Articles tagged with Drug Studies
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
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Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
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Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Biologic disease-modifying anti-rheumatic drugs are effective in treating rheumatoid arthritis, but direct comparisons of their effectiveness are needed. The researchers found that all biologics were very effective, with varying degrees of improvement in symptoms and adverse effect profiles.
A systematic review of 62 trials involving 7,101 women found minimally invasive synthetic suburethral sling operations to be just as effective as traditional open surgery for stress urinary incontinence. The procedures had shorter operating times and were more effective than a second type of open surgery.
Researchers found that combining herbal medicines with lifestyle changes can normalize blood sugar levels and reduce the risk of developing full-blown diabetes. The study of 16 clinical trials involving 1,391 participants showed a significant benefit in those who received herbal formulations.
A new Cochrane Systematic Review found that dynamic exercise programs improve aerobic capacity and muscle strength in RA patients. The study recommends routine practice of aerobic capacity training combined with muscle strength training as a standard treatment for RA.
A randomized trial found that organized phone therapy for depression significantly improved symptoms, leading to a gain of 46 depression-free days over two years. The treatment was cost-effective, with only a $397 increase in outpatient health care costs, compared to $676 for phone care management alone.
A Kaiser Permanente program bundled two generic, low-cost drugs and gave daily doses to 68,560 people with diabetes or heart disease for two years, preventing 1,271 heart attacks and strokes. The study found a 60% reduction in hospitalization rates for heart attack or stroke among those taking the bundled drugs.
A recent study published in PLOS Medicine suggests that individuals prescribed thiazolidinediones for type 2 diabetes are at increased risk of bone fractures. The self-controlled case-series study analyzed data from over 6 million patients and found a nearly one-and-a-half times higher fracture rate among those taking the medication.
The HORIZONS-AMI trial demonstrates that drug-eluting stents are safer and more effective than bare-metal stents for heart attack patients. Bivalirudin anticoagulation enhances safety and efficacy compared to heparin + GPIIb/IIIa inhibitors.
A study published in Circulation Research suggests that compounds related to Viagra can counter heart failure by reducing abnormal cardiac growth. PDE1 inhibitors show promise as a new drug target, potentially combined with Viagra or beta blockers for enhanced efficacy.
The Lancet publishes a landmark Series on the current state of surgical research, highlighting its problems and proposed solutions. A framework called IDEAL is introduced to guide surgeons in evaluating new innovations, aiming to identify beneficial procedures at an earlier stage.
Researchers at Mount Sinai School of Medicine report a promising result from the ADAGIO trial, finding that rasagiline may slow Parkinson's disease progression. The study used a novel design to examine the effect of early treatment on disease progression, and found benefits for patients starting therapy with rasagiline.
A large randomized trial has found that sorafenib plus capecitabine improves the time women live without disease worsening by 74% compared to chemotherapy alone. The treatment was well-tolerated and manageable, with no new side effects observed.
A recent study found inhaled insulin to be inferior to traditional insulin injections in maintaining optimal blood glucose levels. Despite this setback, researchers continue to explore alternative routes of insulin delivery, including MannKind Corporation's Technosphere Insulin.
The SPIRIT IV trial demonstrates enhanced safety and efficacy of everolimus-eluting stents compared to paclitaxel-eluting stents, resulting in a 38% reduction in target lesion failure (TLF) rate at one year. The study also found significant reductions in ischemia-driven TLR and stent thrombosis rates with the everolimus stent.
A meta-analysis of 13 studies found that heart attack rates started to drop immediately following smoking ban implementation, reaching 17% after one year, then continuing to decline over time. The study provides strong evidence for the benefits of smoke-free laws in reducing cardiovascular disease.
Researchers have developed a new vaginal device that delivers at least 10 times more medication to the uterus than existing oral medications, reducing side effects and potentially alleviating menstrual cramp pain. Phase II clinical trials will assess efficacy of the treatment in reducing pain.
A large study on adjuvant endocrine treatment for postmenopausal, hormone-positive breast cancer found that patients who continued to take exemestane or tamoxifen had significantly better outcomes than those who stopped taking the medication. Non-compliance was higher in countries with less stringent guidelines.
Researchers have discovered an experimental compound that selectively kills cancerous B lymphocytes while allowing normal B cells to survive. The study found that K252a disrupts a key signaling pathway involved in the growth of lymphoma cells, offering new hope for treating non-Hodgkin lymphoma.
A new type of sirolimus-eluting stent successfully demonstrated greater neointimal suppression and vessel wall integrity compared to paclitaxel-eluting stents. This study, presented at the TCT scientific symposium, confirms the superiority of the sirolimus-eluting stent for treating coronary artery disease.
A new drug-delivery system using nanoparticles encapsulating nitric oxide or prescription drugs could significantly lessen side effects associated with oral erectile dysfunction medications. The treatment showed improved erectile function in rats and held promise for safer and more effective ED therapy for millions of men.
A new study shows that anemic patients with myelodysplastic syndromes (MDS) can gain long-term benefits from erythropoietin and a myeloid growth factor, with improved survival rates and overall quality of life compared to those receiving supportive care alone.
Scientists create induced pluripotent stem cells from human neural stem cells using a footprint-free methodology, retaining some gene expression of the original donor cells. The study reveals that these cells maintain a 'transcriptional signature' similar to human embryonic stem cells.
A large-scale clinical trial, VOICE, is testing the safety and efficacy of an antiretroviral microbicide gel and pre-exposure prophylaxis (PrEP) regimen to prevent HIV infection in women in four African countries. The study aims to determine which intervention is more effective and acceptable to participants.
A new computed-tomography-based protocol can identify coronary artery narrowing and myocardial ischemia simultaneously, improving diagnostic accuracy for clinically significant coronary artery disease. The study's results compare favorably to SPECT stress imaging and cardiac catheterization, with lower radiation doses.
A meta-analysis of previously published research found that implantable cardioverter-defibrillator therapy does not significantly reduce all-cause mortality in women with advanced heart failure. This suggests that a larger study population may be needed to show any benefit of defibrillator implantation in women.
Research papers published in PLOS Medicine identified gaps in TB treatment guidelines, suggesting improvements are needed. Regimens with shorter rifampin use had higher failure rates, while longer duration and more drugs were associated with lower relapse rates.
A major clinical study has rejected cancer safety fears surrounding the most commonly prescribed group of drugs for heartburn treatment. The study found no link between long-term use of proton pump inhibitors and the development of Barrett's Oesophagus or oesophageal adenocarcinoma, a potentially fatal cancer.
Duke University researchers create a mouse model to study tumor diversity, enabling rapid trial studies and more effective cancer treatment. The study examines genetic pathways and sensitivity to drugs, shedding light on the importance of matching therapies with individual patient characteristics.
The National Institute of Allergy and Infectious Diseases (NIAID) has launched two new clinical trials to investigate the optimal use of antimicrobial drugs in various clinical settings. The trials aim to determine if shorter treatment durations can be effective while reducing the risk of bacterial resistance.
A new study finds that thousands of children and adolescents are using off-license weight-loss drugs, with most stopping use before benefits can be seen. Researchers highlight the need for more support and awareness about potential side effects to prevent misuse.
Researchers develop virtual environments and novel medicines to help military personnel diagnosed with PTSD, and explore the use of psychiatric service dogs. Preliminary data from clinical trials show promising results in treating co-morbid alcohol dependence.
A landmark study published in NEJM found that a new therapy combining CRT-D reduces the risk of death or heart failure by 34%, with a significant reduction in heart failure hospitalizations. This trial demonstrates the effectiveness of CRT-D therapy for patients with mild cardiac disease, improving both survival and quality of life.
A large international study reveals patients with vascular disease experience a surprisingly high rate of recurring events such as strokes, heart attacks, and hospitalizations. Patients in Eastern Europe had the highest rate, while those in Australia and Japan had the lowest.
The ISAR-TEST-4 study found that biodegradable polymer drug-eluting stents are non-inferior to permanent polymer-based DES in preventing cardiac death, myocardial infarction, and revascularisation. The results indicate a comparable one-year clinical efficacy of the biodegradable polymer rapamycin-eluting stent.
The NORDISTEMI study found that patients in rural areas with long transfer delays experience improved treatment outcomes with thrombolysis followed by immediate angiography. The results suggest an early invasive strategy may be preferable to conservative management, reducing the risk of death, reinfarction, or stroke.
A new study published in The Lancet found that proton pump inhibitors do not negate the clinical benefit of clopidogrel or prasugrel in patients after a heart attack. The TRITON-TIMI 38 trial showed that PPIs can be safely used with these antiplatelet drugs to reduce gastrointestinal bleeding.
The TRIANA trial found primary angioplasty superior to thrombolysis in treating acute myocardial infarction (AMI) in patients aged 75 or older. Primary angioplasty showed a significantly lower need for recurrent cardiac ischemia and comparable outcomes compared to thrombolysis.
A new trial aims to determine the best strategy for patients who cannot receive primary percutaneous coronary intervention (P-PCI) by investigating early fibrinolysis with mandated angiography. The study seeks to clarify whether this approach can achieve comparable outcomes to P-PCI.
The SYNTAX Trial interim analyses show CABG is superior to PCI in patients with severe coronary artery disease, especially those with diabetes. A multidisciplinary team approach is recommended for decision-making in complex CAD cases.
Recent observational studies show no overall safety issue with drug eluting stents compared to bare metal stents, with lower risks of death or myocardial infarction. However, late stent thrombosis remains higher and uniquely associated with drug eluting stents, necessitating improved patient selection and treatment strategies.
A study by researchers at the University of Wisconsin found a dramatic decline in rheumatoid vasculitis among US veterans between 2000 and 2006. The prevalence of RV decreased significantly, from 41 to 28 cases per 1,000 RA outpatients and from 32 to 15 cases per 1000 RA inpatients.
The study found that compliant patients have better outcomes with inhaled corticosteroids, while those taking oral controllers had higher treatment benefits and better quality of life. The researchers suggest that 'one size fits all' does not apply when treating asthma patients, emphasizing the need for personalized treatment.
A genetic variation, CYP2C19*2, affects platelet response to clopidogrel and is associated with an increased risk of cardiovascular events. The study found that carriers of the variant had a higher likelihood of experiencing a cardiovascular ischemic event or death compared to non-carriers after 1 year of follow-up.
Researchers at the University of Maryland School of Medicine have identified a common gene variant associated with reduced response to Plavix, a popular anti-clotting medication. The study confirms a previously reported link between the CYP2C19 gene and decreased response to clopidogrel.
Resolvyx Pharmaceuticals announced positive Phase 2 clinical study results for RX-10045, a resolvin administered as a topical eye drop for treating patients with chronic dry eye syndrome. The 28-day trial showed dose-dependent improvements in symptoms and signs of dry eye.
A recent study found carvedilol to be more effective in preventing variceal bleeding in cirrhotic patients compared to traditional treatment with variceal band ligation. The results showed that carvedilol reduced the risk of bleeding by 10% compared to VBL, while survival rates remained unchanged.
A DASH-style diet high in calcium, potassium, and magnesium, and low in sodium, was found to reduce the risk of kidney stone formation. Participants with higher scores on this dietary approach were between 40-45% less likely to develop kidney stones than those with lower scores.
A new study reveals that 95% of older drivers (ages 55+) have medical conditions and take medications, yet only 28% are aware of the potential impact on their driving ability. The researchers emphasize the need for increased education and awareness among health professionals and patients to address this critical issue.
A randomized controlled trial found that low-dose imipramine improved global symptoms and quality of life in patients with IBS who had failed conventional therapy. The study, published in the World Journal of Gastroenterology, is the largest ever conducted on the use of tricyclic antidepressants (TCAs) in IBS patients.
Regular postdiagnosis aspirin use may reduce the risk of dying from colorectal cancer, with a nearly 30% lower risk seen in patients taking aspirin at least twice a week. The benefit is strongest among patients with COX-2-positive tumors.
Researchers from Imperial College London and Pfizer Research and Development found that urine samples can be used to predict how individuals will respond to certain drugs. The study looked at acetaminophen levels in urine before and after consumption and found that compounds like para-cresol sulphate were indicators of drug metabolism.
Researchers at Tel Aviv University developed a tablet-based treatment for Type 1 diabetes, FTS, which restores insulin production and reduces disease progression. The compound has shown positive results in inhibiting diabetes and has the potential to fast-track through FDA regulatory hurdles.
Oral sodium clodronate reduces death by 23% and increases overall survival to 30% at 5 years for patients with advanced prostate cancer. However, in men with localized disease, clodronate shows no improvement in overall survival.
A recent study published in The Lancet Infectious Diseases suggests that extending the vaccination policy could be a more clinically effective and cost-effective strategy for treating seasonal flu. The study analyzed the effectiveness of antiviral treatments and found that vaccination may be a better option for healthy adults, while th...
A randomized study found that a program combining electronic health records and proactive patient outreach kept lipid and blood pressure levels at controlled, healthy levels for two years after discharge. The study's results suggest that using technology can help support patients in maintaining treatment goals and medication adherence.
Researchers found that Relenza and Tamiflu equally prevent common flu symptoms in uninfected individuals, but data on vulnerable groups is lacking. The two drugs may also help combat oseltamivir-resistant influenza, but their effectiveness in preventing transmission among asymptomatic carriers is unknown.
A study found that patients satisfied with their GERD treatment had better health-related quality of life and were more likely to be taken seriously by their physicians. The quality of patient-physician communication was also a key factor in patient satisfaction.
A new comprehensive health care database, DARTNet, aims to advance medical research and improve patient care by facilitating secure data sharing among clinicians and organizations. The database, part of a national health data network, has the potential to transform the quality of healthcare by enabling high-quality observational studies.
The NHLBI has stopped a clinical trial testing sildenafil for pulmonary hypertension in adults with sickle cell disease due to increased risk of severe pain crises and hospitalization. The study found that participants taking sildenafil were more likely to experience serious medical problems compared to those on placebo.
Researchers discovered that a common allergy medication can reduce obesity and type 2 diabetes in mice by stabilizing mast cells. A separate study found regulatory T cells play a crucial role in controlling inflammation in fat tissue, suggesting a new connection between immune function and metabolic conditions.