Articles tagged with Biomarkers
Researchers at NTU Singapore have developed a novel biomarker that can detect tumour cells and release anti-cancer drugs, opening up new doors in nanomedicine, bioimaging, and cancer therapeutics. The biomarker uses near-infrared light to penetrate deep tissue without causing damage to healthy cells.
The International Myeloma Working Group has updated its criteria for diagnosing multiple myeloma, allowing for earlier diagnosis without symptoms. The new guidelines incorporate validated biomarkers to identify patients at risk of progression, enabling targeted therapy and improved patient outcomes.
Scientists have identified two promising candidates for blood-borne biomarkers that could lead to a simple screening test. Abnormal DNA methylation patterns and microRNAs show promise in detecting colorectal cancer.
The institute aims to discover a biomarker that predicts the onset of allergy and leads to novel vaccine approaches, aiming to develop a simple blood test to predict likelihood of resolution or development of an allergy.
A study in JAMA Network found a strong association between tobacco use and the prevalence of oral human papillomavirus type 16 (HPV-16) infection. Tobacco users were more likely to be male, younger, and have higher lifetime oral sexual partners, and had greater levels of biomarkers for tobacco exposure.
Researchers at MD Anderson Cancer Center identified a genetic variant near the KLK3 gene that can predict aggressive prostate cancer in GS7 patients. The study found a single nucleotide polymorphism (SNP) on the KLK3 gene associated with disease aggression, providing potential biomarkers for personalized treatment.
Sok Kean Khoo, a GVSU researcher, has received a $110,000 grant from the Michael J. Fox Foundation to study molecular biomarkers for Parkinson's disease. The goal is to develop a blood test for early detection and potentially improve treatment options for the incurable neurological disorder.
A graphene biosensor has been developed to detect cancer risk biomarkers, such as 8-hydroxydeoxyguanosine (8-OHdG), with high sensitivity and speed. The sensor is capable of detecting concentrations as low as 0.1 ng mL-1, outperforming conventional detection methods.
Researchers found that high levels of VEGF-A and TGF-β1 before treatment correlated with lower survival rates and less complete tumor regression. A blood test for these proteins could help predict patients' pathological response and disease-free survival rates, allowing for more personalized treatment plans.
Researchers found that APOE genotype influences the diagnostic accuracy of CSF biomarkers, particularly beta-amyloid 42 (Aβ42), in diagnosing Alzheimer's disease. In contrast, the APOE gene had no effect on Aβ42 levels in younger individuals.
A large-scale study by Uppsala University researchers reveals that genetics and lifestyle factors play a crucial role in protein levels, enabling the use of more effective biomarkers. The study analyzed 92 protein biomarkers in 1,000 healthy individuals, finding that hereditary factors contribute to over 75% of proteins.
A study published in The Journal of Nutrition found that a blood sample can be used to assess dietary compliance. The researchers identified biomarkers in the blood that reflected consumption of key components of a healthy Nordic diet, including fatty fish, vegetables, and whole grains.
The University of Maryland Schools of Dentistry and Medicine have received a five-year $10.7 million grant from the National Institutes of Health to study the causes, prevention, and treatment of sexually-transmitted diseases. The study aims to identify novel molecular biomarkers of susceptibility to STIs and disease severity.
VCU has received a five-year, $3 million grant to investigate how childhood experiences like severe illnesses and neglect affect health outcomes. Researchers will analyze DNA methylation patterns to identify potential biomarkers for early intervention.
University of Iowa researchers have identified a biomarker that can predict preeclampsia at least 6 weeks into pregnancy, enabling early detection and potentially preventing severe health issues. The study's findings hold significant implications for obstetric care in rural and underserved communities.
A Dartmouth College study found that infant toenails are a reliable way to estimate arsenic exposure before birth. The researchers used plasma mass spectrometry to analyze infant toenails and found a significant correlation between maternal and infant toenail arsenic concentrations.
Alzheimer's disease is a neurodegenerative disorder characterized by memory problems, orientation issues, and behavioral changes. A simplified diagnosis using specific biomarkers improves the accuracy of early-stage diagnoses.
Researchers at Johns Hopkins Bayview Medical Center introduced guidelines and changes to the computerized provider order entry system to reduce redundant biomarker testing. This led to a 66% decrease in tests ordered and saved an estimated $1.25 million in laboratory charges.
Researchers analyzed ancient Neanderthal fecal matter, revealing significant plant intake alongside meat consumption. The study provides new insights into the role of vegetables in the Neanderthal diet.
Researchers developed a unique method to identify oil spills, even after most of it has degraded. They found that some biomarkers degrade within a few years after an oil spill, providing a window into the environment's impact.
Researchers discovered altered salivary biomarker levels in obese children, indicating a potential non-invasive method for identifying early Type 2 diabetes risk. The study's findings provide valuable insights into childhood obesity and metabolic syndrome, paving the way for development of prevention strategies.
Scientists have identified four microRNAs that can aid in the differential diagnosis of malignant pleural mesothelioma (MPM) from non-cancerous pleural tissue. The biomarkers, miR-126, miR-143, miR-145, and miR-652, were found to classify tissue samples with high accuracy.
The ASU Biodesign Institute has developed a high-quality biomarker discovery core competency to identify and select biomarkers for radiation biodosimetry. The team is now optimizing the assay panel and platform workflow to prepare for regulatory clearance from the FDA.
Research found pregnant women with polycystic ovary syndrome (PCOS) exhibit low-grade inflammation, worsening during pregnancy. This abnormal inflammation may contribute to increased risk of pregnancy complications like pre-eclampsia and gestational diabetes.
The American Association of Pharmaceutical Scientists recognizes outstanding researchers in biotechnology with various awards, including the AAPS Excellence in Ligand Binding Assays Award and the Innovation in Biotechnology Awards. These honors celebrate groundbreaking contributions to pharmaceutical biotechnology.
Scientists have developed a device that can process whole blood and isolate genetic material for two potential biomarkers within minutes. This rapid detection method could help determine the course of proper treatment, potentially saving lives.
A blood test using high-sensitivity cardiac troponin T can accurately predict heart attack risk in patients with chest pain, allowing for targeted admissions and reduced hospital costs. The test's negative predictive value was found to be 99.8 percent for heart attack within 30 days.
Researchers suggest aspartic acid could serve as a biomarker for postoperative cognitive dysfunction, based on correlation analysis between changes in hippocampal metabolites and cognitive impairment in aged rats. The study aims to identify potential biomarkers for predicting postoperative cognitive dysfunction.
A team of researchers identified two biomarkers that accurately predict a patient's response to radiation therapy, offering new hope for personalized treatment. The study published in the European Journal of Cancer found these markers can help avoid unnecessary side effects and reduce morbidity.
Researchers identified salivary biomarkers associated with gingivitis, including PGE2 and IL-1. These findings have implications for personalized oral health care, suggesting potential discrimination between gingivitis and health through salivary biomarker analysis.
Researchers use shrink wrap to boost signal of fluorescent markers in biosensing, enabling detection of infectious diseases with lower limits of detection. The technique could lead to a low-cost, highly sensitive diagnostic device using common, everyday materials.
A collaborative study has identified metabolomic biomarkers in urine and serum samples of women with preeclampsia, suggesting an early metabolic profile difference from women with normal pregnancies. The findings may lead to earlier detection and potentially prevent the disease.
A study published in Neurology found that patients with restless legs syndrome had a higher mortality rate than similar men, and were more likely to be diagnosed with cardiovascular disease and hypertension. RLS screening may become more common as a tool for primary care providers to identify patients at risk of serious disease.
Researchers at Washington University School of Medicine found that biomarkers of neuronal injury in Alzheimer's disease decrease as symptoms of dementia appear, contrary to previous findings. This reversal suggests a slowing of cell death and may be an important criterion for assessing the success of treatment trials.
Researchers at NUS created a highly sensitive fluorescence probe to detect Monoamine Oxidase B (MAO-B) activity, which is elevated in patients with Parkinson's disease. The probe can monitor the progression of the disease and has potential as a biomarker.
A new scientific blood analysis uses biomarkers and NMR spectroscopy to predict short-term mortality in the next five years. The study found that biomarker concentrations are crucial for normal metabolism, regardless of known risk factors.
A new study by Mercyhurst University, UPMC Hamot, and Shriners Hospitals for Children is exploring the correlation between pitch count and throwing arm injuries. The researchers will use high-speed motion-capture cameras, shoulder muscle power tests, and biomarkers to analyze the effects of consecutive pitches on fatigue.
Researchers have identified four biomarkers in blood samples that can predict mortality from any disease within five years. The study used NMR spectroscopy to analyze over 17,000 healthy individuals and found that these biomarkers were independent of traditional risk factors, indicating a general frailty in the body.
A new paper diagnostic for cancer has been developed by MIT engineers, which can detect the disease in minutes using a urine sample. The technology relies on nanoparticles that interact with tumor proteins, releasing biomarkers that are easily detectable in urine.
Researchers have identified a biological marker for major depression in teenage boys, combining elevated cortisol levels with depressive symptoms. The study found that these individuals are up to fourteen times more likely to develop major depression than those without these traits.
Human mesenchymal stem cells can undergo spontaneous tumorigenic transformation during cell culture expansion, a finding with significant implications for their clinical application. Researchers identified RNA molecule signatures that may serve as biomarkers to detect these aberrant cells.
Researchers Sarj Patel and Tom Rau aim to identify biomarkers of TBI through blood samples, improving diagnosis and treatment. The goal is to understand how localized injuries affect the entire brain.
Researchers discovered methylation sites linked to hypoxia, immune response, and neuronal differentiation in schizophrenia patients, offering potential avenues for distinct subtype identification and personalized treatment responses.
Researchers at NUS have discovered a biomarker called adenosine deaminase acting on RNA-1 (ADAR1) to diagnose and treat esophageal squamous cell carcinoma (ESCC). ADAR1 over-expression promotes tumor development, with clinical implications for early detection and treatment.
A recent study published in the Journal of the American College of Radiology reveals that there is minimal change in regional variation of imaging utilization between 2007 and 2011. In contrast, regional variation in imaging costs and other major health services categories remains significant.
Measuring changes in proteins in people with amyotrophic lateral sclerosis (ALS) may better predict disease progression, according to scientists at Penn State College of Medicine. Biomarkers from plasma and cerebrospinal fluid identified as useful in predicting disease duration.
A novel role for S100β has been identified as a biomarker for delirium duration in critically ill patients, which may have implications for refining treatment in intensive care units. Delirium duration is associated with increased mortality rates, and higher levels of S100β on day 1 or day 8 are linked to longer delirium duration.
A new method developed by Fred Hutchinson Cancer Center researchers can measure hundreds of proteins in a single assay, paving the way for standardized quantification of the human proteome. This breakthrough could lead to more accurate cancer biomarkers and personalized treatments.
African-American women with high levels of HSET protein were three times more likely to have shorter overall survival, progression-free survival, and metastasis-free survival compared to those with lower levels. The study found that HSET represents a potential new biomarker for poor breast cancer outcomes in African-American women.
Scientists at UCLA and Emory University have identified a biochemical signal in the blood associated with the faster-progressing form of Parkinson's. The researchers discovered that N8-acetyl spermidine is significantly elevated in rapid progressors, suggesting its potential as an early biomarker for the disease.
Researchers are creating new statistical tools to analyze massive amounts of cancer data and identify hidden relationships between biomarkers. The goal is to develop a framework that can combine continuous and noncontinuous variables, allowing for more accurate insights into the complex nature of cancer.
Researchers have identified a biomarker for sepsis in the blood that can be screened for at a patient's bedside, enabling rapid diagnosis and treatment. This breakthrough has the potential to save thousands of lives by reducing diagnosis time from up to two days to just two hours.
A study published in Neurology found that alpha-synuclein, a protein associated with Lewy bodies, is elevated in the skin of people with Parkinson's disease. This could lead to the development of a biomarker for early diagnosis and improved treatment options.
Researchers will investigate methylation markers in blood to predict chronic depression with a $3 million NIH grant. The findings may lead to more tailored treatment plans and improved management of the condition affecting nearly 15 million American adults.
A new study from Japan found that individuals with a history of kidney stones have significantly increased levels of inflammatory chemokines GRO and CXCL1, while those without kidney stones have higher levels of anti-inflammatory cytokine IL-4. This research may lead to the development of new therapeutic drugs for kidney stone formation.
Researchers have identified a metabolite as a biomarker of diabetes risk, revealing that individuals with increased levels are more likely to develop type 2 diabetes. Additionally, the study found that a specific genetic mutation affects muscle performance in elite endurance athletes by altering calcineurin signaling.
A new study published in the Journal of Neurotrauma found that low-level blast explosions can cause symptoms similar to sports concussions, including neurocognitive deficits and self-reported symptoms. The research, conducted on a group of soldiers called 'breachers', identified biomarkers capable of detecting changes in this population.
A novel biomarker, 2-aminoadipic acid (2-AAA), has been identified that can predict diabetes risk up to 12 years in advance. Individuals with high levels of 2-AAA concentrations had a fourfold risk of developing diabetes compared to those with lower levels.
A new study by Robert Gerszten and colleagues has identified 2-aminoadipic acid as a biomarker for Type 2 diabetes risk. Individuals with elevated levels of this metabolite were found to be at higher risk of developing T2D, with detectable levels present up to 12 years before disease onset.
Researchers tracked changes in gene expression to predict kidney damage severity in children with urinary tract obstruction. The study identified specific genes associated with the degree of obstruction, which could help identify children at risk of chronic kidney disease and permanent organ damage.