Research on measurable signals of health and disease. Covers ultrasound imaging pipelines, fetal-distress detection, cancer monitoring, and fatigue biology.
Researchers identified ELTD1 as a promising biomarker for diagnosing gliomas, particularly high-grade glioblastoma multiforme (GBM). Studies found that ELTD1 levels were strongly associated with glioma development and prognosis.
The NIH has launched a collaborative effort to find biomarkers for Parkinson's disease, which could help predict, diagnose, or monitor the condition. Researchers are exploring various approaches, including non-invasive imaging and protein analysis, to identify potential biomarkers that could improve treatment outcomes.
Researchers report on the therapeutic potential of microRNAs in cancer therapy and their role as potential biomarkers for early cancer detection. The stability of miRNAs in body fluids makes them suitable for non-invasive malignancy detection methods, offering exciting opportunities for revolutionizing diagnostics and screening.
Researchers at MIT have developed a new technology that can detect cancer biomarkers in the urine, potentially enabling earlier diagnosis and improved patient outcomes. The system uses nanoparticles to amplify tumor signals, making it easier to identify specific proteins secreted by cancer cells.
Dr Paul Kelly's research will identify and validate biomarkers to improve gut health in children, leading to new approaches to combat stunted growth in developing nations. The study aims to provide insights into environmental enteropathy and its consequences, ultimately guiding scaled-up interventions.
Researchers have identified 48 metabolites linked to cellular ageing and disease risk in mice. The study reveals a strong connection between metabolism and biological age, offering new insights into preventive molecular medicine.
DELSIA and Seaside Therapeutics aim to discover genetic and protein biomarkers to identify patients most likely to benefit from treatment with arbaclofen, a potential treatment for core social impairment in autism. The partnership will help generate critical information to develop targeted treatments.
Researchers explore autism spectrum disorder genetics and biomarker development in a special issue of Disease Markers. Early diagnosis through biomarkers could improve individual outcomes with early behavioral intervention.
Researchers discovered a cognitive biomarker in young adolescents at high risk of developing depression and anxiety. The test can help initiate early intervention, which has proven to be an effective way to combat mental illness.
Researchers at University of Massachusetts Amherst used biomarkers from human feces to establish the first human presence, arrival of grazing animals, and population dynamics in a landscape. The method provides a strong human signal with excellent chronological control, offering valuable insights into past environmental changes.
Researchers used MRI to image patients with mild traumatic brain injury and found that some brains compensate for damage by changing water flow patterns. This compensation is associated with fewer post-concussion symptoms and higher functioning, suggesting a potential new approach to treating traumatic brain injury.
Researchers found that neurotics with high levels of conscientiousness had lower inflammation levels, fewer chronic health conditions, and healthier body mass indices. This suggests that 'healthy neuroticism' may provide a protective effect against long-term health problems.
Researchers developed a method to differentiate patients with Alzheimer's disease from those with other types of dementia using biomarkers in cerebrospinal fluid. The study analyzed five proteins and found that they could accurately diagnose Alzheimer's disease, as well as distinguish it from Parkinson's disease and Lewy body dementia.
Researchers at Scripps Research Institute have developed a new technology that can identify potential biomarkers for ulcerative colitis in animal models. The study focuses on protein arginine deiminases (PAD) and their role in diseases such as cancer, multiple sclerosis, and rheumatoid arthritis.
Researchers aims to develop parallel strategies for protein identification in complex mixtures with potential applications in cancer diagnosis and biomarker discovery. The project builds on existing networks that analyze genetic data and identify potential relationships among genes and proteins.
A study found that detecting specific HPV biomarkers, such as E6/E7 antibodies, in combination with tumor characteristics can help identify patients with a better prognosis. This approach may lead to more targeted treatment for head and neck cancers.
Researchers developed a mass spectrometry protein assay called PRISM that matches the sensitivity and accuracy of clinical antibody-based tests. The technique can identify proteins from blood with high accuracy and speed up development of diagnostic tests and treatments.
Researchers at the University of Iowa have developed a mouse model of Fukuyama's muscular dystrophy, providing insight into disease development. Vitamin B3 has also been shown to aid in fighting staph infections by increasing C/EBPε expression in mice. Meanwhile, a new class of cerebrospinal fluid-based biomarkers for neurodegenerative...
A team from MSU's College of Osteopathic Medicine applies four osteopathic manipulative treatments to patients with moderate to severe COPD. The study aims to determine the biochemical changes in patients' blood following manipulation and correlate it with pulmonary function.
A new study found that higher levels of ceramides in the blood are associated with a 10-fold increased risk of developing Alzheimer's disease. The research suggests that identifying this biomarker could help prevent or delay the disease, which is expected to double globally every 20 years.
Researchers found that pre-injury levels of four biomarkers were associated with an increased likelihood of ACL injury, with one biomarker linked to a 19-fold risk increase.
Researchers at TGen developed a method to isolate protein-rich urinary exosomes, which can help discover biomarkers for better CKD diagnosis and treatment. The study found that the new method produces high yields of miRNA and mRNA, making it suitable for downstream genetic profiling experiments.
Researchers at the University of California, San Diego School of Medicine have identified laboratory-based biomarkers that can help understand brain-based abnormalities in schizophrenia. These endophenotypes could provide clinicians with reliable indicators of brain dysfunction, even when overt symptoms are not apparent.
Research finds that people at risk for early-onset Alzheimer's disease want to know their genetic profile, but struggle with the results. The study also reveals that the general population and those with a family history of late-onset AD tend to be motivated by fear and anxiety when considering genetic testing.
In vitro studies assess propolis' optimal concentration as a radioprotector, finding maximum protection against radiation-induced damage within 120-500 micrograms/mL. The substance does not reveal cytotoxicity or genotoxicity on non-irradiated human lymphocytes.
The study discusses the biology of tumor-derived microvesicles and their clinical application as circulating biomarkers. Microvesicles released by tumor cells may provide a unique biosignature for individual cancers, enabling early detection and targeted therapies.
A new study proposes a highly accurate blood-based screen for pancreatic adenocarcinoma, which could lead to earlier detection and improved survival rates. Researchers identified 40 biomarkers with high sensitivity and specificity, offering hope for developing an effective panel.
A new study suggests that Coenzyme Q10 reduces oxidative damage in patients with Huntington's disease, hinting at its potential to slow progression. The discovery also identifies a new biomarker, 80HdG, which could be used to screen experimental treatments for this and other neurological disorders.
Researchers have identified 29 differentially expressed proteins in maternal serum from pregnancies carrying Down syndrome fetuses. These proteins show promise as potential biomarkers for improving the performance of Down syndrome screening, but further clinical verification is needed.
Researchers identified five biomarkers that can predict the progression of structural damage in the spine of patients with Ankylosing Spondylitis, who are already at high risk of disease progression. These biomarkers include matrix metalloproteinase 3, bone-morphogenetic protein 2, and vascular endothelial growth factor.
A study published in JAMA found that certain biomarker levels, specifically troponin T, measured after noncardiac surgery are associated with an increased risk of death within 30 days. The researchers identified peak troponin T values as the strongest predictors of 30-day mortality.
Researchers at NYU College of Dentistry will screen subjects and collect biological samples to contribute to the overall project on biomarkers of periodontal disease progression. The study aims to identify factors that indicate susceptibility to developing periodontal disease and design more specific treatments.
Researchers at Princeton University have developed a new nanotechnology that amplifies fluorescent signals in biological tests, allowing for the detection of biomarkers at lower concentrations. This breakthrough could lead to improved early detection of diseases like cancer and Alzheimer's, enabling more effective treatment.
Researchers suggest enhanced public funding, partnerships, and open-source consortia may improve biomarker discovery and development. The Supreme Court's move to free medical diagnosis from private ownership could enhance public health.
Researchers identified novel biomarkers in rat feces after radiation exposure, which persisted for at least 21 days. These findings hold promise for rapid, accurate diagnosis of radiation exposure, enabling timely resource allocation for patients in need of intervention.
Researchers have identified a biomarker that can predict which patients will benefit from bevacizumab treatment. The variant in DNA found in blood samples of cancer patients showed predictive value for treatment with bevacizumab, potentially allowing for patient-tailored use of the drug and increasing the chances of survival.
A modified version of Google's PageRank algorithm is used to rank proteins by their genetic relevance to pancreatic cancer progression. Seven proteins were found that can help assess tumor aggressiveness and guide treatment decisions.
SomaLogic and NEC announce the release of SomaSuite, a professional software tool that simplifies the analysis of proteomic data generated by SomaLogic's SOMAscan assay technology. The tool enables researchers to quickly discover significant protein expression changes in their biological samples.
Researchers measured environmental air pollutants and biomarkers for systemic inflammation and thrombosis before, during, and after the 2008 Olympics. Concentrations of particulate and gaseous pollutants decreased substantially, but ozone concentrations increased.
Researchers linked air pollution exposure to increased risk of cardiovascular problems, as shown by significant reductions in blood clotting and inflammation biomarkers during the Beijing Olympics. The study provides evidence that even short-term air pollution reduction improves cardiovascular health.
Researchers from SomaLogic and the University of Washington identified 36 proteins with significant expression changes in lung cancer tissue samples, including 13 new biomarkers. This study provides new insights into NSCLC biology and suggests potential therapeutic targets.
A study of 112 patients with Parkinson's disease and 60 controls found that persistent ocular tremors were universally present in patients with PD, regardless of medication use. This finding suggests that precise oculomotor testing could be a valuable tool for early diagnosis.
Researchers found a decrease in cerebrospinal fluid biomarker P-tau following treatment with bapineuzumab, suggesting potential benefits for Alzheimer's patients. However, further examination is needed to determine if these changes correlate with clinical improvements.
Researchers at Uppsala University have identified potential biomarkers for autism spectrum disorder using advanced mass spectrometry. The study found disruptions in the nervous system and a connection between protein C3 and ASD, which may lead to a reliable blood-based diagnostic tool.
Recent studies have increased interest in salivary biomarkers for diagnostics, but challenges persist in collection, storage, and quantitation of biomarkers. Researchers will discuss standardization procedures and address issues with proteomic methods.
A clinical trial examining the antioxidant effects of a vitamin E and C combination on Alzheimer's disease found no association with changes in cerebrospinal fluid biomarkers. However, the treatment was shown to reduce oxidative stress in the brain, but at the cost of faster cognitive decline.
A recent study found that adding inflammatory biomarkers improves the clinical prediction of mortality in patients with chronic obstructive pulmonary disease (COPD). The addition of a panel of selected biomarkers significantly improved the ability of clinical variables to predict mortality, with a C-statistic of 0.726.
Recent advances in biomarker discovery highlight the potential for personalized medicine, but also pose significant challenges. Biomarkers have been identified for various diseases, including idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease, and systemic lupus erythematosus.
A panel of 10 serum protein biomarkers shows promise in predicting lung cancer risk and aiding early detection. Research suggests that these biomarkers could reduce the number of unnecessary lung biopsies needed, offering a more targeted approach to diagnosis.
The SOMAscan assay identifies and measures thousands of proteins, unlocking protein biomarker discovery for therapeutic and diagnostic applications. This technology empowers personalized medicine by detecting early disease onset in real-time.
Researchers at Arizona State University have identified over 1,200 proteins in umbilical cord blood, providing valuable information for the identification of biomarkers. The findings represent a significant advance in the discovery of early warning indices of disease and toxic exposure.
The Forsyth Institute is developing a low-cost diagnostic tool for tuberculosis (TB), which can quickly and accurately diagnose active TB cases in developing countries. The project focuses on identifying and validating seven proteins of Mycobacterium tuberculosis as biomarkers of active disease.
The University of Louisville will receive a $576,800 grant to develop a low-cost, simple test for diagnosing tuberculosis (TB) in developing countries. Researchers aim to identify and validate TB biomarkers using a disposable sampling plate and breath test.
SomaLogic will develop a low-cost diagnostic tool using its proteomic technology to detect TB biomarkers. The grant aims to improve identification of active TB cases in developing countries.
A short spinning session can increase cardiac biomarkers, similar to a heart attack, but levels return to normal within 24 hours. Researchers hope to raise awareness among emergency treatment teams about the need for accurate assessment in patients with chest pains after exercise.
Henry Ford Hospital researchers have identified two molecules that hold promise as a biomarker for measuring cartilage damage associated with osteoarthritis. Non-coding RNAs in blood were found to be associated with mild cartilage damage in patients one year after ACL reconstruction surgery.
Researchers at Sam Houston State University have discovered a new biomarker, ACTA, in liver samples following cyanide poisoning, which may extend its detection window up to two months. Elevated cyanide concentrations can only be detected for up to two days under current toxicological testing.
A new blood test developed by Ridge Diagnostics analyzes levels of nine biomarkers to accurately diagnose major depressive disorder with a sensitivity of about 90% and specificity of 80%. The test, known as MDDScore, could improve diagnostic accuracy and help track individual patients' response to treatment.
Researchers identified two biomarkers, NGAL and Kim1, that predict poor outcomes in hospitalization and require dialysis treatment. Early detection of acute kidney injury is crucial to devise an adequate treatment strategy for patients.
Researchers identified 56 genes associated with inflammation and lipid metabolism to detect atherosclerosis. The biomarker test uses a blood sample and can predict the risk of silent atherosclerosis in clinical practice.