Research on new and better ways to treat cancer. Covers radiotherapy, targeted microdroplets, nerve-injury protection, drug combinations, and tumor models.
Resveratrol shows therapeutic potential in preventing age-related disorders, including neurodegenerative diseases, inflammation, diabetes, and cardiovascular disease. Low doses improve cell survival, while high doses increase cell death.
A study analyzing the mutator hypothesis found that cancer cells' efficient pathways to cancer are often driven by genetic instability, supporting the hypothesis. This discovery has implications for cancer therapy, as it may enable cancer cells to rapidly evolve resistance.
A new clinical trial found that starting antiretroviral therapy (ART) before CD4+ T cell counts drop below 200 cells/mm3 improves survival for HIV-infected adults. The study's results have the potential to change standard of care for HIV infection in dozens of countries.
The X-Suit NIR stent provides flexible construction to fit any biliary duct and is constructed of Nitinol for durability. It has a proprietary NIRflex cell design that offers superior radial support and reduces stress on the tissue, making it ideal for re-establishing biliary flow.
A Henry Ford Hospital study found an association between microRNAs and natural killer T cells, which can lead to autoimmune diseases and cancer. The discovery could pave the way for new treatment therapies for chronic immune diseases.
The AGA Institute will present exciting data on treatments for Clostridium difficile infection, hepatitis C, and Crohn's disease. The late-breaking session includes studies on optimized therapies and new technologies, which may become the standard of care in the near future.
Researchers found that treating gum disease improved rheumatoid arthritis symptoms, including reduced swollen joints and morning stiffness. The study's results suggest a link between periodontal disease and rheumatoid arthritis, highlighting the importance of good oral health in overall well-being.
Researchers at Mayo Clinic have identified a novel molecular path linked to primary biliary cirrhosis, a disease affecting 1 in 2,500 Americans. The study found variants of two genes, interleukin 12A and interleukin 12RB2, strongly associated with the condition.
The American Thyroid Association has developed comprehensive guidelines for diagnosing, treating, and monitoring patients with Medullary Thyroid Carcinoma (MTC), an uncommon form of thyroid cancer. The guidelines cover a range of clinical topics and propose directions for future research.
A new study found that childhood cancer survivors have a significantly increased risk of developing second primary cancers throughout their lives. The research, published in the Journal of the National Cancer Institute, analyzed data from 47,697 people diagnosed with cancer before age 20 and found a higher incidence rate of new primary...
A new clinical discussion tool, GAIN, has been developed to help physicians discuss potential reasons for using long-acting injectable antipsychotic therapies with patients. The tool addresses barriers such as needle phobia and stigma, aiming to increase patient acceptance and adherence.
Scientists use zebrafish to investigate the role of RAS mutations in melanoma formation and progression. The research found that altering signaling pathways can reduce the effects of RAS mutations, providing a potential therapeutic approach.
Research reveals ILK promotes growth in aggressive ARMS cells, while suppressing ERMS cell growth. Targeting ILK may offer therapeutic strategy for ARMS patients.
A new study found that younger men with advanced prostate cancer have a poorer prognosis than older men, despite having less aggressive tumors. The researchers suspect that young men may have biologically more aggressive forms of the disease.
A study found that mice treated with the algae-derived protein Griffithsin had a 100% survival rate after exposure to the SARS coronavirus, whereas untreated mice only survived 30%. The protein alters sugar molecules on the virus's envelope, preventing it from causing disease.
A randomized study found that RISPERDAL CONSTA significantly delayed time to relapse compared to placebo in patients with Bipolar I Disorder. The median duration of treatment was nine months for the RISPERDAL CONSTA group, which had a lower rate of relapse during the double-blind phase.
Researchers at Medical College of Georgia have identified a critical protein called erbin that regulates insulation in the peripheral nervous system. Impaired myelin formation is linked to neurological and psychiatric diseases, while erbin's role in cancer therapy provides a potential new site for targeted treatment.
New studies demonstrate RISPERDAL CONSTA (risperidone) Long-Acting Treatment significantly improves clinical and functional outcomes for patients with schizophrenia. The treatment reduced rates of rehospitalization among patients, especially those with complex medical histories.
RISPERDAL CONSTA has been approved as both monotherapy and adjunctive therapy in the maintenance treatment of Bipolar I Disorder. The medication offers a convenient and effective choice to delay relapse, with studies demonstrating significant delays in mood episode recurrence.
Overall median survival improved from 3.5 months in period A to 12 months in period C, despite stage of disease at presentation affecting survival. Surgical resection is the only curative treatment, but many patients present with advanced-stage disease.
A physicist at Brookhaven National Laboratory has developed a compact and cost-effective gantry design for delivering tumor-killing particle beams, reducing weight and size by up to 100 times. This new design could make precision particle therapy available to more cancer patients worldwide.
The Multicenter AIDS Cohort Study (MACS) has significantly contributed to the scientific understanding of HIV/AIDS through its 25 years of behavioral and biological data. Key findings include identifying unique features of long-term non-progressors, managing HIV treatment, and the link between viral load and progression of HIV disease.
Richard Junghans, MD, has been awarded a $5.9 million grant from the Department of Defense Breast Cancer Research Program to research gene therapy techniques to modify patients' T cells and create 'designer T cells' to fight breast cancer.
Researchers found that patients with chronic hepatitis C who have achieved a sustained viral response often still carry miniscule amounts of the virus in their bodies. These trace remainders are thought to be infectious, posing a risk to others.
A systematic review found that hospital volume is associated with short-term mortality rates for certain cancer types, but individual studies often fail to show this association. The review concludes that case volume may be an imperfect proxy for healthcare quality and highlights the need for more direct quality measures.
Researchers at VIB develop efficient and safe gene delivery approach based on non-viral genetic elements called transposons, overcoming limitations of viral vectors. This technology may simplify gene therapy, improve safety and reduce costs, treating cancer and genetic disorders.
A ten-year follow-up study of the CHAMPIONS trial shows that early treatment with AVONEX significantly reduces MS relapse rates and improves patient outcomes. Patients treated immediately after their first episode had a lower chance of experiencing a second attack, with 80% having an Expanded Disability Status Scale (EDSS) score less t...
A multidisciplinary study using NASA's electronic nose found that it can detect odour differences between normal and cancerous brain cells, opening up possibilities for new diagnosis and treatment methods. The device has shown promise in detecting cellular trafficking, brain cancer metastasis, and stem cell migration.
A new study predicts a significant increase in US cancer cases over the next 20 years, with the elderly and minority populations bearing the brunt. The projected 45% rise in cancer incidence will be driven primarily by a 67% increase in cancer cases among adults aged 65 and older.
A proteomic analysis of 50 participants from the Women's Health Initiative hormone replacement therapy trial reveals estrogen upregulates proteins involved in major body processes. The study found changes in serum levels of proteins affecting coagulation, metabolism, osteogenesis, and blood vessel morphogenesis.
Researchers at Oregon State University have identified a genetic regulator called CTIP2 that is expressed at higher levels in aggressive types of head and neck cancers. The study found a high correlation between CTIP2 expression and the aggressive nature of cancer.
In a phase II study, lapatinib demonstrated efficacy in treating patients with inflammatory breast cancer, with 49% experiencing a partial response to the treatment. The median overall survival for responding patients was 18.4 months, significantly longer than non-responders.
Researchers have established criteria for reclassifying prostate cancer risk over time, allowing for more tailored treatment approaches. Patients with slow-growing cancer can benefit from reduced therapy burden, while those with more aggressive disease receive definitive care.
A new robotic approach to surgically treat urothelial cancer of the kidney is proving to be effective, offering benefits such as less bleeding and scarring, shorter hospital stays, and faster recovery times. The minimally invasive surgery allows for the preservation of kidney function in patients with stage 3 chronic kidney disease.
A new report reveals a significant increase in the number of people diagnosed with cancer in Ireland, but also shows that survival rates are rising for certain types of cancer. The report highlights the importance of prevention and early detection in reducing the burden of cancer.
MRI technology successfully identifies prostate cancer spread beyond the gland, helping doctors determine if surgery is necessary. The study reviewed 119 patients and found that MRI correctly identified 95% of T2 cases and 75% of T3 disease
A comprehensive review of medical literature by experts found no evidence supporting beneficial effects from blood transfusions. Studies show associations with higher rates of complications like heart attack, stroke, and kidney failure, highlighting the need for restricted practice and safer storage methods.
Research suggests that well-done meats cooked at high temperatures using frying, grilling, or barbecuing methods can form carcinogens linked to pancreatic cancer. Studies found that those who preferred very well done steak had a 60% increased risk of developing the disease.
A study found that moderate wine consumption can reduce the risk of death and relapse in non-Hodgkin's lymphoma patients. The researchers analyzed data from 546 women with the disease, revealing a 76% five-year survival rate among those who drank wine.
A study by Elaine Hardman found that walnut consumption can reduce breast tumor incidence in laboratory mice. Walnut consumption delayed tumors by at least three weeks, with molecular analysis showing increased omega-3 fatty acid intake contributing to the decline.
In a randomized trial, voglibose significantly improved glucose tolerance and delayed disease progression in patients with impaired glucose tolerance. Patients treated with voglibose had a 40% lower risk of progressing to type 2 diabetes than those receiving placebo.
Research identifies genetic variants in MC1R as associated with increased melanoma risk in people with dark hair. The study found that these variants were more common in those who did not typically burn easily from the sun, suggesting a complex relationship between genetics and melanoma risk.
Patients with a history of radiation exposure are more likely to develop aggressive thyroid cancer and experience worse clinical outcomes. The study found that radiation-exposed patients were more likely to undergo total or near-total thyroidectomy, have distant metastases, and die from the disease.
Researchers at Fox Chase Cancer Center found that smaller doses of human chorionic gonadotropin (hCG) can prevent breast cancer in rats. The study suggests that even shorter exposure to hCG may offer protective benefits against the disease.
A genetic analysis revealed that variants in the iNOS gene may predict the risk of recurrence among patients with non-muscle invasive bladder cancer treated with Bacillus-Calmette-Guerin (BCG) therapy. Patients with the variant allele had a significantly longer survival time, up to 96.7 months, compared to those without the variant.
Researchers found that a urine metabolite called NNAL predicts risk of lung cancer in smokers, with higher levels associated with increased risk. The study, published by the American Association for Cancer Research, analyzed data from over 50,000 patients.
Researchers have discovered that biphosphonates can prevent radiation-induced leukemia in laboratory mice, with 75% of treated mice developing the disease compared to 100% in untreated mice. The study suggests that these compounds may have a general effect on leukemia associated with causes other than radiation.
A prospective cohort study found TACE treatments to be well-tolerated and safe for asymptomatic patients with preserved liver function, with a high HCC progression-free survival probability. The study's results support the efficacy of selective TACE in prolonging life expectancy and confirm its role as a key treatment option.
Researchers have identified an epidermal growth factor receptor aberrantly active in approximately a third of human pancreatic cancers, providing a new treatment target for this fatal disease. The discovery also holds promise for developing a blood or urine screening tool to detect pancreatic cancer earlier.
Patients with hepatitis C and B-cell clonality in the liver are at high risk for developing malignant lymphoproliferative disease. Antiviral treatment is suggested as a strategy to prevent this outcome.
A retrospective analysis of 20,713 patients with early bladder cancer found that more intensive treatment was not associated with improved overall survival. In fact, those who received more intense care were more likely to require major medical interventions later on.
Researchers found no correlation between aggressive treatment and improved survival rates for early stage bladder cancer patients. Aggressively treated patients were more likely to undergo major surgery, resulting in higher treatment costs.
The Interactive Autism Network is expanding its research initiative to adults with autism, enrolling individuals to gain insight into their experiences and connect them with researchers. The IAN Project aims to provide much-needed data on the lives of adults with autism, addressing a significant unmet need.
A new study funded by the Canadian Cancer Society has found that childhood cancer survivors, especially those diagnosed with brain tumours, experience poor educational achievement and learning difficulties. This is linked to late effects of treatment and can impact future educational performance and career prospects.
Researchers found a possible genetic cause for increased risk of advanced colorectal cancer in African-Americans, with the Pro72 allele linked to higher mortality rates. The study analyzed 137 tumors and found that African-Americans had a higher frequency of this allele, which was associated with shorter survival rates.
African-Americans with Pro72 protein variant have double the risk of dying from advanced colon cancer compared to whites. The discovery sheds light on racial disparities in cancer and offers new insights into personalized cancer therapies.
The Cancer Genomics Browser is a web-based tool that enables researchers to find patterns in large-scale cancer studies, identifying genetic signatures for predicting therapy responses. By analyzing clinical and genomic data, researchers can gain insights into the complex genetic roots of cancer, leading to improved treatment outcomes.
A study exploring hospice availability in the US found that communities with higher proportions of wealthy and educated residents have greater availability. Hospices also struggle to deactivate implantable defibrillators for end-of-life patients, with few formal policies in place.
Men with high long chain omega-3 fatty acid intake had a reduced risk of aggressive prostate cancer by 63%, while those with low intake and the COX-2 variant saw a five-fold increased risk. Omega-3 fatty acids also appeared to counteract the increased risk associated with the COX-2 variant.
Researchers are developing biomarkers using molecular fingerprints to detect early signs of cancer, such as leukemia, bladder, kidney, and breast cancer. By identifying metabolites that indicate cancer presence and aggressiveness, doctors can tailor optimal treatment and monitor success.