Articles tagged with Biomarkers
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A team of researchers developed a tracer molecule to highlight beta-amyloid in PET brain scans, aiming to diagnose Alzheimer's disease earlier. PET biomarkers could also evaluate the effects of drugs on the brain, potentially improving treatment outcomes for neurodegenerative conditions.
A Yale University study will examine dietary calcium insufficiency in inner city infants, highlighting the alarming trends of decreased calcium intake over the past 30 years. The research aims to establish guidelines for calcium in infants below age three and predict a 10-20% prevalence of abnormal biomarkers.
Researchers emphasize the need for early detection and monitoring of alcohol abuse to prevent dependence issues. Emerging biomarkers, such as genetic analysis, hold promise for accurate diagnosis and treatment compliance.
A recent study published in Archives of Neurology suggests that variations in p-tau 231 levels can predict the structural progression of Alzheimer's disease. The biomarker has been shown to discriminate between AD patients and those with other neurodegenerative disorders, with high accuracy in detecting early-stage disease.
A recent study has associated high expression of interferon-inducible genes with increased disease severity in SLE patients, including kidney disease. The findings suggest that determining the expression of these genes may help select patients for clinical studies.
A new painless diagnostic test for Sjögren's syndrome could be available in two to three years, promising faster diagnosis and reduced severity of symptoms. The test involves analyzing teardrops collected from patients' eyes, which may help identify specific protein biomarkers for the disease.
Researchers found abnormally low levels of N-acetylaspartate in methamphetamine users, but elevated choline levels in early abstainers, suggesting some degree of normalization over time. The study's findings have important implications for understanding addiction and substance abuse treatment.
A new study published in The Lancet identified a biomarker NGAL that can detect kidney failure hours after cardiac surgery, offering hope for earlier diagnosis and treatment. The research found high concentrations of NGAL in urine and blood samples within two hours of surgery, indicating the presence of kidney failure.
Researchers have found a novel biomarker, neutrophil gelatinase-associated lipocalin (NGAL), that can detect kidney failure in children after cardiac surgery in as little as two hours. This early diagnosis enables timely administration of effective therapeutic measures to prevent further complications.
Researchers identified protein biomarkers in amniotic fluid linked to preterm labor, predicting success of cervical stitching. The study also found additional biomarkers suggesting other causes of preterm birth.
Scientists at Northwestern University have developed a new diagnostic test for Alzheimer's disease using bio-bar-code amplification technology. The test can detect miniscule amounts of a toxic protein in human cerebrospinal fluid, which may be responsible for early neurological deterioration.
A $9.7 million grant led by Fred Hutchinson Cancer Center aims to create reliable and inexpensive blood tests for early cancer detection. The collaboration involves institutions worldwide, with a focus on identifying serum biomarkers and protein patterns to detect disease at an early stage.
Researchers at the University of Pittsburgh identified abnormal levels of protein erythrocyte-C4d in patients with lupus, showing high diagnostic sensitivity and specificity for the disease. This finding may lead to improved diagnosis and treatment options for patients with lupus.
Researchers at OHSU have discovered a possible method for early detection and prevention of premature birth by identifying biomarkers associated with intra-amniotic infections in both animal and human studies. The breakthrough technology has the potential to save young lives and may lead to significant health benefits.
Researchers have discovered biomarkers for ALS in cerebrospinal fluid, which could enable rapid diagnosis and prompt treatment. These biomarkers have high sensitivity and specificity, and may be used to monitor drug effectiveness in clinical trials.
A Medical College of Georgia study aims to identify specific protein markers in the blood that indicate how ovarian cancer responds to therapy. By analyzing changes in protein expression over time, researchers hope to develop a better understanding of the disease process and create more effective screening tests.
The Osteoarthritis Initiative aims to identify people at risk for OA and monitor disease progression using biological markers. The study will enroll 5,000 adults over five years, collecting data on joint pain, limited movement, and cartilage loss.
Researchers at Pacific Northwest National Laboratory have identified a vast array of 4,000 distinctive proteins in human blood plasma, surpassing previous reports by 10 times. This significant advance paves the way for the early detection of cancer and other diseases.
Elevated PlGF levels in patients with acute coronary syndromes (ACS) and acute chest pain indicate a significantly increased risk of heart attack or death at 30 days. Measuring PlGF levels may provide a powerful clinical biomarker for vascular inflammation and adverse outcome in ACS patients.
Researchers at the University of Pittsburgh Medical Center have identified protein biomarkers that accurately diagnose ALS with near 100% specificity and sensitivity. The findings may lead to a new test for early-stage ALS, enabling faster diagnosis and monitoring of treatment efficacy.
Research suggests green tea consumption may prevent cancer and reduce oxidative DNA damage, with potential chemopreventive effects of green tea polyphenols. The study also identified novel EGCG analogs with potent anti-tumor activity.
A study by Pollack and colleagues finds that a high Ki-67 biomarker is linked to increased risk of distant metastasis and death in prostate cancer patients. The researchers also suggest that Ki-67 can help identify high-risk patients who may benefit from alternative treatment strategies.
CYC202 demonstrates significant cancer cell death, with 54% of patients testing positive for apoptosis following single agent treatment. Seven patients experienced long-lasting tumour stabilisation in Phase I trials, showcasing potential for selective treatment based on genetic profiles.
Researchers at PNNL and UCLA have discovered six times more proteins in NAF than previously identified, suggesting its potential as a biomarker for breast cancer. The study aims to develop a more accurate, non-invasive method for early diagnosis.
Researchers identified a strong association between EZH2 and ECAD biomarkers and prostate cancer recurrence. Moderate or strong expression of EZH2 coupled with at most moderate expression of ECAD is most strongly associated with biochemical recurrence.
A new study has found that cerebrospinal fluid biomarkers may be effective in detecting early stages of Alzheimer's disease, with a sensitivity of 92% and specificity of 89%. The researchers suggest that these biomarkers could be used to identify people at risk of developing the disease.
A new study finds that ethyl glucuronide (EtG) is a highly effective and sensitive marker of recent alcohol use, detecting consumption up to 80 hours after complete elimination. The marker helps identify patients who have lapsed or relapsed in treatment, ensuring they are alcohol-free for work and other activities.
This year's AACR honorees have made significant advances in understanding and treating cancer. The winners include Mario R. Capecchi, Ronald A. DePinho, Carlos L. Arteaga, Malcom F. Stevens, Martin J. Blaser, David S. Alberts, Graham A. Colditz, Janet D. Rowley, who will receive awards for their outstanding research in various areas of...
Researchers found a connection between HIV antiretroviral therapy and impaired triglyceride metabolism, increasing risk of atherosclerosis. Elevated ApoC-III levels were associated with higher triglycerides in both treatment groups.
The Fred Hutchinson Cancer Center is developing a blood test for breast cancer detection, using biomarkers such as circulating breast-tumor cells and growth factors. The project aims to improve breast-cancer detection and diagnosis by complementing mammography with molecular-screening tools.
The Osteoarthritis Initiative will recruit 5,000 participants aged 50+ at high risk for knee osteoarthritis. The project aims to establish a natural history database for osteoarthritis, allowing researchers to identify potential new disease targets and develop tools for understanding disease progression.
Researchers analyzed biomarker data from over 700 healthy men and 60 rhesus monkeys, finding lower body temperatures, blood insulin levels, and higher DHEAS levels in those on a calorically restricted diet were associated with longer lifespan. The study suggests potential for developing compounds that mimic the benefits of caloric rest...
Researchers develop surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI) for identifying potential biomarkers of early stage breast cancer. The study achieved high sensitivity and specificity, suggesting SELDI may lead to the discovery of additional biomarkers.
Researchers from SurroMed and Penn State University have developed Nanobarcodes particles, which can identify individual particles using optical microscopy. This technology enables multiplexed bioassays in solution, revolutionizing life science research and disease diagnosis.
A study published in The American Journal of Clinical Nutrition found that two major US dietary patterns, prudent and Western, result in distinct health risks. The prudent diet was associated with a favorable biomarker profile, while the Western diet was linked to higher plasma levels of biomarkers for cardiovascular disease risk and l...
A study discovered a link between lower platelet adenylyl cyclase activity and increased risk of alcoholism. Recent alcohol consumption was found to be a confounding variable, and other factors such as major depression and hyperlipidemia were also associated with low AC activity.
Researchers discovered that high levels of BAG-1 protein correlate with better long-term survival and overall survival rates for women with early breast cancer. The study found a significant difference in 10-year survival rates between women with high and low BAG-1 protein levels.
Free-radical activity was found to be roughly doubled in the frontal and temporal lobes of brains of people who died of Alzheimer's disease. The levels of two biochemical markers of free-radical tissue damage were also elevated in these areas, which are critical for memory and intellectual function.