Articles tagged with Cancer Treatments
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Disabling the Skp2 gene after oncogenic stress induces cellular senescence in cancer cells, restricting tumor growth. Researchers believe this could lead to novel agents that suppress tumor development in common types of cancer.
A study found that case management in the National Breast and Cervical Cancer Early Detection Program reduced delays in diagnosis among low-income women by 45% between 1998 and 2007. Free treatment also showed no significant impact on diagnostic or treatment delays.
Researchers at UAB found that Gardasil vaccine reduces the likelihood of HPV-related disease recurring after surgery by approximately 40 percent. This protection can provide crucial follow-up care and overall health planning for teens and women.
Researchers at the University of Leicester have made a new discovery about how the body fights certain types of cancer and autoimmune diseases. A newly discovered protein, HVCN1, regulates antibody production and can be targeted for therapies to treat conditions like lupus and rheumatoid arthritis.
Researchers have found that a seaweed extract has an inhibitory effect on the growth of non-Hodgkin's lymphoma cell lines. The extract also showed a significant pattern of activity in genes linked to apoptosis, or cell death, in lymphoma cells.
A recent study has found that breast cancer is affecting premenopausal women in Iraq, with a significant proportion presenting with advanced stage cancer. The study also highlights the importance of early detection and treatment, as only 32% of women detected a lump on self-examination sought medical advice within the first month.
Researchers have detected a novel oncolytic viral therapy against prostate cancer using the reovirus, showing safety and efficacy in early-stage patients. The study found that the virus induced cancer cell death without replicating in normal tissues, with minimal toxicity reported.
A new study finds that cancer death rates have decreased significantly since the initiation of the 'war on cancer', resulting in a decline of 21% in men and 12% in women. For individuals under 75, this drop translates to approximately 2 million years of potential life gained.
Researchers identified IFN-beta as a natural inhibitor of tumor blood vessel growth, limiting tumor growth and immune cell gene expression. This discovery provides insight into why IFN therapy benefits early cancer development.
A study published in Cell reveals that loss of the molecule miR-328 is essential for progression from chronic to blast crisis phase in chronic myeloid leukemia. Maintaining this microRNA level may represent a new treatment strategy for CML blast crisis patients.
Researchers found that lung cancer patients with optimistic attitudes had a six-month survival advantage over those with pessimistic attitudes. This study builds on existing research to investigate the effect of patient attitudes on outcomes in oncology populations.
A new evaluation tool helps clinicians decide whether to surgically remove or monitor asymptomatic pancreatic cysts. The tool considers overall health, age, cyst size, surgical risk, and patients' quality of life preferences.
Researchers found that bitter melon extract significantly decreased proliferation and induced death in breast cancer cells. The study suggests that this extract may become a chemopreventive agent against breast cancer, but additional studies are needed to confirm its efficacy.
Researchers have identified five SIBLING proteins that can predict oral cancer development in premalignant lesions. The study found that certain SIBLINGs, such as dentin sialophosphoprotein, increase the risk of oral cancer fourfold, while others, like bone sialoprotein, significantly decrease it.
A new study published in The Journal of Urology found that open radical prostatectomy (ORP) and laparoscopic radical prostatectomy (LRP) have similar rates of postoperative mortality and morbidity. LRP was associated with shorter hospital stays and a lower risk of bladder neck or urethral obstruction.
A new survey finds that African Americans are more likely to hold misconceptions about lung cancer, which could interfere with prevention and treatment. The study suggests that tailored public health messages are needed to address these disparities.
Researchers have identified a potential therapeutic target for brain cancer, the A20 protein, which is highly expressed in glioblastoma stem cells. Decreasing levels of A20 in these cells reduces their growth and induces cell death, increasing survival rates in animal models.
Researchers found that African-Americans are more likely to hold fatalistic beliefs and be reluctant to seek medical attention for lung cancer symptoms. The study suggests that targeted public health messages are needed to address racial disparities in lung cancer treatment outcomes.
The American Lymphedema Framework Project establishes a standard of care for breast cancer survivors with lymphedema, providing evidence-based treatment guidelines. Complete decongestive physiotherapy and compression garments are found to be effective methods in reducing swelling.
A new study suggests that clinically-based smoking cessation programs may not be enough to help Latino smokers with asthmatic children kick the habit. Researchers found that a culturally-tailored intervention providing feedback on secondhand smoke exposure was more effective in helping these parents quit smoking.
A software program created by Andrew Cohen analyzes time-lapse images to identify changes in cell behaviors, predicting the types of specialized cells a stem cell will produce. The software is 87% accurate in determining specific 'offspring' a stem cell will ultimately produce, and 99% accurate in predicting when self-renewal will end ...
Researchers have identified NT-3 and its binding molecule TrkC as potential therapeutic targets for treating neuroblastoma. The study found that blocking the interaction between NT-3 and TrkC inhibited tumor growth and metastasis in animal models.
Researchers report on effective treatments targeting racial and ethnic minorities, psychiatric disorders, and families with asthma. Cognitive-behavioral therapy significantly increased quit rates among African-American smokers, while family-focused approaches showed promising results for Latino families.
A Michigan State University researcher is creating a support intervention to help women in treatment for breast cancer identify effective alternative therapies. The study found that 57% of women use complementary and alternative medicines, and those who are sicker are more likely to use multiple therapies.
Researchers enhanced a type of cellular senescence to suppress prostate tumor development and growth in mice. This novel approach uses Pten-loss-induced cellular senescence to prevent cancer progression.
High-coverage HPV vaccination among adolescents and young women has been shown to rapidly reduce the risk of genital warts, cervical cell abnormalities, and diagnostic procedures. The study found significant reductions in risk across all HPV types, paving the way for a notable decrease in cancer rates.
Queen's University researchers discovered a low-dose nitroglycerin treatment may slow and halt prostate cancer disease progression without severe side effects. The study, which targeted 29 men with increasing PSA levels following surgery or radiation, showed significant slowing in disease progression in all but one patient.
Researchers at Georgia Tech have developed a potential new treatment against ovarian cancer using magnetic nanoparticles to attach to and remove cancer cells from the body. The technique has shown promising results in both mouse and human cancer samples.
Researchers at the University of Notre Dame describe a significant advance in imaging cell death using synthetic probes. The new method can distinguish between healthy and dying cells in tumors, potentially aiding in tumor grading and treatment effectiveness measurement.
A team of University of Chicago scientists has developed a new micro-western array technology that enables the examination of hundreds of proteins simultaneously. This breakthrough may lead to more precise diagnoses and individualized treatments for cancers and other diseases.
A new study reveals that genital herpes virus type 2 (HSV-2) frequently reactsivate in the entire genital tract, rather than just one specific area. This finding has important implications for treatment and prevention strategies, suggesting a need for comprehensive approaches to suppress and limit transmission.
The American Association for Cancer Research and International Association for the Study of Lung Cancer honored Dr. Paul A. Bunn Jr., M.D., for his contributions to lung cancer research. The conference emphasized the importance of translational research in improving lung cancer prognosis.
A review of DCIS research highlights the need for accurate identification of patient subsets and modification of treatment guidelines to focus on high-risk lesions. Researchers also emphasize the importance of biomarkers in determining risk status, allowing for targeted aggressive treatment.
A 93-gene signature associated with EGFR mutations in tumors from lung cancer patients was found to be a favorable prognostic marker for early stage lung cancer. The signature is also linked to drug sensitivity to erlotinib and gefitinib in non-small cell lung cancer cell lines.
A study found that drinking green tea could reduce the risk of lung cancer in smokers, particularly those with specific genetic profiles. Among smokers, those who drank at least one cup of green tea per day had a significantly lower risk of lung cancer compared to non-green tea drinkers.
A paracrine pathway involving glial cell-derived neurotrophic factor (GDNF) regulates the migration of pancreatic cancer cells along nerves. The pathway plays a crucial role in preventing nerve invasion and has potential as an adjuvant therapy for pancreatic cancer.
Researchers classified tumors into three growth patterns: destructive, alveolar, and papillary, which were independent predictors for overall survival, disease-specific survival, and disease-free survival. Patients with an alveolar growth pattern had a significantly higher risk of poor prognosis and reduced survival rates.
CSHL scientists have discovered how a protein called DDK triggers DNA replication by releasing a built-in brake on Mcm4. This finding may help shape the development of new cancer therapies.
Researchers found that pomegranate's ellagitannins can suppress estrogen production, inhibiting the growth of hormone-responsive breast cancers. The study suggests that consuming more pomegranates or exploring their juice as a potential preventive agent may have benefits.
A systematic review found IAD to be as effective as continuous androgen deprivation while improving survival rates and sexual potency. The approach has been a valid treatment option for nonmetastatic PCa cases, offering key tolerability and quality of life benefits.
Researchers found that vitamin C stops and reverses accelerated aging in mice with a mutation in the WRN gene, a common cause of premature aging. The study suggests that vitamin C may be beneficial for individuals with progeroid syndromes like Werner's syndrome.
A clinical trial at the University of Western Ontario aims to improve patient treatment for Crohn's disease by evaluating a new combination therapy approach. The REACT study will compare conventional management strategies to a newer paradigm featuring early use of immunosuppression and anti-metabolites.
Researchers have identified two cellular proteins that are important factors in hepatitis C virus infection. The natural compound Quercetin inhibits the synthesis of these proteins, significantly inhibiting viral infection in tissue culture. A Phase I clinical trial will be launched to determine if the compound is safe and effective.
A team of scientists has discovered that the fatal facial tumors decimating Australia's Tasmanian devil population probably originated in Schwann cells. The researchers identified a genetic marker to accurately diagnose the facial cancers, called devil facial tumor disease (DFTD).
Researchers at University of California, Berkeley have discovered a new human reproductive hormone called gonadotropin inhibitory hormone (GnIH), which has the opposite effect from gonadotropin releasing hormone. GnIH may lead to the development of novel contraceptives and treatments for cancer or other diseases.
The Scripps Research Institute has been awarded $1.2 million to develop high-throughput screening tests that will help identify potential small molecule therapies for breast cancer and cardiovascular disease. The project aims to modulate the activity of the LRH-1 receptor, which plays a crucial role in hormone-driven breast cancer.
A new study reveals that three proteins, E2f1, E2f2 and E2f3, play a key role in the transition of stem cells to their final differentiated state. These proteins act as activators in stem cells but switch to repressors when cells begin to differentiate, and can even revert back to activators in cancer cells, promoting tumor growth.
Women with high BMI have poorer breast cancer prognosis, with increased risk of death and reduced treatment effectiveness. Researchers found that adjuvant treatment loses its effect more rapidly in obese patients.
Researchers at the North East England Stem Cell Institute have developed a successful stem cell therapy to treat Limbal Stem Cell Deficiency (LSCD), a painful and blinding disease. The treatment, which uses patients' own stem cells without immunosuppression, shows promise for restoring sight in hundreds of people.
Researchers created algorithm to systematically analyze cancer cell pathways and reveal regulatory code in DNA. This breakthrough could lead to more precise treatments and improve patient outcomes.
A new study found that cancer patients treated with epidermal growth factor receptor inhibitors (EGFRIs) have a high prevalence of skin and nail infections. The researchers discovered that 38% of patients developed these infections, including bacterial infections resistant to common antibiotics.
The Medical College of Georgia is accelerating diabetes research with a $1.8 million stimulus grant, which will support the development of animal models and sophisticated testing procedures. The grant also enables scientists to analyze large datasets and identify key missteps in prostate cancer progression.
A diet rich in pistachios may increase dietary intake and serum levels of gamma-tocopherol, potentially reducing lung cancer risk. Pistachio consumption has also been linked to a lower risk of prostate cancer.
Researchers identified significant gaps in HPV vaccine uptake among low-income minority groups, with disparities in knowledge, awareness, and healthcare provider recommendations. Tailored interventions are necessary to address these barriers and increase vaccination rates.
Researchers found that xanthohumol, a flavonoid derived from hops, blocks the effects of testosterone and prevents prostate cancer. The study suggests that this compound may have beneficial effects in animals, reducing hormone signaling and gene expression in prostate tissue.
A selenium-based antioxidant compound supplementation decreased the risk of developing new colorectal metachronous adenomas in individuals who previously had polyps removed. The study found a 40% reduction in metachronous adenoma incidence after 13 years of follow-up.
Men with prostate cancer who engage in moderate exercise have improved overall survival, while vigorous exercise may decrease death rates from prostate cancer. Researchers found that three or more hours of physical activity per week lowered mortality risk by 35%.
A study found that long-chain omega-3 fatty acid intake was linked to a reduced risk of distal large bowel cancer in white participants. However, the association was not observed among black participants. The researchers suggest an increase in dietary omega-3 fatty acids may be beneficial for colon cancer prevention.
Researchers found that only 3% of breast cancer decline is due to decreased hormone therapy use, while the remaining 4% remains unexplained. Additional studies are needed to determine the source of this unexpected decline in breast cancer cases.
Research reveals that HPV16 oncoprotein silences the production of interferon-kappa, a key protein in the innate immune response. This allows cancer cells to grow unchecked, highlighting a potential new target for cancer treatment. The study provides insight into the mechanisms by which high-risk HPV types cause cervical cancer.