Research on measurable signals of health and disease. Covers ultrasound imaging pipelines, fetal-distress detection, cancer monitoring, and fatigue biology.
Researchers at NUS created a highly sensitive fluorescence probe to detect Monoamine Oxidase B (MAO-B) activity, which is elevated in patients with Parkinson's disease. The probe can monitor the progression of the disease and has potential as a biomarker.
A new study by Mercyhurst University, UPMC Hamot, and Shriners Hospitals for Children is exploring the correlation between pitch count and throwing arm injuries. The researchers will use high-speed motion-capture cameras, shoulder muscle power tests, and biomarkers to analyze the effects of consecutive pitches on fatigue.
A new scientific blood analysis uses biomarkers and NMR spectroscopy to predict short-term mortality in the next five years. The study found that biomarker concentrations are crucial for normal metabolism, regardless of known risk factors.
Researchers have identified four biomarkers in blood samples that can predict mortality from any disease within five years. The study used NMR spectroscopy to analyze over 17,000 healthy individuals and found that these biomarkers were independent of traditional risk factors, indicating a general frailty in the body.
A new paper diagnostic for cancer has been developed by MIT engineers, which can detect the disease in minutes using a urine sample. The technology relies on nanoparticles that interact with tumor proteins, releasing biomarkers that are easily detectable in urine.
Researchers have identified a biological marker for major depression in teenage boys, combining elevated cortisol levels with depressive symptoms. The study found that these individuals are up to fourteen times more likely to develop major depression than those without these traits.
Human mesenchymal stem cells can undergo spontaneous tumorigenic transformation during cell culture expansion, a finding with significant implications for their clinical application. Researchers identified RNA molecule signatures that may serve as biomarkers to detect these aberrant cells.
Researchers Sarj Patel and Tom Rau aim to identify biomarkers of TBI through blood samples, improving diagnosis and treatment. The goal is to understand how localized injuries affect the entire brain.
Researchers discovered methylation sites linked to hypoxia, immune response, and neuronal differentiation in schizophrenia patients, offering potential avenues for distinct subtype identification and personalized treatment responses.
Researchers at NUS have discovered a biomarker called adenosine deaminase acting on RNA-1 (ADAR1) to diagnose and treat esophageal squamous cell carcinoma (ESCC). ADAR1 over-expression promotes tumor development, with clinical implications for early detection and treatment.
A recent study published in the Journal of the American College of Radiology reveals that there is minimal change in regional variation of imaging utilization between 2007 and 2011. In contrast, regional variation in imaging costs and other major health services categories remains significant.
Measuring changes in proteins in people with amyotrophic lateral sclerosis (ALS) may better predict disease progression, according to scientists at Penn State College of Medicine. Biomarkers from plasma and cerebrospinal fluid identified as useful in predicting disease duration.
A novel role for S100β has been identified as a biomarker for delirium duration in critically ill patients, which may have implications for refining treatment in intensive care units. Delirium duration is associated with increased mortality rates, and higher levels of S100β on day 1 or day 8 are linked to longer delirium duration.
African-American women with high levels of HSET protein were three times more likely to have shorter overall survival, progression-free survival, and metastasis-free survival compared to those with lower levels. The study found that HSET represents a potential new biomarker for poor breast cancer outcomes in African-American women.
A new method developed by Fred Hutchinson Cancer Center researchers can measure hundreds of proteins in a single assay, paving the way for standardized quantification of the human proteome. This breakthrough could lead to more accurate cancer biomarkers and personalized treatments.
Scientists at UCLA and Emory University have identified a biochemical signal in the blood associated with the faster-progressing form of Parkinson's. The researchers discovered that N8-acetyl spermidine is significantly elevated in rapid progressors, suggesting its potential as an early biomarker for the disease.
Researchers are creating new statistical tools to analyze massive amounts of cancer data and identify hidden relationships between biomarkers. The goal is to develop a framework that can combine continuous and noncontinuous variables, allowing for more accurate insights into the complex nature of cancer.
Researchers have identified a biomarker for sepsis in the blood that can be screened for at a patient's bedside, enabling rapid diagnosis and treatment. This breakthrough has the potential to save thousands of lives by reducing diagnosis time from up to two days to just two hours.
A study published in Neurology found that alpha-synuclein, a protein associated with Lewy bodies, is elevated in the skin of people with Parkinson's disease. This could lead to the development of a biomarker for early diagnosis and improved treatment options.
Researchers will investigate methylation markers in blood to predict chronic depression with a $3 million NIH grant. The findings may lead to more tailored treatment plans and improved management of the condition affecting nearly 15 million American adults.
A new study from Japan found that individuals with a history of kidney stones have significantly increased levels of inflammatory chemokines GRO and CXCL1, while those without kidney stones have higher levels of anti-inflammatory cytokine IL-4. This research may lead to the development of new therapeutic drugs for kidney stone formation.
A new study published in the Journal of Neurotrauma found that low-level blast explosions can cause symptoms similar to sports concussions, including neurocognitive deficits and self-reported symptoms. The research, conducted on a group of soldiers called 'breachers', identified biomarkers capable of detecting changes in this population.
A novel biomarker, 2-aminoadipic acid (2-AAA), has been identified that can predict diabetes risk up to 12 years in advance. Individuals with high levels of 2-AAA concentrations had a fourfold risk of developing diabetes compared to those with lower levels.
A new study by Robert Gerszten and colleagues has identified 2-aminoadipic acid as a biomarker for Type 2 diabetes risk. Individuals with elevated levels of this metabolite were found to be at higher risk of developing T2D, with detectable levels present up to 12 years before disease onset.
Researchers have identified a metabolite as a biomarker of diabetes risk, revealing that individuals with increased levels are more likely to develop type 2 diabetes. Additionally, the study found that a specific genetic mutation affects muscle performance in elite endurance athletes by altering calcineurin signaling.
Researchers tracked changes in gene expression to predict kidney damage severity in children with urinary tract obstruction. The study identified specific genes associated with the degree of obstruction, which could help identify children at risk of chronic kidney disease and permanent organ damage.
A new biomarker strategy using troponin and copeptin has the potential to change clinical practice with high patient safety, according to the BIC-8 trial. The strategy significantly increased emergency room discharge rates among patients with suspected ACS.
Researchers at the University of Pennsylvania School of Medicine have developed a comprehensive test for protein biomarkers in spinal fluid that shows prognostic and diagnostic value in early stages of Parkinson's disease. The study found that patients with lower levels of tau and alpha synuclein had greater motor dysfunction, while th...
Researchers analyzed cerebrospinal fluid biomarkers in patients with early-stage Parkinson's disease (PD) and healthy controls. Lower levels of Alzheimer's beta-1-42 and tau proteins were found in PD patients, associated with motor severity. The study suggests that these biomarkers have prognostic potential for early-stage PD.
A study published in Molecular Psychiatry found RNA biomarkers in blood associated with suicidal thoughts in patients with bipolar disorder. The researchers identified SAT1 and other markers that were significantly elevated in the blood of both bipolar disorder patients and those who had committed suicide.
A study led by Dr. Elizabeth Osuch found a correlation between the activation of the putamen region in the brain and bipolar disorder symptoms. The discovery may lead to a definitive biological marker for differentiating between major depressive disorder and bipolar disorder, ultimately improving diagnosis and treatment.
A study identified a potential biomarker for Alzheimer's disease in cerebral spinal fluid, suggesting the condition may be detectable a decade before symptoms appear. Researchers hope to find treatments that can prevent or slow the progression of the disease.
The lack of investment in tumor biomarker research, inconsistent regulatory rules, and inadequate payment have created a vicious cycle preventing the development and testing of reliable biomarker tests. Experts recommend reforms to break this cycle and increase the value of tumor biomarker tests.
A clinical study on reduced toxicant prototype cigarettes is investigating whether reducing smoke toxicant exposure affects biomarkers of biological effect. The six-month study, involving 260 healthy adult subjects, aims to assess the longer-term impact of these cigarettes on biological effects.
Researchers at the National Human Genome Research Institute identified biomarkers of kidney damage and demonstrated that antioxidant therapy protected kidney function in mice. These findings offer new tools for monitoring disease progression and may pave the way for clinical trials for patients with methylmalonic acidemia.
Researchers have discovered four biomarkers that characterize the non-genetic form of amyotrophic lateral sclerosis (ALS), a devastating motor neuron disease. These biomarkers could lead to earlier and more accurate diagnostics, as well as new directions for therapeutic research.
A Loyola University Medical Center study found that treating acid reflux through laparoscopic anti-reflux surgery could help prevent chronic rejection in lung transplant patients. Certain biomarkers in lung fluid can predict BOS and immune system activity.
Research reveals a gene called CPT1A, which regulates fat breakdown in the liver, may increase risk of heart disease when methylated. The study found elevated levels of bad cholesterol and triglycerides, and lower adiponectin levels in patients with this genetic switch turned off.
Researchers at the University of Alaska Fairbanks have discovered a novel biomarker that can accurately measure long-term sugar intake from a single blood or hair sample. This breakthrough tool is distinct in corn and sugar cane, which are sources of nearly all sugars found in sugar-sweetened beverages.
Researchers found that a combination of two proteins, S100B and apoA-1, helps most accurately classify head injuries. This study provides significant evidence for the potential use of blood tests in diagnosing mild traumatic brain injury.
New antibody biomarkers could significantly improve diagnosis in rheumatoid arthritis by detecting the disease in patients who test negative for existing diagnostic antibodies. The study found that these biomarkers were present in both early and seronegative disease, indicating their potential to close the diagnostic gap in RA.
A study of 61,650 participants found that elevated levels of C-reactive protein, fibrinogen, and leukocyte count are associated with an increased risk of COPD exacerbations. The risk is even higher in those with milder COPD and no previous exacerbations.
University of Cincinnati researchers have discovered biomarkers for inflammatory bowel disease (IBD), a group of inflammatory conditions affecting the colon and small intestine. These biomarkers, identified through analysis of human serum specimens from the Department of Defense Serum Repository, may help improve diagnosis and treatmen...
A new study has identified four metabolites that can be used to accurately predict mortality in intensive care unit (ICU) patients. The researchers analyzed plasma samples from 90 ICU patients and found that levels of lactate, mannose, gamma-glutamyltyrosine, and stearidonate were associated with high mortality rates.
A new study found a link between sleep-disordered breathing (SDB) and Alzheimer's disease risk factors in cognitively normal elderly patients. Lean SDB patients showed biomarkers of AD risk, including increased P-Tau and T-Tau levels, glucose hypometabolism, and hippocampal atrophy.
Researchers have identified biomarkers that can predict cognitive impairment up to 7.5 years before symptoms develop, with sex, age, and race also playing a role in the prediction. The findings provide valuable evidence for the development of new treatments targeting Alzheimer's disease before symptoms appear.
The team identified 21 microRNAs associated with ovarian cancer survival and 838 target genes linked to its progression. The findings suggest a network-based approach can predict cancer survival and recurrence more accurately than individual biomarkers.
The BIOMARGIN project aims to develop reliable, non-invasive methods to diagnose lesions in transplanted kidneys using integrated 'omics' technologies. The study will consist of four phases, including a retrospective analysis of existing samples to identify biomarkers and validate diagnostic performance.
Researchers at the University of Liege discovered a molecule, miR-146a, that can serve as a biomarker for peripartum cardiomyopathy. Elevated serum miR-146a levels were found in pregnant women who developed PPCM, suggesting its potential use to predict disease risk.
A recent study found that male smokers with low levels of serum bilirubin are at a higher risk of developing lung cancer and dying from the disease. The researchers analyzed data from over 435,000 people in Taiwan and found that lower bilirubin levels were associated with significantly higher rates of lung cancer incidence and mortality.
A recent review article highlights the need for preventive measures, genetic risk factors, and new diagnostic tools to identify the effects of traumatic brain injury (TBI) in athletes and soldiers. Researchers propose large-scale trials and genome-wide association studies to characterize CTE and develop prevention strategies.
Researchers at the University of Washington have developed a new method to analyze single cells using quantum dots, allowing for the simultaneous testing of up to 100 biomarkers. This breakthrough enables more accurate diagnosis and treatment of cancer by examining a cell's unique behavior at its molecular level.
A new study found a link between post-discharge activity levels and the risk of hospital readmission in elderly patients within 30 days. Activity levels were tracked using wearable devices, revealing that those with lower activity were at higher risk of rehospitalization.
A new NIH-funded collaboration aims to accelerate the search for biomarkers in Parkinson's disease by improving collaboration among researchers and involving patients in clinical studies. The initiative, led by Dr. Clemens Scherzer at Brigham and Women's Hospital, seeks to develop biomarkers that can predict, diagnose, or monitor the d...
Scientists at Scripps Research Institute have found a telltale molecular marker for Onchocerciasis in patients' urine, detectable during active infections. The biomarker could form the basis of a non-invasive, portable test with significant advantages over current diagnostic methods.
Northwestern University researchers found that consistent encoding of sound undergirds the reading process, with unstable representation of sound associated with poorer readers. The study suggests that auditory training can improve response consistency and potentially alleviate dyslexia.
Researchers have identified at least four disease subtypes within triple-negative breast cancers, highlighting the need for targeted therapies that target individual biomarkers. The Basal-like subtype is the majority of TN patients, and therapies targeting its unique biology are crucial for therapeutic progress.
A Mayo Clinic-led study has identified two biomarkers, IGFBP-7 and TIMP-2, that can detect acute kidney injury in urine, allowing for early intervention and improved patient outcomes. The study's findings have the potential to revolutionize the diagnosis and management of this deadly condition.
A New York-based physician-researcher has uncovered a potential connection between autism and insulin-like growth factor (IGF) levels in newborns, proposing a study to investigate this hypothesis. IGF plays a crucial role in brain development, and depressed levels may serve as a biomarker for the later development of autism.
Research finds that LGBTQ+ individuals who are out to others have lower stress hormone levels, fewer symptoms of anxiety and depression, and improved overall wellbeing. This study suggests that self-acceptance and disclosure can lead to better physical and mental health outcomes.