Articles tagged with Biomarkers
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
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Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers present data on gene-based blood testing that may help reduce immunosuppression and predict cardiac allograft rejection. Non-invasive molecular testing of routine blood samples provides information on the immune, inflammatory, and injury status of transplanted hearts before tissue damage occurs.
University of Florida chemists develop a new tool to identify biomarkers for serious diseases, potentially leading to earlier detection and improved treatment. The technique uses aptamers to recognize cancer cells and could have applications in disease detection, imaging, and therapy.
Researchers found that poor sleep is strongly associated with high levels of psychological distress, depression, anger, and hostility in women. Women who reported longer time to fall asleep had higher levels of inflammatory proteins and insulin.
A new approach identifies five genes involved in myelination and six genes involved in growth factor signaling as potential biomarkers for high and low mood states. The study suggests that blood biomarkers may offer an informative window into brain functioning and disease state.
Researchers at NIST, NCI, and SAIC developed a new method for detecting HER2 breast cancer using chicken immunoglobulin Y (IgY) antibody tagged with quantum dot. This approach improves the detection of HER2 biomarker by 40-50% compared to existing tests.
Researchers have created a new technique using laser light to analyze breath samples, detecting biomarkers for diseases like asthma and cancer. This non-invasive method could provide rapid and reliable health screenings, addressing existing limitations in breath analysis.
Researchers from NIST and CU-Boulder have developed a technique using optical frequency comb spectroscopy to detect molecules in breath that may be markers for diseases like asthma or cancer. The technique can identify thousands of different molecules simultaneously, providing highly reliable information about various diseases.
Researchers at Yale University have received a $4 million NIH grant to study new biomarkers for detecting acute kidney injury (AKI) after cardiac surgery. The goal is to develop an earlier and more accurate diagnosis, reducing mortality rates.
A new study has discovered a set of 15 proteins found in urine that can distinguish healthy individuals from those with coronary artery disease. The protein panel accurately identifies CAD 83% of the time, with high sensitivity and low false positives.
Researchers have identified 30 new proteins that interact with the amyloid precursor protein, shedding light on its functional role in Alzheimer's disease. Additionally, a study found low variation in platelet protein expression within the elderly population, suggesting potential for clinical biomarkers.
A study published in Clinical Cancer Research demonstrates that a novel mass-spectrometry based proteomic profiling method is more accurate than traditional biomarkers in distinguishing liver cancer patients from patients with hepatitis C liver cirrhosis. The technique, SELDI-TOF MS, identified an 11-protein signature that accurately d...
Researchers have made significant progress in identifying new biomarkers for epithelial ovarian cancer, which can aid in early detection and improve treatment outcomes. The study highlights the potential of these biomarkers as therapeutic and imaging targets.
The JDRF-Lilly project will support cutting-edge research on biomarkers for pancreatic beta cell mass and function, which could indicate the presence of type 1 diabetes. Biomarkers would be a powerful research tool in indicating disease progression and predicting patient responses to treatments.
Scientists have developed a non-invasive method to track neural stem and progenitor cells in the live human brain using MRI technology. This breakthrough could lead to better diagnosis and monitoring of brain tumors and serious neurological disorders.
Scientists will create biomarkers for environmental risk factors in human disease, including cigarette smoke and obesity. The research aims to understand the interaction between genes and environment, using wearable sensors and advanced technologies.
A large study of European patients has identified promising biomarkers to distinguish between patients with a high likelihood and low likelihood of relapse, paving the way for more targeted treatment approaches.
The Center for Excellence in Environmental Toxicology at Penn School of Medicine will study biological indicators of exposure to cigarette smoke using a panel of biochemical markers. The goal is to identify people most at risk of tobacco-related disease and potentially inspire them to quit smoking.
The NIH has funded eight genome-wide association studies to identify novel genetic variants associated with increased risk for common diseases like prostate cancer, diabetes, and heart disease. These studies will also measure personal environmental exposures using wearable sensors.
Scientists at PNNL have developed a portable biosensor that can distinguish between individuals exposed to nerve agents and those who are simply scared. The sensor uses nano-based technology to amplify biomarker signals, enabling precise readings and faster detection.
The Emory research team aims to identify protein biomarkers that correlate with ALS onset and progression. Developing such biomarkers could enable early diagnosis, disease monitoring, and potential prevention of the disease.
Researchers found that smokeless tobacco users are exposed to higher amounts of tobacco-specific nitrosamines than cigarette smokers. The study highlights the dangers of smokeless tobacco and suggests that nicotine replacement therapy may be a safer alternative.
Researchers discovered that blood levels of protein ST2 indicate the presence of heart failure and predict the risk of death, even among patients without heart failure. A combination of ST2 with other biomarkers provides the most accurate prediction for all study participants.
Researchers have identified a potential biomarker, urinary neutrophil gelatinase-associated lipocalin (uNGAL), to predict acute kidney injury (AKI) in critically ill children. The study found that uNGAL levels increased 48 hours before a jump in serum creatinine levels, suggesting its potential as an early warning system for AKI preven...
The new criteria focus on a clinical core of early and significant episodic memory impairment, incorporating biomarker-based tests. Validation studies are necessary to optimize sensitivity, specificity, and accuracy.
Researchers introduce novel methods for evaluating patients with non-alcoholic fatty liver disease (NAFLD), including a blood test to determine caspase three-generated cytokeratin 18 fragment levels. These tests may help differentiate NASH from simple steatosis and predict treatment outcomes, potentially improving patient care.
The AACR-FDA-NCI Cancer Biomarkers Collaborative aims to integrate predictive biomarkers into clinical trials, addressing the translation of cancer knowledge into medical practice. The collaborative will develop guidelines for biomarker validation, informing policies as part of the FDA's Critical Path Initiative.
A Sandia National Laboratories handheld device determines if a patient has gum disease and quantifies its advancement in minutes from a tiny saliva sample. The device's technology also shows promise for detecting biotoxins, improving prostate and breast cancer diagnosis, and measuring animal serum in vaccines.
Biosite has identified a combination of three biomarkers that performed better in assessing risk of sepsis progression. The sepsis biomarker panel may aid in the rapid assessment of patients presenting to the emergency department with signs and symptoms of sepsis.
Researchers at Temple University have found early indicators of inflammation in work-related injuries caused by repetitive motion, signaling potential warning signs for debilitating conditions like carpal tunnel syndrome. The study's findings could lead to early detection and prevention of these conditions.
Researchers at UT Southwestern Medical Center have found a new biomarker test that can predict the recurrence of bladder cancer in patients. The test uses molecular biomarkers to identify patients who are more likely to experience cancer recurrence, allowing for personalized treatment options.
A new study has identified a set of biomarkers using proteomics that could help diagnose myelodysplastic syndromes (MDS) and reduce the need for bone marrow biopsies. The findings, reported in the Proceedings of the National Academy of Sciences, used serum proteomic profiling to distinguish between MDS patients and healthy controls.
A study suggests that even commonly used biomarkers are limited in their ability to predict cardiovascular risk. BNP and urinary albumin content were found to be the most useful in predicting future events, but only slightly improved predictions based on conventional risk factors.
Scientists found that persons with high multimarker scores had a risk of death four times as great and a risk of major cardiovascular events almost two times as great as those with low scores. The study used 3209 participants for 10 years, measuring 10 novel biomarkers in addition to established risk factors.
Scientists at Cornell University have discovered a panel of 23 protein biomarkers in cerebrospinal fluid that can identify patients living with Alzheimer's disease. The biomarkers, known as a 'fingerprint,' were validated through autopsy-proven tests and showed high sensitivity and accuracy.
Researchers have identified amylase, an enzyme in saliva, as a biochemical marker linked to sleep loss. Flies subjected to prolonged sleep deprivation showed increased amylase levels, similar to humans who were kept awake for extended periods. The discovery aims to develop diagnostic tools and improve understanding of sleep disorders.
Researchers at Pacific Northwest National Laboratory have discovered 176 proteins associated with plague virulence, offering promising leads for improved disease detection and treatment. The study's findings may also guide the development of new vaccines and therapies to combat the deadly disease.
Researchers at Emory University's Winship Cancer Institute have identified a novel biomarker called 'soluble attractin' that is elevated in patients with malignant astrocytomas. This protein plays a key role in the migration and recurrence of brain tumors, making it a promising target for future therapeutic intervention.
Researchers at Columbia University Medical Center found that elevated inflammatory biomarkers, such as Lp-PLA2 and hs-CRP, are associated with increased risk of recurrent stroke and mortality after a first stroke. The study's findings may lead to the use of prophylactic treatments to reduce stroke risk in people with elevated biomarkers.
The IU and Purdue Analytical Proteomics Team has been awarded a grant to develop standardized proteomics methodologies to discover proteins relevant to cancer. The team will work with cancer researchers and clinicians at the IU School of Medicine, as well as experts in statistical and computer analysis.
A study analyzing 13 biomarkers found that combinations of neuroendocrine and immune markers were associated with high-risk pathways in men, while systolic blood pressure was linked to female high-risk pathways. Recursive partitioning identified the importance of biological regulatory systems in predicting mortality in later life.
A new biomarker predicting survival in colorectal carcinomas has been discovered, with thymidylate synthase levels in the nucleus and cytoplasm identified as critical markers. The ratio of nuclear to cytoplasmic TS levels also predicts decreased survival, revealing a new potential biomarker for patients with worse prognosis.
The Osteoarthritis Initiative (OAI) has released its first set of data, featuring images and clinical outcome information for nearly 5,000 participants at risk of knee osteoarthritis. The data will facilitate the discovery of biomarkers for development and progression of OA.
A study published in Biochemistry reveals that damage to proteins caused by oxidative stress is linked to a natural byproduct called nitration, which could be used to predict the earliest stages of brain impairment. The research uses the most detailed proteomic analysis of a mammalian brain to date.
Researchers found that certain fatty acid ethyl esters (FAEEs) in meconium are indicative of fetal exposure to alcohol during pregnancy. The presence of these biomarkers was significantly higher in infants exposed to alcohol, suggesting potential as a reliable indicator of fetal alcohol effects.
New research finds ancient oil droplets containing biomarkers from eukaryotes and cyanobacteria that lived before the planet's glaciation, contradicting previous theories. The study suggests oxygen was produced long before the atmosphere became oxygenated, supporting life in extreme conditions.
Researchers have identified new biomarkers that correlate with patient response to anti-TNFá therapy, improving the treatment of spondylarthritis. The study found changes in synovial tissue features, such as macrophage and PMN cell changes, associated with disease activity and treatment effectiveness.
Researchers have developed a completely penetrant mouse model of head and neck squamous cell carcinoma, recapitulating the human disease at both pathological and molecular levels. The model enables testing of combinations of targeted therapies and prevention approaches for HNSCC.
Precision biochemistry techniques track DNA damage in fish, identifying low-level lesions that correlate with pollution. These biomarkers can provide a direct measure of contaminant impact and assess pollution remediation efforts.
Scientists from the University of Florida's Institute on Aging found that reducing calories by 8% and exercising moderately extended lifespan and improved liver function in rats. This discovery suggests that even slight calorie moderation can have significant effects on health, with potential implications for human aging.
A UK study found that saliva can be tested for signs of periodontal disease, a condition characterized by persistent inflammation and tissue breakdown. The research team identified biomarkers in saliva that could aid in diagnosing and monitoring the disease.
Researchers have identified a multi-marker panel of 20 proteins that correctly recognize over 98% of serum samples from women with ovarian cancer, offering higher diagnostic power than any other published assay. The study uses novel technology to analyze multiple proteins in a single drop of blood or serum and aims to develop this scre...
Researchers at Purdue University have developed a fast chemical-analysis tool called desorption electrospray ionization (DESI) that can detect cancer, explosives and biomarkers. The technology has numerous promising uses in fields such as airport security, medical diagnostics and disease detection.
Scientists have developed a standardized saliva RNA test for oral cancer detection, showing high accuracy rates in detecting oral cancer. The test has been confirmed to be highly accurate in identifying four saliva oral cancer RNA biomarkers, reducing mortality and morbidity for oral cancer patients.
Researchers have identified new molecular indicators of aging in the skin that could be used to evaluate anti-aging therapies. The biomarkers are changes to the DNA of cellular organelles called mitochondria and correlate with the aging process.
Several biomarkers emerged as potentially clinically useful in predicting CAD-related and all-cause death. Increases in plasma levels of IL-6 and total homocysteine were associated with higher risks of death in patients with known CAD.
Researchers used high-tech brain imaging and measurement of beta-amyloid protein fragments in cerebrospinal fluid to detect Alzheimer's disease. The study found that greater amounts of beta-amyloid containing plaques were associated with lower levels of amyloid-beta 1-42, a major component of amyloid plaques.
Researchers at Yale University School of Medicine used Automated Quantitative Analysis (AQUA TM ) technology to standardize biomarker detection methods. The study found that antibody concentration can dramatically alter the relationship between biomarker levels and clinical outcome, particularly for breast cancer biomarkers.
A study by David L. Rimm and colleagues found that high biomarker antibody concentrations were associated with low patient survival in breast cancer patients, while low concentrations were linked to good outcomes. Another study examined the impact of long-term storage on circulating DNA levels in lung cancer patients.
Researchers found two biomarkers, sVCAM-1 and NT-proBNP, significantly predict recurrent ischemic stroke risk in patients. High levels of these markers are associated with a 3.6 times increased risk, indicating potential new therapeutic targets for blood pressure-lowering therapies.
Researchers have identified a strong biomarker, MDM2, that predicts more aggressive forms of prostate cancer. This overexpression is associated with an increased chance of metastasis and death from the disease.