Research on new and better ways to treat cancer. Covers radiotherapy, targeted microdroplets, nerve-injury protection, drug combinations, and tumor models.
A study found that estrogen therapy reduced the risk of fractures after menopause, particularly in women aged 50-64 years. The use of post-menopausal hormone replacement therapy increased greatly during this period and was estimated to cause nearly half of the decline in fracture rates among women.
Researchers discovered a previously unknown link between two genes associated with aging and certain types of cancer. A low-calorie diet affects the activity of these genes in worms, slowing aging progression. The study's findings have implications for understanding metabolism, longevity, and disease in humans.
The Journal of Nuclear Medicine is now free and open to the public six months after publication, accelerating access to new research and advancing understanding of nuclear medicine and molecular imaging. This move reflects the journal's exceptional quality and influence as an academic and professional resource.
Researchers may develop new treatments for diseases like multiple sclerosis, rheumatoid arthritis, and sepsis by understanding the role of fibrin in blood coagulation. The NIH grant will support a four-year study to identify how cytokines regulate fibrin levels.
Researchers found that changes in physical health status during the first year after diagnosis can predict long-term survival. Patients who died within five years exhibited no recovery in their scores, while those who survived showed improvement at the one-year mark.
A new breast cancer vaccine has been tested in mice and shown to completely eliminate HER2-positive tumors, even those resistant to current therapy. The vaccine uses activated immunity to target the HER2 receptor, potentially eliminating the need for existing therapies.
Listeriosis is a serious foodborne illness that affects healthy individuals but is life-threatening for pregnant women, the elderly, and those with weakened immune systems. In Canada, recent outbreaks linked to deli meats and cheese have prompted guidelines for symptom management and risk reduction.
Scientists have identified a crucial molecular pathway linking cortisol to fatty liver accumulation, offering new insights into the development of metabolic diseases. The study reveals that blocking cortisol receptors in the liver activates HES1 protein, which counteracts fat accumulation.
Researchers at Mount Sinai Hospital have developed a new once-weekly treatment for type 2 diabetes that mimics the action of GLP-1, a naturally occurring hormone. The treatment showed significant improvements in glucose control and reduced side effects compared to twice-daily injections.
Researchers have identified African-Americans as having a greater risk of developing lung cancer from chronic obstructive pulmonary disease (COPD), with a more than sixfold increased risk. Hay fever was also found to be protective among African-Americans, reducing the risk by 44%.
A new study suggests that down-staging hepatocellular carcinoma can improve post-transplant outcomes for patients who undergo treatment. The research found that tumors with more favorable biology respond well to treatment and do well after liver transplantation.
A recent study found that positron emission tomography (PET) scans led to changes in treatment plans for more than half of patients with suspected recurrent colorectal cancer. The study, conducted at four sites in Australia, involved 191 patients and showed that PET scans identified additional disease sites in 48% of patients, allowing...
A study by Fox Chase Cancer Center found 27% of college students exhibit symptoms of tanning dependence, similar to substance addictions. Thinness and cigarette smoking are linked to higher rates of tanning dependence, suggesting potential avenues for prevention.
Researchers at the University of California and the University of Newcastle are sharing their work on telomerase, a protein that allows cancer cells to grow. The lecture aims to improve treatment outcomes for breast cancer through early detection and prevention.
Researchers discovered a link between atomic bomb exposure and adult-onset papillary thyroid cancer, with a higher risk among younger people. The study found that radiation dose, age at the time of bombing, and elapsed time since exposure were independently associated with the development of the disease.
The Endocrine Society has released a new clinical practice guideline for the detection, diagnosis, and treatment of primary aldosteronism. The guidelines recommend using the aldosterone-to-renin ratio to diagnose PA in higher-risk patients.
A study published in European Urology found that vardenafil, a PDE5 inhibitor, is more efficacious when used on-demand in men with erectile dysfunction following bilateral nerve-sparing radical prostatectomy. On-demand use of vardenafil was associated with significantly greater erectile function and sexual intercourse completion rates ...
A global survey found that people in high-income countries underestimate the risk of alcohol consumption, while those in low- and middle-income countries have more pessimistic beliefs about cancer treatment. The survey also reveals a preference for doctors to make treatment decisions in lower-income countries.
Concomitant zoledronic acid prevents bone loss and improves bone-mineral density in premenopausal women with breast cancer during adjuvant endocrine therapy. After treatment, zoledronic acid even increases bone-mineral density.
A large clinical trial found that B vitamin supplementation did not reduce death or cardiovascular events in patients with coronary artery disease. The study, which involved over 3,000 participants, also showed a numerically lower incidence of stroke but higher incidence of cancer in the groups receiving folic acid.
Researchers have developed a prototype test that can predict clinical outcome for melanoma patients, distinguishing between rapid and slow progression to Stage IV cancer. The test uses gene signature analysis and shows promise in identifying patient subtypes, which could improve treatment decisions and reduce clinical trial sizes.
The American Society of Hematology honors Clara D. Bloomfield, Kenneth Anderson, and Robert Kyle for their significant contributions to the understanding of hematologic diseases. Drs. Bloomfield and Anderson will be recognized for their work on acute myelogenous leukemia and multiple myeloma, respectively.
A randomized trial found that radical prostatectomy reduces prostate cancer death rates, with benefits lasting beyond 10 years. However, the applicability of these results to modern prostate cancer patients is unclear due to the widespread use of PSA screening.
Researchers at USC School of Dentistry have discovered a new pathway that contributes to palate formation, bypassing the TGF-ß signaling molecule. This finding has implications for understanding cleft palate, tooth development, and diseases like cancer.
Researchers at Washington University School of Medicine discovered a gene's effect on height that may change tumor disorder treatment for patients with neurofibromatosis type 1. The study found that the NF1 gene affects stature through a different pathway than previously focused on for cancer treatment.
Scientists discovered a new Prevotella species in the mouth, which could help understand oral diseases. The finding confirms that oral bacteria can invade tissues and individual cells, paving the way for new prevention measures and treatments.
A recent American Cancer Society study found that nearly half of cancer survivors used complementary methods such as prayer and meditation to cope with their condition. The study also revealed that women, younger survivors, and those with higher incomes were more likely to use these methods.
A new study published in Ophthalmology reveals that Asian men are at a higher risk of developing age-related macular degeneration (AMD) due to smoking. In contrast, high levels of outdoor activity in childhood may prevent or control myopia in children, according to researchers. These findings suggest that environmental factors play a s...
A multicenter U.S. registry study found that endoscopic circumferential ablation effectively cleared high-grade dysplasia in 90.2% of patients with Barrett's esophagus, offering a promising alternative to surgery and other therapies. The procedure also showed good safety profiles and comparable outcomes to PDT, EMR, and esophagectomy.
The W.M. Keck Foundation has announced its 2008 class of Distinguished Young Scholars in Medical Research, recognizing outstanding young scientists making significant contributions to biomedical research. The awardees will receive grants of up to $1 million to support their research activities for five years.
Researchers at Duke University Medical Center have identified 48 'poised gene cassette' genes that are tightly controlled in tumors, making them potential targets for cancer treatment. These genes showed subtle yet significant differences in expression between highly metastatic and non-metastatic cells.
The addition of hormone therapy following vaccine treatment improved overall survival in patients with castration-resistant prostate cancer. Vaccines can be safely and effectively combined with other therapies, including hormones.
A team of scientists has developed a system to detect potential 'biomarkers' of early forms of cancer by analyzing sugar molecules attached to proteins. The system aims to provide more accurate early diagnosis and monitoring of cancer progression.
A new study from the University of Michigan Comprehensive Cancer Center finds that more than three-quarters of bladder cancer patients are unaware of the link between smoking and bladder cancer. Quitting smoking can decrease the risk of developing bladder cancer by 40% within four years.
Researchers discovered young women's breast cancers share unique genomic traits, including activated gene sets that distinguish them from older woman's tumors. These findings may lead to the development of targeted therapies for younger patients.
Research published in BMC Health Services Research found that only a small minority of eligible elderly patients receive recommended treatments for obstructive respiratory diseases. The study revealed significant disparities in care, including low rates of bronchodilator inhaler use and lung function exams.
Researchers are developing new treatments targeting Crohn's disease by blocking autoimmune responses and strengthening the intestinal lining. The goal is to provide more effective options for patients who have lost response to current treatments.
Researchers found that ovarian cancer has a distinct scent different from other cancers, which can be detected by trained dogs. Early-stage and low-grade ovarian cancers emit the same scent as advanced tumors.
Researchers discovered how filopodia extensions are generated and integrated with lamellipodia/ruffles in human cancer cells. The study reveals a complex interplay between these actin-based structures, suggesting that suppression of filopodia is needed for efficient cell migration.
Researchers at Fox Chase Cancer Center have discovered a small molecule that locks an essential enzyme in an inactive form, potentially leading to the development of new antibiotics. The discovery targets morpheeins, proteins made from individual components that can reconfigure themselves within living cells.
Patients with early stage PAH treated with bosentan show reduced clinical decline, improved exercise capacity, and lower risk of worsening events compared to placebo. Bosentan treatment is associated with improvements in pulmonary vascular resistance and prevention of clinical deterioration.
Two images, one showing neuroendocrine cancer relapse and the other a foot infection, demonstrate molecular imaging's ability to provide precise snapshots of disease anatomy. Imaging techniques are increasingly being used in combination to improve treatment planning and patient outcomes.
A unique drug combination, Lisofylline and Islet Neogenesis Associated Protein peptide, has shown promising results in reversing Type 1 diabetes in diabetic mice. The study found that the combination led to a remission rate of 70% in mice with high blood glucose levels.
A substantial proportion of rectal cancer patients receive inappropriate surgical care due to wide variations in practice. The use of abdominoperineal excision (APE) rates have declined, but disparities persist among different regions and surgeon experience levels.
Researchers at the University of Minnesota have developed a new standard of care for children with recessive dystrophic epidermolysis bullosa (RDEB) using cord blood and bone marrow transplants. The treatment has shown promising results in improving skin quality and reducing blisters, offering new hope for these patients.
A new study found strong evidence for a genetic marker on chromosome 5 linked to nearsightedness, which explains 80% of axial length variations. The research also highlights the importance of using vitamins and minerals correctly to prevent AMD vision loss in patients.
Researchers combined two biotherapies to induce an anti-tumor response, showing a 19% overall response rate in stage 4 melanoma patients. The treatment was found to be tolerable in terms of toxicity.
Scientists have discovered two novel compounds produced by soil bacteria that show promise in combating MRSA infections and cancer. The breakthroughs come after years of genome mining, which identifies pathways to produce new compounds from microbial DNA sequences.
A study led by Dana-Farber Cancer Institute researchers found that black patients with advanced cancer were more likely to die in a hospital intensive care unit than white patients. The findings suggest that black patients may have a stronger preference for life-extending treatment, despite having a terminal prognosis.
Researchers have identified a combination of novel anti-cancer compounds that can kill chronic myelogenous leukemia cells previously resistant to conventional therapy. The combination involves a Bcr/Abl kinase inhibitor and a histone deacetylase inhibitor, which work together to induce programmed cell death in CML cells.
A recent study suggests that dehydrated tomato products containing the organic carbohydrate FruHis may have strong anti-cancer properties. In an animal study, rats fed with a diet rich in FruHis and tomato paste showed longer survival from cancer compared to those without these ingredients.
A recent analysis found that most US health news stories have major failings in reporting, including inadequate discussion of costs, harms, and benefits. The study graded 500 US health news stories, resulting in a high rate of poor reporting, highlighting the need for improved standards in health journalism.
A recent study published in the journal Cancer found that pre-operative assessments by physical therapists can detect and treat lymphedema, a chronic condition caused by excess lymph fluid. The study showed that early detection and management can prevent the condition from progressing to a chronic stage.
Researchers found that noninvasive ventilation (NIV) relieved symptoms more quickly than standard oxygen therapy, remaining effective after three hours. NIV also significantly reduced morphine use in the first 24 hours, improving communication with caregivers and relatives.
A genetic test has shown promise in predicting lung cancer recurrence in early-stage patients. The test uses five high-risk gene signatures to identify patients at highest risk of cancer return, potentially leading to more aggressive treatment.
A new study by the University of North Carolina at Chapel Hill suggests that radiofrequency ablation is a highly effective treatment for dysplasia in people with Barrett's esophagus. The procedure destroyed up to 85% of abnormal cells, leaving behind no evidence of Barrett's in 74% of patients.
A University of Nebraska Medical Center-led pilot study found that antidepressants significantly reduced the risk of depression in head and neck cancer patients. The study, led by Drs. William Lydiatt and Bill Burke, showed that only 15% of patients who took antidepressants experienced depression, compared to 50% of those who did not.
A new study shows that DCE-MRI plus DWI can accurately diagnose residual or recurrent prostate cancer, improving patient outcomes. The two imaging studies have a combined accuracy rate of about 72% in detecting cancer after HIFU ablation.
Early nursing intervention and effective strategies can decrease lymphedema incidence, manage chronic lymphedema, and improve quality of life in breast cancer patients. Nurses play a crucial role in educating patients about triggers and symptoms, conducting regular assessments, and pursuing research to address this issue.
Only a small proportion of diagnosed low-risk prostate cancers will progress to life-threatening disease during a patient's lifetime. Recorded incidence has increased due to screening and improved diagnosis, but mortality rates have not kept pace, suggesting that most low-risk cases may remain stable or even decrease over time.