Articles tagged with Cancer Treatments
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The AAO-HNSF miniseminars discussed presbycusis, a growing concern for older adults with hearing loss. The researchers also presented new medullary thyroid cancer guidelines, highlighting the need for familiarity with unique diagnostic and treatment paradigms. Additionally, safety concerns in pediatric ambulatory surgery were emphasized.
A new analysis reveals that male partners of women with breast cancer are at a significantly higher risk of developing severe mood disorders requiring hospitalization. The study found a 39% increased risk of being hospitalized with an affective disorder among men whose partners had breast cancer, compared to those without.
A study analyzing Canadian data shows a decline in breast cancer incidence among postmenopausal women as hormone therapy prescriptions fell. The decline, which coincided with a drop in hormone replacement therapy use, suggests that HRT may be linked to an increased risk of breast cancer.
A study found that breast cancer survivors with functional limitations affecting motion, strength, and dexterity are at risk of dying from other causes, but not breast cancer recurrence. The study highlights the importance of addressing physical limitations in cancer survivorship plans.
Researchers discover normal protein function, not cell buildup, causes muscle weakness and other symptoms of a rare neurodegenerative disease. The finding offers hope for treatment and a new model for understanding the mechanism at work in common nervous system disorders like Parkinson's and Alzheimer's diseases.
A new study published in The Lancet Oncology found that imatinib treatment interruption after 3 years results in rapid relapse and low progression-free survival. Patients who stopped treatment experienced significant tumour growth and poor overall survival, highlighting the need for continuous treatment to maintain cancer control.
Cells rapidly repair and maintain their structure when exposed to stress, thanks to a newly discovered protein called zyxin. This protein plays a crucial role in maintaining the cell's internal framework, or cytoskeleton, which is essential for cell function.
Researchers have discovered that an enzyme called NOX4 produces hydrogen peroxide after a stroke, leading to nerve cell death. Inhibiting this enzyme with a new drug reduces brain damage and preserves brain functions in mice with stroke.
Global cancer leaders call for non-communicable diseases (NCDs) to be included in the Millennium Development Goals to address the growing health issue. NCDs, responsible for 35 million deaths worldwide, face a lack of indicators and inadequate funding, with less than 2% of overseas development aid allocated to these diseases.
Scientists at Huntsman Cancer Institute link loss of Apc to DNA demethylase, a system that erases DNA methylation. This system stalls normal intestinal cell development, leading to stem cell-like cells. Inhibition of the demethylase restores normal development and provides new opportunities for colon cancer treatment.
Researchers found a possible link between successful gum-disease treatment and reduced preterm birth risk in pregnant women. Successful treatment was associated with lower inflammation levels, no increased probing depth, and loosening of teeth.
A study of 43,987 men aged 55-74 found that those with low PSA levels did not have a significant reduction in prostate cancer deaths. Men with high PSA levels benefited more from screening and treatment. The results suggest that aggressive follow-up testing and treatment may not be beneficial for men with low PSA values.
Researchers describe an indirect approach to reducing JAK2 activity by pharmacologically targeting HSP90. Inhibiting HSP90 normalized blood counts and improved survival in two mouse models of MPN, promoting JAK2 degradation in samples from patients with the disease.
Researchers discovered an indirect approach to reducing JAK2 activity by targeting HSP90, which stabilized JAK2. This treatment normalized blood counts and improved survival in mouse models of myeloproliferative neoplasms. Inhibiting c-Met also decreased mTOR signaling and blocked cyst formation in a mouse model of autosomal dominant p...
The special issue of Translational Research presents an in-depth view of stem cell research, considering its potential for therapy in various human diseases. Despite scientific and technical advancements, serious ethical concerns remain, including issues of privacy and consent.
A new risk prediction model for venous thromboembolism (VTE) in cancer patients has been developed, incorporating two new biomarkers. The model improves the classification of patients into different risk categories, with a significant increase in accurate predictions of VTE development.
Scientists warn of a global shortage of medical isotopes, used for diagnostic and treatment procedures, putting patient care at risk. The lack of these life-saving materials could lead to less accurate tests, higher radiation doses, and increased healthcare costs.
Researchers at Mount Sinai School of Medicine have discovered a major mechanism underlying the development of tolerance to chronic morphine treatment. They identified changes in the brain and spinal cord that occur during the development of morphine tolerance, providing a therapeutic target for preventing it.
The US Neurology guidelines provide a framework for diagnosing and treating infantile spasms, with a focus on early intervention and personalized treatment strategies. The consensus among experts is that broad clinical evaluation, vigabatrin or adrenocorticotropic hormone (ACTH) as first-line treatment, and timely assessment of treatme...
A study found that oxygen therapy provides no additional benefit over regular air in relieving persistent breathlessness in patients with life-limiting illness. The researchers suggest less burdensome strategies should be considered for these patients.
A new study from Duke University Medical Center found that half of patients with advanced disease in palliative care settings don't benefit from oxygen therapy, and receiving pure oxygen or room air offers equal relief. The study suggests alternative methods, such as using a small fan, may be equally effective.
Researchers at Salk Institute discover a novel mechanism by which adenovirus disables p53 in infected cells, paving the way for targeted cancer therapies. The study reveals two key proteins, E1B-55K and E4-ORF3, that work together to neutralize p53's tumor suppressor function.
Scientists have created diseased liver cells from human skin samples to model a range of inherited disorders. The breakthrough could lead to personalized treatments and cell-based therapy for those suffering from liver diseases.
A global shortage of medical isotopes, used in diagnostic and therapeutic procedures, poses a threat to patient care and may force doctors to use less accurate tests. The shortage is attributed to the unexpected shutdown of major isotope production facilities, leaving only 10-15% of isotopes produced domestically.
Researchers are investigating the effects of radiation on human bone strength to improve treatment for cancer patients with bone metastases. The study aims to establish the mechanical strength of bone before and after stereotactic radiosurgery, which has been shown to cause high fracture rates in post-treatment patients.
Researchers at Tufts University develop nanoparticles to deliver therapeutic genes to the retina, delaying onset of eye disease and preserving vision. The treatment, using a gene for GDNF, shows temporary but significant protection against photoreceptor cell death.
Researchers at SUNY Downstate Medical Center have identified proteins (Ligatin, MCT-1 and DENR) that can enhance the progression of viruses and cancer cells by promoting eIF2-independent translation initiation. This novel mechanism is a potential target for therapeutic inhibition to counteract viral infections.
A recent study published in JNCI Journal of the National Cancer Institute found that estrogen alone was not associated with increased lung cancer mortality among postmenopausal women. In contrast, combined hormone therapy showed a statistically significant increase in breast cancer incidence and a reduction in colorectal cancer.
Scientists have developed a new approach to deliver therapeutic genes into brain cancer cells, using chlorotoxin from deathstalker scorpion venom and nanoparticles of iron oxide. This method has shown promise in inducing nearly twice the amount of gene expression in brain cancer cells compared to traditional approaches.
Researchers at the University of Minnesota have successfully treated children with recessive dystrophic epidermolysis bullosa, a fatal skin disease, using bone marrow stem cell therapy. The treatment has shown promising results, increasing collagen production and improving skin resistance to blister formation.
A randomized controlled trial found that adding raltegravir to standard antiretroviral therapy had no effect on low-level viral load in HIV-positive individuals. The study suggests that residual viremia may be due to the release of HIV from stable reservoirs, requiring new therapeutic strategies to cure HIV infection.
Magnetic nanoparticles are injected into tumors to generate heat for cancer treatment. Magnetic relaxometry measures the relaxation of magnetic moments to determine particle quantity, allowing for selective tumor treatment.
The SPRINT-1 study found that adding boceprevir to standard hepatitis C treatment can significantly increase the response rate for genotype 1 patients. The addition of boceprevir to peginterferon and ribavirin regimens resulted in higher rates of sustained virological response compared to the control group.
A newly discovered molecular mechanism helps control the amount and effectiveness of a substance that mimics an active ingredient in marijuana. The study suggests that the enzyme ABHD6 plays a crucial role in degrading this substance, which is produced by the body's own nerve cells.
The Harold C. Simmons Comprehensive Cancer Center at UT Southwestern Medical Center has attained NCI designation, recognizing its innovative research and excellent patient care. The center will receive a $7.5 million support grant over five years to advance cancer research and provide patients access to promising new treatments.
A study of 342 early-stage lung cancer survivors found that nearly 60% experienced long-term dyspnea, with associated risk factors including reduced physical activity and depression. Targeting post-treatment rehabilitation strategies to improve breathlessness may be effective in improving outcomes.
The Louisiana Tumor Registry has been designated as a SEER Program cancer registry, providing high-quality cancer incidence and survival data. The registry's data is used to inform prevention, early detection, treatment, and survival strategies.
A study by FDA researchers found a higher incidence of malignancy in children using TNF blockers like infliximab and etanercept. The reporting rate for U.S. cases of malignancy in children was 4-18 times the estimated background rate for the general pediatric population.
Researchers found that African women are more likely to develop triple-negative breast cancer, a condition characterized by the absence of estrogen and progesterone receptors. The study suggests that African ancestry may be associated with a higher risk of hereditary predisposition for breast cancer related to BRCA1 gene mutations.
Two studies examine the effects of oral steroids and propranolol on infantile hemangiomas, revealing potential side effects and complications. Researchers aim to develop safer treatment options for this common childhood skin disorder.
Researchers at the University of Edinburgh have developed a method to alter viral conditions, reducing mutation and building resistance. This approach can target multiple viruses simultaneously and is being explored for use in treating influenza.
Scientists discovered that inhibiting a protein called N-cadherin prevents cancer cells from forming groups and migrating. This new approach could lead to more effective therapies for cancer treatment.
Researchers discover unique combinations of cells and mutations that drive the formation of different cancer subtypes, revealing a potential breakthrough in understanding and treating ependymomas. The study also identifies the first gene linked to ependymoma and creates an accurate laboratory model of this disease.
A new study finds that many US states are cutting mental health funding due to budget crises, while others have reduced Medicaid payments. However, a few countries are investing in stimulus-funded services to address recession-related mental health disorders, such as the UK's training of psychotherapists and nurses.
A Michigan State University researcher is using $1.7 million in federal funding to study the role of microRNAs in regulating genes that control cell behavior. The goal is to determine how arsenic exposure leads to tumor development and identify potential treatments.
A new treatment strategy using rituximab has shown comparable benefits to the current standard of care in reducing disease activity and inducing remission for patients with ANCA-associated vasculitis. Early results also suggest improved outcomes for patients with relapsing disease, making this a major treatment advance.
Researchers discover Lgl and Mahjong proteins help identify how healthy cells fight cancer cells. Normal cells surround cancer cells, leading to their death, while cancerous cells break free and divide.
The new guidelines update Osteoporosis Canada's recommendations on vitamin D intake for Canadians, citing the need for more research into optimal doses and safe upper limits. The recommended daily supplements range from 400-1000 IU for adults under 50, with higher doses required for those over 50.
Gene therapy holds promise in treating prostate cancer, but challenges remain in achieving effective treatment. Researchers call for better testing systems and innovative approaches to advance the field. Prostate cancer is a leading cause of cancer death among men in the US.
Researchers found a compound called P7C3 that improves newborn neuron survival and reduces programmed cell death in the brain's memory hub. This discovery offers new hope for treating Alzheimer's disease by targeting the underlying neuroprotective mechanism.
The foundation named 18 new Damon Runyon Fellows for their innovative cancer research, including studies on gene regulation, immune response, and tumor development. The recipients will receive $156,000 each to pursue novel ideas.
The Hebrew University of Jerusalem has been selected to participate in the CREATE program, focusing on cellular and molecular mechanisms of inflammation. The research aims to develop diagnostic/prognostic indicators and novel therapeutics for inflammatory diseases.
Liver transplant patients receiving cyclosporine for immunosuppression are at higher risk of developing de novo cancer, particularly those transplanted in recent years and younger than 50. The study found a significant association between C2 monitoring and increased early de novo cancer risk.
A new study has identified a key role for adrenal glucocorticoids in resetting the internal body clock, a finding that could lead to new treatments for jet lag. The research also highlights the importance of timing and location in regulating circadian rhythms.
African-American women have more advanced breast cancer at diagnosis and poorer survival outcomes compared to non-Hispanic whites. Despite similar surgical care and adjuvant therapy, African-Americans experience lower overall and breast cancer-specific survival rates due to socio-demographic factors.
Research suggests that biologics-naïve Juvenile Idiopathic Arthritis (JIA) patients may have an elevated risk of cancer compared to the general population. The Swedish study found a higher incidence of cancers among paediatric JIA patients identified during the last 40 years.
A recent study found that patients with early-stage lung cancer often forego surgery due to misconceptions about prognosis, communication with doctors, and personal life after treatment. The research also highlights racial disparities in surgical rates among black patients compared to their white counterparts.
Researchers analyzed surgical outcomes of non-small cell lung cancer patients over 30 years, finding improved survival rates with earlier stage diagnoses. The increase in patients diagnosed with early-stage adenocarcinoma is thought to contribute significantly to the favorable results.
A new study reveals that disparities in cancer stage and treatment account for the majority of excess deaths among uninsured and Medicaid-insured rectal cancer patients. Improving insurance coverage and reducing cost-related barriers to primary care and high-quality treatment can help mitigate these disparities.
A new gene on chromosome 13 has been identified as a potential cause of bowel cancer spread and progression. The discovery is based on a large family study that analyzed the genetic profiles of 81 family members over five generations.