Articles tagged with Biomarkers
The Australian Imaging, Biomarker and Lifestyle Flagship Study of Ageing (AIBL) has secured a three-year collaboration with Pfizer Australia, valued at over $1.1 million. The partnership aims to identify blood-based biomarkers for early diagnosis and test new disease-modifying therapies.
Scientists have identified potential biomarkers in plasma samples from premature infants to detect infection and type of microbe. Eight proteins associated with immune responses were found to be consistently over-expressed in infected neonates.
Researchers will analyze human blood samples to discover proteins that could serve as biomarkers of infectious diseases. The goal is to identify specific biomarkers present in infected individuals but absent in uninfected people, guiding diagnostics, therapies, and vaccines.
Researchers propose a nested case-control study design called PRoBE to evaluate biomarker classification accuracy, minimizing bias. Regular NSAID use is associated with a 12% relative risk reduction in breast cancer risk, according to a meta-analysis of 38 studies involving 2,788,715 women.
Researchers are developing a simple blood test to diagnose Alzheimer's disease by identifying biomarkers in the blood. The study aims to provide an early and accurate diagnosis, allowing for effective treatment to be given sooner.
Researchers are exploring new biomarkers to detect myocardial infarction, which could lead to faster diagnosis and improved treatment outcomes. Currently, cardiac troponin is the gold standard for diagnosing myocardial necrosis, but its limitations include delayed detection and low sensitivity to ischemia.
The Bach study reveals MR-proANP is equally useful as BNP and NT-proBNP for diagnosing acute congestive heart failure. Adding PCT marker supports differential diagnosis of pneumonia vs. heart failure in patients with shortness of breath.
A linear mathematical model allows for estimation of minimal detectable tumor sizes, based on blood tumor biomarker assays. The model relates secreted blood biomarker levels to tumor sizes, providing a tool for cancer screening and monitoring.
A two-year study found that low-carbohydrate and Mediterranean diets were as effective as low-fat diets in achieving weight loss. The Mediterranean diet showed significant improvements in cholesterol levels and fasting glucose, while the low-carb diet improved HDL cholesterol and triglycerides.
A team of scientists has developed a system to detect potential 'biomarkers' of early forms of cancer by analyzing sugar molecules attached to proteins. The system aims to provide more accurate early diagnosis and monitoring of cancer progression.
A panel of seven biomarkers can predict prostate cancer risk with high accuracy, offering a major step forward in patient care. Elevated levels of these biomarkers were associated with increased risk of relapse, and the combination of all seven variables accurately predicted risk 86.6 percent of the time.
Researchers have pinpointed four proteins - apoA1, transthyretin, clusterin and albumin - that react strongly to bovine growth hormone, potentially serving as biomarkers for growth hormone activity in humans. The discovery could offer a wider testing window for detecting recombinant human growth hormone misuse.
Researchers have identified potential biomarkers for growth hormone that could aid in detecting doping in athletes. Several proteins increased or decreased in the blood of mice treated with growth hormone, offering new possibilities for testing.
Researchers at UT Southwestern Medical Center have identified a panel of seven biomarkers that can predict prostate cancer recurrence with 86 percent accuracy. This finding holds promise for personalized medicine and targeted therapy, potentially improving treatment outcomes and patient care.
Researchers identified five biomarkers linked to early development of pancreatic cancer in mice that also apply to early stages in humans. These findings bring scientists closer to developing a blood test to detect the disease early, when cure rates are highest.
Researchers present data on gene-based blood testing that may help reduce immunosuppression and predict cardiac allograft rejection. Non-invasive molecular testing of routine blood samples provides information on the immune, inflammatory, and injury status of transplanted hearts before tissue damage occurs.
University of Florida chemists develop a new tool to identify biomarkers for serious diseases, potentially leading to earlier detection and improved treatment. The technique uses aptamers to recognize cancer cells and could have applications in disease detection, imaging, and therapy.
Researchers found that poor sleep is strongly associated with high levels of psychological distress, depression, anger, and hostility in women. Women who reported longer time to fall asleep had higher levels of inflammatory proteins and insulin.
A new approach identifies five genes involved in myelination and six genes involved in growth factor signaling as potential biomarkers for high and low mood states. The study suggests that blood biomarkers may offer an informative window into brain functioning and disease state.
Researchers at NIST, NCI, and SAIC developed a new method for detecting HER2 breast cancer using chicken immunoglobulin Y (IgY) antibody tagged with quantum dot. This approach improves the detection of HER2 biomarker by 40-50% compared to existing tests.
Researchers from NIST and CU-Boulder have developed a technique using optical frequency comb spectroscopy to detect molecules in breath that may be markers for diseases like asthma or cancer. The technique can identify thousands of different molecules simultaneously, providing highly reliable information about various diseases.
Researchers have created a new technique using laser light to analyze breath samples, detecting biomarkers for diseases like asthma and cancer. This non-invasive method could provide rapid and reliable health screenings, addressing existing limitations in breath analysis.
Researchers at Yale University have received a $4 million NIH grant to study new biomarkers for detecting acute kidney injury (AKI) after cardiac surgery. The goal is to develop an earlier and more accurate diagnosis, reducing mortality rates.
A new study has discovered a set of 15 proteins found in urine that can distinguish healthy individuals from those with coronary artery disease. The protein panel accurately identifies CAD 83% of the time, with high sensitivity and low false positives.
Researchers have identified 30 new proteins that interact with the amyloid precursor protein, shedding light on its functional role in Alzheimer's disease. Additionally, a study found low variation in platelet protein expression within the elderly population, suggesting potential for clinical biomarkers.
A study published in Clinical Cancer Research demonstrates that a novel mass-spectrometry based proteomic profiling method is more accurate than traditional biomarkers in distinguishing liver cancer patients from patients with hepatitis C liver cirrhosis. The technique, SELDI-TOF MS, identified an 11-protein signature that accurately d...
Researchers have made significant progress in identifying new biomarkers for epithelial ovarian cancer, which can aid in early detection and improve treatment outcomes. The study highlights the potential of these biomarkers as therapeutic and imaging targets.
The JDRF-Lilly project will support cutting-edge research on biomarkers for pancreatic beta cell mass and function, which could indicate the presence of type 1 diabetes. Biomarkers would be a powerful research tool in indicating disease progression and predicting patient responses to treatments.
Scientists have developed a non-invasive method to track neural stem and progenitor cells in the live human brain using MRI technology. This breakthrough could lead to better diagnosis and monitoring of brain tumors and serious neurological disorders.
Scientists will create biomarkers for environmental risk factors in human disease, including cigarette smoke and obesity. The research aims to understand the interaction between genes and environment, using wearable sensors and advanced technologies.
A large study of European patients has identified promising biomarkers to distinguish between patients with a high likelihood and low likelihood of relapse, paving the way for more targeted treatment approaches.
The Center for Excellence in Environmental Toxicology at Penn School of Medicine will study biological indicators of exposure to cigarette smoke using a panel of biochemical markers. The goal is to identify people most at risk of tobacco-related disease and potentially inspire them to quit smoking.
The NIH has funded eight genome-wide association studies to identify novel genetic variants associated with increased risk for common diseases like prostate cancer, diabetes, and heart disease. These studies will also measure personal environmental exposures using wearable sensors.
Scientists at PNNL have developed a portable biosensor that can distinguish between individuals exposed to nerve agents and those who are simply scared. The sensor uses nano-based technology to amplify biomarker signals, enabling precise readings and faster detection.
The Emory research team aims to identify protein biomarkers that correlate with ALS onset and progression. Developing such biomarkers could enable early diagnosis, disease monitoring, and potential prevention of the disease.
Researchers found that smokeless tobacco users are exposed to higher amounts of tobacco-specific nitrosamines than cigarette smokers. The study highlights the dangers of smokeless tobacco and suggests that nicotine replacement therapy may be a safer alternative.
Researchers discovered that blood levels of protein ST2 indicate the presence of heart failure and predict the risk of death, even among patients without heart failure. A combination of ST2 with other biomarkers provides the most accurate prediction for all study participants.
Researchers have identified a potential biomarker, urinary neutrophil gelatinase-associated lipocalin (uNGAL), to predict acute kidney injury (AKI) in critically ill children. The study found that uNGAL levels increased 48 hours before a jump in serum creatinine levels, suggesting its potential as an early warning system for AKI preven...
The new criteria focus on a clinical core of early and significant episodic memory impairment, incorporating biomarker-based tests. Validation studies are necessary to optimize sensitivity, specificity, and accuracy.
Researchers introduce novel methods for evaluating patients with non-alcoholic fatty liver disease (NAFLD), including a blood test to determine caspase three-generated cytokeratin 18 fragment levels. These tests may help differentiate NASH from simple steatosis and predict treatment outcomes, potentially improving patient care.
The AACR-FDA-NCI Cancer Biomarkers Collaborative aims to integrate predictive biomarkers into clinical trials, addressing the translation of cancer knowledge into medical practice. The collaborative will develop guidelines for biomarker validation, informing policies as part of the FDA's Critical Path Initiative.
A Sandia National Laboratories handheld device determines if a patient has gum disease and quantifies its advancement in minutes from a tiny saliva sample. The device's technology also shows promise for detecting biotoxins, improving prostate and breast cancer diagnosis, and measuring animal serum in vaccines.
Biosite has identified a combination of three biomarkers that performed better in assessing risk of sepsis progression. The sepsis biomarker panel may aid in the rapid assessment of patients presenting to the emergency department with signs and symptoms of sepsis.
Researchers at Temple University have found early indicators of inflammation in work-related injuries caused by repetitive motion, signaling potential warning signs for debilitating conditions like carpal tunnel syndrome. The study's findings could lead to early detection and prevention of these conditions.
Researchers at UT Southwestern Medical Center have found a new biomarker test that can predict the recurrence of bladder cancer in patients. The test uses molecular biomarkers to identify patients who are more likely to experience cancer recurrence, allowing for personalized treatment options.
A new study has identified a set of biomarkers using proteomics that could help diagnose myelodysplastic syndromes (MDS) and reduce the need for bone marrow biopsies. The findings, reported in the Proceedings of the National Academy of Sciences, used serum proteomic profiling to distinguish between MDS patients and healthy controls.
Scientists found that persons with high multimarker scores had a risk of death four times as great and a risk of major cardiovascular events almost two times as great as those with low scores. The study used 3209 participants for 10 years, measuring 10 novel biomarkers in addition to established risk factors.
A study suggests that even commonly used biomarkers are limited in their ability to predict cardiovascular risk. BNP and urinary albumin content were found to be the most useful in predicting future events, but only slightly improved predictions based on conventional risk factors.
Scientists at Cornell University have discovered a panel of 23 protein biomarkers in cerebrospinal fluid that can identify patients living with Alzheimer's disease. The biomarkers, known as a 'fingerprint,' were validated through autopsy-proven tests and showed high sensitivity and accuracy.
Researchers have identified amylase, an enzyme in saliva, as a biochemical marker linked to sleep loss. Flies subjected to prolonged sleep deprivation showed increased amylase levels, similar to humans who were kept awake for extended periods. The discovery aims to develop diagnostic tools and improve understanding of sleep disorders.
Researchers at Pacific Northwest National Laboratory have discovered 176 proteins associated with plague virulence, offering promising leads for improved disease detection and treatment. The study's findings may also guide the development of new vaccines and therapies to combat the deadly disease.
Researchers at Emory University's Winship Cancer Institute have identified a novel biomarker called 'soluble attractin' that is elevated in patients with malignant astrocytomas. This protein plays a key role in the migration and recurrence of brain tumors, making it a promising target for future therapeutic intervention.
Researchers at Columbia University Medical Center found that elevated inflammatory biomarkers, such as Lp-PLA2 and hs-CRP, are associated with increased risk of recurrent stroke and mortality after a first stroke. The study's findings may lead to the use of prophylactic treatments to reduce stroke risk in people with elevated biomarkers.
The IU and Purdue Analytical Proteomics Team has been awarded a grant to develop standardized proteomics methodologies to discover proteins relevant to cancer. The team will work with cancer researchers and clinicians at the IU School of Medicine, as well as experts in statistical and computer analysis.
A study analyzing 13 biomarkers found that combinations of neuroendocrine and immune markers were associated with high-risk pathways in men, while systolic blood pressure was linked to female high-risk pathways. Recursive partitioning identified the importance of biological regulatory systems in predicting mortality in later life.
A new biomarker predicting survival in colorectal carcinomas has been discovered, with thymidylate synthase levels in the nucleus and cytoplasm identified as critical markers. The ratio of nuclear to cytoplasmic TS levels also predicts decreased survival, revealing a new potential biomarker for patients with worse prognosis.
The Osteoarthritis Initiative (OAI) has released its first set of data, featuring images and clinical outcome information for nearly 5,000 participants at risk of knee osteoarthritis. The data will facilitate the discovery of biomarkers for development and progression of OA.
A study published in Biochemistry reveals that damage to proteins caused by oxidative stress is linked to a natural byproduct called nitration, which could be used to predict the earliest stages of brain impairment. The research uses the most detailed proteomic analysis of a mammalian brain to date.
Researchers found that certain fatty acid ethyl esters (FAEEs) in meconium are indicative of fetal exposure to alcohol during pregnancy. The presence of these biomarkers was significantly higher in infants exposed to alcohol, suggesting potential as a reliable indicator of fetal alcohol effects.
New research finds ancient oil droplets containing biomarkers from eukaryotes and cyanobacteria that lived before the planet's glaciation, contradicting previous theories. The study suggests oxygen was produced long before the atmosphere became oxygenated, supporting life in extreme conditions.