Research on new and better ways to treat cancer. Covers radiotherapy, targeted microdroplets, nerve-injury protection, drug combinations, and tumor models.
The Louisiana Tumor Registry has been designated as a SEER Program cancer registry, providing high-quality cancer incidence and survival data. The registry's data is used to inform prevention, early detection, treatment, and survival strategies.
A study by FDA researchers found a higher incidence of malignancy in children using TNF blockers like infliximab and etanercept. The reporting rate for U.S. cases of malignancy in children was 4-18 times the estimated background rate for the general pediatric population.
Researchers found that African women are more likely to develop triple-negative breast cancer, a condition characterized by the absence of estrogen and progesterone receptors. The study suggests that African ancestry may be associated with a higher risk of hereditary predisposition for breast cancer related to BRCA1 gene mutations.
Two studies examine the effects of oral steroids and propranolol on infantile hemangiomas, revealing potential side effects and complications. Researchers aim to develop safer treatment options for this common childhood skin disorder.
Researchers at the University of Edinburgh have developed a method to alter viral conditions, reducing mutation and building resistance. This approach can target multiple viruses simultaneously and is being explored for use in treating influenza.
Scientists discovered that inhibiting a protein called N-cadherin prevents cancer cells from forming groups and migrating. This new approach could lead to more effective therapies for cancer treatment.
Researchers discover unique combinations of cells and mutations that drive the formation of different cancer subtypes, revealing a potential breakthrough in understanding and treating ependymomas. The study also identifies the first gene linked to ependymoma and creates an accurate laboratory model of this disease.
A new study finds that many US states are cutting mental health funding due to budget crises, while others have reduced Medicaid payments. However, a few countries are investing in stimulus-funded services to address recession-related mental health disorders, such as the UK's training of psychotherapists and nurses.
A Michigan State University researcher is using $1.7 million in federal funding to study the role of microRNAs in regulating genes that control cell behavior. The goal is to determine how arsenic exposure leads to tumor development and identify potential treatments.
A new treatment strategy using rituximab has shown comparable benefits to the current standard of care in reducing disease activity and inducing remission for patients with ANCA-associated vasculitis. Early results also suggest improved outcomes for patients with relapsing disease, making this a major treatment advance.
Researchers discover Lgl and Mahjong proteins help identify how healthy cells fight cancer cells. Normal cells surround cancer cells, leading to their death, while cancerous cells break free and divide.
The new guidelines update Osteoporosis Canada's recommendations on vitamin D intake for Canadians, citing the need for more research into optimal doses and safe upper limits. The recommended daily supplements range from 400-1000 IU for adults under 50, with higher doses required for those over 50.
Gene therapy holds promise in treating prostate cancer, but challenges remain in achieving effective treatment. Researchers call for better testing systems and innovative approaches to advance the field. Prostate cancer is a leading cause of cancer death among men in the US.
Researchers found a compound called P7C3 that improves newborn neuron survival and reduces programmed cell death in the brain's memory hub. This discovery offers new hope for treating Alzheimer's disease by targeting the underlying neuroprotective mechanism.
The foundation named 18 new Damon Runyon Fellows for their innovative cancer research, including studies on gene regulation, immune response, and tumor development. The recipients will receive $156,000 each to pursue novel ideas.
The Hebrew University of Jerusalem has been selected to participate in the CREATE program, focusing on cellular and molecular mechanisms of inflammation. The research aims to develop diagnostic/prognostic indicators and novel therapeutics for inflammatory diseases.
Liver transplant patients receiving cyclosporine for immunosuppression are at higher risk of developing de novo cancer, particularly those transplanted in recent years and younger than 50. The study found a significant association between C2 monitoring and increased early de novo cancer risk.
A new study has identified a key role for adrenal glucocorticoids in resetting the internal body clock, a finding that could lead to new treatments for jet lag. The research also highlights the importance of timing and location in regulating circadian rhythms.
African-American women have more advanced breast cancer at diagnosis and poorer survival outcomes compared to non-Hispanic whites. Despite similar surgical care and adjuvant therapy, African-Americans experience lower overall and breast cancer-specific survival rates due to socio-demographic factors.
Research suggests that biologics-naïve Juvenile Idiopathic Arthritis (JIA) patients may have an elevated risk of cancer compared to the general population. The Swedish study found a higher incidence of cancers among paediatric JIA patients identified during the last 40 years.
A recent study found that patients with early-stage lung cancer often forego surgery due to misconceptions about prognosis, communication with doctors, and personal life after treatment. The research also highlights racial disparities in surgical rates among black patients compared to their white counterparts.
Researchers analyzed surgical outcomes of non-small cell lung cancer patients over 30 years, finding improved survival rates with earlier stage diagnoses. The increase in patients diagnosed with early-stage adenocarcinoma is thought to contribute significantly to the favorable results.
A new study reveals that disparities in cancer stage and treatment account for the majority of excess deaths among uninsured and Medicaid-insured rectal cancer patients. Improving insurance coverage and reducing cost-related barriers to primary care and high-quality treatment can help mitigate these disparities.
A new gene on chromosome 13 has been identified as a potential cause of bowel cancer spread and progression. The discovery is based on a large family study that analyzed the genetic profiles of 81 family members over five generations.
A study published in Cancer Research found that high calcium intake, even from non-dairy sources such as soy and green vegetables, may increase prostate cancer risk in Chinese men. The research, which analyzed data from over 27,000 men, showed a 25% increased risk of prostate cancer among those consuming higher amounts of calcium.
Only 5% of cancer research funds are spent on investigating metastases, yet it kills 90% of all cancer patients. The European CanCer Organisation highlights this discrepancy in funding and calls for increased emphasis on tackling metastases.
Researchers found that Wikipedia's cancer information is accurate but poorly readable compared to peer-reviewed sites like the National Cancer Institute's PDQ. Readability was highly statistically significant, with Wikipedia written at a college level while PDQ was suitable for a 9th grader.
Researchers present studies demonstrating progress in using the R.E.N.A.L. Nephrometry Scoring system to standardize surgical decision-making and improve patient outcomes for patients with kidney cancers. The system captures anatomical features of renal masses, allowing for more accurate evaluation of treatment strategies.
Researchers from the University of Navarra have identified a link between specific gene mutations and more severe forms of leukemia. The study analyzed patients from 19 hospitals across Europe, confirming that these genetic alterations can be used to monitor disease progression and identify potential therapeutic targets.
Research reveals that group visits can significantly improve blood pressure in diabetics with hypertension but not blood sugar levels. Colorectal cancer risk increases with age and birth cohort, suggesting a potential burden to society. Opioid treatment agreements may not reduce misuse, and a new complication from contaminated cocaine ...
Researchers found that pancreatic cancer patients with circulating tumor cells tend to have worse outcomes, and some types of cells may predict poorer survival. The presence of MUC1 protein-expressing circulating tumor cells is particularly associated with shorter overall survival.
A recent study found that antiretroviral treatment (ART) significantly reduces the risk of HIV transmission in heterosexual couples, with a 92% lower rate of transmission among those on ART compared to those not on treatment. The greatest benefit was seen in individuals with CD4 counts below 200 cells per μL.
A study found that patients taking bisphosphonates are often uninformed about the drug's possible side effects on oral health, including bisphosphonate-associated osteonecrosis of the jaw (BON). The researchers interviewed 73 participants and discovered that 82% were unsure if their physicians had informed them about potential adverse ...
Two teams of researchers identified biomarkers that predict excellent graft function in kidney transplant recipients who stop taking immunosuppressive drugs. A molecular signature indicative of future organ failure was also found. The signatures may help physicians design personalized treatment regimens for kidney transplant recipients.
Researchers examined the impact of uninterrupted clopidogrel on postpolypectomy bleeding rates and found a significant increase in risk when used with aspirin/nonsteroidal anti-inflammatory drugs, but the overall outcome is favorable and the risk is small.
A recent study by S. Eggener et al. discusses the significance and impact of focal therapy for low-risk prostate cancer patients, highlighting its potential as an alternative to whole-gland treatment. The study reviews patient selection criteria, diagnostic imaging, biopsy schemes, and treatment modalities available for focal therapy.
A recent study found that most patients with localized papillary thyroid cancer can expect favorable outcomes without treatment. The 20-year survival rate for these patients is estimated to be around 97%, similar to those who received treatment. Clinicians and patients can feel comfortable considering observation as an option.
Researchers have identified a previously undiagnosed condition and treated it with a stem cell transplant, saving the patient's life. The key to unlocking the reason for the patient's symptoms was contracting a rare version of glandular fever.
T-ALL is caused by interplay of various factors including genetic errors that disrupt white blood cell formation. The study identifies PTPN2 as a tumor suppressor gene lost in leukemia patients, contributing to cancerous cell proliferation.
Researchers found that females receiving CRT-D therapy had a 70% reduction in heart failure progression and a 72% reduction in death from any cause. Men received some benefit, but not the out-of-the-park results seen in women.
Melanoma cells can self-renew and induce new tumors, defying the traditional cancer stem cell model. Targeting both bulk tumor cells and slow-growing JARID1B-positive subpopulations is proposed as a dual therapy to combat therapy resistance.
A study in fruit flies reveals a molecular pathway involved in dietary choices, which has implications for humans sharing the same pathway. The research opens doors to developing treatments for metabolic disorders by addressing nutritional imbalances.
The cost of cancer treatment in the US has nearly doubled over the past two decades, with private insurance and Medicaid bearing a growing burden. Inpatient hospital admissions account for a smaller share of costs, while outpatient expenditures increase.
Elderly patients with localized kidney cancer may benefit from conservative care, such as observation or treatments that spare the noncancerous parts of their kidneys. The study found no significant difference in survival rates between those who had their entire kidney removed and those who received active monitoring.
Special issue of Journal of the American College of Cardiology explores controversy surrounding cardiac imaging tests. Experts call for balance between risks and benefits, emphasizing that these tests should only be used when clinical benefit exceeds potential harm.
Research finds common intestinal bacteria promote tumor growth in genetically susceptible mice, but an inhibiting protein enzyme suppresses growth, increasing survival time. The study's findings could lead to a new form of treatment for familial adenomatous polyposis, a genetic condition that increases the risk of colon cancer.
A recent study published in the journal Surgery found that mechanical bowel preparations (MBPs) do not reduce perioperative infectious complications in patients undergoing pancreaticoduodenectomy. The researchers analyzed data from over 200 patients and concluded that MBPs have no clinical benefit for this procedure.
Researchers developed a simple genetic test using three genes to classify breast cancer into sub-types, highlighting the importance of molecular classification in treatment outcomes. The study's findings suggest that these models are robust and can aid clinicians in making therapeutic decisions.
Scientists developed a multistage nanovector system to deliver siRNA, significantly lengthening the therapeutic effects of treatment in mouse models of ovarian cancer. The system provides sustained delivery of siRNA for up to three weeks, targeting the EphA2 oncoprotein.
Researchers have made significant advancements in diagnosing and treating Barrett's esophagus and inflammatory bowel disease. A new study found that endoscopic radiofrequency ablation can effectively eliminate the condition in most instances, with five-year durability outcomes showing 46 of 50 patients remained free of disease.
A new national survey found that public support for nanotechnology increases when informed of its risks alongside benefits. However, discussing risks decreased support among those who had never heard of nanotechnology before the survey.
Researchers found that pre-treatment quality-of-life scores can predict malignancy in patients with pancreatic lesions and survival in those who have cancer. Patients with lower quality-of-life scores were more likely to have poor survival rates.
A new study published in the Journal of the American College of Surgeons found that more than 90% of breast cancer patients had their expectations met or exceeded with regard to dates of service. The study highlights the importance of balancing timeliness with safety, effectiveness and equity in patient satisfaction.
A study suggests that preoperative breast MRI can reduce local breast cancer recurrences at follow-up, particularly in young patients with dense breast tissue. The study found that patients who received a contrast-enhanced MRI prior to surgery had significantly fewer local recurrence cases.
The National Cancer Institute Alliance for Nanotechnology in Cancer is making significant progress, promising earlier disease diagnosis, targeted treatments, and improved survival rates.
A recent review found that approximately 25% of breast cancers and 60% of prostate cancers detected by screening tests may not be destined to cause symptoms or death due to overdiagnosis. This phenomenon leads to unnecessary treatment and other harms, emphasizing the need for strategies to address it.
Research found a strong correlation between heavy alcohol use and shortened telomeres, increasing cancer risk. Telomere length was nearly half as long in heavy drinkers compared to non-abusers.
Researchers found elevated EGFR levels in blood of women with breast cancer 17 months prior to diagnosis, increasing risk by 2.9-fold. This marker shows promise as an early detection biomarker for breast cancer.
A systematic review of 111 studies involving 4,394 patients found that a third could undergo resection after neoadjuvant therapy, with similar survival rates to those judged resectable before treatment. The study suggests including locally advanced/unresectable tumors in neoadjuvant protocols.
Researchers at Fox Chase Cancer Center have identified NEDD9 as a key molecular player in the formation of HER2-driven breast tumors. The study shows that mice with the Nedd9 gene are more likely to develop tumors over an 18-month period, highlighting the protein's potential as a biomarker.