Research on measurable signals of health and disease. Covers ultrasound imaging pipelines, fetal-distress detection, cancer monitoring, and fatigue biology.
Researchers at Northwestern University's Auditory Neuroscience Laboratory have discovered a biological marker in the auditory system that can reliably diagnose concussions. The study found that children who suffered concussions had a distinct pattern in their brain activity when exposed to sound, which could be used to identify them.
A new study found that urinary epidermal growth factor levels provided improved ability to distinguish between patients with kidney involvement and those without. The biomarker was also associated with overall lupus damage, suggesting its potential role in monitoring disease progression.
A team of scientists has developed a miniaturized lab-on-chip approach for detecting cancer DNA biomarkers in blood, promising early diagnosis and treatment. The method uses optofluidic chips to analyze multiple targets on a silicon-based molecular detection platform.
The Special Focus Issue covers multi-analyte measurement of endogenous metabolites using various technologies and statistical techniques. It provides new tools for discovering novel biomarkers in precision medicine.
A new biomarker associated with an overactive stress system has been found in suicidal individuals, according to a study published in Translational Psychiatry. The biomarker, linked to higher cortisol levels, was discovered in cell-free blood plasma of patients who had attempted suicide.
Researchers identified four unique depression subtypes based on brain connectivity patterns, providing potential biomarkers for diagnosis and treatment. These subtypes differ in clinical symptoms and response to transcranial magnetic stimulation therapy.
A DNA methylation biomarker called PITX2 has been identified as a reliable predictor of prostate cancer recurrence. The study found that patients with high PITX2 methylation levels were at significantly increased risk for recurrence. This breakthrough could lead to more personalized treatment strategies for prostate cancer patients.
A study published in ACS Central Science reveals that MAO activity increases with Aβ plaque formation in patients with Alzheimer's, suggesting it could serve as a biomarker for diagnosis and monitoring. The research also identified three distinct phases of MAO activity that change along with disease progression.
A new study finds that inflammatory marker AGP better predicts mortality than IL-6, offering insights for personalized medicine. Researchers used data from 1997 to 2015 on 6545 adults aged 45-69, revealing the potential for inflammation markers to predict disease risk and death.
A new sweat-sensing skin patch can track biomarkers like electrolytes, glucose, and pH to monitor health and fitness. The device was tested in healthy volunteers and showed reliable results with minimal discomfort.
A wearable device measures key biomarkers in sweat to monitor health during exercise and detect diseases like cystic fibrosis. The low-cost, flexible device analyzes biomarker concentrations using colorimetric analysis and provides real-time results.
The Biogerontology Research Foundation and collaborators announce the development of a novel approach to analyzing transcriptomic data sets, titled iPANDA. The system applies deep learning algorithms to identify patient-specific pathway signatures associated with breast cancer patients.
Insilico Medicine developed a novel tool, iPANDA, to derive new insights from gene expression repositories. The method combines precalculated gene coexpression data with gene importance factors for obtaining pathway activation scores, producing highly consistent sets of biologically relevant biomarkers.
The Origami Diagnostics project aims to detect individuals carrying malaria parasites without symptoms, using a paper microfluidics-based test. The test is 100 times more sensitive and retains low cost and simplicity.
Researchers from Mayo Clinic identified a new biomarker for brain and spinal cord inflammation, allowing for faster diagnosis and treatment of patients with autoimmune meningoencephalomyelitis. The biomarker, an antibody targeting glial fibrillary acidic protein, helps diagnose the disease earlier and promotes more effective therapy.
Researchers at Stanford University have identified several biological markers that can measure the progression of Huntington's disease in non-neural tissues. The team found that levels of mitochondrial DNA were elevated in plasma samples from patients with the disease, and P110 treatment corrected these levels.
Researchers have developed a new metabolomics-based screening approach that can identify multiple different inborn errors of metabolism (IEMs) in a single urine sample. This method has the potential to detect numerous IEMs, which were previously detected in various bodily fluids such as blood and cerebrospinal fluid.
The US FDA has awarded Critical Path Institute three grants to develop data standards for HIV treatment, Clostridium difficile-associated diarrhea, and improved animal efficacy studies. C-Path will collaborate with CDISC to create therapeutic area data standards to accelerate clinical research and medical product development.
Researchers at Kumamoto University have developed a new method to detect pancreatic cancer using blood biomarkers, enabling early-stage diagnosis and improving prognosis. The discovery of insulin-like growth factor binding protein 2 (IGFBP2) and IGFBP3 as promising biomarkers shows promise for screening various types of cancer.
The Innovative Medicines Initiative (IMI) SAFE-T and C-Path PSTC have obtained regulatory support from the US FDA and EMA for four new liver safety biomarkers. These biomarkers, including cytokeratin 18, HMGB1, osteopontin, and MCSFR1, show promise in predicting drug-induced liver injury and may improve early prediction of liver toxici...
Researchers aim to create personalized brain signatures for effective PTSD treatment using biomarkers and functional MRI scans. The study will track 160 veterans receiving psychotherapy to evaluate the predictive value of cognitive biomarkers.
A systematic review and meta-analysis of 19 randomized controlled trials found potential beneficial effects of flavanol-rich cocoa on cardiometabolic health. Flavanol intake may reduce dyslipidemia, insulin resistance, and systemic inflammation, which are major subclinical risk factors for cardiometabolic diseases.
Researchers developed an MRI-based method to track the state and progression of genetically mutated brain cancer using a new biomarker 2HG. This non-invasive method provides a diagnosis when neurological risk from surgery is too high, and allows for rapid assessment of treatment response.
Researchers at MUSC discovered novel biomarkers that significantly improve the prediction of therapeutic efficacy in lupus nephritis. A targeted panel of urinary biomarkers, combined with machine learning modeling, provides an early decision-support tool for predicting outcomes.
Scientists have long assumed chimeric RNA indicates cancer, but new research reveals these fusions can also be a normal part of human genetics. Researchers are working to develop more accurate biomarkers and therapeutic targets by understanding the complexities of normal genetic programming.
Researchers at the University of Manchester developed a universally applicable method to assess senescence across biomedicine. The new biomarker provides unprecedented advantages over existing products, being sensitive, specific, and easy-to-use.
Ghedin aims to identify key drivers of disease severity and biomarkers predictive of neurological problems. The grant supplements an existing research program focusing on influenza infections.
Italian researchers identified a biomarker bio-Adrenomedullin that correlates with good microcirculation and longevity in centenarians. The study found that low levels of this peptide hormone are associated with efficient blood perfusion, similar to that in younger individuals.
A study by Helmholtz Zentrum München found that myeloid-derived suppressor cells (MDSC) are increased in the blood of patients with idiopathic pulmonary fibrosis (IPF), correlating with lung function decline. MDSC may serve as a biomarker for IPF diagnosis and disease progression.
Researchers at UAB found that the biomarker detected 14 of 15 bacterial infections in cerebrospinal fluid, outperforming the current diagnostic gold standard. The test showed excellent diagnostic capability with a sensitivity of 93% and specificity of 86%. This breakthrough could improve patient care and reduce healthcare expenses by d...
A recent study has found that four biomarkers in the blood are associated with an increased risk of stroke. These biomarkers include homocysteine, vascular endothelial growth factor, C-reactive protein, and tumor necrosis factor receptor 2. Adding these biomarkers to existing methods of predicting stroke risk improved accuracy.
Six individuals, including Becca Levy and Luigi Ferrucci, have been recognized by the Gerontological Society of America for their groundbreaking research on aging and Alzheimer's disease. Their study found that negative age stereotypes can predict Alzheimer's disease biomarkers, highlighting the importance of cultural factors in aging.
A new gene expression analysis method, GlobinLockTM, overcomes technical bias in blood sample analysis caused by erythrocytes, allowing for more effective biomarker identification. The patented assay minimizes reagent and sample material needs, making it a robust tool for biotechnology companies.
A study published in Neurology tracks neural changes in patients with Parkinson's disease and two similar conditions over time. Researchers found decreased activity in specific brain regions, which could provide a new tool for testing experimental medications.
Researchers developed a non-invasive way to track Parkinson's disease progression using functional magnetic resonance imaging, revealing areas of progressive brain decline. This biomarker could help evaluate experimental treatments and measure neurological changes behind symptoms.
A research team at the Krembil Research Institute has discovered two tissue biomarkers that directly contribute to harmful joint degeneration associated with spine osteoarthritis. Elevated levels of these biomarkers cause inflammation, cartilage destruction, and collagen depletion.
A new study published in Genetic Testing and Molecular Biomarkers found that analyzing cell-free DNA using next-generation sequencing is more accurate than the current standard approach of Sanger sequencing. This method can detect genetic abnormalities responsible for myelodysplastic syndrome (MDS) with greater sensitivity.
A team of researchers from the University of Sheffield has identified 788 biomarkers in blood that could be used to develop an early stage cancer screening test. The comprehensive list of relevant cancer blood biomarkers has been compiled through a systematic review of 4,000 studies published over the last five years.
Researchers found that consuming five or more servings of nuts per week lowered biomarkers of inflammation, such as C-reactive protein and interleukin 6. Substituting nuts for red meat also reduced inflammatory biomarkers. The study suggests a possible mechanism by which nuts may benefit cardiometabolic health.
A new study published in the American Journal of Clinical Nutrition found a positive association between tree nut intake and lower levels of inflammatory biomarkers. Higher nut consumption was associated with reduced C-reactive protein and Interleukin 6, which increase during inflammation.
Researchers propose combining multiple methods to identify cheating athletes, including hemoglobin mass, gene expression changes, ironomics, and blood storage-related biomarkers. These new tools offer a potential solution to detecting autologous blood transfusions.
The Moffitt Imaging Biomarker Validation Center will discover, develop and validate biomarkers for risk assessment, detection and molecular diagnosis of early cancer. The center is part of the National Cancer Institute's Early Detection Research Network.
A new clinical study found that exclusive e-cigarette use significantly reduces exposure to harmful chemicals similar to complete smoking cessation. The study measured biomarkers in urine, blood, and exhaled breath, revealing reductions of over 75% in carbon monoxide levels and over 80% in volatile organic compounds.
A study of 85 Gulf War veterans identified three types of white blood cells and six proteins in the blood that can help diagnose Gulf War Illness with 90% accuracy. The research found chronic inflammation as a key component of the illness, supporting the hypothesis that it is a well-defined chronic inflammatory disease.
Researchers have identified various miRNAs that can predict the response of metastatic renal cancer patients to anti-angiogenic agents. These biomarkers have been shown to be stable and detectable, allowing for personalized treatment. The study provides a promising tool for improving patient outcomes.
A recent study reveals that nearly 60 percent of people have preclinical heart failure stages A and B, with stage B individuals at increased risk for death. The findings highlight the importance of targeting prevention efforts at the earliest HF stages to avoid death, particularly among men and older adults.
A new biomarker, phosphorylated protein kinase LRRK2, has been found in patient urine samples and correlates with the presence and severity of Parkinson's disease. Elevated levels of this biomarker predict the risk for onset of Parkinson's disease and may be a promising guide for future clinical treatments.
Researchers discovered that tiny micro-vesicle structures in blood carry tell-tale proteins associated with Alzheimer's disease, enabling the prediction of mild cognitive impairment (MCI) progression. The findings represent a quicker and less invasive way to identify impending cognitive decline.
Researchers developed biomarker ratio imaging microscopy (BRIM) to differentiate between aggressive and non-aggressive ductal carcinoma in situ (DCIS). The technique combines traditional pathology and mathematical analysis, identifying biomarkers that can indicate the potential for cancer to become invasive.
Researchers at University of Birmingham develop test to predict sepsis in burn victims using biomarkers of neutrophil function. The test shows promise in identifying patients at risk of developing sepsis, a life-threatening condition that can be fatal if left untreated.
Researchers have discovered biomarkers using non-invasive liquid biopsies to identify aggressive disease in prostate cancer patients before surgery. The study uses urine samples from 210 patients and identifies a range of proteins that can help predict which patients have slow-growing versus aggressive cancer.
A meta-analysis of phase I clinical trials involving thousands of patients found that precision medicine treatment arms showed a higher response rate (30%) compared to non-personalized arms (4.9%), leading to improved outcomes and longer disease remission.
The Wilke Cohen Lyme Disease Project has received a $3 million pledge from the Steven & Alexandra Cohen Foundation to support its research into potential biomarkers for Lyme disease. The project aims to develop more effective diagnostics and treatments, building on initial discoveries made by ISB researchers.
Insilico Medicine presents research on applying deep learning to biomarker development and cosmetics applications at INNOCOS World Beauty Innovation Summit. The company's app RYNKL evaluates anti-aging interventions using machine learning methods, minimizing animal testing.
Researchers discover USP14 as a promising biomarker for predicting endometrial cancer recurrence. Women with high levels of USP14 are seven times more likely to recur than those with low levels, highlighting the potential for tailored treatment approaches.
The IsoPSA test detects prostate cancer by identifying molecular changes in the prostate specific antigen (PSA) protein. It also differentiates between high-risk and low-risk disease, as well as benign conditions.
Researchers at Tufts University have developed a method to stabilize blood samples for long periods without refrigeration, using air-dried silk protein. This technique has broad applications for clinical care and research, particularly for underserved populations.
A new study published in Frontiers in Pediatrics investigated the effects of a steroid treatment on children with ARDS, finding improved ventilation and blood oxygenation without affecting mortality rates. The study identified key biomarkers associated with lung inflammation and injury, paving the way for targeted treatment development.
Using clinical data from over 7 million US armed forces members, researchers identified patients with Crohn's disease and found that specific antimicrobial antibodies in their serum samples were associated with increased risk of complications. These biomarkers could potentially predict IBD development and inform preventive strategies.
A new study shows that current carrier screening methods are insufficient and can give prospective mothers a false sense of security. Whole genome studies are needed to ensure both mates don't carry recessive mutations in the same gene(s). DNA-based screening can detect many more disease-causing genetic variations