A themed issue of Future Medicinal Chemistry highlights academia's role in drug discovery, discussing industry-academia alliances and novel models. The issue features expert commentaries on bridging the translational research gap and implementing open innovation platforms.
The journal published a Special Focus issue documenting advancements in oncology since its debut in 2005. Review articles cover topics such as immunotherapy and stereotactic body radiotherapy, providing insights into the latest scientific and clinical issues in cancer research.
Researchers identified associations between genetic variants and differential drug response in patients of Hispanic and Caucasian ethnicity. The study found that genetic ancestry strongly influences a person's response to anticancer drug treatments, with notable associations for drugs like temozolomide and etoposide.
Protein misfolding diseases are rising in incidence and seeing increasing financial and healthcare burden. Recent advances in understanding these disorders provide fresh ideas for their future therapy.
A special issue of Future Science OA examines nitric oxide's role in human biology, its challenges in quantification, delivery, and generation, as well as its applications in cancer and cardiovascular diseases. The publication aims to stimulate discussion and further research on harnessing NO's therapeutic potential.
Animal models are still crucial for medical research, according to experts, as they have led to tremendous progress in treating human and animal diseases. The authors argue that alternative methods, such as in vitro research, are not yet ready to replace animal models entirely.
Researchers discuss emerging antischistosomal drug candidates and address clinical resistance concerns. Praziquantel, the current 'wonder drug,' is being reevaluated due to its drawbacks and potential for clinical resistance.
Researchers explore nanocarriers and microbubbles for efficient thrombus treatment, addressing limitations of existing drugs. The review highlights potential solutions for improving outcomes in ischemic heart disease and stroke, where millions die annually.
The article highlights lessons learned from monitoring complex HIV clinical trials in Africa over 15 years, including the use of on-site and central monitoring, local monitor teams, and standardized processes. The authors encourage global trial teams to publish their practical observations to improve best practices.
The UK Parkinson's Excellence Network is a multi-disciplinary effort bringing together patients, healthcare professionals, and social care experts to develop patient-centered care. The network aims to improve treatment and raise awareness of the need for better care, with a focus on education and service development.
A special issue of Future Oncology explores the role of biomarkers and next-generation sequencing in advancing cancer research and treatment. The issue highlights the potential of these technologies to provide a more precise picture of cancer and identify effective treatments.
The newly redesigned Oncology Central is now live, featuring a dedicated Pipelines and Trials section, webinars, and exclusive multimedia content. The platform offers easy navigation and access to peer-reviewed journal articles, regular cancer news updates, and exciting features.
A special issue of Immunotherapy explores emerging concepts in adoptive cell immunotherapy (ACT) to extend its effects to a wider range of solid and hematological cancers. The journal reviews new strategies to address challenges and potentially improve treatment options for more cancer types.
The journal celebrates its 10-year milestone with a special issue featuring articles on blood pressure targets, cardiac care for women, and pharmacogenomics. Recent advances and emerging challenges in specific areas of cardiology are reviewed.
The journal Regenerative Medicine has published a special focus issue on methods to avoid immune rejection in regenerative medicine. The field is immature, but research continues to address the importance of immunity in progress and development.
A new study supports the screening and treatment of depression in brain tumor patients, who are at high risk of depressive symptoms that can impact care outcomes. The authors recommend using reliable screening tools and refer patients with positive results for detailed psychiatric assessment.
A comprehensive review of research on inhibiting beta amyloid production offers insights into the potential for Alzheimer's treatment. The study examines the role of proteolytic secretases and their viability as therapeutic targets.
Researchers explored the efficacy of biosimilar monoclonal antibody CT-P13 in treating rheumatic diseases, including its similarities and differences with the reference drug infliximab. The study found that CT-P13 is almost identical to infliximab and has similar immunogenicity, but more real-world data are needed on switchability.
A new study estimates that using a diagnostic test for candidemia can reduce hospital costs by up to $5,858,448 per year. The T2Candida Panel provides species-specific Candida detection and identification directly from whole blood in 3-5 hours.
A new review published in Future Microbiology highlights the current state of polio vaccines and future research efforts to ensure eradication. The virus can be prevented through vaccination, with live attenuated oral polio vaccine and inactivated polio vaccine being used to achieve eradication.
A special focus issue in Nanomedicine examines the intersection of nanomedicine and regenerative medicine, showcasing advancements in nanotopography, nanofunctionalization, and stem cell research. The field of nanoregeneration has grown exponentially over the last 15 years, with potential applications in drug discovery and cell targeting.
The article highlights the importance of antimicrobial resistance, citing its impact on human and animal health. Global collaboration and innovative approaches are necessary to tackle this complex issue.
A recent Phase III study has shown that alirocumab significantly lowers LDL-C levels compared to ezetimibe. The treatment's safety profile is comparable to ezetimibe, making it a viable option for patients with primary hypercholesterolemia at moderate CV risk.
Recent research published in the Lancet has shown that nursing home patients with severe Alzheimer's disease experienced significantly improved cognitive function when treated with donepezil. Additionally, data suggests that these drugs are effective in patients with milder forms of Alzheimer's disease, sparking hope for a potential re...