A recent study proposes a quality control framework for umbilical cord blood-sourced allografts, outlining future safety and potency benchmarks. The study identifies a unique liaison among the UCB-sourced allograft, host mesenchymal stem cells, and their secreted exosomes that influences tissue regeneration in vivo.
A new virus- and oncogene-free induced pluripotent stem cell (iPSC) technology has been developed to produce safer pluripotent stem cells from cord blood and peripheral blood. This approach aims to address safety challenges inherent with pluripotent stem cell therapies.
A new study examines Canadian clinics marketing unproven stem cell treatments, highlighting regulatory gaps and potential risks to patients. The majority of marketed treatments target orthopedic and musculoskeletal conditions, with some companies advertising for a wide range of disorders.
The journal Bioanalysis has released a Special Focus Issue on biomarker assay validation (BAV), highlighting the evolution of regulatory activities and recent developments. The issue features expert opinions and scientific insights into BAV, including parallelism assessments and clinical biomarker validation.
A Special Focus Issue explores novel LC-MS assays for evaluating DDI potentials early in development, expanding interest in using sensitive and selective assays. The issue discusses multiplexing, HRMS, and sample pooling approaches to improve DDI evaluations.
A special focus issue of Therapeutic Delivery explores emerging concepts and advances in nanotechnology for drug delivery, covering topics such as lipoprotein nanoparticles and micro- and nanomotors. The issue aims to emphasize the importance and challenges facing this field.
A new tool using biomedical photonics is being explored to improve uterine transplant surgery by providing real-time data on tissue perfusion and viability. The study found that multispectral imaging proved effective in mapping oxygen saturation over the entire graft, demonstrating advantages over existing methods.
The journal Bioelectronics in Medicine explores the innovative field of bioelectronic neural prostheses, aiming to revolutionize healthcare. The first issue features articles on vagus nerve stimulation, neuromodulation, and peripheral nerves, among others.
The 2017 WRIB White Papers cover topics such as LCMS small molecules, hybrid LBA/LCMS biotherapeutics, and immunogenicity assays. An interactive Decennial Index of the White Papers provides a decade-long overview of recommendations on bioanalysis and biomarkers.
Researchers found non-progression during treatment correlates with gains in health-related quality of life in metastatic Merkel cell carcinoma patients. The study demonstrated that reduction in tumor size improves patients' health status, as measured by HRQoL instruments.
A new digital platform provides lay summaries of hot-topic articles from leading international academics, bridging the gap between researchers and individuals outside academia. The ultimate aim is to stimulate conversations in all sectors on the impact of regenerative medicine on society.
This special focus issue of Future Oncology explores current and future image-guided interventions in oncology, including techniques such as fluorescence and optical imaging. The issue aims to provide a platform for researchers and clinicians to discuss recent advances in radiotherapy and personalized treatment approaches.
The new Special Focus Issue explores key perspectives on regenerative medicine innovation, including regulatory developments and challenges to international harmonization. The issue aims to facilitate discussions among stakeholders, ensuring safe, ethical, and regulated translation of research from bench to bedside.
CancerLinQ is a big-data, real-world health information technology system that enables near real-time access to individual patient data for informed decision-making. The platform allows practitioners and researchers to tap into longitudinal, de-identified data and analytics.
A Special Focus Issue on 'Bioanalysis of Biopharmaceuticals' has been published by Bioanalysis journal, highlighting recent advances in analysis and development. The issue explores the challenges and novel strategies in bioanalysis of biopharmaceuticals.
Researchers developed a microfluidics-based approach to detect PD-L1 and other biomarkers in patient blood samples. The novel assay demonstrated a mean detection rate of 22.8% for PD-L1 and PD-L2 expression levels, offering promise for non-invasive cancer diagnosis and treatment monitoring.
The special focus issue of Bioanalysis examines models and trends in outsourcing, featuring insights from key opinion leaders. The issue highlights the rapidly evolving aspect of drug discovery and development.
A special focus issue on immunotherapy has been published in Future Medicinal Chemistry, discussing the discovery and development of novel immunotherapeutic agents for use as anti-inflammatories and cancer treatments. The issue addresses recent scientific advances and challenges in this rapidly evolving field.
US stem cell clinics are successfully registering for-profit, pay-to-participate studies on ClinicalTrials.gov, often with serious ethical and scientific flaws. These studies fail to disclose that patients are charged to participate in clinical research, using inappropriate inclusion and exclusion criteria.
The World Health Organization predicts 135.5 million dementia cases by 2050, yet all neurodegenerative diseases are incurable. This Special Focus issue addresses challenges and advancements in therapy.
Advances in lab-on-a-chip technology allow for more accurate analysis and translation of research to the clinic. Organ-on-a-chip (OOAC) technology has great potential in helping screen drugs in a more cost-effective manner, reducing failures and costs.
Researchers have developed a new approach to create integration-free, Myc- and Lin28-free human induced pluripotent stem cells. This breakthrough method reduces the neoplastic risk associated with IPSC generation, enabling their utility in regenerative medicine and personalized medicine.
The article reviews current screening practice for melanoma in the US, highlighting risk groups and proposing full screening recommendations. The authors critically assess the USPSTF's 2016 Draft Recommendation Statement and propose evidence-based guidelines for screenings.
Researchers at Fraunhofer Institute develop a prototype lab-on-a-chip platform for automating molecular pathogen detection, enabling diagnostics in previously inaccessible situations. The platform integrates multiple processes without increasing complexity, promising to simplify pathogen analysis.
A new survey investigates ideal qualities of microfluidics-based 3D cell culture systems, finding a positive attitude among the biomedical community. However, a gap remains between desired and available features, including complexity, user-friendliness, physiological relevance, and controllability.
A study of 180 HIV-infected patients reveals a prevalence of 20% for AIDS-defining illnesses associated with ART. This investigation aims to educate physicians treating patients with HIV/TB, shedding light on the importance of timely treatment initiation.
The Journal of 3D Printing in Medicine covers all aspects of bioprinting and 3D printing relevant to medicine, providing a forum for research, reviews, and commentary. The journal presents key data and opinions on emerging developments in the field.
The new special issue of Future Oncology explores the field of psycho-oncology, which aims to integrate biomedical and psychosocial aspects of cancer care. The issue highlights the importance of developing a multi-disciplinary approach to cancer care, from both social and biomedical standpoints.
The Special Focus Issue covers multi-analyte measurement of endogenous metabolites using various technologies and statistical techniques. It provides new tools for discovering novel biomarkers in precision medicine.
Recent developments in dendritic cell vaccines and oncolytic immunotherapy have led to improved outcomes in melanoma patients. Various vaccine candidates are being developed and tested in clinical trials, offering new avenues for treating this malignancy.
The 10-Year Anniversary Special Focus Issue of Regenerative Medicine explores the past decade's progress in regenerative medicine, including reviews, perspectives, and special reports. The journal has remained at the forefront of the field since its inception in 2006 and continues to showcase the latest research.
Researchers at the University of Bonn present a new scaffold concept that combines structural key compounds and reaction criteria for a more consistent definition. The analog series-based scaffolds (ASB) framework provides a unique insight into compound diversity and structure-activity relationships.
A special issue of Future Oncology examines the latest breakthroughs in prostate cancer imaging, including multiparametric MRI and PET imaging. The issue aims to provide a comprehensive overview of the field's current state and future directions.
Researchers developed a multivariate approach to improve cognitive testing for Alzheimer's disease, identifying five distinct patient groups. The model suggests that multivitamins may slow progression only in certain groups, particularly those with mild impairment in recalling.
The study found that patients with diabetes and solid-organ malignancies had significantly more frequent hospitalizations and multiple hospitalizations compared to those without diabetes. Hospital stay was also longer on average for diabetic patients.
The article introduces common definitions for 3D bioprinting-related terms, including 3D printing, bioadditive manufacturing, and biomimetic printing. The definitions aim to provide clarity in the rapidly expanding field of 3D bioprinting in medical applications.
Sarcopenic obesity is a combination of low muscle mass and high fat mass, common in older adults. Research suggests that public health strategies are needed to prevent and treat this condition, which increases risks of mobility issues, metabolic disease, and mortality.
A recent special issue of Future Oncology examines the field of oncofertility, highlighting its importance in cancer survivors' well-being. The focus on preserving fertility in cancer patients has revolutionized reproductive medicine and biology, with direct impact on oncology.
The article reviews national and international guidelines for folic acid supplementation, analyzing its potential risks and benefits on maternal and fetal outcomes. Folic acid is known to prevent neural tube defects, but its effects on other pregnancy outcomes are controversial.
A new article explores the effect of frailty on diabetes in older people, suggesting a regressive course with increased risk of hypoglycemia. The review highlights the importance of regular medication reviews and gradual reduction or withdrawal of hypoglycemic medications.
The International Radiosurgery Oncology Consortium has developed consensus guidelines for the safe implementation and practice of Stereotactic Body Radiation Therapy (SBRT) for primary renal cell carcinoma. SBRT is a non-invasive treatment option with favorable comparisons to existing treatments, offering a cost-effective and widely av...
The new Illumina MethylationEPIC BeadChip array provides a powerful tool for elucidating the role of the human epigenome in complex diseases. With its significantly increased coverage in gene regulatory regions, it enables DNA methylation analysis at an unprecedented scale.
The Journal of Comparative Effectiveness Research discusses new recommendations from the Center for Medical Technology Policy's Green Park Collaborative for evaluating oncology treatment sequences. The framework developed by GPC-USA aims to fill evidence gaps and identify patient-important outcomes, ultimately improving cancer patient ...
A special issue of Future Medicinal Chemistry explores the diverse field of chemical biology, highlighting its expanding scope and sub-disciplines. The issue features reviews, opinion pieces, and primary research papers on topics such as protein-protein interactions, epigenetic modulators, and tissue regeneration.
The special focus issue brings together experts from various fields to discuss the past, present, and future of nanomedicine. It addresses current debates and future perspectives on nanomedical research, including social, ethical, and safety aspects.
The special issue of Biomarkers in Medicine focuses on advances in biomarker research for regulatory science. Biomarkers are used to predict response to therapies, disease prognosis, and establish baseline risk. The journal aims to facilitate translation of research knowledge into clinical practice.
Researchers have discovered that autism-relevant biomarkers can be measured in adult saliva, providing a promising avenue for non-invasive diagnosis and treatment. The study, which analyzed levels of 10 biomarkers in saliva from neurotypical adults, brings us closer to effectively diagnosing and treating autism.
The article reviews lessons learned from Alzheimer's disease research to advance the development of screening and diagnostic algorithms for Parkinson's disease. It explores MCI-AD research, clinical trials incorporating biomarkers and genetics, and emerging therapeutic strategies targeting specific biological mechanisms.
Future Science OA has been accepted by the Database of Open Access Journals (DOAJ) for indexing, achieving high levels of openness and publishing standards. The journal's gold open access model ensures unbiased and scientifically accurate content through independent double-blind peer review.
Researchers review emerging magnetic particle-based techniques to track cells in vivo, providing a promising concept for treating diseases. The techniques can be used for cell therapy, combining diagnosis and treatment.