Research on new and better ways to treat cancer. Covers radiotherapy, targeted microdroplets, nerve-injury protection, drug combinations, and tumor models.
Researchers at University of Leeds have identified a promising new target for hepatitis C treatment: the p7 protein. The study found that genetic variations among HCV strains affect sensitivity to certain drugs, highlighting the need for tailored combination treatments.
An analysis of a phase III clinical trial showed that VIDAZA can improve patient responses, achieving an overall response rate of 51% in higher-risk MDS patients. Continued treatment with VIDAZA led to better outcomes for almost half of responders.
Researchers found identical survival rates among African Americans and white patients after autologous bone marrow transplants. However, African Americans were less likely to receive the treatment due to pre-existing medical conditions and socio-economic factors.
A new global evaluation system for neuroblastoma has been recommended to improve treatment outcomes for children. The system, developed by the International Neuroblastoma Risk Group, will enable quicker identification of optimal treatments and facilitate clinical research.
Researchers are exploring the PI3-kinase pathway's role in cancer, with studies showing its inhibition can suppress tumor growth and cell survival. The pathway is also involved in angiogenesis, differentiation, and cell growth, making it a critical target for novel therapies.
A recent study published in Cancer Research found that Latina women with higher European ancestry are at a greater risk of developing breast cancer. The risk increases by 79% for every 25% increase in European ancestry, regardless of other factors.
A randomized trial found that systematic pelvic lymphadenectomy did not improve disease-free or overall survival in women with stage I endometrial cancer. Lymphadenectomy was associated with improved surgical staging and detection of disease spread to pelvic lymph nodes, but no therapeutic benefit.
A tracking and feedback system reduced racial disparities in adjuvant therapy among women with early-stage breast cancer, increasing consultations with medical oncologists by 14 percentage points. The study found a decrease in underuse of adjuvant treatment, particularly among black and Hispanic women.
Research suggests melatonin therapy may prevent ocular inflammation in uveitis, reducing symptoms and protecting the blood-ocular barrier. Melatonin treatment has anti-inflammatory effects, potentially benefiting patients with chronic uveitis.
A program called Project Early Awareness teaches high school girls about breast health and self-exams, resulting in a 39% increase in comfort with performing a self-exam and a 69% increase in correct answers to breast cancer questions. The goal is for breast self-exams to become routine among young women.
A recent study found that Latina women are 5.6 times more likely to express regret over their breast cancer treatment compared to white women. The researchers discovered that despite similar treatment, Latinas reported higher dissatisfaction and a desire for more culturally tailored information.
Researchers found that calorie restriction and exercise can modify pathways leading to mTOR, a molecule involved in cell growth. Calorie restriction showed more global effects on cell signaling, suggesting it may produce a more potent anti-cancer effect.
A recent study found that individuals with lower socioeconomic status are more likely to be diagnosed with late-stage colorectal cancer, leading to poorer survival rates. The research highlights the importance of removing barriers to healthcare services, including screening tests and treatment for colorectal cancer.
A study published in Clinical Oncology found that funding decisions for cancer patients with exceptional circumstances are influenced by their location rather than their health needs. This has led to a postcode lottery, where some patients receive funding while others do not, despite similar circumstances.
Researchers found that home-based diet and exercise interventions improved physical functioning in older, long-term cancer survivors. Participants in the intervention group demonstrated significant improvements in their diet and exercise behaviors, as well as measures of basic and advanced lower extremity functioning.
ER/PR negative tumors associated with higher risk of poorer prognosis and limited treatment options. African-American women have higher risk due to race, socioeconomic characteristics and other tumor characteristics.
A study found that women with a strong family history of breast cancer but without BRCA1 or BRCA2 mutations are at increased risk for developing the disease. These women had a four-fold higher risk than average, highlighting the importance of genetic testing and preventive measures.
Research identified three genes linked to fat processing that could raise kidney cancer risk, according to a study presented at the American Association for Cancer Research. Variants of nitric oxide synthase 2A and prostaglandin-endoperoxide 2 were found to increase risk, while apolipoprotein E1 was associated with reduced risk.
Researchers studied DNA methylation in former smokers and found differences between those with lung cancer and disease-free individuals. Altered methylation levels may explain why some former smokers develop lung cancer despite quitting smoking.
Researchers have found strong links between smoking and two forms of esophageal cancer, as well as a form of stomach cancer. Drinking alcohol is strongly associated with one form of esophageal cancer, with the risk increasing fivefold for those who drink four glasses a day.
A large clinical trial found that calcium supplementation reduced colorectal adenoma recurrence risk by 32% only in those with low magnesium to calcium ratio. This suggests a personalized diet/supplementation regimen considering both nutrients may be more effective than supplementing with one alone.
A new research study at Cardiff University aims to understand and regulate a patient's immune response to infections, which is crucial for treating end-stage kidney disease. The three-year grant will enable the multidisciplinary team to investigate the consequences of bacterial infection on patients with peritoneal dialysis.
A new study by Indiana University found that young female breast cancer survivors experience significant problems related to sexual arousal, desire, and orgasm. Many reported vaginal dryness, genital pain, premature menopause, fatigue, and fertility issues, highlighting the need for research on strategies to address these challenges.
A study of over 200 cancer patients found that age was not a significant factor in survival rates. Instead, factors like physical quality of life and metastatic dissemination played a crucial role. The findings suggest that older patients should not be excluded from clinical trials due to their age.
Researchers have developed approaches to visualize eosinophils in real-time, which may help diagnose asthma and assess treatment efficacy. Additionally, genetic defects underlying two kidney conditions and a type of liver cancer have been identified, suggesting potential therapeutic targets for these diseases.
A new study reveals that therapy targeting cyclin D1 can block the expansion of breast cancer cells, which are involved in therapy resistance and tumor recurrence. The findings provide a potential new treatment approach for targeted therapies at cancer stem cells in humans.
Researchers have identified 11 single-nucleotide polymorphisms that show a significant association with esophageal cancer. Individuals with more than four unfavorable genotypes are three times more likely to develop the disease.
A study found that daily folic acid and B vitamin supplements had no impact on cancer risk in high-risk women. The results suggest a lack of benefit for total invasive cancer and breast cancer, with age modifying the effect.
A recent study found MDCT scans correctly identified 29 of 30 complications in patients with airway stents. The non-invasive imaging test has the potential to replace bronchoscopy for routine surveillance and early detection of complications.
Scientists have discovered similarities in a region of chromosome 7q31 among siblings with colon cancer, suggesting a potential gene cause. Siblings sharing this genetic region tend to develop cancer 3.8 years earlier than non-sharing siblings.
A non-invasive oral rinse screening method has shown promise in detecting high-risk human papillomavirus (HPV) infections in patients with head and neck cancers. The study found that oral HPV16 infections were significantly more common among patients with HPV-positive tumors, indicating a potential link between the two.
Women experiencing severe gestational hypertension may give birth to sons with a lower risk of developing testicular cancer. Hormonal imbalances and increased levels of pregnancy-related hormones like human Chorionic Gonadotropin may contribute to this protective effect.
Research found skewed X inactivation in women with BRCA1 gene mutations, associated with a later onset of breast or ovarian cancer. The Impact of Cancer scale was also refined and validated, providing a tool to measure long-term psychosocial impact on cancer survivors.
Researchers found that video-assisted thoracic surgery (VATS) for stage I non-small cell lung cancer results in shorter post-operative hospital stays and faster removal of chest tubes compared to traditional open surgery. The study also showed comparable outcomes in terms of surgical success and complication rates.
New report finds lung cancer media coverage is on the rise, but with a significant decrease in positive coverage and an overemphasis on smoking as a risk factor. Despite this, breast cancer coverage remains more favorable, often featuring personal stories of survivors.
Advances in nerve repair, miniature implantable medical devices and proton therapy were showcased at the AVS 55th International Symposium. Researchers developed new technologies to print cells for artificial organs and created microscopic medical devices that can deliver drugs and monitor health.
Researchers found that photodynamic therapy, combining a topical photosensitizer and laser treatment, increases collagen levels and produces other skin changes in sun-damaged skin. The treatment may be particularly effective for skin with severe sun damage.
A team of researchers has discovered a mechanism for the rapid growth of infantile hemangioma, a common childhood tumor. The study found that endothelial cells, which line the blood vessels, are responsible for the tumors' growth and can be targeted with anti-VEGF therapy.
The Mattel UCLA NanoPediatrics Program will explore the future of personalized medicine for children using nanotechnology. Researchers will develop new diagnostic tools and treatments to improve health outcomes for young patients.
A study published in Cancer Research found that nicotine can promote breast tumor growth and metastasis by binding to nicotinic receptors on mammary cells. The researchers also discovered that nicotine potentiates tumorigenesis when combined with other factors.
Long-term follow-up data from the APPROVe trial confirm that rofecoxib substantially increases the risk of stroke, heart attack, and death compared to placebo. The relative risk of reaching cardiovascular events was increased by 79% in the rofecoxib group.
Researchers at Florida State University discovered dramatic changes in DNA replication order during embryonic stem cell differentiation. The findings bridge a critical knowledge gap, enabling scientists to better understand the complex process of DNA reorganization during cell specialization.
A Mayo Clinic-led study finds that infliximab administered alone or in combination with azathioprine is more effective for moderate to severe Crohn's disease than azathioprine alone. The study demonstrates improved patient outcomes, including higher remission rates and mucosal healing.
The new guidelines provide a tiered system of resource allocation to implement early detection, diagnosis, and treatment programs. The initiative aims to improve breast health outcomes in low- and middle-income countries, where cancer mortality rates are highest.
Researchers found that endoscopic therapy was successful in treating esophageal cancer, with a 90% success rate and low recurrence rates. Patients treated endoscopically had higher survival rates compared to those who underwent surgery.
Research found that people with H. pylori strains carrying a gene called CagA were almost half as likely to get adenocarcinoma of the esophagus. The study suggests that declining rates of H. pylori in developed populations may contribute to the increase in esophageal adenocarcinomas.
Researchers at the MUHC categorized timeframes involved in getting pediatric oncology patients to initial therapy, finding that it takes approximately one month to get a diagnosis from a pediatric oncologist. The study also identified disparities in treatment times based on cancer type and patient age.
A new report card shows that the Midwest leads in palliative care access, while Southern and for-profit hospitals struggle. States like Vermont, Montana, and New Hampshire earned top grades for their palliative care programs, while Oklahoma, Alabama, and Mississippi received F's.
Researchers have identified five biomarkers in saliva that can confirm the presence of oral squamous cell carcinoma with 93% accuracy. The study, led by David T. Wong and Shen Hu, demonstrates a new approach for cancer biomarker discovery using saliva proteomics.
Scientists identified P-Cadherin as a key molecule in causing colon cancer, with abnormal expression leading to pre-cancerous growths in the bowel. Their findings hold promise for preventative therapies and lifestyle changes to prevent or treat the disease.
A large Danish observational study found that women taking hormone replacement therapy (HRT) who used it on a cyclical basis, through skin or vaginal application, had a reduced risk of heart attacks. This contradicts previous research and suggests that certain HRT regimens may be safer than others.
A new study published in the New England Journal of Medicine found that patients can still benefit from dissolving blood clots in the brain up to 4.5 hours after a stroke. The study, known as ECASS 3, involved 826 patients who received either the thrombolytic drug alteplase or a placebo, with better response rates and no increased mort...
Researchers found three subgroups of glioblastomas with varying degrees of methylation, leading to improved survival times in the subgroup with mixed levels. The study highlights the importance of methylation status in determining treatment outcomes and potential biomarkers for this disease.
Researchers found that undetectable EBV DNA levels during treatment significantly reduced cancer recurrence risk, while detectable levels increased the risk of recurrence and metastasis. The study suggests using biomarker tests before and during treatment to guide clinical therapy.
Researchers have identified TEM1 as a specific genetic marker for the vascular cells associated with tumor growth in ovarian cancer. High levels of TEM1 were correlated with decreased survival rates, making it a potential screening tool for early detection.
Researchers developed a 'suicide gene' delivery approach that successfully kills pancreatic cancer cells by over 95 percent, targeting only cancer cells with minimal harm to normal ones. This innovative strategy uses mesothelin DNA linked to diphtheria toxin, effectively hijacking cancer cell machinery.
A new instrument uses multispectral imaging to analyze multiple proteins in a single cancer sample, providing more information for therapy development and personalized treatment. The technology is fast, automated, and provides a quantitative read-out of protein expression levels.
The American Urological Association has released a best practice statement on cryosurgery, recommending it as an option for men with clinically organ-confined prostate cancer. The panel of experts emphasized the importance of case selection and recommended maximizing results through temperature monitoring and double freeze cycles.
A study published in the Archives of Internal Medicine found that physicians rarely responded empathically to patients' concerns about mortality, symptoms, or treatment options. The researchers identified 384 moments of
A study found that estrogen therapy reduced the risk of fractures after menopause, particularly in women aged 50-64 years. The use of post-menopausal hormone replacement therapy increased greatly during this period and was estimated to cause nearly half of the decline in fracture rates among women.