Research on new and better ways to treat cancer. Covers radiotherapy, targeted microdroplets, nerve-injury protection, drug combinations, and tumor models.
A new study links an oncometabolite to widespread gene expression alterations in brain cancer and leukemia, promoting tumorigenesis. The research suggests that targeting the metabolic pathway may guide the development of new cancer therapies.
Researchers at the Trudeau Institute and St. Jude Children's Research Hospital are studying white blood cell migration in response to viral infections, which could lead to improved vaccine strategies. The study has major implications for developing vaccines that promote immunity to respiratory infections.
The TEAM study found that sequential treatment of tamoxifen followed by exemestane yields a comparable disease-free survival rate to exemestane alone, yet with distinct side effect profiles. This implies the need to tailor treatment regimens for specific patient groups.
Ryan Salinas, a 2nd-year medical student at UCSF, received the Lucien Rubenstein Award for his outstanding research on histone demathylase JMJD3 as a potential treatment target for glioblastoma. The American Brain Tumor Association selected Salinas from a group of 10 Medical Student Summer Fellows.
A new NIH study projects that cancer costs will increase to at least $158 billion in 2020 due to the growing US population and cancer trends. The projected costs are based on an aging population and the introduction of new, expensive cancer treatments.
Researchers found that 5a-reductase inhibitors, used to treat BPH and hair loss, can cause significant adverse effects in some individuals, including loss of libido, erectile dysfunction, and depression. The study suggests that caution should be exercised before prescribing these medications to patients.
A study found that a behavioral training program significantly reduced incontinence episodes in men with persisting symptoms after radical prostatectomy. The program included pelvic floor muscle training, bladder control strategies, and fluid management, yielding a 55% reduction in incontinence episodes at 8 weeks.
Researchers have discovered the molecular mechanism of measles virus infection, which could lead to a targeted cancer therapy. The study found that modifying the attachment protein is crucial for infectivity, and this discovery brings the dream of using measles virus as a cancer weapon closer to reality.
Researchers at UCLA found that the Nrf2 protein, thought to protect against oxidative stress, actually promotes atherosclerosis by raising plasma cholesterol levels and increasing plaque formation in arteries. The study suggests that antioxidant therapies targeting this protein may not be as effective due to these additional mechanisms.
The Damon Runyon Cancer Research Foundation has awarded grants totaling $1.9M to 12 early-career researchers conducting innovative cancer research. The fellowships provide independent funding to support novel projects and enable recipients to pursue careers in cancer research.
Scientists have identified a protein biomarker that predicts the efficacy of hepatitis C treatment, enabling improved patient management. The discovery of IP-10 as a prognostic biomarker could lead to the development of a diagnostic test to distinguish between effective and ineffective treatments.
A recent study published in PLoS ONE found that Longevinex exerts a greater influence on genes than resveratrol, leading to improved heart health outcomes. The research demonstrated that Longevinex reduced the size of heart attacks and protected against cell death, while also improving microRNA activity.
Researchers found that arsenic trioxide inhibits the growth of medulloblastoma and Ewing sarcoma cell lines by blocking the Hedgehog/GLI1 signaling pathway. The compound improved survival in a mouse model of medulloblastoma, suggesting its potential as a therapeutic option.
A new study suggests that the presence of tumor cells in the circulating blood of patients with squamous cell cancer of the head and neck may predict disease recurrence and reduced survival. The study found a correlation between an increasing number of circulating tumor cells (CTCs) and a worse outcome.
Patients with oral squamous cell carcinoma who experience early or lymph node recurrence after initial treatment tend to have poorer outcomes. The study suggests that local recurrences within six months are associated with worse survival rates, while regional recurrences at longer intervals also negatively impact survival.
A new study found that black patients with early-stage liver cancer have a higher mortality rate than white patients, with median survival times ranging from 8-10 months. The disparity in treatment access also affects the survival rates of Hispanic and black patients compared to white patients.
A new study by Stanford University School of Medicine researchers found that expanded HIV screening and treatment could prevent up to 212,000 new infections over the next 20 years. The strategy of one-time screening for low-risk individuals and annual screening for high-risk individuals is cost-effective.
A recent study found racial disparities in liver cancer survival rates, with black patients experiencing higher mortality rates compared to white and Hispanic patients. Despite receiving similar treatments, black patients had a 12% increased rate of death, indicating poor access to care and subpar treatment outcomes.
Researchers at UAB found that robotic surgery for upper airway and digestive track malignant tumors is as effective as standard minimally invasive techniques, with a two-year survival rate of 86.3%. The study also showed improved swallowing function in patients.
The Elsevier Foundation has awarded grants to institutions in Africa and Asia for projects focusing on telemedicine, infrastructure-building, and the preservation of primary source content. The grants aim to improve access to health information and support global health development.
Researchers have discovered a protein that can prevent chronic tissue inflammation and boost the immune system. The therapeutic vaccine has been shown to effectively treat conditions like multiple sclerosis and rheumatoid arthritis.
Researchers found that ovarian cancer screening can only slightly reduce mortality rates, highlighting the need for prevention and better treatments. For high-risk women, targeted screening may offer more hope in reducing deaths from ovarian cancer.
Mr Davis McCarthy has won a $150,000 scholarship to undertake a PhD at UC Berkeley, focusing on developing statistical analysis techniques to help biologists understand the mechanisms of diseases such as cancer and diabetes. He aims to make significant scientific contributions internationally.
Scientists at King's College London have made a critical discovery about the role of beta-catenin in leukemia stem cells. By suppressing this protein, they were able to reverse leukaemic stem cells to a pre-leukaemic stage and 're-sensitize' resistant cells to treatment.
Incorporating ovarian cancer subtypes into screening models reduces predicted mortality rates. However, catching slower-growing cancers won't significantly impact deaths compared to more lethal tumors.
A study published in Neurology found that nearly 40% of brain tumor patients use alternative therapies, including homeopathic remedies and vitamin supplements. Younger people, women, and those with more education were more likely to use these treatments, which they often sought to add benefits to conventional care.
A study found that combining epigenetic therapy and molecular targeted therapy can improve outcomes for patients with elevated E-cadherin levels in advanced lung cancer. The treatment achieved significantly improved overall survival rates compared to erlotinib alone.
A La Jolla Institute team has validated a computer model's ability to predict key information on nasal insulin treatment regimens in type 1 diabetes. The platform accurately predicted biomarker onset and therapeutic outcome, confirming its potential as a valuable research tool.
A groundbreaking clinical trial is examining the safety of hypothermia in elderly stroke patients, aiming to improve outcomes and prevent neurological damage. The study, led by top researchers, will enroll 400 patients at multiple US and European sites and investigate the effectiveness of therapeutic brain cooling.
Researchers at Mayo Clinic found that JAK inhibitors CYT387 and TG101348 effectively reduce spleen size and alleviate constitutional symptoms in myelofibrosis patients. These targeted treatments have shown significant clinical benefits, including improved anemia rates and reduced white blood cell counts.
Researchers found that apixaban was more effective than enoxaparin in preventing major venous thromboembolism without increasing bleeding risk. This innovative treatment has improved methods for patients undergoing hip or knee replacement surgery, and may also be beneficial for cancer patients with VTE.
A study found that decreased physician reimbursement for hormone therapy reduced its use in low-risk prostate cancer cases by 40%. However, AST usage remained unchanged in patients with metastatic disease. The decrease is attributed to the real effect of reimbursement change.
A study presented at the Radiological Society of North America annual meeting found that diagnosis uncertainty can be as stressful as knowing a serious illness, with breast biopsy patients reporting significantly higher anxiety levels. Healthcare providers can alleviate patient stress by improving communication and shaping expectations.
A new study finds that a less invasive method for determining lung cancer stage improves detection of metastases and reduces surgical procedures. The method, which combines endosonography and ultrasound, was more effective than traditional surgical staging in identifying patients who needed further treatment.
A study published in Cancer Research reveals that microRNA-375 plays a crucial role in breast cancer cells, leading to increased estrogen receptor alpha levels. Blocking this microRNA effectively slows down cancer cell growth, offering potential new strategies for treatment.
During pregnancy, pregnant women can experience significant changes in their oral health, including gingivitis, pregnancy tumors, and mild to severe gingival enlargement. Regular dental check-ups and proper oral hygiene can help alleviate gum inflammation and prevent worsening of conditions.
A Johns Hopkins study found that delayed HIV treatment adds tens of thousands of dollars in care costs and reduces survival rates. Patients who wait too long to receive treatment require more expensive antiretroviral therapy, antibiotics, and hospitalizations.
High-throughput DNA sequencing of gut bacteria confirmed that antibiotic treatment disrupts bacterial patterns, which precedes VRE colonization and bloodstream invasion. Monitoring fecal bacteria content could identify patients at high risk of life-threatening infections.
The 2010 Golf Atlanta charity golf tournament raised $105,000 to support investigations into pancreatic cancer at The Translational Genomics Research Institute. The event drew 124 players and included a high-end auction with donations supporting TGen's life-changing research.
Geraldine Dawson, Ph.D., has been recognized as a "Rock Star of Science" for her extensive contributions to autism research and advocacy. Her work aims to discover the causes and effective treatments for autism, with a focus on improving lives for individuals with autism and their families.
A study found that targeting HDMX overcomes p53 suppression and resistance to selective HDM2 inhibition, restoring tumor suppressor pathway in cancers expressing both proteins. The research enables new therapeutic strategies for human cancer, including those resistant to current treatments.
A new indicator, TLR9 receptor, has been found to mark rapidly progressing idiopathic pulmonary fibrosis, potentially leading to new treatments. Researchers identified the receptor in patients' lungs and showed its role in fibrotic tissue growth using human cells and mice.
A study published in JNCI Journal of the National Cancer Institute found that men taking androgen deprivation therapy for prostate cancer have a 30-40% increased risk of colorectal cancer. The longer treatment duration, the greater the risk.
A new study shows that bihemispheric transcranial direct current stimulation (tDCS) coupled with physical and occupational therapy significantly improves motor function in stroke patients. The therapy rebalances brain activity on both sides of the brain, enhancing recovery.
Despite strong evidence of its effectiveness, only one-third of eligible young women complete the recommended three-dose regimen for the human papillomavirus (HPV) vaccine. Persistent infection with certain HPV types may lead to cervical cancer.
A study found that physical activity reduces the risk of endometrial cancer, even among overweight women. Women exercising for 150 minutes per week had a 34% lower risk compared to inactive counterparts.
A study analyzing European Prospective Investigation into Cancer and Nutrition data found that current hormone therapy use increases the risk of ovarian cancer by 29%. The risk did not differ by type or duration of hormone therapy, suggesting a potential long-term hazard.
Neonatal mice separated from their mothers for a prolonged period developed mammary tumors twice as fast as those with short or no maternal separation. Estrogen receptor alpha levels were also significantly higher in mice exposed to prolonged separation, increasing breast cancer risk.
A large prospective cohort study found that smoking significantly increased the risk of breast cancer progression and overall death among multiethnic women. Current or past smokers had a 39% higher rate of dying from breast cancer.
A study by LSU Health Sciences Center researchers found that Docosahexaenoic acid (DHA), a fish oil component, can protect brain tissue and promote recovery in acute ischemic stroke even when treatment is delayed. DHA treatment reduced swelling and facilitated neurobehavioral recovery.
A study found that high soy isoflavone intake was associated with a 30% decreased risk of invasive breast tumors and a 60% decreased risk of grade 1 tumors. In premenopausal women, the highest isoflavone intake reduced the risk of stage I disease, tumor size, and stage 2 breast cancer by significant margins.
Researchers found distinct DNA alterations in lung tumors from smokers and never-smokers, suggesting two possible disease pathways. The study suggests that lung cancers in never-smokers require further investigation to improve detection and treatment strategies.
Weill Cornell Medical College researchers discovered secondary mutations in prostate cancer cells that make them lethal. This finding could lead to better tests and individualized therapy for deadly prostate cancers.
Researchers found that narciclasine, a natural compound in daffodil bulbs, markedly reduces cancer cell proliferation and migration. The study suggests that narciclasine selectively inhibits the growth of very aggressive cancer cells while avoiding adverse effects on normal cells.
Recent studies have identified 20 genes associated with multiple sclerosis susceptibility, paving the way for more accurate understanding of the disease. New therapies targeting neuroinflammation and regenerative stem cells hold promise for controlling the disease, mirroring progress made in AIDS treatment.
The VCU Massey Cancer Center has received a $2.4 million grant from the Virginia Tobacco Commission to expand its community outreach programs and grow its clinical research capabilities. This funding will support the extension of cancer prevention and control initiatives into tobacco counties in Southside and Southwest Virginia.
Researchers found a microRNA binding variant linked to improved survival rates in early-stage colorectal cancer patients, particularly those with KRAS mutations. The variant, previously associated with poor outcomes, was unexpectedly beneficial due to an unidentified compensatory pathway controlling the gene.
Demetrius H. Bagley, M.D., a renowned urologist and researcher at Thomas Jefferson University, has received the Karl Storz Lifetime Achievement Award in Endourology for his pioneering work in ureteroscopic management of upper tract pathology.
Groopman's research identified the link between environmental carcinogens and liver cancer, providing new prospects for prevention in high-risk populations worldwide. His work elucidated the role of aflatoxins in inducing hepatocellular carcinoma, a major cause of mortality in developing countries.
Researchers at IRIC discovered a protein complex, EJC, that controls the production of MAPK protein, which acts directly on cells. Targeting this complex could prevent abnormal signal transmission that triggers several cancers.