Research on new and better ways to treat cancer. Covers radiotherapy, targeted microdroplets, nerve-injury protection, drug combinations, and tumor models.
A large-scale study of 769 men with low-grade prostate cancer found that closely monitoring the disease without immediate treatment does not raise the risk of death. Men who undergo active surveillance are less likely to need subsequent surgery or radiation if their cancer progression is carefully monitored.
A new study suggests that less invasive lymph-node biopsy can accurately diagnose lymph node status in patients with early stage endometrial cancer, reducing the risk of surgical complications. The procedure has been shown to be safe and effective, with a negative predictive value of 97% and sensitivity of 84%.
A new study published by NCI and CDC found a significant shift in the distribution of cancers in the HIV/AIDS population. Cases of AIDS-defining cancers decreased threefold between 1991-95 and 2001-05, while cases of other cancers increased tripled during the same period.
Hebrew University researchers have discovered a new mechanism by which tumor cells become invasive, involving a program of genes that confer invasive properties on epithelial cells. The study suggests that p53, a key tumor suppressor, may play a critical role in cancer prevention through its inhibition of cell invasion.
Researchers at University of Michigan have developed a novel gene therapy, NP2, that shows promise in providing substantial pain relief for patients with unrelenting cancer-induced pain. The study demonstrates the safety and efficacy of NP2 in reducing pain by up to 80% over four weeks.
A survey of US primary care physicians found that making treatment recommendations changes the way physicians think about medical decisions. In scenarios involving colon cancer and avian influenza, physicians chose different treatments for themselves versus those they recommended to patients.
The number of AIDS-defining cancers decreased, while non-AIDS-defining cancers increased significantly between 1991-2005. Lung cancer emerged as the most common malignancy in people with HIV but not AIDS.
A new study published in the Journal of the American Heart Association found that video game treatment can significantly improve upper-arm motor function in stroke survivors. Virtual reality games showed promise as a promising and potentially useful alternative to traditional physiotherapy.
Research discovers TBL1 protein plays critical role in fatty liver development; higher triglyceride levels associated with lower TBL1 production. This finding may enable early identification of high-risk individuals and targeted dietary interventions.
An observational study found that women with poor physical health scores had a 27% increased risk of cancer recurrence or new breast cancer. Physical health also impacted survival, with a 65% greater risk of death among those with poorer health scores.
Researchers investigated the association between bleeding and mortality in patients on dual antiplatelet therapy (DAPT) versus aspirin alone. The study shows patients with moderate or severe bleeding had a higher incidence of all-cause, cardiovascular and cancer mortality.
Researchers at Fox Chase Cancer Center have found a direct correlation between the expression of a key tumor suppressor protein and premature aging in mice. The study suggests that blocking cell proliferation induced by the p16 protein leads to features of premature aging, not just molecular damage.
A recent study suggests that estrogen-only hormone therapy may decrease the risk of breast cancer in women who have had a hysterectomy. However, experts caution against long-term use due to unknown consequences and conflicting evidence from previous studies.
Research reveals that people with AIDS have a significantly higher risk of developing stomach and esophageal malignancies, including a 6.9-fold increased incidence of stomach cancer and a 2.7-fold increased risk of esophageal cancer compared to the general population.
Researchers found significantly higher rates of HPV antibodies in people with lung cancer compared to those without the disease. High-risk types of HPV were particularly prevalent, suggesting a potential link between HPV infection and lung cancer development.
A recent study published by the American Association for Cancer Research found that nicotine at doses similar to those found in most nicotine replacement therapies did not increase lung cancer tumor incidence, frequency or size. The researchers concluded that nicotine replacement therapy is probably a safe option.
A recent study presents a promising serum test that can identify lung cancer in people who have never smoked. The test uses a panel of biomarkers to analyze blood samples and has shown high sensitivity and specificity in distinguishing lung cancer from non-cancerous conditions.
Researchers have developed a novel biomarker test that can detect proteins secreted from tumors caused by asbestos exposure with high accuracy. The test, which uses aptamer proteomics platform, showed an 80% sensitivity rate in detecting stage 1 or 2 malignant pleural mesothelioma, a type of aggressive and often fatal lung cancer.
Researchers found that individuals with metabolic syndrome are at higher risk for developing liver cancers, including hepatocellular carcinoma and intrahepatic cholangiocarcinoma. The study, presented at the AACR 102nd Annual Meeting, highlights the importance of metabolic syndrome in increasing liver cancer incidence.
Researchers have identified an oncogenic gene fusion of KRAS in a metastatic prostate cancer cell line, shedding light on the genetic characteristics of this disease. This finding may enable better prognostic information to separate slow-growing tumors from aggressive ones, ultimately improving treatment strategies.
A study found that improved quality of life and reduced stress response were associated with changes in telomere length in cancer patients. Psychological counseling had a potential impact on modulating telomere length, but the findings require further exploration.
The US saw a decline in cancer death rates between 2003 and 2007, with the overall rate of cancer deaths falling by an average of slightly less than 1 percent per year. Despite this encouraging trend, experts caution that more efforts are needed to prevent and treat cancer effectively.
New modeling studies support EU policy efforts to address HCV-related morbidity and mortality. With ambitious policies, HCV-related mortality could decrease by up to 12% over nine years, corresponding to a relative impact of 117% compared to current practice.
A new interventional radiology treatment blocks blood supply to men's enlarged prostate glands, showing comparable clinical results to transurethral resection of the prostate. The minimally invasive treatment has none of the risks associated with TURP, such as sexual dysfunction and urinary incontinence.
Researchers found that a specific type of immune cell attacks the heart muscle because it fails to develop tolerance against a unique protein. This leads to inflammation and potentially fatal consequences, highlighting the need for targeted therapies. The study's findings have significant implications for treating autoimmune myocarditis.
A new study found that certain women with early-stage breast cancer experience excessive worrying about cancer recurrence, affecting medical care and quality of life. The research identified factors associated with high levels of worry, including younger age, employment, pain, fatigue, and radiation treatment.
A new U-M study finds that nearly half of Latinas who speak little English express a great deal of worry about breast cancer recurrence. The study highlights the need for culturally sensitive counseling to help women understand their risk and manage anxiety.
A new study found that nearly half of elderly men in their seventies underwent PSA screening, while those aged 85 and older screened just as often as those in their early fifties. The high rate of unnecessary screenings may lead to complications such as incontinence and impotence.
A team of international researchers from Fred Hutchinson Cancer Research Center and University of Washington have made significant contributions to understanding human papillomavirus (HPV) infections. They developed the HPV vaccine, which has the potential to prevent over half a million HPV-associated cancers worldwide.
The American Association for Cancer Research (AACR) recognizes leaders in the minority cancer community with the Minority-Serving Institution Faculty Scholars in Cancer Research Awards. The awards aim to increase scientific knowledge, encourage research, and inspire students to pursue careers in cancer research.
A team of researchers at Marshall University has identified and analyzed unique adult animal stem cells that can transform into neurons, which could pave the way for novel therapies for slowly progressing diseases like Parkinson's and multiple sclerosis. The discovery is especially interesting as it involves using readily available and...
The American Association for Cancer Research has awarded grants to researchers studying carcinoid tumors and pancreatic neuroendocrine tumors. These grants will support the development of new treatments and therapies for these cancers, including those targeting the menin-regulated signaling pathway and oncolytic viral therapy.
The American Association for Cancer Research (AACR) has awarded 27 undergraduate students with the AACR-Thomas J. Bardos Science Education Award, recognizing their dedication to advancing cancer research. The award aims to inspire science students at the undergraduate level to pursue careers in cancer research.
New research explores the role of microRNAs in understanding immunoregulation, inflammation, and autoimmune diseases. MicroRNAs are also being investigated as therapeutic targets in cancer and potential biomarkers for various diseases.
The donation will support recruitment of a world-class physician-researcher at the hospital's largest and most advanced therapeutic endoscopy program, treating over 14,000 patients annually. This initiative aims to establish St. Michael's as a leading centre for gastrointestinal endoscopy in Canada.
Dr. Hoang's research aims to understand and explain the underlying mechanisms of tumor progression in osteosarcoma, a type of aggressive bone cancer that often relapses with low survival rates. The award recognizes his work advancing knowledge on how to develop therapies for patients with untreatable sarcomas.
The study found a global prevalence of 2.4% for bipolar spectrum disorder, with severe symptoms primarily affecting depressive episodes. Treatment needs are often unmet, especially in low-income countries where only 25.2% received mental health treatment.
The Society of Surgical Oncology is presenting the James Ewing Layman's Award to Kimberly Duchossois for her leadership and vision in improving cancer care. Her family's dedication began after her mother died from cancer, leading them to create and endow the American Cancer Society Patient Navigation Services.
Researchers found a significant association between IL28B genotypes and interferon-based antiviral treatment outcomes, as well as graft inflammation caused by hepatitis C virus (HCV). The presence of G-allele serves as a marker for severe HCV-induced graft inflammation and predictor of unsuccessful treatment.
Researchers at St. Jude Children's Research Hospital have identified a protein called FLIP as playing a pivotal role in controlling programmed cell death pathways, offering new potential targets in the fight against cancer and virus-infected cells.
By analyzing CD8+ T cells from healthy blood donors, researchers created a statistical model that accurately predicts the age and quality of T cells. This allows clinicians to transfer only young functional cells back into patients' bodies, potentially improving therapeutic outcomes for various cancers.
Breast cancer is a significant global health issue, with most deaths occurring in low- and middle-income countries. A Personal View published in The Lancet Oncology suggests that population-based mammography screening is not practical or cost-effective in these countries.
A new study found that uterine fibroid treatment significantly improved quality of life for women, with non-minimally invasive options such as MRgFUS showing better outcomes. The study surveyed over 197 women who underwent different treatments, including hysterectomy and UAE.
A new gene expression test distinguishes between metastasizing and non-metastasizing head and neck cancers with high accuracy. The test was validated in a large multi-center cohort, predicting the absence of metastasis in 89% of cases.
A study found that women with melanoma report higher levels of both positive and negative impacts of cancer, including increased worries about UV radiation. Women also adjust their sun behavior more often and experience difficulties in getting life insurance as a result of their diagnosis.
A new quadruple therapy regimen with omeprazole and a three-in-one capsule has been shown to be more effective in eradicating Helicobacter pylori infection than the standard 7-day treatment regimen. The study found that eradication rates were 80% for the quadruple therapy group versus 55% for the standard therapy group.
A team of internationally recognized molecular biologists, epidemiologists, and clinicians have been honored for their groundbreaking work on human papillomavirus (HPV) research. Their collaborative efforts have led to significant advances in understanding HPV's role in cancer development and the development of the HPV vaccine.
A new study found that cardiac resynchronization therapy with defibrillator (CRT-D) is significantly more beneficial for women than men in preventing heart disease. Women experienced a 70% reduction in heart failure and a 72% reduction in death, compared to 35% and 45%, respectively.
Researchers have developed a new method for treating genetic diseases using modified mRNAs, which can be administered repeatedly without increasing the risk of cancer or severe immune reactions. In mouse models, this technique successfully restored lung function in mice with a congenital lung defect.
A new therapeutic vaccine has shown a significant response in the majority of AIDS patients, with a decrease in viral load. The vaccine, developed by the Hospital Clinic of Barcelona-IDIBAPS, uses patient's own dendritic cells and has achieved an improvement over previous initiatives.
A deficiency in a protein that fends off aging-related cellular damage may set the stage for estrogen and progesterone receptor-positive breast tumors to develop. Researchers have identified a link between this protein and increased levels of reactive oxygen species, providing a potential biomarker for these tumors.
A study published in JAMA reveals that chromosome changes disrupt a molecular network influencing CLL outcome, providing new targets for treatment. Patients with 13q deletion generally have better prognosis than those with 11q or 17p deletions.
A new study reveals that COPD patients on LTOT are at a higher risk of death from non-respiratory causes such as cardiovascular disease. The study found an increase in mortality due to circulatory and digestive organ diseases, emphasizing the importance of optimized diagnostics and treatment.
Research suggests that breastfeeding can partially offset negative side effects of childhood cancer treatment, including impaired growth and reproductive difficulties. Women who have survived childhood cancer should be advised to breastfeed if they can, as it may help protect them against lasting effects of cancer treatment.
The EurocanPlatform project aims to find more effective ways to prevent, detect and treat cancer. By combining resources and expertise, researchers hope to identify patients at risk for cancer and adapt therapies to individual circumstances.
Researchers have identified a gene, PBRM1, that is mutated in one in three patients with clear cell renal cell carcinoma (ccRCC), the most common form of kidney cancer. This discovery provides new insights into the biology of renal cancer and may lead to new therapeutic directions for treatment.
The Khalifa bin Zayed Al Nahyan Charity Foundation is granting $150 million to support genetic-analysis based research, diagnosis and treatment of cancer at the University of Texas M. D. Anderson Cancer Center.
Researchers have identified a frequently mutated gene, PBRM1, in one in three patients with the most common form of renal cancer. The gene is tied to two previously identified genes on chromosome 3 and plays a role in controlling cell growth and repairing DNA damage.
A study by German Cancer Research Center found that hormone replacement therapy and a lack of physical activity significantly increase breast cancer risk. Behavioral changes in these areas could prevent nearly 30% of postmenopausal breast cancers.
Research highlights the key role of estrogen signaling in maintaining energy balance, as well as the propagation of α-synuclein in Parkinson's disease. Additionally, a new immune cell activator has been identified to protect mice from tumors through an IFN-gamma-independent mechanism.