Articles tagged with Biomarkers
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A study of 61,650 participants found that elevated levels of C-reactive protein, fibrinogen, and leukocyte count are associated with an increased risk of COPD exacerbations. The risk is even higher in those with milder COPD and no previous exacerbations.
University of Cincinnati researchers have discovered biomarkers for inflammatory bowel disease (IBD), a group of inflammatory conditions affecting the colon and small intestine. These biomarkers, identified through analysis of human serum specimens from the Department of Defense Serum Repository, may help improve diagnosis and treatmen...
A new study has identified four metabolites that can be used to accurately predict mortality in intensive care unit (ICU) patients. The researchers analyzed plasma samples from 90 ICU patients and found that levels of lactate, mannose, gamma-glutamyltyrosine, and stearidonate were associated with high mortality rates.
A new study found a link between sleep-disordered breathing (SDB) and Alzheimer's disease risk factors in cognitively normal elderly patients. Lean SDB patients showed biomarkers of AD risk, including increased P-Tau and T-Tau levels, glucose hypometabolism, and hippocampal atrophy.
Researchers have identified biomarkers that can predict cognitive impairment up to 7.5 years before symptoms develop, with sex, age, and race also playing a role in the prediction. The findings provide valuable evidence for the development of new treatments targeting Alzheimer's disease before symptoms appear.
The team identified 21 microRNAs associated with ovarian cancer survival and 838 target genes linked to its progression. The findings suggest a network-based approach can predict cancer survival and recurrence more accurately than individual biomarkers.
The BIOMARGIN project aims to develop reliable, non-invasive methods to diagnose lesions in transplanted kidneys using integrated 'omics' technologies. The study will consist of four phases, including a retrospective analysis of existing samples to identify biomarkers and validate diagnostic performance.
Researchers at the University of Liege discovered a molecule, miR-146a, that can serve as a biomarker for peripartum cardiomyopathy. Elevated serum miR-146a levels were found in pregnant women who developed PPCM, suggesting its potential use to predict disease risk.
A recent study found that male smokers with low levels of serum bilirubin are at a higher risk of developing lung cancer and dying from the disease. The researchers analyzed data from over 435,000 people in Taiwan and found that lower bilirubin levels were associated with significantly higher rates of lung cancer incidence and mortality.
A recent review article highlights the need for preventive measures, genetic risk factors, and new diagnostic tools to identify the effects of traumatic brain injury (TBI) in athletes and soldiers. Researchers propose large-scale trials and genome-wide association studies to characterize CTE and develop prevention strategies.
Researchers at the University of Washington have developed a new method to analyze single cells using quantum dots, allowing for the simultaneous testing of up to 100 biomarkers. This breakthrough enables more accurate diagnosis and treatment of cancer by examining a cell's unique behavior at its molecular level.
A new study found a link between post-discharge activity levels and the risk of hospital readmission in elderly patients within 30 days. Activity levels were tracked using wearable devices, revealing that those with lower activity were at higher risk of rehospitalization.
A new NIH-funded collaboration aims to accelerate the search for biomarkers in Parkinson's disease by improving collaboration among researchers and involving patients in clinical studies. The initiative, led by Dr. Clemens Scherzer at Brigham and Women's Hospital, seeks to develop biomarkers that can predict, diagnose, or monitor the d...
Scientists at Scripps Research Institute have found a telltale molecular marker for Onchocerciasis in patients' urine, detectable during active infections. The biomarker could form the basis of a non-invasive, portable test with significant advantages over current diagnostic methods.
Northwestern University researchers found that consistent encoding of sound undergirds the reading process, with unstable representation of sound associated with poorer readers. The study suggests that auditory training can improve response consistency and potentially alleviate dyslexia.
Researchers have identified at least four disease subtypes within triple-negative breast cancers, highlighting the need for targeted therapies that target individual biomarkers. The Basal-like subtype is the majority of TN patients, and therapies targeting its unique biology are crucial for therapeutic progress.
A Mayo Clinic-led study has identified two biomarkers, IGFBP-7 and TIMP-2, that can detect acute kidney injury in urine, allowing for early intervention and improved patient outcomes. The study's findings have the potential to revolutionize the diagnosis and management of this deadly condition.
A New York-based physician-researcher has uncovered a potential connection between autism and insulin-like growth factor (IGF) levels in newborns, proposing a study to investigate this hypothesis. IGF plays a crucial role in brain development, and depressed levels may serve as a biomarker for the later development of autism.
Research finds that LGBTQ+ individuals who are out to others have lower stress hormone levels, fewer symptoms of anxiety and depression, and improved overall wellbeing. This study suggests that self-acceptance and disclosure can lead to better physical and mental health outcomes.
Researchers identified ELTD1 as a promising biomarker for diagnosing gliomas, particularly high-grade glioblastoma multiforme (GBM). Studies found that ELTD1 levels were strongly associated with glioma development and prognosis.
The NIH has launched a collaborative effort to find biomarkers for Parkinson's disease, which could help predict, diagnose, or monitor the condition. Researchers are exploring various approaches, including non-invasive imaging and protein analysis, to identify potential biomarkers that could improve treatment outcomes.
Researchers report on the therapeutic potential of microRNAs in cancer therapy and their role as potential biomarkers for early cancer detection. The stability of miRNAs in body fluids makes them suitable for non-invasive malignancy detection methods, offering exciting opportunities for revolutionizing diagnostics and screening.
Researchers at MIT have developed a new technology that can detect cancer biomarkers in the urine, potentially enabling earlier diagnosis and improved patient outcomes. The system uses nanoparticles to amplify tumor signals, making it easier to identify specific proteins secreted by cancer cells.
Dr Paul Kelly's research will identify and validate biomarkers to improve gut health in children, leading to new approaches to combat stunted growth in developing nations. The study aims to provide insights into environmental enteropathy and its consequences, ultimately guiding scaled-up interventions.
Researchers have identified 48 metabolites linked to cellular ageing and disease risk in mice. The study reveals a strong connection between metabolism and biological age, offering new insights into preventive molecular medicine.
DELSIA and Seaside Therapeutics aim to discover genetic and protein biomarkers to identify patients most likely to benefit from treatment with arbaclofen, a potential treatment for core social impairment in autism. The partnership will help generate critical information to develop targeted treatments.
Researchers explore autism spectrum disorder genetics and biomarker development in a special issue of Disease Markers. Early diagnosis through biomarkers could improve individual outcomes with early behavioral intervention.
Researchers discovered a cognitive biomarker in young adolescents at high risk of developing depression and anxiety. The test can help initiate early intervention, which has proven to be an effective way to combat mental illness.
Researchers at University of Massachusetts Amherst used biomarkers from human feces to establish the first human presence, arrival of grazing animals, and population dynamics in a landscape. The method provides a strong human signal with excellent chronological control, offering valuable insights into past environmental changes.
Researchers used MRI to image patients with mild traumatic brain injury and found that some brains compensate for damage by changing water flow patterns. This compensation is associated with fewer post-concussion symptoms and higher functioning, suggesting a potential new approach to treating traumatic brain injury.
Researchers found that neurotics with high levels of conscientiousness had lower inflammation levels, fewer chronic health conditions, and healthier body mass indices. This suggests that 'healthy neuroticism' may provide a protective effect against long-term health problems.
Researchers developed a method to differentiate patients with Alzheimer's disease from those with other types of dementia using biomarkers in cerebrospinal fluid. The study analyzed five proteins and found that they could accurately diagnose Alzheimer's disease, as well as distinguish it from Parkinson's disease and Lewy body dementia.
Researchers at Scripps Research Institute have developed a new technology that can identify potential biomarkers for ulcerative colitis in animal models. The study focuses on protein arginine deiminases (PAD) and their role in diseases such as cancer, multiple sclerosis, and rheumatoid arthritis.
Researchers aims to develop parallel strategies for protein identification in complex mixtures with potential applications in cancer diagnosis and biomarker discovery. The project builds on existing networks that analyze genetic data and identify potential relationships among genes and proteins.
A study found that detecting specific HPV biomarkers, such as E6/E7 antibodies, in combination with tumor characteristics can help identify patients with a better prognosis. This approach may lead to more targeted treatment for head and neck cancers.
Researchers developed a mass spectrometry protein assay called PRISM that matches the sensitivity and accuracy of clinical antibody-based tests. The technique can identify proteins from blood with high accuracy and speed up development of diagnostic tests and treatments.
Researchers at the University of Iowa have developed a mouse model of Fukuyama's muscular dystrophy, providing insight into disease development. Vitamin B3 has also been shown to aid in fighting staph infections by increasing C/EBPε expression in mice. Meanwhile, a new class of cerebrospinal fluid-based biomarkers for neurodegenerative...
A team from MSU's College of Osteopathic Medicine applies four osteopathic manipulative treatments to patients with moderate to severe COPD. The study aims to determine the biochemical changes in patients' blood following manipulation and correlate it with pulmonary function.
A new study found that higher levels of ceramides in the blood are associated with a 10-fold increased risk of developing Alzheimer's disease. The research suggests that identifying this biomarker could help prevent or delay the disease, which is expected to double globally every 20 years.
Researchers found that pre-injury levels of four biomarkers were associated with an increased likelihood of ACL injury, with one biomarker linked to a 19-fold risk increase.
Researchers at TGen developed a method to isolate protein-rich urinary exosomes, which can help discover biomarkers for better CKD diagnosis and treatment. The study found that the new method produces high yields of miRNA and mRNA, making it suitable for downstream genetic profiling experiments.
Researchers at the University of California, San Diego School of Medicine have identified laboratory-based biomarkers that can help understand brain-based abnormalities in schizophrenia. These endophenotypes could provide clinicians with reliable indicators of brain dysfunction, even when overt symptoms are not apparent.
Research finds that people at risk for early-onset Alzheimer's disease want to know their genetic profile, but struggle with the results. The study also reveals that the general population and those with a family history of late-onset AD tend to be motivated by fear and anxiety when considering genetic testing.
In vitro studies assess propolis' optimal concentration as a radioprotector, finding maximum protection against radiation-induced damage within 120-500 micrograms/mL. The substance does not reveal cytotoxicity or genotoxicity on non-irradiated human lymphocytes.
The study discusses the biology of tumor-derived microvesicles and their clinical application as circulating biomarkers. Microvesicles released by tumor cells may provide a unique biosignature for individual cancers, enabling early detection and targeted therapies.
A new study proposes a highly accurate blood-based screen for pancreatic adenocarcinoma, which could lead to earlier detection and improved survival rates. Researchers identified 40 biomarkers with high sensitivity and specificity, offering hope for developing an effective panel.
A new study suggests that Coenzyme Q10 reduces oxidative damage in patients with Huntington's disease, hinting at its potential to slow progression. The discovery also identifies a new biomarker, 80HdG, which could be used to screen experimental treatments for this and other neurological disorders.
Researchers have identified 29 differentially expressed proteins in maternal serum from pregnancies carrying Down syndrome fetuses. These proteins show promise as potential biomarkers for improving the performance of Down syndrome screening, but further clinical verification is needed.
Researchers identified five biomarkers that can predict the progression of structural damage in the spine of patients with Ankylosing Spondylitis, who are already at high risk of disease progression. These biomarkers include matrix metalloproteinase 3, bone-morphogenetic protein 2, and vascular endothelial growth factor.
A study published in JAMA found that certain biomarker levels, specifically troponin T, measured after noncardiac surgery are associated with an increased risk of death within 30 days. The researchers identified peak troponin T values as the strongest predictors of 30-day mortality.
Researchers at NYU College of Dentistry will screen subjects and collect biological samples to contribute to the overall project on biomarkers of periodontal disease progression. The study aims to identify factors that indicate susceptibility to developing periodontal disease and design more specific treatments.
Researchers at Princeton University have developed a new nanotechnology that amplifies fluorescent signals in biological tests, allowing for the detection of biomarkers at lower concentrations. This breakthrough could lead to improved early detection of diseases like cancer and Alzheimer's, enabling more effective treatment.
Researchers suggest enhanced public funding, partnerships, and open-source consortia may improve biomarker discovery and development. The Supreme Court's move to free medical diagnosis from private ownership could enhance public health.
Researchers identified novel biomarkers in rat feces after radiation exposure, which persisted for at least 21 days. These findings hold promise for rapid, accurate diagnosis of radiation exposure, enabling timely resource allocation for patients in need of intervention.
Researchers have identified a biomarker that can predict which patients will benefit from bevacizumab treatment. The variant in DNA found in blood samples of cancer patients showed predictive value for treatment with bevacizumab, potentially allowing for patient-tailored use of the drug and increasing the chances of survival.
A modified version of Google's PageRank algorithm is used to rank proteins by their genetic relevance to pancreatic cancer progression. Seven proteins were found that can help assess tumor aggressiveness and guide treatment decisions.
SomaLogic and NEC announce the release of SomaSuite, a professional software tool that simplifies the analysis of proteomic data generated by SomaLogic's SOMAscan assay technology. The tool enables researchers to quickly discover significant protein expression changes in their biological samples.
Researchers measured environmental air pollutants and biomarkers for systemic inflammation and thrombosis before, during, and after the 2008 Olympics. Concentrations of particulate and gaseous pollutants decreased substantially, but ozone concentrations increased.
Researchers linked air pollution exposure to increased risk of cardiovascular problems, as shown by significant reductions in blood clotting and inflammation biomarkers during the Beijing Olympics. The study provides evidence that even short-term air pollution reduction improves cardiovascular health.
Researchers from SomaLogic and the University of Washington identified 36 proteins with significant expression changes in lung cancer tissue samples, including 13 new biomarkers. This study provides new insights into NSCLC biology and suggests potential therapeutic targets.