silk protein. This technique has broad applications for clinical care and research, particularly for underserved populations.
A new study published in Frontiers in Pediatrics investigated the effects of a steroid treatment on children with ARDS, finding improved ventilation and blood oxygenation without affecting mortality rates. The study identified key biomarkers associated with lung inflammation and injury, paving the way for targeted treatment development.
Using clinical data from over 7 million US armed forces members, researchers identified patients with Crohn's disease and found that specific antimicrobial antibodies in their serum samples were associated with increased risk of complications. These biomarkers could potentially predict IBD development and inform preventive strategies.
A new study shows that current carrier screening methods are insufficient and can give prospective mothers a false sense of security. Whole genome studies are needed to ensure both mates don't carry recessive mutations in the same gene(s). DNA-based screening can detect many more disease-causing genetic variations
Researchers investigate relationship between plasma Aβ levels, cognitive function, and brain volumetrics in Alzheimer's patients. Plasma Aβ measures may serve as biomarkers for early diagnosis of Alzheimer's disease.
Scientists at Oxford University have identified biomarkers that could indicate TB risk and provide clues to assess the effectiveness of potential new vaccines. The discovery was made using immune correlates, also known as biomarkers, which can be measured in the blood.
A University of Colorado Cancer Center study identifies epiregulin as a potential biomarker for lung cancer, with mice lacking the growth factor developing fewer tumors and reduced inflammation. The findings suggest epiregulin increases cell proliferation, promoting tumor growth.
A study published in PLOS ONE found that chronological age was the single best predictor of death in three countries, followed closely by self-reported mobility. Telomere length, previously believed to be a powerful biomarker for aging and mortality, ranked lower than other indicators in predicting mortality.
Researchers at Indiana University have identified blood-based biomarkers and developed questionnaire-based apps that can help clinicians identify female patients at greatest risk of suicidal ideation or behavior. The study found that these tools were able to predict future instances of suicidal thoughts with high accuracy, suggesting p...
A new biomarker-based tool, 'ABC risk score,' allows for personalized treatment to prevent strokes with minimal bleeding complications. The app is available as a web-based instrument and will soon be available as an app.
Researchers identified biological markers in blood samples from latently infected individuals that can predict the risk of developing active TB. These biomarkers may enable targeted therapies to prevent illness in high-risk individuals.
The Operation Brain Trauma Therapy (OBTT) consortium has published results from five therapies for traumatic brain injury, finding Levetiracetam to be the most beneficial treatment. Biomarker GFAP was also found to perform well across studies.
A recent study found that US adults are struggling to adopt healthy lifestyle behaviors, with only 2.7% meeting the criteria for a 'healthy lifestyle' and a low risk of cardiovascular disease. The study measured four key behaviors: good diet, moderate exercise, recommended body fat percentage, and non-smoking habits.
A new technique developed by Stanford chemists has shown promise to be thousands of times more sensitive than current techniques in lab experiments. The test uses DNA screening technology and could enable early detection of diseases such as cancer and HIV.
Researchers have identified promising biomarkers to monitor immunosuppressive drug therapy in organ transplant recipients, with the potential for individualized treatment to reduce rejection and minimize side effects. A panel of experts recommends a preliminary set of tests for use in biomarker-based immunosuppressive drug management.
Researchers have identified new prostate cancer markers in urine that show high specificity and sensitivity. A combination of these biomarkers could lead to a more accurate and reliable test for early diagnosis.
Researchers have identified a new biomarker associated with the activation of an innate immune response to neural damage during early stages of Alzheimer's disease. The concentration of a specific segment of the protein TREM2 in cerebrospinal fluid is significantly elevated in early stages of the disease.
A novel Ebola virus-encoded microRNA-like fragment serves as a biomarker for early diagnosis of Ebola virus disease (EVD). This fragment was found to be detectable in the blood of patients before the development of viremia, suggesting its potential to advance the diagnosable window for EVD.
The ALCF-IASLC Joint Fellowship Award supports novel research with the potential to positively impact lung cancer patients. Dr. Robin Mjelle's project aims to develop a risk-prediction tool and serum poly-marker kit for early lung cancer detection, leveraging pre-diagnostic serum samples from Norway's HUNT biobank.
A new method using proton nuclear magnetic resonance (H-NMR) of blood plasma identifies unique metabolic biomarkers for early and late-stage lung cancer. The technique correctly classifies 78% of patients and 92% of controls, showing promise as a complementary tool to improve lung cancer screening.
EPFL researchers have developed a low-cost, portable microfluidic diagnostic device that can detect various diseases with high accuracy. The device operates on battery power, uses inexpensive microscopes, and requires no pre-treatment of blood samples.
Research has made significant progress in understanding mood and psychotic disorders, enabling individualized treatment approaches. Key findings highlight the potential of biomarkers such as neuroanatomy, neuro-circuitry, and genetic markers to stratify patients into clinically distinct subgroups.
Researchers developed a new technology to detect disease biomarkers in nucleic acids, which can be used as indicators of what's going on inside cells and tissue. The approach uses nanotechnology to identify specific target sequences and quantify them through electronic signatures.
A new DNA-based digital PCR assay has been developed to detect persistent disease in CML patients who appear to be in remission. The assay was found to be more sensitive than current methods, detecting disease in 81% of samples, and may lead to improved treatment decisions for individual patients.
A study published in Neurology found that people taking natalizumab for multiple sclerosis have a higher risk of developing JC virus-related infections, which can lead to fatal brain disease. Researchers monitored levels of anti-JC virus antibodies in patients treated with natalizumab and found a significant increase in risk.