Articles tagged with Biomarkers
A new technology has been developed to identify pregnant women at risk of developing preeclampsia, a leading cause of maternal and neonatal deaths worldwide. The technology employs a panel of biomarkers found in the placenta and could lead to earlier detection and targeted intervention.
Researchers found that testing two inflammation biomarkers, Lp-PLA2 and hs-CRP, improved the prediction of ischemic stroke in patients. Adding both biomarkers to traditional risk factors provided the most accurate picture of stroke risk.
Researchers discovered over 200 serum proteins in umbilical cord blood, revealing changes in protein levels that indicate cigarette smoke exposure. The study identified biomarkers linked to key metabolic pathways, providing insights into the molecular effects of fetal exposure to toxic chemicals.
A team of Stanford researchers has created a prototype blood scanner that can detect cancer biomarkers in the bloodstream at an early stage of the disease. The system uses magnetic nanotechnology to spot cancer proteins, which is tens to hundreds of times more sensitive than existing commercial devices. This technology holds promise fo...
Research suggests ovarian cancer subtypes have distinct biomarker profiles, affecting patient outcomes and treatment strategies. The study analyzed 500 ovarian cancer samples to identify correlations between biomarkers and survival rates, highlighting the need for subtype-specific approaches.
Scientists have discovered biomarkers predicting chronological and physiological age in nematode worms, with implications for human anti-aging therapies. The study's findings, published in Aging Cell, suggest that examining biomarkers over time can provide a scientific baseline for clinical trials.
A study found that interleukin-6, a biochemical marker in the blood, is significantly higher in patients with age-related macular degeneration (AMD) and correlates with oxidative stress. Additionally, collagen crosslinking treatment has shown promising results in stabilizing keratoconus patients' vision.
Researchers at Rhode Island Hospital have identified biomarkers capable of distinguishing changes in the esophagus that signal a precancerous condition. These markers may help identify patients who are likely to progress to esophageal cancer, allowing for earlier intervention.
Research at the American College of Rheumatology 2008 Annual Meeting found that rheumatoid arthritis patients are at a higher risk of dying from heart-related complications after a heart attack. Biomarkers have been identified to determine the most effective treatment for muscle tissue inflammation and age-related bone loss in men and ...
A team led by UC San Diego professor Joseph Wang will create an automated sense-and-treat system that monitors biomarkers and administers treatment in real-time, aiming to improve soldier survival rates.
Researchers found strong associations between intermittent HIV treatment and higher levels of inflammation and blood-clotting biomarkers, leading to a higher risk of death from non-AIDS diseases. Interleukin-6 (IL-6) and D-dimer levels rose significantly in the intermittent-treatment group after one month.
Researchers found strong associations between markers of inflammation and coagulation and increased risk of death from non-AIDS diseases. Biomarkers IL-6 and D-dimer levels were unchanged in patients receiving continuous ART treatment, suggesting a link to intermittent ART.
The Australian Imaging, Biomarker and Lifestyle Flagship Study of Ageing (AIBL) has secured a three-year collaboration with Pfizer Australia, valued at over $1.1 million. The partnership aims to identify blood-based biomarkers for early diagnosis and test new disease-modifying therapies.
Scientists have identified potential biomarkers in plasma samples from premature infants to detect infection and type of microbe. Eight proteins associated with immune responses were found to be consistently over-expressed in infected neonates.
Researchers will analyze human blood samples to discover proteins that could serve as biomarkers of infectious diseases. The goal is to identify specific biomarkers present in infected individuals but absent in uninfected people, guiding diagnostics, therapies, and vaccines.
Researchers propose a nested case-control study design called PRoBE to evaluate biomarker classification accuracy, minimizing bias. Regular NSAID use is associated with a 12% relative risk reduction in breast cancer risk, according to a meta-analysis of 38 studies involving 2,788,715 women.
Researchers are developing a simple blood test to diagnose Alzheimer's disease by identifying biomarkers in the blood. The study aims to provide an early and accurate diagnosis, allowing for effective treatment to be given sooner.
The Bach study reveals MR-proANP is equally useful as BNP and NT-proBNP for diagnosing acute congestive heart failure. Adding PCT marker supports differential diagnosis of pneumonia vs. heart failure in patients with shortness of breath.
Researchers are exploring new biomarkers to detect myocardial infarction, which could lead to faster diagnosis and improved treatment outcomes. Currently, cardiac troponin is the gold standard for diagnosing myocardial necrosis, but its limitations include delayed detection and low sensitivity to ischemia.
A linear mathematical model allows for estimation of minimal detectable tumor sizes, based on blood tumor biomarker assays. The model relates secreted blood biomarker levels to tumor sizes, providing a tool for cancer screening and monitoring.
A two-year study found that low-carbohydrate and Mediterranean diets were as effective as low-fat diets in achieving weight loss. The Mediterranean diet showed significant improvements in cholesterol levels and fasting glucose, while the low-carb diet improved HDL cholesterol and triglycerides.
A team of scientists has developed a system to detect potential 'biomarkers' of early forms of cancer by analyzing sugar molecules attached to proteins. The system aims to provide more accurate early diagnosis and monitoring of cancer progression.
A panel of seven biomarkers can predict prostate cancer risk with high accuracy, offering a major step forward in patient care. Elevated levels of these biomarkers were associated with increased risk of relapse, and the combination of all seven variables accurately predicted risk 86.6 percent of the time.
Researchers at UT Southwestern Medical Center have identified a panel of seven biomarkers that can predict prostate cancer recurrence with 86 percent accuracy. This finding holds promise for personalized medicine and targeted therapy, potentially improving treatment outcomes and patient care.
Researchers have pinpointed four proteins - apoA1, transthyretin, clusterin and albumin - that react strongly to bovine growth hormone, potentially serving as biomarkers for growth hormone activity in humans. The discovery could offer a wider testing window for detecting recombinant human growth hormone misuse.
Researchers have identified potential biomarkers for growth hormone that could aid in detecting doping in athletes. Several proteins increased or decreased in the blood of mice treated with growth hormone, offering new possibilities for testing.
Researchers identified five biomarkers linked to early development of pancreatic cancer in mice that also apply to early stages in humans. These findings bring scientists closer to developing a blood test to detect the disease early, when cure rates are highest.
Researchers present data on gene-based blood testing that may help reduce immunosuppression and predict cardiac allograft rejection. Non-invasive molecular testing of routine blood samples provides information on the immune, inflammatory, and injury status of transplanted hearts before tissue damage occurs.
University of Florida chemists develop a new tool to identify biomarkers for serious diseases, potentially leading to earlier detection and improved treatment. The technique uses aptamers to recognize cancer cells and could have applications in disease detection, imaging, and therapy.
Researchers found that poor sleep is strongly associated with high levels of psychological distress, depression, anger, and hostility in women. Women who reported longer time to fall asleep had higher levels of inflammatory proteins and insulin.
A new approach identifies five genes involved in myelination and six genes involved in growth factor signaling as potential biomarkers for high and low mood states. The study suggests that blood biomarkers may offer an informative window into brain functioning and disease state.
Researchers at NIST, NCI, and SAIC developed a new method for detecting HER2 breast cancer using chicken immunoglobulin Y (IgY) antibody tagged with quantum dot. This approach improves the detection of HER2 biomarker by 40-50% compared to existing tests.
Researchers from NIST and CU-Boulder have developed a technique using optical frequency comb spectroscopy to detect molecules in breath that may be markers for diseases like asthma or cancer. The technique can identify thousands of different molecules simultaneously, providing highly reliable information about various diseases.
Researchers have created a new technique using laser light to analyze breath samples, detecting biomarkers for diseases like asthma and cancer. This non-invasive method could provide rapid and reliable health screenings, addressing existing limitations in breath analysis.
Researchers at Yale University have received a $4 million NIH grant to study new biomarkers for detecting acute kidney injury (AKI) after cardiac surgery. The goal is to develop an earlier and more accurate diagnosis, reducing mortality rates.
A new study has discovered a set of 15 proteins found in urine that can distinguish healthy individuals from those with coronary artery disease. The protein panel accurately identifies CAD 83% of the time, with high sensitivity and low false positives.
Researchers have identified 30 new proteins that interact with the amyloid precursor protein, shedding light on its functional role in Alzheimer's disease. Additionally, a study found low variation in platelet protein expression within the elderly population, suggesting potential for clinical biomarkers.
A study published in Clinical Cancer Research demonstrates that a novel mass-spectrometry based proteomic profiling method is more accurate than traditional biomarkers in distinguishing liver cancer patients from patients with hepatitis C liver cirrhosis. The technique, SELDI-TOF MS, identified an 11-protein signature that accurately d...
Researchers have made significant progress in identifying new biomarkers for epithelial ovarian cancer, which can aid in early detection and improve treatment outcomes. The study highlights the potential of these biomarkers as therapeutic and imaging targets.
The JDRF-Lilly project will support cutting-edge research on biomarkers for pancreatic beta cell mass and function, which could indicate the presence of type 1 diabetes. Biomarkers would be a powerful research tool in indicating disease progression and predicting patient responses to treatments.
Scientists have developed a non-invasive method to track neural stem and progenitor cells in the live human brain using MRI technology. This breakthrough could lead to better diagnosis and monitoring of brain tumors and serious neurological disorders.
Scientists will create biomarkers for environmental risk factors in human disease, including cigarette smoke and obesity. The research aims to understand the interaction between genes and environment, using wearable sensors and advanced technologies.
A large study of European patients has identified promising biomarkers to distinguish between patients with a high likelihood and low likelihood of relapse, paving the way for more targeted treatment approaches.
The Center for Excellence in Environmental Toxicology at Penn School of Medicine will study biological indicators of exposure to cigarette smoke using a panel of biochemical markers. The goal is to identify people most at risk of tobacco-related disease and potentially inspire them to quit smoking.
The NIH has funded eight genome-wide association studies to identify novel genetic variants associated with increased risk for common diseases like prostate cancer, diabetes, and heart disease. These studies will also measure personal environmental exposures using wearable sensors.
Scientists at PNNL have developed a portable biosensor that can distinguish between individuals exposed to nerve agents and those who are simply scared. The sensor uses nano-based technology to amplify biomarker signals, enabling precise readings and faster detection.
The Emory research team aims to identify protein biomarkers that correlate with ALS onset and progression. Developing such biomarkers could enable early diagnosis, disease monitoring, and potential prevention of the disease.
Researchers found that smokeless tobacco users are exposed to higher amounts of tobacco-specific nitrosamines than cigarette smokers. The study highlights the dangers of smokeless tobacco and suggests that nicotine replacement therapy may be a safer alternative.
Researchers discovered that blood levels of protein ST2 indicate the presence of heart failure and predict the risk of death, even among patients without heart failure. A combination of ST2 with other biomarkers provides the most accurate prediction for all study participants.
Researchers have identified a potential biomarker, urinary neutrophil gelatinase-associated lipocalin (uNGAL), to predict acute kidney injury (AKI) in critically ill children. The study found that uNGAL levels increased 48 hours before a jump in serum creatinine levels, suggesting its potential as an early warning system for AKI preven...
The new criteria focus on a clinical core of early and significant episodic memory impairment, incorporating biomarker-based tests. Validation studies are necessary to optimize sensitivity, specificity, and accuracy.
Researchers introduce novel methods for evaluating patients with non-alcoholic fatty liver disease (NAFLD), including a blood test to determine caspase three-generated cytokeratin 18 fragment levels. These tests may help differentiate NASH from simple steatosis and predict treatment outcomes, potentially improving patient care.
The AACR-FDA-NCI Cancer Biomarkers Collaborative aims to integrate predictive biomarkers into clinical trials, addressing the translation of cancer knowledge into medical practice. The collaborative will develop guidelines for biomarker validation, informing policies as part of the FDA's Critical Path Initiative.
A Sandia National Laboratories handheld device determines if a patient has gum disease and quantifies its advancement in minutes from a tiny saliva sample. The device's technology also shows promise for detecting biotoxins, improving prostate and breast cancer diagnosis, and measuring animal serum in vaccines.
Biosite has identified a combination of three biomarkers that performed better in assessing risk of sepsis progression. The sepsis biomarker panel may aid in the rapid assessment of patients presenting to the emergency department with signs and symptoms of sepsis.
Researchers at Temple University have found early indicators of inflammation in work-related injuries caused by repetitive motion, signaling potential warning signs for debilitating conditions like carpal tunnel syndrome. The study's findings could lead to early detection and prevention of these conditions.
Researchers at UT Southwestern Medical Center have found a new biomarker test that can predict the recurrence of bladder cancer in patients. The test uses molecular biomarkers to identify patients who are more likely to experience cancer recurrence, allowing for personalized treatment options.
A new study has identified a set of biomarkers using proteomics that could help diagnose myelodysplastic syndromes (MDS) and reduce the need for bone marrow biopsies. The findings, reported in the Proceedings of the National Academy of Sciences, used serum proteomic profiling to distinguish between MDS patients and healthy controls.
Scientists found that persons with high multimarker scores had a risk of death four times as great and a risk of major cardiovascular events almost two times as great as those with low scores. The study used 3209 participants for 10 years, measuring 10 novel biomarkers in addition to established risk factors.
A study suggests that even commonly used biomarkers are limited in their ability to predict cardiovascular risk. BNP and urinary albumin content were found to be the most useful in predicting future events, but only slightly improved predictions based on conventional risk factors.