Articles tagged with Biomarkers
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Two novel biomarkers, sensitive cardiac troponin assays and copeptin, significantly improve early detection of acute myocardial infarction. These markers enable doctors to diagnose AMI in the vast majority of patients presenting with chest pain, reducing complications and costs.
Two new software programs, caCORRECT and omniBioMarker, have improved the identification of cancer biomarkers from gene expression data. The certified tools remove noise and artifacts, and identify valid biomarkers for personalized cancer treatment.
A study found that testing for blood alcohol levels (BALs) can identify high-risk patients admitted to trauma centers who had denied excessive drinking. Elevated BALs are associated with higher rates of complications and predict the development of delirium treatments.
A multicenter study found that cerebrospinal fluid biomarkers Aβ42, T-tau, and P-tau can accurately identify patients with mild cognitive impairment who will progress to Alzheimer's disease. The study used a large group of patients with MCI and followed them for at least 2 years or until symptoms progressed.
Several statistical and biological issues need to be addressed to improve biomarker identification for early cancer detection. The author suggests using more frequent specimen collection and the paired availability design to enhance the biomarker pipeline.
A study of biomarkers found that measuring known biomarkers slightly improves the ability to predict future heart attacks or strokes in healthy individuals. However, this improvement is not significant enough to change preventive therapies. The study suggests that new technologies may lead to personalized cardiovascular risk prediction.
Several biomarkers, including CRP and N-BNP, showed minimal added benefit in predicting cardiovascular events compared to conventional risk factors. The use of these biomarkers did not result in significant improvements in reclassification of individuals to new risk categories or changes in therapy.
A recent genetic association study failed to support a causal relationship between C-reactive protein levels and coronary heart disease (CHD). The study, published in JAMA, found that variants associated with lower CRP levels were not linked to reduced CHD risk.
A new method detects protein biomarkers in body fluids, increasing the number of diagnostic tests for cancer. The technique is highly reproducible across laboratories and instruments, allowing for early cancer detection.
Researchers at Boston Children's Hospital developed a protein detectable in urine as a potential biomarker for appendicitis. The leucine-rich alpha-2-glycoprotein (LRG) marker showed near-perfect sensitivity and specificity, and was strongly elevated in diseased appendices.
Researchers identified a new biomarker that can predict which patients with recurrent glioblastoma will respond better to anti-vascular endothelial growth factor therapy. The study found that vascular normalization, measured using advanced MRI and blood biomarkers, correlated with survival rates.
A recent study has identified biomarkers in cerebrospinal fluid that can reveal Alzheimer's disease at a very early stage, even in patients with minimal memory impairment. The findings suggest that these biomarkers can predict the risk of deterioration by 27 times higher than the control group.
Researchers have identified N-Myc downstream-regulated gene 4 (NDRG4) as a potential biomarker for colorectal cancer and a candidate tumor suppressor gene. The study found that NDRG4 promoter methylation was more prevalent in colorectal cancers than in noncancerous colon mucosa.
A new blood test has been developed to detect the p16INK4a biomarker, which is strongly correlated with chronological age and behaviors that accelerate aging. The test has been validated in a study of 170 healthy human volunteers, showing a strong correlation between biomarker expression and age.
A new study identified biomarkers associated with inflammation and joint erosion in early rheumatoid arthritis. Levels of sYKL-40 and sMMP3 were consistently linked to disease activity measures, suggesting their potential use as predictors of bone and cartilage damage.
A global study found colorectal cancer incidence rates for males and females increased in 27 countries between 1983 and 2002. The rise is attributed to Westernization and lifestyle changes, including obesity, physical inactivity, and diet.
Scientists at the University of Saskatchewan and Canadian Light Source have identified a chemical fingerprint associated with Barrett's Esophagus, a precursor to esophageal cancer. The discovery uses infrared microscopy to detect biomarkers in individual cells, offering a new diagnostic tool for detecting the condition.
Several novel biomarkers have been discovered in heart failure syndrome, including ST2, troponins, AGEs, adrenomedullin, and estradiol. These biomarkers offer valuable information for diagnosis, risk stratification, and treatment monitoring, as well as providing insights into the disease's underlying pathophysiology.
John P. Cogswell, PhD, has been awarded the 2009 Alzheimer Award for his work on identifying microRNA changes in Alzheimer's disease brain and CSF, which yields putative biomarkers and insights into disease pathways. His research highlights the potential of microRNAs to aid clinical diagnosis.
A new study using cardiac magnetic resonance imaging found that marathon runners experience transient heart dysfunction after competition. The study showed that these fluctuations do not result in true damage to the heart muscle and recover within one week.
Researchers are launching a multi-institutional effort to develop a test to detect early-stage lung cancer in lifetime nonsmokers. The project aims to create a better understanding of the biology of lung cancer and identify potential biomarkers.
Researchers at Ohio State University validated a method to measure variations in histones, promising biomarkers for chronic leukemia diagnosis and treatment response. The study accurately detected differences in histone composition between CLL cells and healthy B lymphocytes.
A team of researchers has established a compendium of 2,516 potential biomarkers for pancreatic cancer, with over 200 genes shortlisted for further study. The findings provide a strategic approach to early detection and could lead to the development of more accurate diagnostic tests.
Researchers have made significant breakthroughs in salivary diagnostics, discovering new biomarkers for detecting oral cancer, acute coronary syndrome, and systemic diseases. The study highlights the potential of saliva as a non-invasive diagnostic tool, offering clear clinical advantages over traditional methods.
Researchers have discovered two efficient biomarker applications that promise even earlier diagnosis and improved treatment of heart failure. Biomarkers N-terminal pro-B-type natriuretic peptide (NT-proBNP) and cystatin C can identify patients at high risk, enabling targeted care and reducing healthcare costs.
Researchers at Penn Medicine have developed a biomarker test that can confirm or rule out Alzheimer's disease by measuring cerebrospinal fluid concentrations of amyloid beta42 peptide and tau protein. The test accurately predicted the conversion from mild cognitive impairment to Alzheimer's disease in 81.8% of cases.
Researchers will analyze frozen blood samples from over 7,000 FHS participants to identify biomarkers associated with heart disease and metabolic syndrome. The goal is to develop simple blood tests to predict high-risk patients.
Researchers in Singapore have identified three specific biomarkers that accurately indicate the severity of Chikungunya fever, which can be easily detected in blood samples. These findings enable quicker and more accurate prognosis for infected patients, distinguishing CHIKF from dengue fever.
A study found significant correlations between PBC stage and AST, APRI, ALT/platelet, and AST/ALT ratios. These biomarkers show promise in reducing the need for liver biopsy, with AST/ALT exhibiting the highest sensitivity and specificity.
Dr. Wenbo Zhi, a postdoctoral fellow at the Medical College of Georgia, has received a two-year fellowship to study biomarkers associated with type 1 diabetes. He aims to identify protein biomarkers that can improve diagnosis and treatment using proteomic techniques.
Yale researchers identified proteins associated with early onset neonatal sepsis, a stealthy bacterial infection linked to premature birth and death. The biomarkers found have diagnostic value for infection and inflammation, allowing for earlier identification of babies at risk.
High levels of specific proteins in spinal fluid may signal the onset of Lou Gehrig's disease. Researchers developed a diagnostic kit using these biomarkers, achieving 92% accuracy in identifying ALS patients.
A recent study by Boston University researchers has identified a class of microRNAs that regulate gene expression changes in airway cells caused by smoking and lung cancer. These findings may lead to a non-invasive biomarker for smoking-related lung diseases, improving early diagnosis and treatment options.
Researchers found that testing two inflammation biomarkers, Lp-PLA2 and hs-CRP, improved the prediction of ischemic stroke in patients. Adding both biomarkers to traditional risk factors provided the most accurate picture of stroke risk.
A new technology has been developed to identify pregnant women at risk of developing preeclampsia, a leading cause of maternal and neonatal deaths worldwide. The technology employs a panel of biomarkers found in the placenta and could lead to earlier detection and targeted intervention.
Researchers discovered over 200 serum proteins in umbilical cord blood, revealing changes in protein levels that indicate cigarette smoke exposure. The study identified biomarkers linked to key metabolic pathways, providing insights into the molecular effects of fetal exposure to toxic chemicals.
Research suggests ovarian cancer subtypes have distinct biomarker profiles, affecting patient outcomes and treatment strategies. The study analyzed 500 ovarian cancer samples to identify correlations between biomarkers and survival rates, highlighting the need for subtype-specific approaches.
A team of Stanford researchers has created a prototype blood scanner that can detect cancer biomarkers in the bloodstream at an early stage of the disease. The system uses magnetic nanotechnology to spot cancer proteins, which is tens to hundreds of times more sensitive than existing commercial devices. This technology holds promise fo...
Scientists have discovered biomarkers predicting chronological and physiological age in nematode worms, with implications for human anti-aging therapies. The study's findings, published in Aging Cell, suggest that examining biomarkers over time can provide a scientific baseline for clinical trials.
A study found that interleukin-6, a biochemical marker in the blood, is significantly higher in patients with age-related macular degeneration (AMD) and correlates with oxidative stress. Additionally, collagen crosslinking treatment has shown promising results in stabilizing keratoconus patients' vision.
Researchers at Rhode Island Hospital have identified biomarkers capable of distinguishing changes in the esophagus that signal a precancerous condition. These markers may help identify patients who are likely to progress to esophageal cancer, allowing for earlier intervention.
Research at the American College of Rheumatology 2008 Annual Meeting found that rheumatoid arthritis patients are at a higher risk of dying from heart-related complications after a heart attack. Biomarkers have been identified to determine the most effective treatment for muscle tissue inflammation and age-related bone loss in men and ...
A team led by UC San Diego professor Joseph Wang will create an automated sense-and-treat system that monitors biomarkers and administers treatment in real-time, aiming to improve soldier survival rates.
Researchers found strong associations between intermittent HIV treatment and higher levels of inflammation and blood-clotting biomarkers, leading to a higher risk of death from non-AIDS diseases. Interleukin-6 (IL-6) and D-dimer levels rose significantly in the intermittent-treatment group after one month.
Researchers found strong associations between markers of inflammation and coagulation and increased risk of death from non-AIDS diseases. Biomarkers IL-6 and D-dimer levels were unchanged in patients receiving continuous ART treatment, suggesting a link to intermittent ART.
The Australian Imaging, Biomarker and Lifestyle Flagship Study of Ageing (AIBL) has secured a three-year collaboration with Pfizer Australia, valued at over $1.1 million. The partnership aims to identify blood-based biomarkers for early diagnosis and test new disease-modifying therapies.
Scientists have identified potential biomarkers in plasma samples from premature infants to detect infection and type of microbe. Eight proteins associated with immune responses were found to be consistently over-expressed in infected neonates.
Researchers will analyze human blood samples to discover proteins that could serve as biomarkers of infectious diseases. The goal is to identify specific biomarkers present in infected individuals but absent in uninfected people, guiding diagnostics, therapies, and vaccines.
Researchers propose a nested case-control study design called PRoBE to evaluate biomarker classification accuracy, minimizing bias. Regular NSAID use is associated with a 12% relative risk reduction in breast cancer risk, according to a meta-analysis of 38 studies involving 2,788,715 women.
Researchers are developing a simple blood test to diagnose Alzheimer's disease by identifying biomarkers in the blood. The study aims to provide an early and accurate diagnosis, allowing for effective treatment to be given sooner.
Researchers are exploring new biomarkers to detect myocardial infarction, which could lead to faster diagnosis and improved treatment outcomes. Currently, cardiac troponin is the gold standard for diagnosing myocardial necrosis, but its limitations include delayed detection and low sensitivity to ischemia.
The Bach study reveals MR-proANP is equally useful as BNP and NT-proBNP for diagnosing acute congestive heart failure. Adding PCT marker supports differential diagnosis of pneumonia vs. heart failure in patients with shortness of breath.
A linear mathematical model allows for estimation of minimal detectable tumor sizes, based on blood tumor biomarker assays. The model relates secreted blood biomarker levels to tumor sizes, providing a tool for cancer screening and monitoring.
A two-year study found that low-carbohydrate and Mediterranean diets were as effective as low-fat diets in achieving weight loss. The Mediterranean diet showed significant improvements in cholesterol levels and fasting glucose, while the low-carb diet improved HDL cholesterol and triglycerides.
A team of scientists has developed a system to detect potential 'biomarkers' of early forms of cancer by analyzing sugar molecules attached to proteins. The system aims to provide more accurate early diagnosis and monitoring of cancer progression.
A panel of seven biomarkers can predict prostate cancer risk with high accuracy, offering a major step forward in patient care. Elevated levels of these biomarkers were associated with increased risk of relapse, and the combination of all seven variables accurately predicted risk 86.6 percent of the time.
Researchers have identified potential biomarkers for growth hormone that could aid in detecting doping in athletes. Several proteins increased or decreased in the blood of mice treated with growth hormone, offering new possibilities for testing.
Researchers at UT Southwestern Medical Center have identified a panel of seven biomarkers that can predict prostate cancer recurrence with 86 percent accuracy. This finding holds promise for personalized medicine and targeted therapy, potentially improving treatment outcomes and patient care.
Researchers have pinpointed four proteins - apoA1, transthyretin, clusterin and albumin - that react strongly to bovine growth hormone, potentially serving as biomarkers for growth hormone activity in humans. The discovery could offer a wider testing window for detecting recombinant human growth hormone misuse.
Researchers identified five biomarkers linked to early development of pancreatic cancer in mice that also apply to early stages in humans. These findings bring scientists closer to developing a blood test to detect the disease early, when cure rates are highest.