Articles tagged with Biomarkers
A new biomarker strategy using troponin and copeptin has the potential to change clinical practice with high patient safety, according to the BIC-8 trial. The strategy significantly increased emergency room discharge rates among patients with suspected ACS.
Researchers at the University of Pennsylvania School of Medicine have developed a comprehensive test for protein biomarkers in spinal fluid that shows prognostic and diagnostic value in early stages of Parkinson's disease. The study found that patients with lower levels of tau and alpha synuclein had greater motor dysfunction, while th...
Researchers analyzed cerebrospinal fluid biomarkers in patients with early-stage Parkinson's disease (PD) and healthy controls. Lower levels of Alzheimer's beta-1-42 and tau proteins were found in PD patients, associated with motor severity. The study suggests that these biomarkers have prognostic potential for early-stage PD.
A study published in Molecular Psychiatry found RNA biomarkers in blood associated with suicidal thoughts in patients with bipolar disorder. The researchers identified SAT1 and other markers that were significantly elevated in the blood of both bipolar disorder patients and those who had committed suicide.
A study led by Dr. Elizabeth Osuch found a correlation between the activation of the putamen region in the brain and bipolar disorder symptoms. The discovery may lead to a definitive biological marker for differentiating between major depressive disorder and bipolar disorder, ultimately improving diagnosis and treatment.
A study identified a potential biomarker for Alzheimer's disease in cerebral spinal fluid, suggesting the condition may be detectable a decade before symptoms appear. Researchers hope to find treatments that can prevent or slow the progression of the disease.
The lack of investment in tumor biomarker research, inconsistent regulatory rules, and inadequate payment have created a vicious cycle preventing the development and testing of reliable biomarker tests. Experts recommend reforms to break this cycle and increase the value of tumor biomarker tests.
A clinical study on reduced toxicant prototype cigarettes is investigating whether reducing smoke toxicant exposure affects biomarkers of biological effect. The six-month study, involving 260 healthy adult subjects, aims to assess the longer-term impact of these cigarettes on biological effects.
Researchers at the National Human Genome Research Institute identified biomarkers of kidney damage and demonstrated that antioxidant therapy protected kidney function in mice. These findings offer new tools for monitoring disease progression and may pave the way for clinical trials for patients with methylmalonic acidemia.
Researchers have discovered four biomarkers that characterize the non-genetic form of amyotrophic lateral sclerosis (ALS), a devastating motor neuron disease. These biomarkers could lead to earlier and more accurate diagnostics, as well as new directions for therapeutic research.
A Loyola University Medical Center study found that treating acid reflux through laparoscopic anti-reflux surgery could help prevent chronic rejection in lung transplant patients. Certain biomarkers in lung fluid can predict BOS and immune system activity.
Research reveals a gene called CPT1A, which regulates fat breakdown in the liver, may increase risk of heart disease when methylated. The study found elevated levels of bad cholesterol and triglycerides, and lower adiponectin levels in patients with this genetic switch turned off.
Researchers found that a combination of two proteins, S100B and apoA-1, helps most accurately classify head injuries. This study provides significant evidence for the potential use of blood tests in diagnosing mild traumatic brain injury.
Researchers at the University of Alaska Fairbanks have discovered a novel biomarker that can accurately measure long-term sugar intake from a single blood or hair sample. This breakthrough tool is distinct in corn and sugar cane, which are sources of nearly all sugars found in sugar-sweetened beverages.
New antibody biomarkers could significantly improve diagnosis in rheumatoid arthritis by detecting the disease in patients who test negative for existing diagnostic antibodies. The study found that these biomarkers were present in both early and seronegative disease, indicating their potential to close the diagnostic gap in RA.
A study of 61,650 participants found that elevated levels of C-reactive protein, fibrinogen, and leukocyte count are associated with an increased risk of COPD exacerbations. The risk is even higher in those with milder COPD and no previous exacerbations.
University of Cincinnati researchers have discovered biomarkers for inflammatory bowel disease (IBD), a group of inflammatory conditions affecting the colon and small intestine. These biomarkers, identified through analysis of human serum specimens from the Department of Defense Serum Repository, may help improve diagnosis and treatmen...
A new study has identified four metabolites that can be used to accurately predict mortality in intensive care unit (ICU) patients. The researchers analyzed plasma samples from 90 ICU patients and found that levels of lactate, mannose, gamma-glutamyltyrosine, and stearidonate were associated with high mortality rates.
A new study found a link between sleep-disordered breathing (SDB) and Alzheimer's disease risk factors in cognitively normal elderly patients. Lean SDB patients showed biomarkers of AD risk, including increased P-Tau and T-Tau levels, glucose hypometabolism, and hippocampal atrophy.
Researchers have identified biomarkers that can predict cognitive impairment up to 7.5 years before symptoms develop, with sex, age, and race also playing a role in the prediction. The findings provide valuable evidence for the development of new treatments targeting Alzheimer's disease before symptoms appear.
The team identified 21 microRNAs associated with ovarian cancer survival and 838 target genes linked to its progression. The findings suggest a network-based approach can predict cancer survival and recurrence more accurately than individual biomarkers.
The BIOMARGIN project aims to develop reliable, non-invasive methods to diagnose lesions in transplanted kidneys using integrated 'omics' technologies. The study will consist of four phases, including a retrospective analysis of existing samples to identify biomarkers and validate diagnostic performance.
Researchers at the University of Liege discovered a molecule, miR-146a, that can serve as a biomarker for peripartum cardiomyopathy. Elevated serum miR-146a levels were found in pregnant women who developed PPCM, suggesting its potential use to predict disease risk.
A recent study found that male smokers with low levels of serum bilirubin are at a higher risk of developing lung cancer and dying from the disease. The researchers analyzed data from over 435,000 people in Taiwan and found that lower bilirubin levels were associated with significantly higher rates of lung cancer incidence and mortality.
A recent review article highlights the need for preventive measures, genetic risk factors, and new diagnostic tools to identify the effects of traumatic brain injury (TBI) in athletes and soldiers. Researchers propose large-scale trials and genome-wide association studies to characterize CTE and develop prevention strategies.
Researchers at the University of Washington have developed a new method to analyze single cells using quantum dots, allowing for the simultaneous testing of up to 100 biomarkers. This breakthrough enables more accurate diagnosis and treatment of cancer by examining a cell's unique behavior at its molecular level.
A new study found a link between post-discharge activity levels and the risk of hospital readmission in elderly patients within 30 days. Activity levels were tracked using wearable devices, revealing that those with lower activity were at higher risk of rehospitalization.
A new NIH-funded collaboration aims to accelerate the search for biomarkers in Parkinson's disease by improving collaboration among researchers and involving patients in clinical studies. The initiative, led by Dr. Clemens Scherzer at Brigham and Women's Hospital, seeks to develop biomarkers that can predict, diagnose, or monitor the d...
Scientists at Scripps Research Institute have found a telltale molecular marker for Onchocerciasis in patients' urine, detectable during active infections. The biomarker could form the basis of a non-invasive, portable test with significant advantages over current diagnostic methods.
Northwestern University researchers found that consistent encoding of sound undergirds the reading process, with unstable representation of sound associated with poorer readers. The study suggests that auditory training can improve response consistency and potentially alleviate dyslexia.
Researchers have identified at least four disease subtypes within triple-negative breast cancers, highlighting the need for targeted therapies that target individual biomarkers. The Basal-like subtype is the majority of TN patients, and therapies targeting its unique biology are crucial for therapeutic progress.
A Mayo Clinic-led study has identified two biomarkers, IGFBP-7 and TIMP-2, that can detect acute kidney injury in urine, allowing for early intervention and improved patient outcomes. The study's findings have the potential to revolutionize the diagnosis and management of this deadly condition.
A New York-based physician-researcher has uncovered a potential connection between autism and insulin-like growth factor (IGF) levels in newborns, proposing a study to investigate this hypothesis. IGF plays a crucial role in brain development, and depressed levels may serve as a biomarker for the later development of autism.
Research finds that LGBTQ+ individuals who are out to others have lower stress hormone levels, fewer symptoms of anxiety and depression, and improved overall wellbeing. This study suggests that self-acceptance and disclosure can lead to better physical and mental health outcomes.
Researchers identified ELTD1 as a promising biomarker for diagnosing gliomas, particularly high-grade glioblastoma multiforme (GBM). Studies found that ELTD1 levels were strongly associated with glioma development and prognosis.
The NIH has launched a collaborative effort to find biomarkers for Parkinson's disease, which could help predict, diagnose, or monitor the condition. Researchers are exploring various approaches, including non-invasive imaging and protein analysis, to identify potential biomarkers that could improve treatment outcomes.
Researchers report on the therapeutic potential of microRNAs in cancer therapy and their role as potential biomarkers for early cancer detection. The stability of miRNAs in body fluids makes them suitable for non-invasive malignancy detection methods, offering exciting opportunities for revolutionizing diagnostics and screening.
Researchers at MIT have developed a new technology that can detect cancer biomarkers in the urine, potentially enabling earlier diagnosis and improved patient outcomes. The system uses nanoparticles to amplify tumor signals, making it easier to identify specific proteins secreted by cancer cells.
Researchers have identified 48 metabolites linked to cellular ageing and disease risk in mice. The study reveals a strong connection between metabolism and biological age, offering new insights into preventive molecular medicine.
Dr Paul Kelly's research will identify and validate biomarkers to improve gut health in children, leading to new approaches to combat stunted growth in developing nations. The study aims to provide insights into environmental enteropathy and its consequences, ultimately guiding scaled-up interventions.
DELSIA and Seaside Therapeutics aim to discover genetic and protein biomarkers to identify patients most likely to benefit from treatment with arbaclofen, a potential treatment for core social impairment in autism. The partnership will help generate critical information to develop targeted treatments.
Researchers explore autism spectrum disorder genetics and biomarker development in a special issue of Disease Markers. Early diagnosis through biomarkers could improve individual outcomes with early behavioral intervention.
Researchers discovered a cognitive biomarker in young adolescents at high risk of developing depression and anxiety. The test can help initiate early intervention, which has proven to be an effective way to combat mental illness.
Researchers used MRI to image patients with mild traumatic brain injury and found that some brains compensate for damage by changing water flow patterns. This compensation is associated with fewer post-concussion symptoms and higher functioning, suggesting a potential new approach to treating traumatic brain injury.
Researchers at University of Massachusetts Amherst used biomarkers from human feces to establish the first human presence, arrival of grazing animals, and population dynamics in a landscape. The method provides a strong human signal with excellent chronological control, offering valuable insights into past environmental changes.
Researchers found that neurotics with high levels of conscientiousness had lower inflammation levels, fewer chronic health conditions, and healthier body mass indices. This suggests that 'healthy neuroticism' may provide a protective effect against long-term health problems.
Researchers developed a method to differentiate patients with Alzheimer's disease from those with other types of dementia using biomarkers in cerebrospinal fluid. The study analyzed five proteins and found that they could accurately diagnose Alzheimer's disease, as well as distinguish it from Parkinson's disease and Lewy body dementia.
Researchers at Scripps Research Institute have developed a new technology that can identify potential biomarkers for ulcerative colitis in animal models. The study focuses on protein arginine deiminases (PAD) and their role in diseases such as cancer, multiple sclerosis, and rheumatoid arthritis.
Researchers aims to develop parallel strategies for protein identification in complex mixtures with potential applications in cancer diagnosis and biomarker discovery. The project builds on existing networks that analyze genetic data and identify potential relationships among genes and proteins.
A study found that detecting specific HPV biomarkers, such as E6/E7 antibodies, in combination with tumor characteristics can help identify patients with a better prognosis. This approach may lead to more targeted treatment for head and neck cancers.
Researchers developed a mass spectrometry protein assay called PRISM that matches the sensitivity and accuracy of clinical antibody-based tests. The technique can identify proteins from blood with high accuracy and speed up development of diagnostic tests and treatments.
Researchers at the University of Iowa have developed a mouse model of Fukuyama's muscular dystrophy, providing insight into disease development. Vitamin B3 has also been shown to aid in fighting staph infections by increasing C/EBPε expression in mice. Meanwhile, a new class of cerebrospinal fluid-based biomarkers for neurodegenerative...
A team from MSU's College of Osteopathic Medicine applies four osteopathic manipulative treatments to patients with moderate to severe COPD. The study aims to determine the biochemical changes in patients' blood following manipulation and correlate it with pulmonary function.
A new study found that higher levels of ceramides in the blood are associated with a 10-fold increased risk of developing Alzheimer's disease. The research suggests that identifying this biomarker could help prevent or delay the disease, which is expected to double globally every 20 years.
Researchers found that pre-injury levels of four biomarkers were associated with an increased likelihood of ACL injury, with one biomarker linked to a 19-fold risk increase.
Researchers at the University of California, San Diego School of Medicine have identified laboratory-based biomarkers that can help understand brain-based abnormalities in schizophrenia. These endophenotypes could provide clinicians with reliable indicators of brain dysfunction, even when overt symptoms are not apparent.
Researchers at TGen developed a method to isolate protein-rich urinary exosomes, which can help discover biomarkers for better CKD diagnosis and treatment. The study found that the new method produces high yields of miRNA and mRNA, making it suitable for downstream genetic profiling experiments.
Research finds that people at risk for early-onset Alzheimer's disease want to know their genetic profile, but struggle with the results. The study also reveals that the general population and those with a family history of late-onset AD tend to be motivated by fear and anxiety when considering genetic testing.
In vitro studies assess propolis' optimal concentration as a radioprotector, finding maximum protection against radiation-induced damage within 120-500 micrograms/mL. The substance does not reveal cytotoxicity or genotoxicity on non-irradiated human lymphocytes.
The study discusses the biology of tumor-derived microvesicles and their clinical application as circulating biomarkers. Microvesicles released by tumor cells may provide a unique biosignature for individual cancers, enabling early detection and targeted therapies.