Articles tagged with Drug Studies
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Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
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BG-12, an investigational oral therapy, shows promising results in reducing inflammation and neuroprotection in patients with relapsing-remitting multiple sclerosis (RRMS) and rheumatoid arthritis (RA). The compound has activated the Nrf2 pathway, which defends against oxidative-stress induced neuronal death and supports myelin integrity.
A new study suggests that cost-effectiveness analyses based on data from randomized clinical trials may not be realistic enough to accurately inform policy. The researchers found a significant difference in cost-effectiveness between two painkillers when using routine clinical practice data compared to trial data.
A phase II clinical trial shows that carfilzomib induces a response in 45% of patients with relapsed or resistant multiple myeloma, reducing neuropathy side effects. The drug also demonstrates good tolerability and dose flexibility.
The pivotal trial data demonstrate that the RNS System significantly reduced seizure frequency among people with medically intractable partial onset epilepsy. The device delivered brief and mild electrical stimulations to suppress seizures, with a mean percentage reduction of 29% in disabling seizures.
Researchers at the University of Texas M.D. Anderson Cancer Center have found that second-line CML drugs, such as nilotinib and dasatinib, provide quicker and better responses compared to traditional front-line therapy, imatinib. The studies show improved complete cytogenetic response rates and major molecular response rates in patient...
Recent studies on anticoagulants suggest that aspirin and heparin may not be effective in preventing unexplained, recurrent miscarriages. In contrast, a new study shows that dabigatran etexilate is as safe and effective as warfarin for treating venous thromboembolism.
A new study reveals that research participants perceive high-paying medical trials as being associated with higher risks. This perception affects their interest in participating and influences the amount of time they spend researching trial risks.
A UCLA study found that nearly 20% of stroke survivors were not taking antithrombotic medications, with non-Hispanic, older, and male patients more likely to be on these medications. The study suggests further research is needed to understand the reasons behind this disparity in medication adherence.
Case Western Reserve researchers identified two new metabolic pathways involving 4-hydroxyacids, a breakthrough that sheds light on the mechanisms of action for lipid peroxidation and drug abuse products. The study, published as 'Paper of the Week' in the Journal of Biological Chemistry, has significant implications for understanding o...
According to a University of Michigan report, physicians can safely skip pre-surgery stress tests and beta blockers for patients with stable heart disease. This change could save lives and reduce costs by 50-70%. The new guidelines recommend reserving these medications for high-risk patients undergoing complicated surgeries.
Researchers found that antipsychotic medications increase levels of inflammatory markers, contributing to the risk of diabetes, hypertension, and heart disease in patients. The study highlights the need for monitoring cardiovascular risk markers in antipsychotic-treated patients.
A study found that patients with a specific gene variant are twice as likely to develop congestive heart failure, suggesting a genetic link between vitamin D action and heart disease. The research analyzed the genetic profiles of 617 subjects and identified a critical enzyme associated with the development of congestive heart failure.
A Phase II clinical study found that OptiNose's novel device delivered significant reductions in polyp size and improvements in symptoms, including facial pressure, nasal obstruction, and sense of smell. The treatment resulted in a substantial proportion of patients experiencing complete removal of polyps.
A new study released on World AIDS Day found that viral failure was twice as likely among patients given Epzicom when compared to those treated with Truvada, especially in those starting therapy with high viral loads. The study also showed a shorter time to virologic failure and adverse events for patients taking Truvada.
A recent study found that low-dose aspirin may offer mild protection from AMD, reducing the risk by 18% in women who took the medication. However, statins did not show a significant impact on advanced AMD risk, with patients taking statins actually at a slightly higher risk of developing advanced disease.
A 24-week trial found that combining risperidone with parent training significantly reduced disruptive behaviors, tantrums, and aggression in children with autism. The study also showed a lower dose of risperidone was needed for the combination therapy group compared to medication-only treatment.
Researchers analyzed internet offers for free or discounted prescription medications and found that their value is low compared to retail costs. The studies also revealed that efficacy and safety information were often de-emphasized in favor of promotional messaging.
Patients treated with team-based care involving pharmacists achieved lower blood pressure levels and were more likely to reach blood pressure control goals compared to those without this approach. The study found significant improvements in mean blood pressure and overall blood pressure control rates.
A UBC study found significant associations between sedatives, antidepressants, and anti-psychotics with falling among seniors. Safer alternatives like counseling and less-sedating therapies may be more appropriate for certain conditions.
A meta-analysis of 22 studies found that sedatives and hypnotics, antidepressants, and benzodiazepines significantly increase the risk of falling in older adults. The study suggests that psychotropic medications contribute to falls and fracture risks, emphasizing the need for careful medication management in elderly populations.
Researchers analyzed all clinical trials of rofecoxib before its market withdrawal and found an association between the drug and increased cardiovascular risk as early as December 2000. The study provided a roadmap for assessing drug safety after product introduction, highlighting the importance of public disclosure of trial results.
A team of investigators analyzed 30 randomized trials of Vioxx and found a strong concern for cardiovascular events or death as early as December 2000. The analysis showed a 35-43% increased risk of cardiovascular events or death, highlighting the need for informed treatment decisions and public health efforts.
A study funded by NIMH found that a combination of medication and structured parent training significantly reduced serious behavioral problems in children with autism. The treatment protocol showed greater benefits compared to medication alone, including a lower dose of medication needed for symptom control.
A new trial study in Tomsk, Russia aims to integrate alcohol screening, treatment and referral into routine tuberculosis care. The study assesses the feasibility of delivering pharmacotherapy and behavioral treatments for alcohol use disorders alongside TB treatment, with promising results.
A pivotal study has shown that PSD502 delays ejaculatory latency and improves sexual satisfaction in men with premature ejaculation. The treatment, a proprietary formulation of lidocaine and prilocaine, was well-tolerated and produced significant improvements in patient-reported outcomes.
Research at Thomas Jefferson University found that inhibiting GRK2 reduces acute ischemia injury to the myocardium, protecting cardiac myocytes from damage. The absence of GRK2 activity leads to improved recovery from acute cardiac damage.
A new NIH study led by Stanford University School of Medicine researcher Mark Hlatky found that drug therapy is more cost-effective than angioplasty for diabetic patients with mild-to-moderate heart disease. The study showed an average savings of $11,000 per patient over four years.
The prevalence of high LDL cholesterol levels in the US decreased from 31.5% to 21.2% between 1999-2000 and 2005-2006. However, high-risk individuals still face barriers to screening and treatment, with only 35.5% of those with high LDL-C levels being unscreened in 2005-2006.
The NIH has awarded $8.5 million to support research on pharmaceuticals for children, with a focus on determining outcome measures to facilitate future studies. The grants will support studies in pediatric cardiology, neonatology, and pediatric neurology, aiming to improve the quality of pediatric research.
Researchers successfully delivered high-dose chemotherapy to malignant brain tumors via intra-arterial Avastin, potentially avoiding common side effects of systemic chemotherapy. The innovative technique has shown promising results in early trials and may offer a new treatment option for patients with resistant brain tumors.
A new study found that Transcendental Meditation significantly reduced the risk of heart attacks, strokes, and death in African American patients with coronary heart disease by nearly 50%. The nine-year trial also showed a clinically significant reduction in blood pressure and psychological stress.
Flibanserin, originally developed as an antidepressant, has been shown to improve sexual desire and satisfaction in women with low libido. The results of pooled clinical trials found significant improvements in sexual encounters, desire, and distress associated with sexual dysfunction.
Research highlights the need to address hemophilia treatment disparities in developing countries. A new study from North Carolina State University found that prevalence of hemophilia A has increased over time due to improved treatments, but access to life-saving clotting factor VIII remains severely limited.
Flibanserin demonstrates significant improvements in sexual functioning, desire, and distress related to low sexual desire in pre-menopausal women with Hypoactive Sexual Desire Disorder (HSDD). The treatment increased satisfying sexual events and sexual desire, while decreasing distress associated with HSDD.
A study by LA BioMed found sustained improvements in exercise capacity among PAH patients treated with ambrisentan for two years. The researchers also observed a low risk of death and clinical worsening from the disease.
The research found that patients with schizophrenia from diverse countries and healthcare systems shared similar symptoms, treatment regimens, and socio-economic challenges. Key findings included high rates of antipsychotic polypharmacy and hospitalizations, as well as significant sexual dysfunction.
INTUNIV, a selective alpha-2A agonist, shows no unique adverse effects when coadministered with amphetamine or methylphenidate. The study demonstrated improved ADHD symptoms using the ADHD Rating Scale-IV (ADHD-RS-IV) in children and adolescents.
A systematic review and meta-analysis found that low-level laser therapy (LLLT) significantly reduces pain after treatment for non-specific neck pain. LLLT is a non-invasive, painless treatment that can be administered in primary-care settings, with no reports of serious adverse effects.
A study of 234 male college athletes found those using performance-enhancing substances were more likely to admit to heavy drinking and recreational drug use. They also experienced elevated rates of substance-related problems, including missing classes or getting into fights.
A study found that computerized alerts can reduce the prescription of heavily marketed sleep medications by 23.3% compared to generic equivalents. The alerts provided additional information on co-payments and patient education, leading to a change in clinician behavior.
Researchers will use web-based, patient-controlled personal health records to improve health and HIV prevention outcomes for HIV positive patients. The studies aim to assess the effectiveness of mobile phone text messages and a strategy called SBIRT in reducing drug and alcohol use and improving antiretroviral medication adherence.
A clinical trial has begun testing a novel compound, STX107, that selectively targets the synaptic defect underlying Fragile X syndrome. The study aims to evaluate safety and tolerability in healthy volunteers, with potential progression to phase 2 trials in adults and pediatric safety assessments.
A Phase IIIb study of Daytrana found significant improvements in ADHD symptoms in adolescents aged 13-17 years, with most adverse events mild to moderate. Pharmacokinetic data also showed similar exposure to d-MPH in both children and adolescents.
Research at the University of Missouri found that individuals with disabilities and limited English proficiency experience significantly lower health literacy rates than the general population. Effective communication strategies, such as training medical students and using telehealth communications, can help address these disparities.
Research by Johns Hopkins Bloomberg School of Public Health finds that consumer electronics can aid in improving clinical outcomes like smoking cessation. Consumer health informatics applications provide personalized information to help patients better manage their health.
A HealthCore study found that Metanx tablets reduced anticonvulsant medication use by 31% among patients diagnosed with peripheral neuropathy. The treatment also resulted in a 30% reduction in medical costs related to diabetes-related peripheral neuropathy.
A study found that second-generation antipsychotic medications were associated with significant weight gain, increased fat mass, and waist circumference in pediatric patients. The researchers also observed adverse changes in cholesterol and triglyceride levels, as well as an increased risk of metabolic syndrome and hyperglycemia.
Changing behavior strategies such as pill boxes and reducing daily doses can improve medication adherence in older adults. Researchers found that these strategies have a greater impact than educating patients about the need for medication.
Two University of Washington studies show that drinking alcohol doubles the risk of non-adherence to HIV medication. A third study found that peer support, electronic pagers, or both had no lasting impact on adherence rates. The challenges of adhering to life-long HIV treatment highlight the need for individualized comprehensive programs.
Research suggests that drinking V8 100% vegetable juice can help people meet daily vegetable guidelines, leading to improved health outcomes such as weight loss and lower blood pressure. The addition of portable drink was more successful than nutrition education or counseling in increasing veggie intake.
Researchers have identified a drug that could provide the first treatment for scleroderma, a chronic connective tissue disease. In a study of 30 patients with diffuse scleroderma, Gleevec improved skin scores by 23% and lung function tests by 9.6% after one year.
In the Phase 2b trial, TC-5214 outperformed placebo in treating major depressive disorder, achieving high statistical significance on all secondary outcome measures. The study demonstrated a favorable tolerability profile and potential as an augmentation treatment for SSRI-resistant depression.
A new decision aid tool, developed by Mayo Clinic clinicians and designers, helps patients with type 2 diabetes make informed decisions about their medication. The tool, a set of cards, involves patients in the decision-making process and leads to better patient-centered care.
A recent study published in the journal Transplantation has found that a newer, less expensive anti-rejection drug is just as effective as its more expensive counterpart, alemtuzumab. The researchers, led by Alan C. Farney, compared the two drugs and found similar survival rates for patients and transplanted organs.
Researchers confirm association between higher blood urate levels and slower disease progression in Parkinson's patients. The study suggests that elevated urate levels may have a protective influence on brain cells, but the exact mechanism is unclear.
A study funded by NIH found that individuals with higher urate levels in their blood and cerebrospinal fluid have a slower rate of disease progression. A clinical trial is underway to examine the safety and benefits of supplemental urate elevation for recently diagnosed patients.
The new guidelines from the American Academy of Neurology identify riluzole as a treatment that can slow disease progression in ALS patients. Using an assisted-breathing device is also expected to increase life expectancy and quality of life for these patients.
Researchers found no significant difference in visual outcomes between Bevacizumab and Ranibizumab treatments for age-related macular degeneration after 6 months. The study suggests that both drugs are effective, with Bevacizumab being a more affordable option.
Researchers found that adding budesonide to tiotropium resulted in a 62% reduction in severe exacerbations and significant improvements in lung function, signs and symptoms, and quality of life. Triple therapy also improved morning activities and reduced hospitalizations.
A clinical trial found that a supplement containing SE5-OH and Natural S-equol improved menopausal symptoms, including reducing hot flashes by 58.7 percent, in postmenopausal Japanese women. The study also showed positive improvements in other menopause symptoms.