Research on new and better ways to treat cancer. Covers radiotherapy, targeted microdroplets, nerve-injury protection, drug combinations, and tumor models.
Researchers have discovered a cellular process that seeks out and fights Type 1 herpes simplex virus. The study, published in Nature Immunology, found that the nuclear membrane of infected cells can unmask the virus and stimulate the immune system to disintegrate it.
Researchers have developed hollow gold nanospheres that target and destroy melanoma cells using near-infrared light, showing eight times more damage to skin tumors than solid gold nanoparticles.
Cancer patients experiencing malnutrition are at a higher risk of psychological distress. Researchers found that the level of distress is positively correlated with nutritional status, highlighting the need for evaluation of nutrition in cancer care.
The study found that PSA screening can reduce prostate cancer deaths by 20%, saving one life for every 1,408 men screened. The European Association of Urology's largest prostate cancer screening study provides robust evidence for the effectiveness of screening on prostate cancer mortality.
Patients with gastrointestinal stromal tumor (GIST) who received adjuvant imatinib after surgery experienced increased recurrence-free survival compared to those given placebo. Imatinib significantly improved recurrence-free survival at one year, with the most impact on tumors over 10cm in size.
A recent study found that media health reporting is improving in terms of accuracy, with online news services showing a notable five percent increase over four years. However, the overall quality of health reporting remains poor, particularly for commercial current affairs programs.
Dr. Mo Kwan Kang has been recognized for his groundbreaking research on the senescence process in human oral keratinocytes, aiming to understand health and disease of human oral mucosa. He has authored over 30 research articles and won several major research awards.
The European Association of Urology has released new clinical guidelines for kidney cancer treatment, emphasizing the use of targeted agents and nephron-sparing surgery. The guidelines recommend first-line therapies for low- and intermediate-risk patients, as well as second-line options for high-risk patients.
Researchers discovered a correlation between Ang2 concentrations in blood samples and disease progression in metastatic malignant melanoma. Higher Ang2 levels were associated with larger tumors and more advanced disease stages.
Researchers found that high levels of iron cause oxidative stress and lead to the death of cancer cells. The study suggests a novel approach for treating cutaneous T cell lymphoma by selectively releasing iron.
Leading scientists issue a challenge to find a way to purge latent HIV infection and eliminate the need for chronic therapy. A drug-free remission goal requires understanding of persistent infection reservoirs and combination approaches.
A study found that pretreatment MRI and PET/CT can direct women with stage IB cervical cancer to optimal therapy choices, avoiding trimodality therapy. The imaging modalities resulted in the highest percentage of correct primary treatment (89%) and saved the most patients from trimodality therapy (95%).
A new intervention being tested at Case Western Reserve University aims to improve the lives of men with incontinence problems from prostate cancer treatments. The 'Stay Dry' program combines pelvic floor muscle exercises with biofeedback techniques and therapy, and will be compared to standard care in a four-year study.
Patients who undergo liver transplantation for hepatitis B-related liver damage are at risk of disease recurrence if antiviral treatment is withdrawn, according to a new study. Researchers found that these patients lack cellular immunity against the disease, making lifelong antiviral therapy necessary.
The Damon Runyon Cancer Research Foundation has awarded prestigious three-year fellowships to 13 outstanding postdoctoral scientists conducting basic and translational cancer research. The fellowships aim to encourage promising young investigators to pursue careers in cancer research, providing independent funding for innovative projects.
Researchers found that PSA levels are more predictive of three-year prostate cancer risk in African-American men compared to Caucasian men with a family history. The study's findings suggest that PSA levels may be used to identify high-risk patients for earlier screening.
Research suggests that discontinuing routine PSA screening in elderly men (75+ years old) with low PSA levels may not increase undetected lethal disease rates. Instead, it could avoid unnecessary treatments and reduce diagnostic costs. Men over 75 with PSA < 3ng/ml have a low risk of developing high-risk prostate cancer.
A new study reveals liver cancer incidence has tripled in the US since 1975, with African-Americans and Hispanics experiencing significant increases. Survival rates have improved significantly, with one-year rates rising from 25% to 47%, thanks to earlier diagnosis and treatment.
A meta-analysis of 36 studies found that cancer survivors are 1.37 times more likely to be unemployed than healthy control participants, with higher risks for breast and gastrointestinal cancers. Long-term medical and psychological effects may cause social functioning impairments, including employment difficulties.
A new study published by the American Cancer Society found that black women with uterine cancer are more likely to die from the disease than their white counterparts. The researchers discovered that black patients were diagnosed at younger ages and had more advanced and aggressive tumors, which contributed to the survival disparity.
A new study published in Cancer found that pregnancy does not affect breast cancer severity or survival rates, but can delay diagnosis and treatment. Women who develop breast cancer while pregnant or shortly after have similar outcomes to those without a history of pregnancy.
Research reveals that epigenetic regulation of 13 microRNAs is associated with higher mortality in patients with acute lymphoblastic leukemia. The study identifies these microRNAs as potential targets for new therapeutic options, offering hope for improved treatment outcomes.
A study by Michigan State University found that higher medical mistrust among minority women led to late breast cancer screening. The AACR is working to address these issues through research and education. Recruiting diverse patients into clinical trials also poses challenges, with incentives often not effective.
Research suggests that gut bacteria convert linoleic acid into conjugated linoleic acid (CLA), which has anti-cancer properties and may provide therapy for inflammatory bowel disease. The 'good' form of CLA is found in dairy products.
A study found that rural physicians in Arizona estimated they could increase their endoscopic procedures by 53.1%, while urban physicians estimated an additional 35.7% with improved compensation. The potential increase is attributed to the growing population of older individuals moving to warmer climates.
Despite high awareness, African-Americans are underrepresented in HPV vaccination due to misinformation, lack of education, and societal pressures. The survey found that most participants believed the vaccine was safe and effective, but caregivers were often unaware of its benefits.
The ELLA Binational Breast Cancer Study reveals significant differences in breast cancer risk factors between Hispanic and non-Hispanic women. Hispanic women are at a higher risk of triple-negative breast cancer due to family history, while those born in Mexico exhibit increased risk due to geography and environment.
Survivors of early-stage lung cancer who engage in regular physical activity experience improved mood, vigor, and physical functioning. Moderate exercise, such as brisk walking a few times a week, may promote better quality of life and reduce depressive symptoms.
Researchers discovered that atypical spitzoid tumors (ASTs) respond well to treatment, with 27 patients experiencing complete remission after a lymph node biopsy. The study suggests ASTs behave differently from other types of melanoma and may not be as aggressive.
A new study confirms that estrogen and progesterone increase the risk of breast cancer more than estrogen alone. The study suggests a two-year safe period for hormone replacement therapy.
A clinical decision model using MR spectroscopy can help patients avoid unnecessary biopsies and treatments by identifying whether a new lesion is due to a recurrent tumor or post-radiation changes. The technique analyzes ratios of three metabolites, including choline, creatine, and NAA, to determine the likelihood of a recurrent tumor.
Scientists have discovered a link between chronic inflammation and colon cancer, with the Stat3 protein playing a crucial role in tumor development. The study found that stimulation of Stat3 by inflammatory chemicals promotes cell survival and growth, leading to increased colonic tumor incidence.
The University of Pittsburgh Graduate School of Public Health has been awarded a seven-year $11 million grant to coordinate the Hepatitis B Clinical Research Network, a consortium of 15 US and Canadian institutions. The network will conduct translational research on hepatitis B, aiming to find a lasting cure for the infection.
Lifetime risk of alcohol-use disorders for men exceeds 20% and women less than half that, with 15% at risk for abuse and 10% for dependence. Effective recovery strategies exist and can begin with doctor visits.
The University of Texas at San Antonio has received a $1.2 million gift to purchase an aberration-corrected electron microscope, one of only two worldwide. This instrument will aid researchers in developing new cancer therapies and treatments, while also advancing research globally across various disciplines.
Two studies identified a novel biomarker for metastatic bladder cancer and discovered stem cell factor's role in airway remodeling in asthma. Additionally, researchers found that Staphlococcus aureus beta-toxin causes lung injury in pneumonia, while rosiglitazone may reduce the severity of scleroderma.
Researchers have found that certain measles virus vaccine strain derivatives can effectively infect, replicate in and kill prostate cancer cells. This type of treatment, called virotherapy, shows promise as a potential cure for locally advanced or metastatic prostate cancer.
Cachexia is a wasting disease that can be life-threatening if left untreated. It's often linked to an underlying disease and requires specialized care from a physician familiar with the condition.
A study examines racial disparities in survival among black patients diagnosed with early-stage lung cancer. Despite recommended treatment, black patients have lower five-year survival rates compared to white patients.
The special issue highlights various new treatment options, including mobile phones, Internet-based interventions, and computers. Researchers have seen promising results, such as a high number of students logging on to screening programs and increased access for hard-to-reach populations.
Researchers have determined the three-dimensional structure of TIGAR, an enzyme that helps regulate energy production in cells. The discovery may lead to earlier cancer detection or preventative treatments.
Research suggests that genetic variations in DNA repair patterns can predict a threefold increased risk of pancreatic cancer, while others may decrease it by up to 77 percent. The study analyzed nine single nucleotide polymorphisms among patients with and without pancreatic cancer.
Researchers have identified a mechanism for an effective immune response to brain tumors by combining immunotherapy and strategies to kill tumor cells. The study suggests that this combination may provide effective treatment for glioblastoma multiforme, the most aggressive form of brain cancer.
A genome-wide study has identified a new subtype of childhood acute lymphoblastic leukemia associated with a poor treatment outcome. The study found that patients with this subtype have a high relapse rate and poor disease-free survival, highlighting the need for further research and treatment options.
Researchers have shown that maslinic acid significantly inhibits cell proliferation and induces apoptosis in colon-cancer cells. The compound may provide a cheap and effective way to control colon cancer and is being investigated as a potential chemotherapeutic agent.
Researchers are studying the mechanisms behind cytomegalovirus-induced cell death in the retina, which may lead to new treatment targets. Understanding this process could also provide insights into how the retina responds to other insults such as diabetes or infection.
Researchers found that silencing of a crucial gene in lung cancer leads to impairment in genome-wide changes, contributing to cancer development and progression. Tobacco use is strongly linked to modification of the MTHFR gene, which triggers global hypomethylation and deregulation of DNA synthesis.
A study by researchers from the University of Kentucky found that grape-seed extract induces apoptosis in leukemia cells by activating the JNK pathway, leading to cell cycle regulation and death. The extract has shown promise as a potential agent for preventing or treating hematological malignancies.
Researchers developed a method to analyze genetic variations in HCV-infected patients, predicting their response to antiviral therapy. This approach may lead to a test that identifies targets for new antiviral drugs.
Researchers developed an approach that predicted treatment response by analyzing genome-wide amino-acid sequence variation in HCV-infected patients. The data has implications for developing a predictive test to identify individual responses to treatment, which could help target new antiviral drugs and reduce treatment failures.
Researchers at Memorial Sloan Kettering Cancer Center developed a new generation of microscopic particles, called C dots, that are biologically safe and stable. These particles can be customized to target specific molecules on tumor surfaces, enabling earlier detection and more personalized treatment options.
A new study finds that hospice services are restricted by eligibility criteria that reduce usage among patients who need it most, particularly African Americans. The researchers suggest revising the criteria to prioritize those with greater needs for specific services like pain management.
A UCLA study found that low-income men are more likely to present with advanced prostate cancers, highlighting the need for increased access to screening services. The study also revealed that diagnosis rates for lower-risk cancers did not increase over time among IMPACT patients, unlike in more affluent populations.
A study at University of Rochester Medical Center discovered a gene mutation in the placenta that is also influential in cancer development. The SENP2 gene's role in early embryo development was not known until now.
University of Texas Medical Branch researchers have identified a promising new target for colon cancer therapy by mapping the biochemical pathway critical to the spread of tumors. High levels of the enzyme Akt2 are found in association with other cancers, and its inhibition shows promise in stopping colon cancer's spread.
The five-year study aims to determine which rehabilitation therapies are most successful in improving outcomes for patients with different types and severities of traumatic brain injuries. The researchers will analyze data from over 2,300 patients to identify effective treatments.
A subanalysis of the AZA-001 phase III trial reveals Vidaza extends overall survival and reduces death risk in elderly higher-risk MDS patients. The treatment also improves one-year survival rates in all response categories.
A landmark analysis found that continuous treatment with Revlimid and dexamethasone improved overall survival and time to disease progression in multiple myeloma patients. Patients who continued therapy had significantly longer overall survival rates compared to those who discontinued treatment after 10 months or less.
A new analysis of the AZA-001 phase III clinical trial shows that Vidaza significantly improves response rates for higher-risk MDS patients. Continued treatment with Vidaza leads to improved responses in nearly half of patients, offering hope for those who initially have a weak response.
The ECOG E4A03 study found that Revlimid plus low-dose dexamethasone improved three-year overall survival rates to 75% in the intent-to-treat population. Continuous therapy also achieved a 91% overall response rate with a high complete response and very good partial response rate.