Articles tagged with Cancer Treatments
University of Minnesota researchers have initiated a groundbreaking clinical trial to determine the optimal dose and safety of T regulatory cells from umbilical cord blood in decreasing the risk of immune reactions common in patients undergoing blood and marrow transplantation. The study aims to enhance blood and marrow recovery, reduc...
A specific gene mutation, BRAF V600E, is associated with increased risk of recurrence and death in thyroid cancer patients. The mutation can help guide treatment options and follow-up care, including aggressive surgery and radioiodine therapy.
Researchers at the University of Chicago Medical Center found that family-based treatment, which involves parents, doubled the percentage of teens who abstained from binge eating and purging after six months. The study involved 80 adolescents with bulimia nervosa or partial bulimia nervosa.
Researchers identified a region on chromosome 5p associated with dense breast tissue, a known risk factor for breast cancer. Women with dense breasts are three to five times more likely to develop breast cancer than those with less dense breasts.
A study by St. Jude Children's Research Hospital reveals the loss of Arf gene and BCR-ABL mutation leaves cells vulnerable to growth-enhancing environment of bone marrow, promoting immunity to anti-leukemia drug imatinib.
A research letter investigates the feasibility of self-collected HPV specimens for testing among women at high risk of cervical cancer. The study found that outreach nurses were able to recontact 81.4% of participants who tested positive and referred them for further testing.
Patients with Medicaid and those lacking insurance have a higher risk of being diagnosed with advanced-stage laryngeal cancer at diagnosis. This association holds true across various demographic groups, emphasizing the importance of access to healthcare for cancer screening and treatment.
Researchers have discovered that sulforaphane can prevent severe blistering and skin breakage associated with the rare genetic disease EBS. The study, funded by various organizations, found marked improvement in treated mice, suggesting a potential therapeutic for this condition.
Researchers at Durham University have created a chemical compound containing fluorine that can be used in a 'chemically-sensitive MRI scan' to identify disease progression without biopsies. The compound reacts differently according to body acidity levels, highlighting tumors on the resulting scan.
Researchers found that bursts of waves drive immune system 'soldiers' toward invaders, using a signaling protein to direct cell movement. The discovery may lead to strategies to block cancer growth and treat heart disease.
Researchers discovered the p75NTR receptor plays a key role in glioma invasion, with expression sufficient to induce aggressive tumor growth. This finding highlights a previously unknown function of the receptor and suggests it may be a novel therapeutic target.
Researchers found that green tea concentrate increased GST enzyme activity by up to 80% in people with low levels, suggesting a potential mechanism for its anti-cancer properties. The study suggests that green tea may help strengthen metabolic defense against toxins capable of causing cancer.
Researchers at Virginia Commonwealth University identified two key proteins, KLF2 and EKLF, that regulate overlapping groups of genes during red blood cell development. The study may lead to future gene therapies for sickle cell anemia and beta-thalassemia.
Researchers found radiofrequency ablation to be 93% effective in eradicating malignant kidney tumors, with minimal discomfort and no serious complications. The study's lead author suggests this treatment is an excellent option for patients who are not good operative candidates or have multiple renal tumors.
A study of 125 kidney tumors treated with radiofrequency ablation showed a high cure rate and low complication rate. The procedure achieved a 93% success rate for all treated tumors, making it an alternative method for patients who are not good surgical candidates.
A Mayo Clinic-led collaborative study finds that focused ultrasound treatment of uterine fibroids offers sustained symptom relief and durable outcomes. The more complete destruction of tumors by focused ultrasound results in improved quality of life and lower incidence of severe side effects.
Children with cancer in the UK have shorter survival rates compared to other European countries due to inadequate surveillance and care. Experts recommend rigorous assessment of routine surveillance and primary care to improve childhood cancer outcomes.
Researchers found that a disruption of gut bacteria plays a key role in the effectiveness of radiation therapy for cancer. In mice, radiation therapy boosted immune cells' ability to fight tumors, and gut bacteria were crucial to this effect.
A study published in the Journal of the National Cancer Institute found that experienced surgeons perform more successful prostate cancer surgeries, with a steeper learning curve. As surgeons gain experience, patient outcomes improve, but beyond 250 operations, additional experience has little influence on cancer recurrence rates.
A new study published in CANCER journal found that group therapy does not prolong the lives of women with metastatic breast cancer. However, women with estrogen receptor-negative tumors showed a survival benefit from group therapy.
A new combination treatment of fludarabine plus cyclophosphamide significantly improves progression-free survival and response rates in patients with chronic lymphocytic leukaemia. The treatment also shows better quality of life compared to single-agent treatments, but may have more severe side effects.
Pawel Walewski, a health editor with Poland's biggest selling weekly magazine Polityka, has been awarded the European School of Oncology's Best Cancer Reporter Award for 2007. The award recognizes his outstanding cancer reporting and aims to promote better quality media coverage of cancer.
A new study has achieved four successful pregnancies using immature oocytes collected from unstimulated ovaries, matured in vitro, and then vitrified, marking a significant breakthrough in fertility preservation. The research has the potential to become an important option for patients with PCOS or those who cannot undergo ovarian stim...
Researchers at M. D. Anderson Cancer Center have identified a new oncogene, insulin-like growth factor binding protein 2 (IGFBP2), that contributes to the formation of two types of brain malignancies, astrocytoma and oligodendroglioma.
Experimental studies suggest that targeting angiogenesis with dopamine agonists and dendritic cell inhibitors may inhibit endometrial lesions and decrease cancer risk. Mouse models show reduced blood vessel formation and increased old blood vessels in treatment groups.
Researchers found that two proteins, HEF1 and Aurora A, control the temporary disappearance of cilia during normal cell division, leading to an untimely disassembly. This loss of cilia may contribute to cancer development by disrupting cellular response to environmental cues.
A study by University of Illinois Chicago researchers found that young adults who want to quit smoking are less likely to use evidence-based behavioral treatment. Only 4-5% of young adult smokers use any form of treatment, compared to 32% of older smokers.
Patients treated with bisphosphonates are at higher risk of jaw bone deterioration or infection. The use of intravenous bisphosphonates has been associated with osteonecrosis of the jaw or facial bones, a condition caused by poor blood supply to the area.
Researchers have made progress in treating neuroblastoma, a difficult pediatric cancer, with new approaches such as radioactive isotopes and targeted therapies. However, further understanding of the disease's precise biology is needed to guide optimal treatment choices.
UC Irvine scientists use mathematical theory to understand how cancer cells alter their genetic makeup, accelerating tumor growth. The study found that tumors thrive when unstable in early stages and become stable later on, providing insight into future cancer treatments.
Long-term steroid treatment decreases the risk of rheumatoid arthritis-related lymphoma, with benefits observed regardless of when treatment was started. The most pronounced protective effect was seen in diffuse large B-cell lymphoma subtype.
Preliminary results show that 59% of patients receiving certolizumab pegol 200mg plus methotrexate achieved a 20% improvement in symptoms after 24 weeks, compared to 14% for those taking methotrexate alone. The treatment combination also resulted in higher ACR70 responses and lower discontinuation rates due to adverse events.
Recent studies found a decline in Kaposi sarcoma and non-Hodgkin lymphoma incidence among AIDS patients treated with HAART, associated with increased CD4 cell counts. Additionally, researchers identified the CCRK gene as potentially involved in glioblastoma multiforme development.
A new study has shown that long-term biologic treatment can significantly reduce disability in patients with rheumatoid arthritis, while maintaining a safe and effective profile. The analysis of over 2,000 patients demonstrates improvements in disability whilst safety was also sustained over the long-term.
ChemGenex's lead compound Ceflatonin demonstrates clinical activity against Gleevec-resistant CML patients with the T315I Bcr-Abl mutation. A significant reduction in T315I levels and complete disappearance of the mutation were observed, indicating a potential therapeutic alternative for these patients.
Researchers have identified a set of molecular markers that can distinguish between healthy and tumor blood vessels, paving the way for more selective anticancer therapeutics. The study reveals 13 genes selectively overexpressed in tumor blood vessels, offering new targets for developing safer therapies.
Researchers suggest targeting beta1-integrin to treat cancer by reducing tumour cell proliferation and inducing cellular senescence, potentially preventing metastases. Blocking this protein function in transgenic mice with pancreatic insulinomas resulted in tumour cells becoming senescent and unable to form new tumours.
Researchers at Rambam Health Care Campus in Israel have found that PET/CT imaging can accurately diagnose and localize vascular graft-related infections. The study shows promise as a single-step, noninvasive technique for complex patients, potentially sparing unnecessary high-risk operations.
The Revlimid data presented at ASCO demonstrates a greater one-year survival advantage for patients receiving low dose dexamethasone compared to those receiving the standard high dose of the steroid. In all age ranges, patients benefit from Revlimid with the low dose dexamethasone, showing improved survival rates.
Researchers found a widening disparity in life expectancy between white and black women with advanced breast cancer, with median survival rates differing by up to 8.8% over the last two decades. Socio-economic factors, such as access to healthcare and treatment options, are suspected to be contributing factors.
The partnership aims to create programs and provide grants that support tangible improvements in access to and delivery of cancer care, particularly for disparities and clinical trials. The initiative also focuses on solutions to the projected shortfalls of the oncology workforce and addresses the unique needs of cancer survivors.
New research shows that cigarette smoke can cause changes in the DNA sequence of sperm cells, altering the genetic composition of offspring. The study found that male mice exposed to cigarette smoke had higher rates of genetic mutations than non-smoking mice, with the duration of exposure increasing the likelihood of damage.
The Novo-TTF device has been shown to disrupt tumor growth by interfering with cell division of cancerous cells, causing them to stop proliferating and die off. In a pilot trial, 10 patients with recurring GBM experienced improved survival rates, with median overall survival doubling compared to historical data.
A Phase II clinical trial suggests that extracorporeal photopheresis (ECP) is effective in treating clinically active Crohn's disease, with a 50% response rate after 3 months of treatment. Patients who responded to ECP therapy experienced notable improvements in disease symptoms and signs within six weeks.
A new procedure using concentrated radio waves has been found to be safe and effective in treating abnormal cell growth in the esophagus, a precursor to cancer. The treatment, called radiofrequency ablation, destroys abnormal cells with fewer side effects than current methods.
Researchers at VCU Medical Center report nearly all patients with hepatitis C treated successfully have no detectable virus after seven years. The study validates the use of 'cure' to describe successful treatment, offering hope for those affected by the disease.
A study of over 500 women who survived breast cancer found that maintaining vigorous exercise levels significantly improved everyday functioning and reduced symptoms, while those who started exercising after diagnosis saw a positive impact on their quality of life
Researchers have developed targeted nanoparticles incorporating siRNA that can slow tumor growth without eliciting toxicities. The nanoparticles' structure and biological function are characterized using physicochemical and biological methods, offering insights into designing more effective carriers.
Researchers found a strong correlation between initial PSA levels and future diagnosis of advanced disease. Men with high PSA levels had a higher risk of developing advanced disease, emphasizing the importance of early testing.
Researchers found no association between lycopene and prostate cancer prevention, contrary to previous studies. A diet rich in beta-carotene, another antioxidant, was linked to an increased risk of aggressive prostate cancer.
Researcher William Helferich reviews the science on soy and breast cancer, noting that some studies have yielded contradictory findings. He suggests that exposure to genistein before puberty may reduce breast tumor growth, but warns about the risks of using isoflavone supplements in midlife women.
A new study found that cancer survivors are more likely to attend support groups compared to people with other chronic conditions. However, few survivors receive referrals to such programs from their physicians. The study also revealed that predictors of use include female gender, Caucasian race, and symptoms of depression or anxiety.
The Burroughs Wellcome Fund has awarded $14 million to support the first class of physician-scientists through the Career Awards for Medical Scientists program. The recipients will receive career development funding to advance their research and transition into independent academic careers.
Researchers are developing a new type of particle accelerator that could lead to more effective cancer treatment, greener electricity, and reduced nuclear waste. The CONFORM* project aims to build a non-scaling fixed field alternating gradient (NS-FFAG) accelerator, which has the potential to be used in medical applications, renewable ...
A new study identified genetic markers that can distinguish between chronic pancreatitis and pancreatic cancer, as well as predict patient outcomes. The discovery represents a significant advancement in cancer diagnostics and may lead to improved therapy options.
A study analyzing records from a large children's hospital found that the proportion of chronically ill young children dying in intensive care rose from 80% to 91% between 1997 and 2004. Many deaths occurred after the child had been treated elsewhere, suggesting that terminally ill children were still being actively treated.
Scientists at the University of Texas Medical Branch have discovered a cellular protein, PAK1, that interferes with hepatitis C virus replication. The finding may lead to new drug development to fight the virus, which affects approximately 170 million people worldwide.
A recent study by the University of Alberta highlights the need for improved reporting and surveillance to better understand the incidence of adverse events in children treated with spinal manipulation. Serious injuries, such as stroke and paraplegia, were found to be rare but warrant further investigation.
The Iris Cantor Chair will support a translational researcher in bringing laboratory discoveries to patient treatment. This endowed position aims to advance progress in fighting digestive cancers, which affect various organs worldwide.
A sharp decline in breast-cancer incidence in 2003, followed by relative stabilization, is attributed to the drop in hormone-replacement therapy among postmenopausal women. Researchers estimate a 44,000 fewer breast cancers over two years, with the reduction most evident in estrogen-receptor-positive tumors.