Articles tagged with Cancer Treatments
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A panel of MS experts provides comprehensive recommendations for selecting and managing patients with MS receiving TYSABRI. The guidelines emphasize the need to weigh treatment benefits against potential risks, including PML and serious adverse events.
Research suggests that only half of Americans with hepatitis C virus infection are aware of their diagnosis, leading to a decline in antiviral therapy treatment rates. By 2030, less than 15% of liver-related deaths from HCV will be prevented by antiviral therapy if the trend continues.
Johns Hopkins researchers found that a protein called vascular endothelial growth factor (VEGF) is responsible for the cell overgrowth in chronic rhinosinusitis with polyps. This discovery gives scientists a new target for treating this form of the disease, which typically resists current treatments.
Research highlights vitamin D's critical role in immune function, inflammation, and heart health, with evidence suggesting it may boost innate immunity and prevent infections. Vitamin D deficiency is a widespread problem worldwide, affecting nearly one billion people, and experts are considering increasing recommended daily intake.
Pediatric immunologist Dr. Jordan Orange received the American Philosophical Society's Judson Daland Prize for his contributions to researching and treating inherited immune deficiency diseases. His work focuses on natural killer cells, which have an inherent ability to destroy cancer or virus-infected cells.
A new study published in the Journal of the National Cancer Institute found that patient-reported symptoms were more highly associated with day-to-day health status, while clinician reports were more predictive of death and hospitalization. The study suggests that both perspectives are valuable for a comprehensive understanding of trea...
Daily text-message reminders significantly increased sunscreen application among participants over a six-week period. The study found that adherence rates were 56.1% with daily reminders compared to 30% without reminders.
A new study from the University of Minnesota shows that patients with acute leukemia who receive two units of umbilical cord blood have a significantly lower likelihood of leukemia recurrence compared to those receiving one unit. The finding has the potential to change current medical practice and give hope to more leukemia patients.
Researchers found that nutlin-3 activates the p53 pathway and suppresses tumor growth in mice models of chemoresistant neuroblastoma. Oral administration of nutlin-3 as a single agent reduced tumor growth and metastasis, providing a potential treatment option for advanced-stage and chemoresistant neuroblastoma.
A new study suggests that progression-free survival (PFS) is a reasonable primary endpoint for clinical trials of metastatic cancer when the median survival post-progression (SPP) is less than 6 months. However, PFS benefit does not always translate to overall survival (OS) benefit in cases where SPP is longer than 12 months.
A small group of patients with severe Graves' eye disease showed rapid improvement after treatment with rituximab, reducing inflammation and optic nerve damage. The study suggests that rituximab may offer sustained benefits as an alternative to high-dose steroids.
A new therapeutic approach targets proliferation of cancer cells without affecting normal cells, showing promise for selective eradication of human cancers. Researchers developed a phenanthridine derived polyADP-ribose polymerase (PARP) inhibitor that efficiently kills breast cancer cells while leaving healthy cells untouched.
A team of researchers has identified a promising drug candidate for treating spinal muscular atrophy (SMA), a genetic disease that affects approximately 1 in 6,000 babies born in the US. The tetracycline-like compound boosts SMN protein levels by fixing an RNA splicing error, resulting in increased functional protein production.
New research reveals that statin therapy significantly reduces the risk of developing venous thromboembolism (VTE) in patients with atherosclerosis. Patients on higher doses of statins had the lowest likelihood of developing VTE, suggesting a dose-related response.
Researchers at the University of Gothenburg discovered that two genes, one causing cancer on its own and the other reducing RAS activity, together lead to aggressive leukemia. This unexpected finding opens new avenues for treating blood cancer cells with NF1 mutations.
The American Association of Physicists in Medicine (AAPM) has developed new guidelines for radiation dose delivery and reporting in brachytherapy procedures. The task force aims to provide consistent and reproducible dosimetric information, improving treatment accuracy and patient outcomes.
Family health history disclosure may not improve clinical decision making, according to researchers. Meanwhile, community-based interventions in developing countries have been shown to effectively reduce blood pressure. Early treatment of rheumatoid arthritis may also benefit from conventional DMARD therapy or biologics, but their cost...
Research finds that lung cancer patients treated in public hospitals are more likely to have advanced stage cancer than those in private hospitals. The study highlights the need for an organized and timely approach to diagnosis and treatment to reduce health care disparities.
A new study aims to prevent brain complications in children with sickle cell disease by comparing two treatments: standard therapy of monthly blood transfusions and chelation vs. a daily dose of hydroxyurea and monthly phlebotomy. The goal is to reduce the risk of first strokes in high-risk patients with sickle cell anemia.
Researchers at the Oklahoma Medical Research Foundation have made a groundbreaking discovery that could help treat traumatic injuries and severe diseases. They found an antibody that can counteract histones' deadly effects on blood vessels, potentially preventing uncontrolled bleeding and fluid buildup.
A relative utility curve is a simple method to evaluate risk prediction in medical decision-making frameworks. The author illustrates its application in analyzing previously published data involving breast density and risk prediction models for invasive breast cancer.
Researchers found that administration of APC protein slowed disease progression and extended survival in mice with inherited ALS. The study suggests activating APC might benefit patients with inherited and possibly sporadic ALS, but warns of potential risks.
Researchers at Fox Chase Cancer Center discovered the Id3 protein plays a crucial role in directing blood cell progenitors to become gamma-delta T cells. These unique cells possess attributes of both the adaptive and innate arms of the immune system, providing enhanced protection against infections and diseases.
The article suggests that nephrologists should consider the potential quality of life for frail elders with end-stage renal disease (ESRD) when deciding between dialysis and conservative therapies. Larger studies are needed to determine the actual benefit of dialysis for this population.
Common human papillomavirus (HPV) genotypes in northern India are primarily HP-16 and HP-18. These types cause 75 percent of cervical cancers in the region, according to researchers.
The Translational Genomics Research Institute has been awarded $691,930 to develop brain tumor research using in silico simulations. The project will utilize comprehensive genomic data involving 40 brain tumor models and 20 proven types of targeted therapies.
Researchers found overexpression of leptin receptor in 80% of thyroid cancer samples, associated with poor disease survival, older age, larger tumor size, advanced stage, and metastasis. Leptin's role in stimulating growth and preventing death in cancer cells was also observed.
A new analysis from the University of Michigan Comprehensive Cancer Center reveals that radiation costs can range from $1,700 for conventional techniques to over $16,000 for Cyberknife treatment. Fewer treatments have also been shown to be equally effective in relieving bone pain associated with cancer.
A study published in The Lancet Oncology found that immunodeficiency increases the risk of multiple cancers in HIV patients. Lower CD4 counts were linked to higher risks of certain cancers, while antiretroviral therapy reduced this risk. Effective cancer screening programs are recommended for HIV-positive individuals.
The National Heart, Lung and Blood Institute has awarded $16.7 million to researchers at the Fred Hutchinson Cancer Center for developing stem- and progenitor-cell tools and therapies. The goal is to identify and characterize progenitor cell lines and develop new clinical strategies to address blood diseases.
A study found that genetic variation of the CYP2D6 enzyme is associated with clinical outcomes for women treated with tamoxifen. Women with reduced or absent CYP2D6 function had higher breast cancer event rates and poorer survival rates compared to those with extensive metabolism.
Researchers investigated the effects of curcumin on head and neck squamous cell carcinoma growths in response to nicotine. Curcumin was found to block the nicotine from activating cancer-causing cells.
A combination of PET/CT tests expedited diagnosis of lung cancer in a fast-tracked setting, demonstrating high sensitivity and accuracy. Researchers evaluated 114 patients and made accurate diagnoses for 92%, with malignancy detected in 84%. This approach allows for timely treatment initiation without delays.
A Swiss study found that prostate cancer patients with lower incomes receive worse care and have a higher risk of dying from the disease. The research suggests that socioeconomic status plays a significant role in prostate cancer mortality, with poorer patients receiving less comprehensive treatment and more advanced stages at diagnosis.
Van Andel Institute researchers found the gene RhoB is crucial in the progression of Myelodysplastic Syndrome (MDS), a bone marrow disease affecting up to 15,000 people annually. The study's findings may lead to new treatments for late-stage MDS and its potential applications in leukemia and solid tumors.
A study by BUSM researchers suggests a connection between low testosterone levels and an increased risk of heart disease. The findings, published in the Journal of Andrology, support the idea that androgen replacement therapy could help reduce cardiovascular risk in hypogonadal men.
Hilde Cheroutre's groundbreaking proposal aims to pinpoint molecular events underlying autoimmunity susceptibility, enabling early detection and potentially preventing the disease. Her innovative approach could also lead to new therapies for those at high risk or already affected by autoimmunity.
Researchers discovered a genetic variation near the interferon gene IL28B associated with people's response to treatment. This finding could lead to the development of a diagnostic test and more effective treatments for hepatitis C, reducing adverse effects and improving outcomes.
Cancer experts are developing a tool to work out the percentage risk a woman has of developing cervical cancer. The tool uses cervical precancer, defined as histological cervical intraepithelial neoplasia grade 3 (CIN3) or more severe, as a surrogate for cervical cancer.
A large trial found that hormone replacement therapy (HRT) increases the risk of death from lung cancer, especially non-small-cell lung cancer. Women taking HRT were 71% more likely to die from lung cancer than those on placebo, with higher risks also seen in current and long-term past smokers.
Chronic pain affects 80% of those living with it, and up to 10% gain access to effective treatments; a national strategy is long overdue to address the issue's significant economic and personal burden.
Research on endothelin-1 (ET-1) reveals its role in promoting fibrosis in pancreatic stellate cells. ET-1 stimulates cell activation, leading to inflammation and fibrosis. Inhibition of ET-1 may offer a novel approach to treating chronic pancreatitis and pancreatic cancer.
Treatments like insulin and metformin do not reduce inflammatory biomarkers, such as hsCRP, despite improving glucose control. No consistent association was found between glucose reduction and improvement in inflammatory status.
A study found improved survival rates for men with localized prostate cancer diagnosed between 1992 and 2002 compared to earlier eras. The 10-year prostate cancer-specific mortality rate was 8.3% for well-differentiated tumors, lower than previous reports.
A recent meta-analysis published in Cancer found that depression is associated with a higher risk of death in cancer patients, with death rates up to 25% higher for those experiencing depressive symptoms. The study highlights the need for systematic screening and treatment of psychological distress in cancer patients.
Researchers have developed a new method to detect early signs of oxidative stress in cancer, which can be used to tailor treatments. The method identifies sulfenic acid in proteins, a marker of oxidative stress, and reveals that different individuals and tumor types have unique redox profiles.
Scientists have developed nanoparticles that can target and destroy glioblastoma multiforme (GBM) brain cancer cells using light-sensitive titanium dioxide material. The 'nanobio hybrids' killed up to 80% of brain cancer cells after exposure to focused white light, making them a promising part of brain cancer therapy.
Researchers induced pathological damage to a normal pancreas with an immune adjuvant and found that it triggered a strong anti-self response, which suppressed autoimmunity. The study highlights the complexity of immune responses in different organs and may lead to new therapeutic approaches for cancer treatment
The DFG has established five new Clinical Research Units to study highly topical medical issues such as bowel cancer metastases and hormone-related obesity. The units aim to develop individual forms of treatment for conditions like glomerulonephritis and improve diagnostic strategies,
Researchers at UM Medical Center have identified haptoglobin 2 precursor as the molecular link to zonulin, a protein associated with inflammatory disorders. This discovery could lead to new treatments and diagnostic tools for celiac disease and other autoimmune conditions.
A new probe identifies over 190 proteins that undergo oxidation due to ROS, offering insights into disease processes and potential targets for treatments. The discovery may lead to strategies for fighting diseases involving excessive oxidation reactions.
A pooled analysis of six clinical trials found that pretreatment quality of life can predict overall survival in patients with advanced stage NSCLC. Patients with low self-assessed quality of life have twice the risk of death as those with high scores.
Researchers at Northwestern University developed a novel gene delivery technology using nanodiamonds, achieving 70 times greater delivery efficiency than conventional methods. The surface-modified particles successfully delivered DNA into mammalian cells while preserving biocompatibility.
Researchers at Mayo Clinic have found that early stage cancers of the esophagus can be treated effectively with less-invasive, organ-sparing endoscopic therapy. This approach was compared to traditional surgical removal of the esophagus and showed comparable overall mortality rates.
Researchers identified Hexokinase 2 as a key player in glucose metabolism and cell survival for breast cancer patients with brain metastases. Patients with high levels of Hexokinase 2 expression in their brain metastasis had significantly lower median survival rates compared to those with lower expression.
Researchers at Fox Chase Cancer Center found that long travel distances to high volume centers pose a barrier to optimal cancer care for some patients. The study showed that increased travel distances were more common among patients with less common cancers, such as esophageal and pancreatic cancer.
Studies suggest that raising hemoglobin levels with erythropoietin can improve exercise tolerance in heart failure patients. However, a large-scale trial is needed to determine if higher Hb targets are associated with adverse cardiovascular events.
Research reveals distinct patterns of intestinal response to arterial, venous, or total mesenteric ischemia/reperfusion, influencing the severity of injury. This knowledge could lead to targeted therapies for specific conditions, including venous occlusion, arterial ischemia, and transplant procedures.
A recent study published in the Journal of Thoracic Oncology found that tumor size and level of visceral pleura invasion significantly impact the survival of non-small cell lung cancer (NSCLC) patients. Researchers analyzed data from over 9,700 surgical resection cases and divided patients into nine groups based on tumor size and VPI.
A recent study led by Keith Lindor found that patients with primary sclerosing cholangitis (PSC) who received high-dose ursodeoxycholic acid experienced poorer clinical results compared to those receiving a placebo. The therapy was associated with an increased risk of death, transplantation, and liver damage.