Articles tagged with Cancer Treatments
The Mattel UCLA NanoPediatrics Program will explore the future of personalized medicine for children using nanotechnology. Researchers will develop new diagnostic tools and treatments to improve health outcomes for young patients.
A study published in Cancer Research found that nicotine can promote breast tumor growth and metastasis by binding to nicotinic receptors on mammary cells. The researchers also discovered that nicotine potentiates tumorigenesis when combined with other factors.
Long-term follow-up data from the APPROVe trial confirm that rofecoxib substantially increases the risk of stroke, heart attack, and death compared to placebo. The relative risk of reaching cardiovascular events was increased by 79% in the rofecoxib group.
Researchers at Florida State University discovered dramatic changes in DNA replication order during embryonic stem cell differentiation. The findings bridge a critical knowledge gap, enabling scientists to better understand the complex process of DNA reorganization during cell specialization.
A Mayo Clinic-led study finds that infliximab administered alone or in combination with azathioprine is more effective for moderate to severe Crohn's disease than azathioprine alone. The study demonstrates improved patient outcomes, including higher remission rates and mucosal healing.
The new guidelines provide a tiered system of resource allocation to implement early detection, diagnosis, and treatment programs. The initiative aims to improve breast health outcomes in low- and middle-income countries, where cancer mortality rates are highest.
Researchers found that endoscopic therapy was successful in treating esophageal cancer, with a 90% success rate and low recurrence rates. Patients treated endoscopically had higher survival rates compared to those who underwent surgery.
Research found that people with H. pylori strains carrying a gene called CagA were almost half as likely to get adenocarcinoma of the esophagus. The study suggests that declining rates of H. pylori in developed populations may contribute to the increase in esophageal adenocarcinomas.
Researchers at the MUHC categorized timeframes involved in getting pediatric oncology patients to initial therapy, finding that it takes approximately one month to get a diagnosis from a pediatric oncologist. The study also identified disparities in treatment times based on cancer type and patient age.
A new report card shows that the Midwest leads in palliative care access, while Southern and for-profit hospitals struggle. States like Vermont, Montana, and New Hampshire earned top grades for their palliative care programs, while Oklahoma, Alabama, and Mississippi received F's.
Researchers have identified five biomarkers in saliva that can confirm the presence of oral squamous cell carcinoma with 93% accuracy. The study, led by David T. Wong and Shen Hu, demonstrates a new approach for cancer biomarker discovery using saliva proteomics.
Scientists identified P-Cadherin as a key molecule in causing colon cancer, with abnormal expression leading to pre-cancerous growths in the bowel. Their findings hold promise for preventative therapies and lifestyle changes to prevent or treat the disease.
A large Danish observational study found that women taking hormone replacement therapy (HRT) who used it on a cyclical basis, through skin or vaginal application, had a reduced risk of heart attacks. This contradicts previous research and suggests that certain HRT regimens may be safer than others.
A new study published in the New England Journal of Medicine found that patients can still benefit from dissolving blood clots in the brain up to 4.5 hours after a stroke. The study, known as ECASS 3, involved 826 patients who received either the thrombolytic drug alteplase or a placebo, with better response rates and no increased mort...
Researchers found three subgroups of glioblastomas with varying degrees of methylation, leading to improved survival times in the subgroup with mixed levels. The study highlights the importance of methylation status in determining treatment outcomes and potential biomarkers for this disease.
Researchers found that undetectable EBV DNA levels during treatment significantly reduced cancer recurrence risk, while detectable levels increased the risk of recurrence and metastasis. The study suggests using biomarker tests before and during treatment to guide clinical therapy.
Researchers have identified TEM1 as a specific genetic marker for the vascular cells associated with tumor growth in ovarian cancer. High levels of TEM1 were correlated with decreased survival rates, making it a potential screening tool for early detection.
Researchers developed a 'suicide gene' delivery approach that successfully kills pancreatic cancer cells by over 95 percent, targeting only cancer cells with minimal harm to normal ones. This innovative strategy uses mesothelin DNA linked to diphtheria toxin, effectively hijacking cancer cell machinery.
A new instrument uses multispectral imaging to analyze multiple proteins in a single cancer sample, providing more information for therapy development and personalized treatment. The technology is fast, automated, and provides a quantitative read-out of protein expression levels.
The American Urological Association has released a best practice statement on cryosurgery, recommending it as an option for men with clinically organ-confined prostate cancer. The panel of experts emphasized the importance of case selection and recommended maximizing results through temperature monitoring and double freeze cycles.
A study published in the Archives of Internal Medicine found that physicians rarely responded empathically to patients' concerns about mortality, symptoms, or treatment options. The researchers identified 384 moments of
A study found that estrogen therapy reduced the risk of fractures after menopause, particularly in women aged 50-64 years. The use of post-menopausal hormone replacement therapy increased greatly during this period and was estimated to cause nearly half of the decline in fracture rates among women.
Researchers discovered a previously unknown link between two genes associated with aging and certain types of cancer. A low-calorie diet affects the activity of these genes in worms, slowing aging progression. The study's findings have implications for understanding metabolism, longevity, and disease in humans.
The Journal of Nuclear Medicine is now free and open to the public six months after publication, accelerating access to new research and advancing understanding of nuclear medicine and molecular imaging. This move reflects the journal's exceptional quality and influence as an academic and professional resource.
Researchers may develop new treatments for diseases like multiple sclerosis, rheumatoid arthritis, and sepsis by understanding the role of fibrin in blood coagulation. The NIH grant will support a four-year study to identify how cytokines regulate fibrin levels.
Researchers found that changes in physical health status during the first year after diagnosis can predict long-term survival. Patients who died within five years exhibited no recovery in their scores, while those who survived showed improvement at the one-year mark.
A new breast cancer vaccine has been tested in mice and shown to completely eliminate HER2-positive tumors, even those resistant to current therapy. The vaccine uses activated immunity to target the HER2 receptor, potentially eliminating the need for existing therapies.
Listeriosis is a serious foodborne illness that affects healthy individuals but is life-threatening for pregnant women, the elderly, and those with weakened immune systems. In Canada, recent outbreaks linked to deli meats and cheese have prompted guidelines for symptom management and risk reduction.
Scientists have identified a crucial molecular pathway linking cortisol to fatty liver accumulation, offering new insights into the development of metabolic diseases. The study reveals that blocking cortisol receptors in the liver activates HES1 protein, which counteracts fat accumulation.
Researchers at Mount Sinai Hospital have developed a new once-weekly treatment for type 2 diabetes that mimics the action of GLP-1, a naturally occurring hormone. The treatment showed significant improvements in glucose control and reduced side effects compared to twice-daily injections.
Researchers have identified African-Americans as having a greater risk of developing lung cancer from chronic obstructive pulmonary disease (COPD), with a more than sixfold increased risk. Hay fever was also found to be protective among African-Americans, reducing the risk by 44%.
A new study suggests that down-staging hepatocellular carcinoma can improve post-transplant outcomes for patients who undergo treatment. The research found that tumors with more favorable biology respond well to treatment and do well after liver transplantation.
A recent study found that positron emission tomography (PET) scans led to changes in treatment plans for more than half of patients with suspected recurrent colorectal cancer. The study, conducted at four sites in Australia, involved 191 patients and showed that PET scans identified additional disease sites in 48% of patients, allowing...
A study by Fox Chase Cancer Center found 27% of college students exhibit symptoms of tanning dependence, similar to substance addictions. Thinness and cigarette smoking are linked to higher rates of tanning dependence, suggesting potential avenues for prevention.
Researchers at the University of California and the University of Newcastle are sharing their work on telomerase, a protein that allows cancer cells to grow. The lecture aims to improve treatment outcomes for breast cancer through early detection and prevention.
Researchers discovered a link between atomic bomb exposure and adult-onset papillary thyroid cancer, with a higher risk among younger people. The study found that radiation dose, age at the time of bombing, and elapsed time since exposure were independently associated with the development of the disease.
The Endocrine Society has released a new clinical practice guideline for the detection, diagnosis, and treatment of primary aldosteronism. The guidelines recommend using the aldosterone-to-renin ratio to diagnose PA in higher-risk patients.
A study published in European Urology found that vardenafil, a PDE5 inhibitor, is more efficacious when used on-demand in men with erectile dysfunction following bilateral nerve-sparing radical prostatectomy. On-demand use of vardenafil was associated with significantly greater erectile function and sexual intercourse completion rates ...
A global survey found that people in high-income countries underestimate the risk of alcohol consumption, while those in low- and middle-income countries have more pessimistic beliefs about cancer treatment. The survey also reveals a preference for doctors to make treatment decisions in lower-income countries.
Concomitant zoledronic acid prevents bone loss and improves bone-mineral density in premenopausal women with breast cancer during adjuvant endocrine therapy. After treatment, zoledronic acid even increases bone-mineral density.
A large clinical trial found that B vitamin supplementation did not reduce death or cardiovascular events in patients with coronary artery disease. The study, which involved over 3,000 participants, also showed a numerically lower incidence of stroke but higher incidence of cancer in the groups receiving folic acid.
Researchers have developed a prototype test that can predict clinical outcome for melanoma patients, distinguishing between rapid and slow progression to Stage IV cancer. The test uses gene signature analysis and shows promise in identifying patient subtypes, which could improve treatment decisions and reduce clinical trial sizes.
The American Society of Hematology honors Clara D. Bloomfield, Kenneth Anderson, and Robert Kyle for their significant contributions to the understanding of hematologic diseases. Drs. Bloomfield and Anderson will be recognized for their work on acute myelogenous leukemia and multiple myeloma, respectively.
A randomized trial found that radical prostatectomy reduces prostate cancer death rates, with benefits lasting beyond 10 years. However, the applicability of these results to modern prostate cancer patients is unclear due to the widespread use of PSA screening.
Researchers at USC School of Dentistry have discovered a new pathway that contributes to palate formation, bypassing the TGF-ß signaling molecule. This finding has implications for understanding cleft palate, tooth development, and diseases like cancer.
Researchers at Washington University School of Medicine discovered a gene's effect on height that may change tumor disorder treatment for patients with neurofibromatosis type 1. The study found that the NF1 gene affects stature through a different pathway than previously focused on for cancer treatment.
Scientists discovered a new Prevotella species in the mouth, which could help understand oral diseases. The finding confirms that oral bacteria can invade tissues and individual cells, paving the way for new prevention measures and treatments.
A recent American Cancer Society study found that nearly half of cancer survivors used complementary methods such as prayer and meditation to cope with their condition. The study also revealed that women, younger survivors, and those with higher incomes were more likely to use these methods.
A new study published in Ophthalmology reveals that Asian men are at a higher risk of developing age-related macular degeneration (AMD) due to smoking. In contrast, high levels of outdoor activity in childhood may prevent or control myopia in children, according to researchers. These findings suggest that environmental factors play a s...
A multicenter U.S. registry study found that endoscopic circumferential ablation effectively cleared high-grade dysplasia in 90.2% of patients with Barrett's esophagus, offering a promising alternative to surgery and other therapies. The procedure also showed good safety profiles and comparable outcomes to PDT, EMR, and esophagectomy.
The W.M. Keck Foundation has announced its 2008 class of Distinguished Young Scholars in Medical Research, recognizing outstanding young scientists making significant contributions to biomedical research. The awardees will receive grants of up to $1 million to support their research activities for five years.
Researchers at Duke University Medical Center have identified 48 'poised gene cassette' genes that are tightly controlled in tumors, making them potential targets for cancer treatment. These genes showed subtle yet significant differences in expression between highly metastatic and non-metastatic cells.
The addition of hormone therapy following vaccine treatment improved overall survival in patients with castration-resistant prostate cancer. Vaccines can be safely and effectively combined with other therapies, including hormones.
A team of scientists has developed a system to detect potential 'biomarkers' of early forms of cancer by analyzing sugar molecules attached to proteins. The system aims to provide more accurate early diagnosis and monitoring of cancer progression.
A new study from the University of Michigan Comprehensive Cancer Center finds that more than three-quarters of bladder cancer patients are unaware of the link between smoking and bladder cancer. Quitting smoking can decrease the risk of developing bladder cancer by 40% within four years.
Researchers discovered young women's breast cancers share unique genomic traits, including activated gene sets that distinguish them from older woman's tumors. These findings may lead to the development of targeted therapies for younger patients.
Research published in BMC Health Services Research found that only a small minority of eligible elderly patients receive recommended treatments for obstructive respiratory diseases. The study revealed significant disparities in care, including low rates of bronchodilator inhaler use and lung function exams.
Researchers are developing new treatments targeting Crohn's disease by blocking autoimmune responses and strengthening the intestinal lining. The goal is to provide more effective options for patients who have lost response to current treatments.
Researchers found that ovarian cancer has a distinct scent different from other cancers, which can be detected by trained dogs. Early-stage and low-grade ovarian cancers emit the same scent as advanced tumors.
Researchers discovered how filopodia extensions are generated and integrated with lamellipodia/ruffles in human cancer cells. The study reveals a complex interplay between these actin-based structures, suggesting that suppression of filopodia is needed for efficient cell migration.