Research on new and better ways to treat cancer. Covers radiotherapy, targeted microdroplets, nerve-injury protection, drug combinations, and tumor models.
Scientists have discovered that Rho GDI1 plays a crucial role in balancing the levels of other Rho proteins, which are involved in cell migration, proliferation, and death. This finding may lead to new therapies targeting the balance of these proteins to prevent cancer.
Researchers have evaluated a blood test that identifies patients with low-grade, low-stage prostate cancer who are at risk of needing treatment. The study found that a biomarker called Prostate Health Index was significant in predicting unfavorable biopsy conversion.
A blood test and DNA analysis accurately predict which men with low-grade prostate cancers may need treatment, say Johns Hopkins scientists. The prostate health index and DNA content in biopsy tissue can detect the progression of small prostate cancers.
The study demonstrates a potential new treatment paradigm in oncology with improved overall survival rates for metastatic castration-resistant prostate cancer patients. The treatment, Sipuleucel-T, was shown to have well-balanced prognostic factors and mild adverse events.
Patient advocates and researchers at Vanderbilt Ingram Cancer Center presented an interactive game show on cancer research to increase awareness, particularly of clinical trials. The event resulted in a 20% increase in participants' knowledge and high engagement rates.
Research reveals higher breast cancer rates among Latinas due to early diagnosis and poorer outcomes. Studies also show significant disparities in healthcare access and knowledge about screening practices among Mexican and Latina women living in the US.
The EORTC 30904 study found that conservative surgery is not inferior to radical renal surgery or nephrectomy, with a slightly higher complication rate. Overall survival rates were shorter on the conservative arm for all randomized patients, but not different for RCC or clinically/pathologically eligible patients.
A new study found a link between chronic HBV and progression to cancers other than hepatocellular carcinoma, specifically Non-Hodgkin Lymphoma (NHL) and Cholangiocarcinoma. Higher levels of viral replication were associated with increased risk, indicating a potential causal effect.
A large patient cohort study found that genomic-based portraits can predict liver cancer recurrence. Two gene signatures were identified to identify patients with poor disease outcomes, enabling preventive therapies. The study also highlights potential therapeutic targets for adjuvant treatment following surgical intervention.
Researchers identified childhood cancer survivors at increased risk for deteriorating lung health due to bone marrow transplants. Long-term monitoring and early intervention, as well as educating high-risk patients on avoiding tobacco smoke and air pollution, are recommended to prevent respiratory problems.
Researchers discovered a network of genes responsible for initiating and managing primary cilia formation. The study may lead to new therapies for ciliopathies, a group of genetic diseases caused by defects in primary cilia function or structure.
New data presented at the American Academy of Neurology annual meeting showed that patients with moderate to severe RLS using rotigotine achieved sustained improvements in symptoms over 5 years. The study confirmed the safety and efficacy of rotigotine, with over a third of patients remaining symptom-free after 5 years.
A study published in The Lancet Oncology found that men with prostate cancer are at increased risk of potentially life-threatening blood clots. Patients receiving endocrine therapy had the highest risk, especially younger men and those with advanced disease.
Researchers at the University of Texas M. D. Anderson Cancer Center have developed a new way to predict prognosis in pediatric leukemia patients using a common complete blood count test. The study found that combining the minimal residual disease indicator and absolute lymphocyte count provides better results than MRD alone, identifyin...
Researchers at UEA have discovered a new group of molecules that can inhibit glycosyltransferases, enzymes used by cells to create sugar chains. This breakthrough could lead to significant advances in cancer treatment and therapy.
Sudden sensorineural hearing loss (SSNHL) affects one ear, often associated with tinnitus and vertigo. Short-course corticosteroids are recommended for patients with suspected SSNHL after ruling out life-threatening causes.
Researchers at Van Andel Research Institute have identified key proteins involved in the development of prostate cancer. Understanding their interaction could lead to more effective treatments by targeting this molecular link.
A new study published in the Journal of Thoracic Oncology found that sleeve lobectomy offers superior survival and better postoperative pulmonary function compared to pneumonectomy in selected patients. The study analyzed 210 lung cancer patients and reported lower mortality rates for those who underwent a sleeve lobectomy.
Researchers found that certain buckyball configurations, such as the tris configuration, caused premature senescence in human skin cells. This could lead to disease development if not properly understood. The study provides early foundations for worker protection and highlights the need for federal regulations on nanomaterial use.
Rylander aims to create a multi-component treatment planning computational model for nanoparticle-medicated laser therapy to achieve selective and effective cancer treatment. She will also develop a course on nanotherapeutics and establish an education and outreach plan for underprivileged schools.
A pilot study reveals that many children with cancer enrolled in clinical trials do not fully comprehend their treatment options or feel involved in decision-making. The study's findings underscore the importance of clearer communication between physicians and patients.
A recent meta-analysis of 14 trials found that pregnancy after breast cancer diagnosis reduces the risk of death by 42%. The study suggests that hormonal changes during pregnancy may have an inhibitory effect on breast cancer cells, and that foetal antigens may also play a role in reducing the risk of recurrence. The findings support t...
Researchers at EPFL discovered how tumors create a tolerant microenvironment by mimicking key features of lymph nodes. This allows tumors to avoid detection by the immune system, leading to cancer progression.
St. Jude Children's Research Hospital investigators have identified a protein that plays a pivotal role in protecting the intestinal tract from colitis. The Nlrp3 protein helps maintain healthy colon function by triggering production of epithelial cells to compensate for damage caused by colitis.
Disabling the Skp2 gene after oncogenic stress induces cellular senescence in cancer cells, restricting tumor growth. Researchers believe this could lead to novel agents that suppress tumor development in common types of cancer.
A study found that case management in the National Breast and Cervical Cancer Early Detection Program reduced delays in diagnosis among low-income women by 45% between 1998 and 2007. Free treatment also showed no significant impact on diagnostic or treatment delays.
Researchers at UAB found that Gardasil vaccine reduces the likelihood of HPV-related disease recurring after surgery by approximately 40 percent. This protection can provide crucial follow-up care and overall health planning for teens and women.
Researchers at the University of Leicester have made a new discovery about how the body fights certain types of cancer and autoimmune diseases. A newly discovered protein, HVCN1, regulates antibody production and can be targeted for therapies to treat conditions like lupus and rheumatoid arthritis.
Researchers have found that a seaweed extract has an inhibitory effect on the growth of non-Hodgkin's lymphoma cell lines. The extract also showed a significant pattern of activity in genes linked to apoptosis, or cell death, in lymphoma cells.
A recent study has found that breast cancer is affecting premenopausal women in Iraq, with a significant proportion presenting with advanced stage cancer. The study also highlights the importance of early detection and treatment, as only 32% of women detected a lump on self-examination sought medical advice within the first month.
Researchers have detected a novel oncolytic viral therapy against prostate cancer using the reovirus, showing safety and efficacy in early-stage patients. The study found that the virus induced cancer cell death without replicating in normal tissues, with minimal toxicity reported.
A new study finds that cancer death rates have decreased significantly since the initiation of the 'war on cancer', resulting in a decline of 21% in men and 12% in women. For individuals under 75, this drop translates to approximately 2 million years of potential life gained.
Researchers identified IFN-beta as a natural inhibitor of tumor blood vessel growth, limiting tumor growth and immune cell gene expression. This discovery provides insight into why IFN therapy benefits early cancer development.
A study published in Cell reveals that loss of the molecule miR-328 is essential for progression from chronic to blast crisis phase in chronic myeloid leukemia. Maintaining this microRNA level may represent a new treatment strategy for CML blast crisis patients.
Researchers found that lung cancer patients with optimistic attitudes had a six-month survival advantage over those with pessimistic attitudes. This study builds on existing research to investigate the effect of patient attitudes on outcomes in oncology populations.
A new evaluation tool helps clinicians decide whether to surgically remove or monitor asymptomatic pancreatic cysts. The tool considers overall health, age, cyst size, surgical risk, and patients' quality of life preferences.
Researchers found that bitter melon extract significantly decreased proliferation and induced death in breast cancer cells. The study suggests that this extract may become a chemopreventive agent against breast cancer, but additional studies are needed to confirm its efficacy.
Researchers have identified five SIBLING proteins that can predict oral cancer development in premalignant lesions. The study found that certain SIBLINGs, such as dentin sialophosphoprotein, increase the risk of oral cancer fourfold, while others, like bone sialoprotein, significantly decrease it.
A new study published in The Journal of Urology found that open radical prostatectomy (ORP) and laparoscopic radical prostatectomy (LRP) have similar rates of postoperative mortality and morbidity. LRP was associated with shorter hospital stays and a lower risk of bladder neck or urethral obstruction.
A new survey finds that African Americans are more likely to hold misconceptions about lung cancer, which could interfere with prevention and treatment. The study suggests that tailored public health messages are needed to address these disparities.
Researchers have identified a potential therapeutic target for brain cancer, the A20 protein, which is highly expressed in glioblastoma stem cells. Decreasing levels of A20 in these cells reduces their growth and induces cell death, increasing survival rates in animal models.
Researchers found that African-Americans are more likely to hold fatalistic beliefs and be reluctant to seek medical attention for lung cancer symptoms. The study suggests that targeted public health messages are needed to address racial disparities in lung cancer treatment outcomes.
The American Lymphedema Framework Project establishes a standard of care for breast cancer survivors with lymphedema, providing evidence-based treatment guidelines. Complete decongestive physiotherapy and compression garments are found to be effective methods in reducing swelling.
A new study suggests that clinically-based smoking cessation programs may not be enough to help Latino smokers with asthmatic children kick the habit. Researchers found that a culturally-tailored intervention providing feedback on secondhand smoke exposure was more effective in helping these parents quit smoking.
A software program created by Andrew Cohen analyzes time-lapse images to identify changes in cell behaviors, predicting the types of specialized cells a stem cell will produce. The software is 87% accurate in determining specific 'offspring' a stem cell will ultimately produce, and 99% accurate in predicting when self-renewal will end ...
Researchers have identified NT-3 and its binding molecule TrkC as potential therapeutic targets for treating neuroblastoma. The study found that blocking the interaction between NT-3 and TrkC inhibited tumor growth and metastasis in animal models.
Researchers report on effective treatments targeting racial and ethnic minorities, psychiatric disorders, and families with asthma. Cognitive-behavioral therapy significantly increased quit rates among African-American smokers, while family-focused approaches showed promising results for Latino families.
A Michigan State University researcher is creating a support intervention to help women in treatment for breast cancer identify effective alternative therapies. The study found that 57% of women use complementary and alternative medicines, and those who are sicker are more likely to use multiple therapies.
Researchers enhanced a type of cellular senescence to suppress prostate tumor development and growth in mice. This novel approach uses Pten-loss-induced cellular senescence to prevent cancer progression.
High-coverage HPV vaccination among adolescents and young women has been shown to rapidly reduce the risk of genital warts, cervical cell abnormalities, and diagnostic procedures. The study found significant reductions in risk across all HPV types, paving the way for a notable decrease in cancer rates.
Queen's University researchers discovered a low-dose nitroglycerin treatment may slow and halt prostate cancer disease progression without severe side effects. The study, which targeted 29 men with increasing PSA levels following surgery or radiation, showed significant slowing in disease progression in all but one patient.
Researchers at Georgia Tech have developed a potential new treatment against ovarian cancer using magnetic nanoparticles to attach to and remove cancer cells from the body. The technique has shown promising results in both mouse and human cancer samples.
Researchers at the University of Notre Dame describe a significant advance in imaging cell death using synthetic probes. The new method can distinguish between healthy and dying cells in tumors, potentially aiding in tumor grading and treatment effectiveness measurement.
A team of University of Chicago scientists has developed a new micro-western array technology that enables the examination of hundreds of proteins simultaneously. This breakthrough may lead to more precise diagnoses and individualized treatments for cancers and other diseases.
A new study reveals that genital herpes virus type 2 (HSV-2) frequently reactsivate in the entire genital tract, rather than just one specific area. This finding has important implications for treatment and prevention strategies, suggesting a need for comprehensive approaches to suppress and limit transmission.
The American Association for Cancer Research and International Association for the Study of Lung Cancer honored Dr. Paul A. Bunn Jr., M.D., for his contributions to lung cancer research. The conference emphasized the importance of translational research in improving lung cancer prognosis.
A review of DCIS research highlights the need for accurate identification of patient subsets and modification of treatment guidelines to focus on high-risk lesions. Researchers also emphasize the importance of biomarkers in determining risk status, allowing for targeted aggressive treatment.
A 93-gene signature associated with EGFR mutations in tumors from lung cancer patients was found to be a favorable prognostic marker for early stage lung cancer. The signature is also linked to drug sensitivity to erlotinib and gefitinib in non-small cell lung cancer cell lines.
A study found that drinking green tea could reduce the risk of lung cancer in smokers, particularly those with specific genetic profiles. Among smokers, those who drank at least one cup of green tea per day had a significantly lower risk of lung cancer compared to non-green tea drinkers.
A paracrine pathway involving glial cell-derived neurotrophic factor (GDNF) regulates the migration of pancreatic cancer cells along nerves. The pathway plays a crucial role in preventing nerve invasion and has potential as an adjuvant therapy for pancreatic cancer.