Articles tagged with Drug Studies
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
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Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
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A randomized controlled trial found heat therapy to be as effective as intravenous sodium stibogluconate in treating Leishmania major skin lesions. The study suggests that a rugged, battery-operated device like the ThermoMed could effectively treat cutaneous leishmaniasis.
Research on ocular cancer has expanded to involve well-designed, multi-center collaborative studies that help continue the advancement of knowledge in the field. These studies allow for large patient recruitment, foster field-wide agreement on terminology, and provide cost savings by avoiding duplication of efforts.
Researchers develop culturally-tailored intervention program to reduce tobacco exposure, improve medication adherence and enhance attack readiness. The program has already proven useful in other populations, resulting in significant reductions in emergency department visits, hospitalizations and school absences.
A Canadian study found that collaborative care between family physicians and community pharmacists improved patient outcomes, including increased medication adjustments and lifestyle changes. However, the study showed no significant impact on cholesterol control.
A comprehensive clinical trial established an evidence-based approach for initial drug therapy of childhood absence epilepsy. Ethosuximide was found to provide the best combination of seizure control and fewest attentional side effects, making it a sensible choice for initial monotherapy.
Belatacept, a new transplant drug, preserves kidney function while avoiding toxicity in patients, with similar graft survival rates to standard immunosuppressive drugs. The drug's side effect profile is more favorable, with lower blood pressure and cholesterol levels.
People with Parkinson's disease struggle to recognize emotions in others' faces and voices. Deep brain stimulation appears to exacerbate this issue, particularly with fear and sadness expressions.
A new hand-held device delivering magnetic pulses to the back of the head effectively treats migraine with aura in some patients, reducing pain and associated symptoms. The treatment is well-tolerated and non-inferior to sham stimulation for symptom improvement, making it a promising acute treatment option.
A study of corporate executives found that only 68% took their cholesterol-lowering medication as prescribed. Executives who took statins were twice as likely to meet their cholesterol goals and achieved better outcomes than those who didn't take the medication, even sporadically.
A new clinical trial, PINC Trial, is testing the effectiveness of chloroquine in treating pre-invasive breast cancer. The trial aims to prevent breast cancer cells from becoming deadly by killing pre-invasive cancer cells using a novel therapy with chloroquine.
Researchers at The Johns Hopkins University School of Medicine have unveiled the downstream processes of ion channel inactivation. Two studies show that Cav1.3 channels undergo distinct molecular endpoints during Ca2+-dependent and voltage-dependent inactivation, with a 'shield' mechanism repelling lid closure.
A study found that individuals with a low ankle-brachial index (ABI) did not significantly reduce their risk of cardiovascular or cerebrovascular events with aspirin use. Alternative therapies, such as statins or more potent antiplatelet agents, may be considered for these high-risk patients.
Researchers found that lacosamide 400 mg/day provides good efficacy and tolerability for patients with uncontrolled partial-onset seizures, while higher doses may provide additional benefits. The study confirms the safety and effectiveness of adjunctive lacosamide treatment in reducing seizure frequency and severity.
Patients treated based on 'time last seen normal' did just as well as those with witnessed strokes, having no more disabilities and reduced risk of bleeding in the brain. Treatment within 3 hours after last seen normal may be beneficial for patients with unwitnessed strokes.
A randomized, double-blind Phase III clinical trial will enroll approximately 1,140 people to test the safety and efficacy of progesterone in treating traumatic brain injuries. The trial aims to reduce mortality and long-term disability, building on promising laboratory testing and previous clinical trial results.
A study by researchers at the University of Cincinnati Neuroscience Institute supports the use of Keppra as an alternative to Dilantin for preventing seizures in patients after a brain injury. Patients treated with Keppra had fewer side effects and better long-term outcomes compared to those receiving Dilantin.
The ACCOMPLISH study shows that initial treatment with benazepril plus amlodipine reduces CKD progression more effectively than benazepril plus hydrochlorothiazide. This benefit was seen in patients at high risk for cardiovascular events.
Researchers found that erlotinib is marginally cost-effective for treating patients with advanced non-small cell lung cancer, with an incremental cost-effectiveness ratio of $94,638 per life-year gained. The treatment's cost-effectiveness may be improved through targeted patient selection and biomarker-guided therapy.
Physicians need to educate patients about migraine triggers and lifestyle factors, such as stress, sleep schedule, and diet. Preventative therapy is often ineffective, with only 50% or more of patients experiencing a reduction in headache frequency.
Heart specialists at Michigan Medicine call for clarity on beta blocker prescribing before surgery. Previous studies have differing methods and results, making it hard to determine who should get beta blockers and at what dosage.
A study of 21,506 glaucoma patients found that those taking glaucoma medications had a 74% reduced risk of death over a 4-year period. The association was observed for both single-agent and combination use of glaucoma medications.
The majority of ex-smokers stop smoking without assistance, with most reporting cessation as less difficult than expected. Pharmaceutical companies' influence on cessation studies has led to an overemphasis on assisted methods.
A clinical trial of the experimental drug dimebon found it to be safe and improved cognition in patients with Huntington's disease. The study, led by University of Rochester Medical Center neurologist Karl Kieburtz, showed statistically significant benefits for patients taking the drug compared to those receiving a placebo.
Researchers at Iowa State University's Ames Lab have discovered the binding site of antiviral drug amantadine on the flu virus. The study shows that amantadine blocks the flu virus by attaching to a site within a proton channel, preventing it from infecting healthy cells.
A recent study by Kaiser Permanente has compared the effectiveness of two AMD drugs, ranibizumab (Lucentis) and bevacizumab (Avastin), while a global report highlights retinal vein occlusion prevalence worldwide. Additionally, research reveals that central vision impairment significantly increases the risk of falls in older adults.
A recent study found that ulipristal acetate is more effective than levonorgestrel in preventing pregnancy after unprotected sex. The new findings provide women and healthcare providers with an alternative option for emergency contraception, available up to five days post- intercourse.
A landmark study published in JAMA found that catheter ablation significantly improves quality of life and reduces symptoms of atrial fibrillation compared to drug therapy. The treatment, which destroys abnormal heart tissue, resulted in a 66% success rate for patients with no recurrent irregular heartbeats or symptoms.
Researchers found that PrEP prevented rectal and intravenous HIV transmission in humanized mice with 90% protection rate. The study suggests PrEP can block multiple routes of HIV transmission, providing a promising approach to prevent new infections.
Research suggests NSAIDs like ibuprofen may be more effective for relieving period pain compared to paracetamol. The updated review of 73 trials involving 5,156 women found that NSAIDs are very effective for treating period pain, with some evidence suggesting they work better than paracetamol.
Treadmill training can improve walking movements and reduce gait hypokinesia in Parkinson's patients. The systematic review found positive effects on walking speed, stride length, and walking distance but no improvement in cadence.
A Cochrane Systematic Review found that home-based nursing in HIV/AIDS patients significantly improves self-reported knowledge of HIV, awareness of medications, and self-reported adherence to medication programmes. Home-based care also had a positive impact on HIV stigma, worry, and physical functioning.
Researchers at George Mason University are conducting a clinical trial to treat late-stage colorectal cancer patients with tailored therapies based on their tumor's protein profile. The trial uses a novel drug target mapping technology and Gleevec, a medicine typically prescribed for leukemia and gastrointestinal tumors.
Researchers found that patients with diabetes, high blood pressure, and high cholesterol who ordered medications by mail were more likely to take them as prescribed. Mail-order pharmacy users had a financial incentive to fill prescriptions and lived farther from local pharmacies.
The sequencing of parasitic wasp genomes has revealed over 7,000 genes with recognizable counterparts in humans, offering a new genetic system for studying genetics and evolution. The discovery also highlights the potential of these wasps in controlling pests and producing artificial diets for mass rearing.
A new clinical trial at UC Davis aims to test a neuroprotective drug called allopregnanolone on patients with severe traumatic brain injuries. The goal is to reduce brain damage, post-traumatic epileptic seizures, and improve patients' quality of life.
Research from the Women's Health Initiative Memory Study finds elevated blood pressure increases white matter lesions, a known risk factor for dementia. Maintaining normal blood pressure may help prevent brain damage and associated cognitive decline.
A recent study found that HIV patients who switch from lopinavir-ritonavir to raltegravir experience a reduction in blood fat levels, but the rate of viral suppression is lower in the raltegravir group. The results suggest that clinicians need to consider individual patient factors when making treatment decisions.
A study by Prof. Talma Kushnir found that physicians' moods significantly affect their professional behavior, including communication with patients, medication prescriptions, and referral to specialists. On good mood days, doctors tend to talk more and prescribe fewer medications, while on bad mood days they do the opposite.
A recent study found that nursing home residents with the highest antipsychotic prescribing rates are more likely to receive the medication, with 16.4% of those without a clinical indication for therapy receiving it. The study suggests that organizational culture may play a role in encouraging high prescribing rates.
A study examines the effect of FDA safety warnings on atypical antipsychotics prescribed to patients with dementia, revealing a decline in usage among the elderly population. The findings highlight the need for improved risk communication between physicians and patients.
Researchers have developed a new survival prediction equation for pulmonary arterial hypertension (PAH), improving upon an outdated NIH equation. The new formula shows vastly improved survival rates, highlighting the need for accurate hemodynamic assessment.
A meta-analysis of randomized trials found that antidepressant medications provide substantial benefit for patients with very severe depression, but little to no benefit for those with mild or moderate symptoms. The study suggests that the efficacy of these medications largely depends on the severity of depression symptoms.
Two head-to-head studies found that Peginterferon alpha-2a (PegIFNα2a) plus ribavirin (RBV) produces a significantly higher sustained virological response (SVR) rate than peginterferon alpha-2b (PegIFNα2b) plus RBV for patients with chronic hepatitis C. The SVR rates were 66% and 54% for PegIFNα2a and PegIFNα2b, respectively.
Researchers at UT Southwestern Medical Center have found that an experimental drug, imetelstat, blocks telomerase activity in isolated human cells and tumor-initiating cells from glioblastoma and prostate cancer patients. The drug shows promise in fighting the diseases by inhibiting telomerase activity.
A study suggests that older adults can use unusual motor tasks, such as patting their heads, to reduce repetition errors in taking daily medications. The research found that participants who performed a complex motor task while taking their medication made significantly fewer mistakes than those who did not.
A new ALS drug, talampanel, has shown some ability to slow the loss of major daily life activities such as speaking, walking and dressing. The study found that talampanel slowed progression of ALS by 30 percent, according to the ALS Functional Rating Scale.
Pharmacists at the University at Buffalo improved diabetes care for patients with Type 2 diabetes, reducing their A1C levels by an average of 1.1% over six months. This improvement came with significant cost savings, with monthly costs per patient decreasing by approximately $212.
A study found that nearly 80 high-risk cardiovascular devices received FDA approval based on data from a single study, highlighting the need for high-quality research. The review of 123 summaries of safety and effectiveness data revealed discrepancies between enrolled and analyzed patients, which may introduce bias.
Two studies found that small changes to a protein's chemistry can eliminate signs of Huntington's disease in mice. Researchers identified two amino acids critical for regulating the toxic protein, suggesting potential targets for drug therapy.
Researchers have found that figitumumab has antitumor activity in Ewing's sarcoma, a cancer commonly affecting male teenagers. The drug targets the insulin-like growth factor signalling pathway, and initial studies have shown safety and efficacy in patients with refractory Ewing's sarcoma.
The BALANCE study shows that combination therapy with lithium plus valproate is more effective in preventing relapse in people with bipolar I disorder than valproate monotherapy. The benefit is significant and maintained for up to 2 years, regardless of baseline severity of illness.
Researchers successfully treated psoriasis patients with a reduced dose of steroid medication using the placebo effect, improving treatment for chronic diseases. The new technique could maximize drug benefits, reduce side effects and increase patient adherence.
According to a study by Dr. Khaled El Emam, approximately 41% of Canadian clinical trials have moved away from paper records, with industry-funded trials being more likely to use electronic data capture tools. Pediatric trials also showed increased adoption of technology.
A new study found that antidepressant medication during inpatient treatment can significantly reduce the risk of hospital readmission among suicidal adolescents. The research also highlights concerns over the use of multiple medications in this population, which was associated with a three-fold increased risk of readmission.
Patients with a rare, deadly disease experienced significant reduction in breathlessness using treprostinil, shifting from Class III to Class II NYHA functional class. The treatment improved walking distance and reduced Borg scores, offering substantial improvement in daily capabilities.
A new study published in JAMA found that tarenflurbil, a drug intended to reduce amyloid-β levels, showed no benefit in slowing cognitive decline or improving daily activities in patients with mild Alzheimer's disease. The researchers concluded that interventions targeting amyloid have not yet been shown to alter the course of AD.
A study found racial disparities in medication use among elderly adults, with blacks facing higher rates of non-adherence and related problems. Blacks were prescribed fewer medications but had significantly more issues, highlighting the need for tailored strategies to improve medication quality for this group.
A study found that 44% of patients believe they are receiving a medication they don't need, and 96% cannot recall at least one prescribed medication. The study highlights the importance of patient knowledge in preventing medication errors.
The American Society for Gastrointestinal Endoscopy has issued new guidelines for managing antithrombotic agents during endoscopic procedures. Aspirin and NSAIDs may be continued for all elective procedures, while temporary anticoagulation therapy should be completed before proceeding.
A study found that 22.3% of dialysis patients receiving percutaneous coronary intervention (PCI) received contraindicated antithrombotic medications, leading to increased rates of in-hospital major bleeding and death. The researchers emphasize the need for educational efforts targeting clinicians and quality improvement interventions.