Research on measurable signals of health and disease. Covers ultrasound imaging pipelines, fetal-distress detection, cancer monitoring, and fatigue biology.
Children of depressed mothers who show increased pupil dilation to sad faces are at higher risk of developing depressive symptoms and diagnoses over two years. The study suggests pupillometry could be used as a low-cost tool for pediatricians to identify children at highest risk.
Changes in key biomarkers of Alzheimer's disease during midlife may help identify those who will develop dementia years later. The study found that drops in amyloid beta 42 levels among cognitively normal participants are linked to the appearance of plaques in brain scans years later.
The study provides a comprehensive review of folate biomarkers, which can be used to assess an individual's or population group's folate status. Adequate folate intake is critical during fetal development to prevent birth defects such as spina bifida.
Researchers at University of California, San Diego School of Medicine found that early indicators of Alzheimer's disease are not fixed in a specific sequence, complicating diagnosis efforts. The study suggests that different neurobiological pathways lead to the expression of the disease.
Researchers at Hiroshima University found a correlation between telomere G-tail length and endothelial dysfunction, as well as stroke and dementia, in patients with chronic cerebrovascular disease. The study suggests that telomere G-tail length may be a useful biomarker for predicting cardiovascular risk.
Researchers at University of California, San Diego School of Medicine have identified a biological marker for mental illness in female patients. The study found that specific genes, including XIST, are over-produced in women with mental illnesses like bipolar disorder, major depression, and schizophrenia.
A special issue of Future Oncology explores the role of biomarkers and next-generation sequencing in advancing cancer research and treatment. The issue highlights the potential of these technologies to provide a more precise picture of cancer and identify effective treatments.
Researchers used social network analysis to identify cancer biomarkers in patient genomic microarray data, dramatically decreasing the number of features to analyze. The approach has been successfully demonstrated for three types of cancer: lymphoma, colon cancer, and leukemia.
The discovery of microfossils in rocks dating back 1.5 billion years has confirmed the existence of eukaryotes, shedding light on their evolution and origins. The analysis of steroid molecules revealed no signs of contamination, contradicting previous findings.
Researchers at the University of Pittsburgh School of Medicine have identified two new classes of RNAs associated with breast cancer biomarker YB-1, which may play a role in prostate cancer progression. The discovery could lead to the development of new cancer treatments and provide insights into human biology.
Researchers have discovered a novel biomarker that tracks Parkinson's progression in the brain, providing a new tool for diagnosis and treatment. The study uses MRI-based diffusion imaging to measure changes in brain tissue fluid levels, which can inform treatment decisions and identify promising new therapies.
Researchers found that patients with anti-TP53 autoantibodies can detect ovarian cancer up to 13 months before rising CA125 levels. The study suggests a novel assay method for earlier detection of the disease.
Researchers have discovered a protein biomarker that may indicate the presence of more aggressive prostate cancer. The biomarker, Runx2 phosphorylation, is closely associated with aggressive disease and has the potential to be a new drug target.
Researchers developed a new approach to identify reliable blood biomarkers for Parkinson's disease, which may lead to early diagnosis and targeted treatments. The study found RNA signatures that correlate with the disease-causing mutations in the LRRK2 gene.
Researchers at Scripps Research Institute aim to identify biomarkers for accelerated drug development of disorders including autism spectrum disorder, epilepsy, and intellectual disability. By validating biomarkers in mice, they hope to create tools and methods for developing new therapeutics.
Researchers have identified blood-based biomarkers that accurately diagnose active tuberculosis (TB) disease, monitor treatment response, and predict cure. These markers differentiate between latent TB infection and active TB with high specificity and sensitivity.
Researchers at Brown University have identified four blood proteins that can accurately signal mild traumatic brain injury within hours after a concussion. These biomarkers, which include copeptin, galectin 3, matrix metalloproteinase 9, and occludin, show significant changes in the bloodstream of patients shortly after a concussion.
Researchers propose two novel gas-sensing systems to measure intestinal gases, which may contribute to gastrointestinal diseases. These non-invasive methods could provide medical devices that reduce medical costs and improve healthcare system efficiency.
A new study found that cerebral blood flow recovery is a biomarker of concussion outcomes in college football players. The research, published in JAMA Neurology, suggests that reduced blood flow in the brain can indicate severity and potential for slow recovery.
Researchers are advancing blood biomarker capabilities using the Simoa technology, which offers unprecedented improvement in sensitivity proteins for detecting traumatic brain injury. The technology allows for more effective measurement of low concentrations of proteins such as tau, enabling more accurate diagnosis and treatment.
Researchers identified key immune biomarkers that can help distinguish between HIV patients who experience life-threatening complications and those who fare well on treatment. The findings suggest that personalized approaches may be necessary for these patients, as a one-size-fits-all approach could worsen outcomes.
A Pitt study links biomarkers to long-term kidney damage and death in critically ill, highlighting the importance of early intervention. Researchers found that tissue inhibitor metalloproteinase-2 (TIMP-2) and IGF-binding protein-7 (IGFBP7) can identify patients at increased risk for adverse outcomes.
A study published in The Lancet Respiratory Medicine found that smokers who metabolize nicotine quickly have better quit rates with varenicline, a non-nicotine replacement therapy drug. In contrast, slow metabolizers have similar success with the nicotine patch but without side effects.
A new study confirmed that people born weighing 6 pounds or less face an increased risk for type 2 diabetes as adults. The research identified specific biomarkers with relative predictive value, giving doctors potential new tools to understand individual risk among low birthweight women.
A study published in Genetic Testing and Molecular Biomarkers found that specific variations in the ADIPOQ gene may increase or decrease colorectal cancer risk. The research suggests that these genetic variations interact with environmental factors, such as red meat intake, to affect cancer risk.
Researchers developed a new biomarker called SDMA that can identify chronic kidney disease in cats earlier than existing tests. Special diets have been shown to slow the progression of this disease once identified, and may help extend the lives of affected cats.
Researchers at NTU Singapore have developed a novel biomarker that can detect tumour cells and release anti-cancer drugs, opening up new doors in nanomedicine, bioimaging, and cancer therapeutics. The biomarker uses near-infrared light to penetrate deep tissue without causing damage to healthy cells.
The International Myeloma Working Group has updated its criteria for diagnosing multiple myeloma, allowing for earlier diagnosis without symptoms. The new guidelines incorporate validated biomarkers to identify patients at risk of progression, enabling targeted therapy and improved patient outcomes.
Scientists have identified two promising candidates for blood-borne biomarkers that could lead to a simple screening test. Abnormal DNA methylation patterns and microRNAs show promise in detecting colorectal cancer.
The institute aims to discover a biomarker that predicts the onset of allergy and leads to novel vaccine approaches, aiming to develop a simple blood test to predict likelihood of resolution or development of an allergy.
A study in JAMA Network found a strong association between tobacco use and the prevalence of oral human papillomavirus type 16 (HPV-16) infection. Tobacco users were more likely to be male, younger, and have higher lifetime oral sexual partners, and had greater levels of biomarkers for tobacco exposure.
Sok Kean Khoo, a GVSU researcher, has received a $110,000 grant from the Michael J. Fox Foundation to study molecular biomarkers for Parkinson's disease. The goal is to develop a blood test for early detection and potentially improve treatment options for the incurable neurological disorder.
Researchers at MD Anderson Cancer Center identified a genetic variant near the KLK3 gene that can predict aggressive prostate cancer in GS7 patients. The study found a single nucleotide polymorphism (SNP) on the KLK3 gene associated with disease aggression, providing potential biomarkers for personalized treatment.
A graphene biosensor has been developed to detect cancer risk biomarkers, such as 8-hydroxydeoxyguanosine (8-OHdG), with high sensitivity and speed. The sensor is capable of detecting concentrations as low as 0.1 ng mL-1, outperforming conventional detection methods.
Researchers found that high levels of VEGF-A and TGF-β1 before treatment correlated with lower survival rates and less complete tumor regression. A blood test for these proteins could help predict patients' pathological response and disease-free survival rates, allowing for more personalized treatment plans.
Researchers found that APOE genotype influences the diagnostic accuracy of CSF biomarkers, particularly beta-amyloid 42 (Aβ42), in diagnosing Alzheimer's disease. In contrast, the APOE gene had no effect on Aβ42 levels in younger individuals.
A large-scale study by Uppsala University researchers reveals that genetics and lifestyle factors play a crucial role in protein levels, enabling the use of more effective biomarkers. The study analyzed 92 protein biomarkers in 1,000 healthy individuals, finding that hereditary factors contribute to over 75% of proteins.
A study published in The Journal of Nutrition found that a blood sample can be used to assess dietary compliance. The researchers identified biomarkers in the blood that reflected consumption of key components of a healthy Nordic diet, including fatty fish, vegetables, and whole grains.
The University of Maryland Schools of Dentistry and Medicine have received a five-year $10.7 million grant from the National Institutes of Health to study the causes, prevention, and treatment of sexually-transmitted diseases. The study aims to identify novel molecular biomarkers of susceptibility to STIs and disease severity.
VCU has received a five-year, $3 million grant to investigate how childhood experiences like severe illnesses and neglect affect health outcomes. Researchers will analyze DNA methylation patterns to identify potential biomarkers for early intervention.
University of Iowa researchers have identified a biomarker that can predict preeclampsia at least 6 weeks into pregnancy, enabling early detection and potentially preventing severe health issues. The study's findings hold significant implications for obstetric care in rural and underserved communities.
Alzheimer's disease is a neurodegenerative disorder characterized by memory problems, orientation issues, and behavioral changes. A simplified diagnosis using specific biomarkers improves the accuracy of early-stage diagnoses.
A Dartmouth College study found that infant toenails are a reliable way to estimate arsenic exposure before birth. The researchers used plasma mass spectrometry to analyze infant toenails and found a significant correlation between maternal and infant toenail arsenic concentrations.
Researchers at Johns Hopkins Bayview Medical Center introduced guidelines and changes to the computerized provider order entry system to reduce redundant biomarker testing. This led to a 66% decrease in tests ordered and saved an estimated $1.25 million in laboratory charges.
Researchers analyzed ancient Neanderthal fecal matter, revealing significant plant intake alongside meat consumption. The study provides new insights into the role of vegetables in the Neanderthal diet.
Researchers developed a unique method to identify oil spills, even after most of it has degraded. They found that some biomarkers degrade within a few years after an oil spill, providing a window into the environment's impact.
Researchers discovered altered salivary biomarker levels in obese children, indicating a potential non-invasive method for identifying early Type 2 diabetes risk. The study's findings provide valuable insights into childhood obesity and metabolic syndrome, paving the way for development of prevention strategies.
Scientists have identified four microRNAs that can aid in the differential diagnosis of malignant pleural mesothelioma (MPM) from non-cancerous pleural tissue. The biomarkers, miR-126, miR-143, miR-145, and miR-652, were found to classify tissue samples with high accuracy.
The ASU Biodesign Institute has developed a high-quality biomarker discovery core competency to identify and select biomarkers for radiation biodosimetry. The team is now optimizing the assay panel and platform workflow to prepare for regulatory clearance from the FDA.
Research found pregnant women with polycystic ovary syndrome (PCOS) exhibit low-grade inflammation, worsening during pregnancy. This abnormal inflammation may contribute to increased risk of pregnancy complications like pre-eclampsia and gestational diabetes.
The American Association of Pharmaceutical Scientists recognizes outstanding researchers in biotechnology with various awards, including the AAPS Excellence in Ligand Binding Assays Award and the Innovation in Biotechnology Awards. These honors celebrate groundbreaking contributions to pharmaceutical biotechnology.
Scientists have developed a device that can process whole blood and isolate genetic material for two potential biomarkers within minutes. This rapid detection method could help determine the course of proper treatment, potentially saving lives.
A blood test using high-sensitivity cardiac troponin T can accurately predict heart attack risk in patients with chest pain, allowing for targeted admissions and reduced hospital costs. The test's negative predictive value was found to be 99.8 percent for heart attack within 30 days.
Researchers suggest aspartic acid could serve as a biomarker for postoperative cognitive dysfunction, based on correlation analysis between changes in hippocampal metabolites and cognitive impairment in aged rats. The study aims to identify potential biomarkers for predicting postoperative cognitive dysfunction.
A team of researchers identified two biomarkers that accurately predict a patient's response to radiation therapy, offering new hope for personalized treatment. The study published in the European Journal of Cancer found these markers can help avoid unnecessary side effects and reduce morbidity.
Researchers identified salivary biomarkers associated with gingivitis, including PGE2 and IL-1. These findings have implications for personalized oral health care, suggesting potential discrimination between gingivitis and health through salivary biomarker analysis.
Researchers use shrink wrap to boost signal of fluorescent markers in biosensing, enabling detection of infectious diseases with lower limits of detection. The technique could lead to a low-cost, highly sensitive diagnostic device using common, everyday materials.
A collaborative study has identified metabolomic biomarkers in urine and serum samples of women with preeclampsia, suggesting an early metabolic profile difference from women with normal pregnancies. The findings may lead to earlier detection and potentially prevent the disease.
Researchers at Washington University School of Medicine found that biomarkers of neuronal injury in Alzheimer's disease decrease as symptoms of dementia appear, contrary to previous findings. This reversal suggests a slowing of cell death and may be an important criterion for assessing the success of treatment trials.
A study published in Neurology found that patients with restless legs syndrome had a higher mortality rate than similar men, and were more likely to be diagnosed with cardiovascular disease and hypertension. RLS screening may become more common as a tool for primary care providers to identify patients at risk of serious disease.