Articles tagged with Cancer Treatments
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A study of over 500 women who survived breast cancer found that maintaining vigorous exercise levels significantly improved everyday functioning and reduced symptoms, while those who started exercising after diagnosis saw a positive impact on their quality of life
Researchers have developed targeted nanoparticles incorporating siRNA that can slow tumor growth without eliciting toxicities. The nanoparticles' structure and biological function are characterized using physicochemical and biological methods, offering insights into designing more effective carriers.
Researchers found a strong correlation between initial PSA levels and future diagnosis of advanced disease. Men with high PSA levels had a higher risk of developing advanced disease, emphasizing the importance of early testing.
Researchers found no association between lycopene and prostate cancer prevention, contrary to previous studies. A diet rich in beta-carotene, another antioxidant, was linked to an increased risk of aggressive prostate cancer.
Researcher William Helferich reviews the science on soy and breast cancer, noting that some studies have yielded contradictory findings. He suggests that exposure to genistein before puberty may reduce breast tumor growth, but warns about the risks of using isoflavone supplements in midlife women.
A new study found that cancer survivors are more likely to attend support groups compared to people with other chronic conditions. However, few survivors receive referrals to such programs from their physicians. The study also revealed that predictors of use include female gender, Caucasian race, and symptoms of depression or anxiety.
The Burroughs Wellcome Fund has awarded $14 million to support the first class of physician-scientists through the Career Awards for Medical Scientists program. The recipients will receive career development funding to advance their research and transition into independent academic careers.
Researchers are developing a new type of particle accelerator that could lead to more effective cancer treatment, greener electricity, and reduced nuclear waste. The CONFORM* project aims to build a non-scaling fixed field alternating gradient (NS-FFAG) accelerator, which has the potential to be used in medical applications, renewable ...
A new study identified genetic markers that can distinguish between chronic pancreatitis and pancreatic cancer, as well as predict patient outcomes. The discovery represents a significant advancement in cancer diagnostics and may lead to improved therapy options.
A study analyzing records from a large children's hospital found that the proportion of chronically ill young children dying in intensive care rose from 80% to 91% between 1997 and 2004. Many deaths occurred after the child had been treated elsewhere, suggesting that terminally ill children were still being actively treated.
Scientists at the University of Texas Medical Branch have discovered a cellular protein, PAK1, that interferes with hepatitis C virus replication. The finding may lead to new drug development to fight the virus, which affects approximately 170 million people worldwide.
A recent study by the University of Alberta highlights the need for improved reporting and surveillance to better understand the incidence of adverse events in children treated with spinal manipulation. Serious injuries, such as stroke and paraplegia, were found to be rare but warrant further investigation.
The Iris Cantor Chair will support a translational researcher in bringing laboratory discoveries to patient treatment. This endowed position aims to advance progress in fighting digestive cancers, which affect various organs worldwide.
A sharp decline in breast-cancer incidence in 2003, followed by relative stabilization, is attributed to the drop in hormone-replacement therapy among postmenopausal women. Researchers estimate a 44,000 fewer breast cancers over two years, with the reduction most evident in estrogen-receptor-positive tumors.
Researchers at the University of Massachusetts have found that nanoparticles can cause DNA damage in breast cancer cells, increasing the risk of cancer. The study suggests that smaller particles are more likely to enter cells and cause toxicity, highlighting the need for further research on nanoparticle safety.
A University of Tennessee researcher has been awarded a $296,000 Komen grant to conduct a groundbreaking study on treating depression in breast cancer patients using behavior therapy. The study aims to determine the effectiveness of two treatments: problem-solving therapy and brief behavior activation therapy.
A study found that breast cancer risk is associated with epigenetic changes related to racial group, smoking status, and infant and childhood size. Researchers analyzed DNA methylation patterns in a cohort of women born between 1959 and 1966, finding correlations between these factors and increased breast cancer susceptibility.
A study found that inhibiting the protein ATM can kill cancer cells with dysfunctional DNA repair pathways, offering hope for a new treatment. Additionally, researchers discovered that inhibiting the protein CaMKII can drive leukemic cells to mature and die, providing an alternative strategy for treating acute promyleocytic leukemia.
A study by Dana-Farber Cancer Institute researchers found that inhibiting the ATM protein can kill tumor cells with dysfunctional DNA repair pathways. Individuals with one mutant copy of a key gene are also at increased risk of developing cancer, as their remaining gene becomes mutated in specific cell types.
Aflac has expanded its support for the American Association for Cancer Research (AACR), providing funding for four young investigators in pediatric cancer research through the AACR-Aflac Career Development Award. The awards also enhance education for early-career scientists attending the AACR Annual Meeting.
Ambassador Nancy Brinker, founder of Susan G. Komen for the Cure, will receive a Centennial Medal for her sustained effort in fighting breast cancer. Lance Armstrong, cancer survivor and seven-time Tour De France winner, will be honored for his advocacy work.
The American Association for Cancer Research (AACR) has awarded $1.275 million in grants to 18 promising cancer scientists. The career development awards and research fellowships support early-career scientists at various stages of their careers.
A mouse model has been developed to study the relationship between hypoxia and cancer progression in renal cell cancer. The researchers observed that Fh1-deficient mice developed clonal and proliferative renal cysts with characteristic overexpression of HIF, leading to renal failure.
A recent study found that one-third of ovarian cancer patients in the US fail to receive recommended comprehensive surgical treatment. Factors associated with undertreatment include age, race, and insurance status. The study highlights the need for increased access to specialized care from gynecologic oncologists.
Researchers at the University of Illinois Chicago found that knocking down a specific RNA-binding protein can inhibit ovarian tumor cell growth and invasiveness. The study suggests this protein could be a new target for diagnosis or treatment of ovarian and other cancers.
Researchers at UCSD School of Medicine have identified two variants of the natural tumor suppressor enzyme PHLPP, which control three different disease pathways. The findings suggest that therapies targeting PHLPP1 could improve insulin regulation in diabetes, while therapies targeting PHLPP2 could enhance cell survival in heart and ne...
A detectable PSA level is first indicator of recurrent prostate cancer after radical prostatectomy, with a doubling time of less than three months indicating imminent death from prostate cancer. Patients with longer doubling times are at significant risk for disease recurrence and cancer-specific death.
A new study led by the University of Georgia finds that older breast cancer survivors experience persistent physical and emotional challenges, with reduced quality of life. The research highlights the need for targeted interventions to improve well-being among this population.
Immunology researchers at Jefferson University have found that blood-brain barrier damage correlates with multiple sclerosis (MS) severity. The study used mice models and found that permeability changes are critical in disease development, with even mice lacking immune system components able to develop disease.
New study finds that PSA measurement is associated with prostate cancer prognosis but poorly predicts lethal cancer. Researchers emphasize the need for improved surveillance strategies to identify life-threatening tumors.
Danishefsky's work has provided major fundamental advances in organic synthesis and impacted the treatment of cancer, with novel compounds currently in clinical trials. He is recognized as one of the world's leading chemists and a celebrated researcher, with numerous awards and honors including the Wolf Prize in Chemistry.
The Wesley Research Institute Tissue Bank has collected its first batches of cancer tissue, providing a valuable resource for researchers to study the cause, progression, and potential treatment of cancer. This step forward in cancer research is expected to lead to significant advancements in diagnosis and treatment.
The American Association for Cancer Research (AACR) established a new lecture in honor of Princess Takamatsu, recognizing Webster K. Cavenee's groundbreaking research on genetic mechanisms of cancer predisposition. Cavenee will present his inaugural lecture on April 17, highlighting the importance of collaborations in cancer research.
Researchers identify PGC-1alpha as a key genetic component and potential therapeutic target for Duchenne muscular dystrophy. Experimental elevation of PGC-1alpha improves DMD symptoms in mouse models, offering new therapeutic promise.
The AACR-Bardos Awards program offers financial support to third-year undergraduate students majoring in science, allowing them to attend the Annual Meeting 2007 and present their research. Winners also participate in the Undergraduate Student Caucus and Poster Competition.
The study reveals that nanobubbles formed by the collapse of one bubble become new nucleation sites for later bubbles, allowing them to form earlier and at lower temperatures. This discovery may impact technologies such as inkjet printing and thermal cancer therapies.
Researchers, Lucille Sanzero Eller and Elise Lev, are developing a targeted intervention to address physical and psychological symptoms in men with prostate cancer. The study aims to improve quality of life by reducing symptoms such as urinary and bowel incontinence and depression.
A study found that survivors of acute lymphoblastic leukemia have a significantly increased risk of secondary cancers developing over time. The cumulative incidence of secondary neoplasms increases from 4.17% at 15 years to 10.85% at 30 years, with the majority being low-grade tumors.
A study by St. Jude Children's Research Hospital found that adults who survived childhood acute lymphoblastic leukemia (ALL) are at a higher risk of developing secondary neoplasms during adulthood. Most of these late-onset tumors are low-grade and curable, but some can cause significant health issues.
A University of Missouri study found that negative news stories about clinical trials deter people from participating in medical research. The study analyzed 216 New York Times and 124 Washington Post articles, revealing a significant correlation between negative coverage and decreased willingness to participate.
Researchers from the University of Washington developed a new antibacterial strategy using Gallium, which inhibits the growth of Pseudomonas aeruginosa and prevents biofilm formation. Additionally, studies suggest that Nutlin-3a may reactivate the p53 pathway to treat Kaposi's sarcoma virus-induced lymphomas. Another study found that a...
The Damon Runyon-Rachleff Innovation Award provides seed funding for junior scientists with high-risk, high-reward ideas in cancer research. The program aims to apply a venture capital philosophy to scientific research, investing in fresh perspectives and innovative approaches.
Researchers discovered Nutlin-3a induces apoptosis in human PEL cell lines by disrupting LANA-p53 interaction, causing substantial tumor regression in mice with established PEL. This reactivation of the p53 pathway may provide a viable therapeutic option for individuals with KSHV-induced lymphomas.
Researchers at the University of Helsinki have discovered a new effective treatment modality for KSHV-infected lymphomas by reactivating the p53 pathway. The study shows that Nutlin-3a, a small-molecule inhibitor, selectively induces massive apoptosis in PEL cells.
Researchers have discovered a peptide that can free the protein p73, which induces tumor cell death, and effectively kills both p53-sufficient and p53-deficient human tumor cell lines. The study suggests targeting the p73-mediated pathway could provide a new avenue for developing anticancer therapeutics.
A multi-center study found that CT screening for current and former smokers did not reduce deaths from lung cancer, despite finding nearly three times as many lung cancers. The study also found an increased risk of invasive procedures and unnecessary treatments due to false positives.
Researchers found that a combination of green tea polyphenol EGCG and COX-2 inhibitor celecoxib can slow the growth of human prostate cancer. The study demonstrated a synergistic effect, where both agents triggered cellular pathways that were more powerful when combined.
Nanotechnology has the potential to provide less-industrialized countries with powerful new tools for diagnosing and treating disease. The technology could revolutionize health care in developing countries by making treatments more readily available for diseases that claim millions of lives annually.
Research suggests treating HSV-2 infections reduces genital and systemic levels of HIV-1 RNA, with potential implications for treatment and management of co-infections.
A global survey of healthcare professionals found that they rank childhood immunization and cancer treatment for smokers lowest, while prioritizing spending on younger populations. The study highlights the disconnect between professional priorities and actual spending patterns in most countries.
Researchers found that telomere length shortens with every successive generation in families with Li-Fraumeni syndrome, resulting in more severe cancers at an earlier age. This discovery could represent the first biological marker for clinical monitoring in these families.
Researchers have identified the liver as a promising target for cancer gene therapy using viral vectors, taking advantage of the structural disorganization in cancer cells. The study demonstrates that adenoviral vectors can selectively infect cancer cells while leaving normal liver cells unharmed.
The Mayo Clinic team has proposed a system of lung surgery quality indicators to demonstrate best practices for positive patient outcomes. The proposed measures include patient-centered processes prior to, during, and after surgery, such as pulmonary function testing, electrocardiogram, smoking history documentation, and timely pain co...
Researchers investigate fatigue in various populations, finding distinct definitions for tiredness, fatigue, and exhaustion. The study aims to prevent progression from tiredness to exhaustion, emphasizing the importance of recognizing changes consistent with fatigue and exhaustion.
Researchers have adapted bacteria in the human gut to produce human growth factors that repair colon cells, reducing inflammation in IBD. The treatment uses a plant sugar called xylan, found in tree bark, to control the release of the medicine.
Researchers developed a simple and non-invasive gene probe to diagnose early stage lung cancer in current and former smokers. The test identified 76% of stage I lung cancer patients whose tumors also showed the same genetic loss, outperforming existing sputum cytology tests.
Scientists identified an approach to boost the activity of dasatinib, a potent anti-cancer agent, by combining it with PD184352. This combination resulted in increased apoptosis in leukemia cells, particularly those resistant to imatinib mesylate.
Researchers at VCU Massey Cancer Center created a new method to improve leukemia treatment by triggering programmed cell death in cancer cells. The study found that combining agents like ABT-737 with those that reduce Mcl-1 levels can activate pro-apoptotic proteins and induce apoptosis.
Researchers have found a selective marker in nestin that could lead to earlier detection and better treatment of basal epithelial breast tumors, a highly aggressive form of breast cancer. High levels of nestin were detected in 14 out of 16 tumor samples examined.
Researchers have identified pancreatic polypeptide as a potential solution to appetite suppression, which may lead to a new obesity treatment. The hormone is naturally released in the gut and acts as a neurotransmitter to indicate fullness to the brain.