Articles tagged with Cancer Treatments
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A new study presented at the Experimental Biology Annual Meeting shows that Dermytol produces a significant reduction in malignant melanoma cell growth. The compound has demonstrated potential in reducing damage to skin cells and may be used in anti-aging and sun-protection products.
A comprehensive review of breast cancer research identifies key gaps in treatment and patient care, calling for increased attention on prevention, detection, and spread. The charity Breast Cancer Campaign is already funding innovative projects to fill these gaps and improve survival rates.
A new study has found that hormone replacement therapy (HRT) increases the risk of breast cancer recurrence in women who have survived breast cancer. The HABITS trial, which followed over 200 breast cancer survivors for four years, found that HRT significantly increased the risk of disease recurrence.
Researchers found that only about 45% of cases used tumor markers AFP and HCG, with all three markers measured in just 16% of the time. This suggests low usage rates despite the importance of tumor markers in showing patient response to treatment and disease recurrence.
A gene therapy treatment has been developed to restore a missing liver enzyme in people with glycogen storage disease type Ia (GSD-Ia). The treatment has shown promising results in animal studies, with protected blood glucose levels for up to a year. Further research is needed to test the safety and efficacy of the treatment in humans.
The American Association for Cancer Research (AACR) provides financial support to 10 undergraduate students through the AACR-Thomas J. Bardos Science Education Awards for Undergraduate Students. The program allows students to present research, learn from educational sessions and symposia, and network with experts in the field.
A nationwide study in the Netherlands found that women diagnosed with early-stage ovarian cancer treated at semispecialized or specialized hospitals survived longer than those treated at general hospitals. The estimated five-year survival improved with increasing specialization of the treatment facility, from 38% to 40.3%.
The Burroughs Wellcome Fund has awarded $9.75 million to 13 translational researchers through its Clinical Scientist Awards in Translational Research. These awards support established physician-scientists exploring scientific questions, applying knowledge at the bedside, and bringing insights back to the laboratory.
Research found that indoor tanning is a concern for all age groups, with 20% of 18-39 year olds and 10% of 50-64 year olds tanning indoors. Older adults who tan indoors have higher skin cancer risk due to cumulative exposure.
Researchers have created a highly accurate mouse model of inflammatory bowel disease (IBD), which closely resembles the most serious form of human ulcerative colitis. Treating the mice with broad-spectrum antibiotics reduced gut inflammation and increased survival, providing hope for new treatments.
A recent study by the University of Pennsylvania School of Medicine found that curcumin, an active ingredient in turmeric, had a low response rate in patients with psoriasis. Despite laboratory evidence showing its potential, the study suggests that the placebo effect or natural remission may be responsible for the limited results.
A concentrated broccoli sprouts extract cut bladder tumor development in animal models, with isothyiocyanates delivering potent protective action. The study's results reinforce associations between cruciferous vegetable intake and reduced bladder cancer risk.
A Dutch study found that only 17% of individuals who survive pediatric cancer receive follow-up care at age 35, highlighting the need for family doctors to be involved. The study suggests that shared care between dedicated clinics and family practitioners can increase surveillance for adverse effects.
A new study finds that women with higher levels of perceived stress are more likely to have an impaired immune response to HPV16, increasing their risk of developing cervical cancer. Most HPV infections in healthy women will disappear spontaneously over time.
Researchers have identified a key role for a glaucoma gene, sFRP1, in the development of the disease, which causes high pressure in the eye. Over-expression of this gene disrupts the WNT-signaling pathway, leading to elevated intraocular pressure and vision loss.
Researchers at the University of Granada have found that maslinic acid, a compound present in olive skin wax, has anti-cancer properties. The compound regulates cell growth and is selective in its action on carcinogenic cells.
A study published in the Journal of the National Cancer Institute found that HPV-positive head and neck cancer patients have higher response rates to chemoradiation therapy and better two-year overall survival rates compared to HPV-negative patients.
A new molecular signature predicts response to lenalidomide in patients with myelodysplastic syndrome without chromosome 5q deletions. Gene expression profiling identifies a defect in erythroid differentiation, providing potential treatment insights.
Researchers found that STAT3 has tumor-promoting and tumor-suppressing effects depending on the genetic profile of glioblastoma tumors. This discovery highlights the need for effective therapies tailored to individual glioblastoma tumors.
A study suggests that endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) and its combination with endobronchial ultrasound-guided fine-needle aspiration (EBUS-FNA) can accurately determine lung cancer stage. These minimally invasive methods show high sensitivity rates, potentially replacing traditional surgical procedures.
Researchers have developed a successful test vaccine that prevents the development of prostate cancer in 90% of young mice. The vaccine targets prostate stem cell antigen (PSCA), which is over-expressed in early-stage prostate cancers, and has been shown to mount an immune response against the protein.
A new urine test detects prostate cancer more accurately than current methods, including PSA and PCA3 tests. The test identified 80% of patients with prostate cancer and was 61% effective in ruling out disease.
A study by Dr. Catherine Sabiston found that breast cancer survivors who participated in dragon boat racing reported significantly improved physical and mental health. The social aspect of the activity provided a sense of community and empowerment, helping women cope with post-recovery trauma.
Dr. Vivian Cheung, a pediatric neurologist at Children's Hospital of Philadelphia, has been selected as a Howard Hughes Medical Institute Investigator. Her research focuses on translating genetic discoveries into improved medical treatments by analyzing gene expression and its association with disease susceptibility.
Researchers found that self-expanding plastic stents (SEPSs) resulted in frequent stent migration, with over 60% of patients experiencing this issue. Long-term symptom improvement was also limited, with only six percent of procedures resulting in long-term resolution.
Researchers at German Cancer Research Center discovered a new molecule Akirin that plays a crucial role in triggering the innate immune response in fruit flies, mice, and humans. Inhibiting this pathway may lead to new cancer treatments.
A recent study by Children's Hospital of Pittsburgh found that adolescents and young adults with cancer are less likely to be enrolled in clinical trials for cutting-edge treatments. This can lead to lower survival rates compared to younger children, who have seen significant improvements in cure rates over the past 30 years.
Children of BRCA mutation carriers are more likely to support genetic testing, despite potential risks and benefits. A study found that 40% of parents and their adult offspring supported testing minors, with half in favor only in certain circumstances.
Nucleonics has initiated a Phase 1 human safety study of its experimental treatment NUC B1000, an expressed interfering RNA-based product designed to target and destroy HBV within infected cells. The therapy aims to reduce viral antigen load and potentially resolve viral infection in patients with mild to moderate disease.
Researchers found that 77% of methadone users with low levels had no significant cardiac abnormalities, while 60% of non-methadone users had identifiable evidence of cardiac disease. The study suggests a link between methadone and sudden cardiac death, potentially necessitating additional safeguards before therapy.
Researchers found that sirolimus reduced angiomyolipoma size by nearly 50% in TSC and LAM patients. Lung function also improved in LAM patients, with a 10-15% increase in expiratory air flow.
Researchers discovered that a transient and local rise in interleukin-6 (IL-6) is essential for the growth of muscle fibers. This finding could lead to new treatments for reversing or improving muscle loss in diseases such as cancer and AIDS, as well as normal aging.
A new study by Fox Chase Cancer Center reveals that most American adults engage in multiple behaviors increasing their exposure to UV rays, including infrequent sun protection and indoor tanning. The study found that younger adults, men, Caucasians, smokers, and those with fair skin are more likely to engage in these high-risk behaviors.
Cancer risk increases with age, yet elderly nursing home residents receive relatively few cancer care services. According to a recent study, only 28% of patients with late-stage cancer received hospice care, highlighting the need for further investigation into cancer care in this population.
Bevacizumab plus interferon improves progression-free survival in patients with metastatic renal cell carcinoma compared to interferon alone. The new treatment option is expected to provide a better prognosis for patients with renal cancer.
A survey of 367 women with advanced breast cancer underscores the significance of emotional and educational needs, with psychosocial support identified as a high priority. The study also reveals dissatisfaction with treatment experiences and highlights the importance of internet access as an information resource for patients.
A Mayo Clinic program has reduced delays between abnormal mammograms and diagnosis, improving outcomes for women with cancer. The clinic's multidisciplinary breast clinic helped overcome barriers such as lack of transportation and childcare, providing timely care to underserved women.
A study published in Dermatologic Therapy reveals that rituximab effectively treats blistering skin diseases, including paraneoplastic pemphigus, by targeting abnormal immune responses. The drug's efficacy is being explored for other serious dermatological disorders, but its indications are still being defined.
Researchers at UMass Medical School discovered a complex pathway that allows cells to survive and die through autophagy, a process previously misunderstood. The study sheds light on the relationship between autophagy and cell death, with potential implications for cancer, Alzheimer's, and Parkinson's treatments.
Research findings suggest a genetic link between schizophrenia and cancer, while also exploring the relationship between depression and heart disease. Studies on brain overgrowth in autistic children and the development of an animal model for autism have also shed light on these complex conditions.
A phase II trial of Cybor-D, a combination therapy including cyclophosphamide, bortezomib, and dexamethasone, showed an improved response rate compared to traditional lenalidomide-dexamethasone therapy. The treatment resulted in a rapid initial decline and percentage reduction in M protein levels.
A recent study has identified a link between BRCA1 mutations and the loss of the tumor suppressor gene PTEN in breast cancer. This discovery opens up new avenues for treating aggressive forms of breast cancer by targeting proteins in the PTEN pathway.
Researchers found that diets rich in raw vegetables can prevent or slow the growth of some common cancers. Black raspberries may protect against esophageal cancer by reducing oxidative stress, while broccoli sprouts inhibit bladder cancer development through the delivery of cancer prevention agents.
A Virginia Commonwealth University research team has received a $1.3 million NCI grant to improve histone deacetylase inhibitors in treating leukemia. The goal is to develop novel combination regimens incorporating these agents with NF-kappa B antagonists.
A recent survey found that nearly half of respondents would choose an endodontist for their root canal procedure. The American Association of Endodontists reports that endodontists perform an average of 25 root canals per week, significantly more than general dentists who perform about two a week.
A purified bacterial extract spray administered to laboratory mice provided powerful protection against all four major classes of pathogens, including anthrax and bubonic plague. The treatment was shown to stimulate a healthy immune response and increase antimicrobial polypeptides in the lung lining fluid.
A study by American Cancer Society researchers found significant disparities in breast cancer diagnosis, particularly among uninsured and African American women. They are more likely to miss axillary lymph node assessments, which help determine stage and guide treatment decisions.
Researchers identified a role for OX40 in TSLP-induced allergic reactions, finding that blocking its interaction reduced allergic responses in mice and monkeys with asthma. The study suggests OX40-OX40L interactions as a promising therapeutic target for treating allergic diseases.
A study by Dr. Groesbeck Parham found that 90% of HIV-infected women presenting for antiretroviral therapy harbor cervical cell abnormalities, increasing the risk of cervical cancer. Access to screening and treatment is crucial to prevent this life-threatening condition in women living with AIDS.
A recent study found racial discrepancies in breast cancer tumor gene profiles, suggesting inflammation plays a stronger role in development and progression in African-American women. African-American breast cancer patients tend to have a greater prevalence of an aggressive form of cancer less likely to respond to hormone therapy.
A systematic review of recent studies suggests PET imaging can accurately diagnose and stage lung cancer, even in early stages. The imaging modality is found to be more accurate than CT imaging for treatment decisions in non–small-cell lung cancer patients.
A review of 62 Mayo Clinic patients who underwent cryoablation to treat cancerous kidney tumors found that all patients remained cancer-free for up to two and a half years after the procedure. The treatment's effectiveness was demonstrated by the successful elimination of 89 out of 91 tumors in a single treatment session.
Papers published in this issue highlight the value of multidisciplinary collaboration, revealing treatments that spare patients' eyes during cancer treatment and develop new techniques to increase orbital volume. These advancements demonstrate enormous opportunities for knowledge advancement through specialty collaboration.
A structured support program improved prostate cancer patients' and their spouses' lives by addressing symptom management, hope, and couples' communication. The intervention also reduced mental health distress and increased physical quality of life.
Researchers identified distinct molecular markers predicting subsequent invasive cancer after noninvasive breast cancer diagnosis. These biomarkers can stratify women's individual risk and guide aggressive therapy decisions.
Researchers have discovered that the FTO gene influences weight gain by modifying DNA, suggesting a role in controlling hunger and satiety. The study found that the FTO variant is common and associated with increased risk of obesity and diabetes, paving the way for potential therapeutic manipulation.
Researchers at UBC discover a process called chromatin remodeling that allows certain cancer cells to hide from the immune system by altering the structure of chromosomes. This 'instruction manual' enables cancer cells to evade detection and grow unchecked, but the discovery may lead to new therapies within five to 10 years.
A panel of experts proposes a definition of recovery as a voluntarily maintained lifestyle characterized by sobriety, personal health, and citizenship. The proposed definition includes classification of duration of sobriety and recognition of the importance of personal health and citizenship in achieving true recovery.
Researchers at MIT have made significant advances toward a novel therapeutic device that can selectively provide signals to cells traveling through the bloodstream. The technology leverages cell rolling, a biological process that slows down cells as they flow through blood vessels, allowing them to sense signals from nearby tissues.
A new study published in CANCER found that despite significant increases in healthcare expenditures, survival rates for elderly patients with lung cancer remained relatively stable between 1983 and 1997. The average life-expectancy rose by less than one month, while costs increased by over $20,000 per patient.