Articles tagged with Drug Studies
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Researchers found that 79% of patients treated with bronchial thermoplasty experienced a statistically significant and clinically meaningful improvement in their quality-of-life measurements. The procedure addresses an unmet medical need, providing persistent asthma control over the year following treatment.
Researchers found that elevated triglycerides are significantly more likely to result in worsening neuropathy over a year. Doctors can use this predictor to address lowering lipid counts with their diabetes patients with neuropathy, similar to pursuing glucose control.
Researchers found that a self-treatment program for COPD patients led to fewer exacerbation days and increased medication use. This resulted in cost savings due to reduced hospitalizations and healthcare contacts. The study suggested that implementing such programs could help manage COPD effectively.
A study presented at the American Thoracic Society found that automated phone calls increased medication adherence for patients with asthma by 2%, particularly among seniors. The system used a combination of voice messages and branching logic to address barriers to compliance, resulting in significant public health benefits.
A new therapy that increases airway hydration may prevent mucous buildup in cystic fibrosis patients. GS-9411, an aerosol-based agent, prevents sodium absorption and allows the surface to remain moist.
A large, multi-national clinical trial program has demonstrated the effectiveness and safety of pirfenidone in slowing the deterioration of lung capacity in IPF patients. The treatment resulted in a clinically meaningful reduction in the percentage of patients with an absolute decline in lung function.
A new Stanford University study finds that early antiretroviral treatment can reduce the risk of death or complications in HIV-positive patients with serious AIDS-related conditions. The treatment was shown to improve immune system function and increase survival rates by 50 percent.
Data from two presentations will feature Perforomist Inhalation Solution, showing improved pulmonary function and dyspnea in patients with COPD when added to maintenance tiotropium. Patient satisfaction also increased in those treated with Perforomist twice daily compared to ipratropium/albuterol MDI
A recent study found that catheter ablation is more effective than drugs in treating atrial fibrillation, with 63% of patients free of arrhythmias one year after treatment. The procedure involves destroying heart tissue responsible for erratic electrical signals, resulting in improved quality of life and reduced symptoms.
A recent study found that chemotherapy in addition to surgery or radiation improves survival rates among older women with early-stage breast cancer. Combination therapy showed significantly better outcomes than single-drug treatment, with a 17% higher relapse-free survival rate at three years.
A new study finds that hypnotherapy can significantly improve the quality of life for ulcerative colitis patients, with 80% reporting increased control over their disease and a 76% increase in overall well-being. The treatment also reduces flare-ups, with only two of 12 subjects experiencing relapses after one year.
A new study confirms the benefits of diuretic drugs in reducing the risk of heart failure and stroke in high blood pressure patients. The research, which analyzed data from multiple clinical trials, found that diuretics work as well or better than other medications in preventing major complications of hypertension.
A novel therapy using the anti-viral drug ribavirin has shown promising results in treating 30% of cancers, including breast and prostate cancer. The study demonstrated that ribavirin suppresses the eIF4E gene, which is dysregulated in 30% of cancers.
A meta-analysis of 17 randomized controlled trials found that pre-procedural treatment with sodium bicarbonate-based hydration is the optimal strategy to prevent contrast-induced nephropathy. Sodium bicarbonate was superior to normal saline in reducing CIN incidence, with a number needed to prevent one case being 16.
Researchers found that only 22% of participants met trial criteria, had shorter bouts of depression, quicker response to medication, and fewer side effects compared to excluded patients. The study suggests that antidepressants should not be seen as a panacea and calls for more research on treatment-resistant depression patients.
A new analysis of 1,534 cancer studies found that 29% had apparent conflicts of interest, with biases often favoring industry funding. Studies with industry ties were more likely to focus on treatment and report survival advantages.
A randomized clinical trial found that real and simulated acupuncture were more effective than usual care in reducing chronic low back pain. Participants who received acupuncture experienced a clinically meaningful improvement in their level of functioning, compared to those receiving usual care.
A Phase III trial found that adding casopitant mesylate to a conventional two-drug regimen significantly reduced chemotherapy-induced nausea and vomiting events. The study showed that 86% of patients achieved complete response with the new regimen compared to 66% with the placebo.
The Center for Proteomics and Bioinformatics at Case Western Reserve will expand its activities in HIV/AIDS research with a $989,108 grant from NIDA. The grant aims to develop reliable biomarkers for chronic immune activation during HIV disease and explore the effects of current or prior drug use on disease progression.
Intracerebral hemorrhage (IH) is a major public health problem accounting for 2 million strokes worldwide each year. Hospital admissions for IH have increased by 18% in the past 10 years, primarily due to increases in elderly patients with inadequate blood pressure control and anticoagulant use.
A new study by the Society for Cardiovascular Angiography and Interventions found that proton pump inhibitors, commonly used to treat heartburn, can compromise the anti-clotting action of clopidogrel. This can lead to a higher risk of hospitalization for heart attack, stroke, and other serious cardiovascular illnesses.
A landmark study published in the New England Journal of Medicine found that paclitaxel-eluting stents reduce target lesion revascularization rates and binary angiographic restenosis compared to bare-metal stents. The study also showed comparable safety profiles for both types of stents.
A collaborative Canada-France study published in the European Journal of Obstetrics and Gynecology and Reproductive Biology found that metoclopramide worked faster to quell symptoms of nausea and vomiting than droperidol. The treatment protocol improved symptoms more quickly and provided a safer option for pregnant women.
The LUMINATE trials demonstrate the ability of LX211 to significantly improve chronic eye inflammation in patients with uveitis. The study results also show a safety profile for LX211, allowing it to be suitable for chronic use as the first oral treatment for this sight-threatening inflammatory eye disease.
Scientists have developed nanoparticles that release nitric oxide to combat drug-resistant Staphylococcus aureus skin infections, improving wound healing and reducing bacterial counts. The therapy has shown promise in treating MRSA and other infections, with plans for clinical trials.
A meta-analysis of 53 cancer trials found that erythropoiesis-stimulating agents (ESAs) increased mortality in all patients with cancer by 17%. The treatment's benefits must be weighed against the increased risks of death and thromboembolic events.
A new study found that women with arthritis are more likely to leave the workforce, while men may be more likely to remain working and report negative experiences. The study analyzed data from over 9,000 individuals aged 25-64 and found that greater education was associated with being in the labor force for both men and women.
A new study analyzed dialogue between neurologists and epilepsy patients, revealing significant gaps in communication. Discussions of mood- and behavior-related topics occurred in only 22% of visits, while 57% of patients reported issues post-visit that physicians were not aware of.
A Phase IIa clinical trial suggests that targeting glutamate receptor mGluR5 with ADX10059 may prevent migraine attacks before they start. The study found that patients taking ADX10059 were more likely to be pain-free two hours after treatment than those receiving a placebo.
A Phase IIa clinical trial shows that ADX10059, a negative mGluR5 allosteric modulator, significantly improves pain-free status and pain improvement in patients with acute migraine attacks. The study's findings support the potential of targeting mGluR5 signaling for migraine prevention.
A new study shows that taking cladribine tablets just a few times a year can dramatically reduce the chances of a relapse or deterioration of multiple sclerosis. Patients who took part in the trial suffered very few side effects, making it an effective oral therapy without constant injections.
A recent study by the RAND Corporation found that higher out-of-pocket costs for prescription medications deter patients with chronic illnesses from initiating recommended treatments. The delay in treatment is particularly pronounced among those who have not previously used medication, highlighting a potential barrier to care.
A recent study found that only a small percentage of patients with depression qualify for clinical studies, suggesting the results may not be generalizable to most patients. The study showed better outcomes for those who met inclusion criteria, highlighting the need for more inclusive trial designs.
A recent study found that generic substitutes for alpha blockers and 5-alpha reductase inhibitors are less effective in treating lower urinary tract symptoms (LUTS) than their branded counterparts. Men taking these generics experienced increased side effects, including dizziness, nasal congestion, and ejaculatory dysfunction.
Locteron showed a significant reduction in flu-like symptoms compared to PEG-Intron, with patients experiencing an 80% lower severity score. The trial demonstrated comparable anti-viral effects and tolerability with the controlled-release interferon alpha.
A developmental drug, JP4-039, has been shown to protect cells from radiation-induced cell death by assisting the mitochondria in combating irradiation. The study suggests a potential role for the drug as a mitigator of radiation damage.
Preclinical studies highlight PS-targeting antibodies' ability to reverse immune suppressing effects of tumors, change tumor microenvironment, and mobilize immune cells. These findings suggest that PS-targeting antibodies facilitate a cytokine shift in the tumor environment, encouraging multiple types of immune system cells to mount an...
Researchers found that combining grapefruit juice with the cancer drug rapamycin can increase its effectiveness in treating various types of cancer. Twenty-five patients showed stable disease or partial response to the treatment, with some experiencing reduced side effects due to increased bioavailability.
Acetylshikonin has been found to have potent anti-tumor effects on human gastric adenocarcinoma, with increased cell death and apoptosis observed in both in vitro and in vivo studies. The drug's mechanism involves the regulation of Bax and Bcl-2 levels, suggesting potential therapeutic applications.
A low-dose of naltrexone reduced symptoms of pain and fatigue by an average of 30% in women with fibromyalgia, according to a Stanford pilot study. The drug's use was found to be particularly promising due to its low cost and limited side effects.
Patients in the active treatment group experienced significant improvements in nasal symptoms, sense of smell, and a reduction in nasal swelling. The study showed a highly significant improvement to a normal state in the nasal mucosa, with peak nasal inspiratory flow and rhinosinusitis outcome measures also significantly improved.
New studies suggest male impotence drugs like Viagra, Levitra, and Cialis may also treat female sexual dysfunction. Researchers found the drugs relax blood vessels in females differently than males, with some women more sensitive to certain medications.
The UCLA center aims to prevent second strokes in survivors by exploring innovative models of care and neighborhood interventions that reduce risk factors. Researchers will collaborate with community partners on studies to develop effective preventive treatments.
Veterinary oncologists at MU's Scott Endowed Program in Veterinary Oncology participated in COTC's first trial, investigating a novel method to deliver the TNF-α gene to tumor blood vessels. The study showed a dramatic decrease in tumor size and provided insight into safe dosage for both human and canine patients.
Researchers developed a test to quickly assess the effectiveness of Alzheimer's drugs in reducing amyloid beta production, which builds brain plaques. The test, SILK, was used to study LY450139, an Eli Lilly drug candidate, and showed a dose-dependent drop in A-beta production.
A randomised controlled trial found that a single annual infusion of zoledronic acid improved bone mineral density by 4.1% compared to daily risedronate's 2.7%. This increase in BMD is associated with reduced fracture risk and acceptable safety and tolerability profiles.
A new study by the American Lung Association found that heartburn medication does not help control asthma symptoms in adults with poorly controlled asthma and no significant heartburn symptoms. Despite using a high dose of esomeprazole, participants showed no improvement in asthma episodes or control.
A new national study found that prescription heartburn medication is ineffective for treating asthma in patients without acid reflux symptoms. The study, led by Northwestern University researchers, randomly gave 402 patients either the medication or a placebo, finding no difference in lung function or asthma control episodes.
A new study suggests that silent GER does not play a role in worsening asthma symptoms and control, contradicting previous beliefs. Researchers found no differences between patients treated with reflux medication and those who were not.
Proton-pump inhibitor drugs do not stop recurrent attacks in people with the lung disease. Researchers found no benefit from using these medications solely to temper asthma symptoms, even among those with silent acid reflux. The study suggests that these expensive treatments may be unnecessarily prescribed.
A study published in JAMA Network found that cognitive behavior therapy (CBT) significantly improved anxiety symptoms, worry severity, and depressive symptoms in older adults with generalized anxiety disorder. CBT was more effective than enhanced usual care in reducing anxiety and improving overall mental health outcomes.
A new phase III trial found that golimumab significantly improved active psoriatic arthritis and associated skin and nail psoriasis. The study also showed improved physical function, health-related quality of life, and enthesitis symptoms.
Two new studies published in Annals of Internal Medicine propose an intensive disease management approach to help smokers quit successfully, including repeated or intensive interventions that include pharmacotherapy and counseling. The studies also suggest targeting healthier older patients with colorectal cancer screening and using LD...
Researchers found a significant increase in serious heart rhythm disturbances associated with bisphosphonate therapy. However, non-serious cases showed no overall increased risk of atrial fibrillation. The study urges additional investigations to determine the link between the two conditions.
A new, smaller, and lighter implantable heart pump has been shown to be effective in bridging patients with severe heart failure to eventual transplantation. The device, called a left ventricular assist device (LVAD), was tested on 98 patients and found to improve their quality of life and survival rates.
A large study found that glitazone diabetes drugs increase the risk of diabetic macular edema by 60%, a condition that can lead to progressive visual loss. The study's results suggest that ophthalmologists should consider the role of glitazones when treating patients with DME.
A new catheter-based treatment has been successfully trialled to reduce high blood pressure in patients who resist conventional drug treatments. The technique, which disrupts nerves around the kidneys, showed a large and persistent decrease in blood pressure.
A blood test can predict the seriousness of a head injury and detect the status of the blood-brain barrier, offering a simpler and faster alternative to CT scans. The test, known as S-100B, has shown accuracy in predicting traumatic abnormalities and could lead to a 30% reduction in unnecessary CT scans.
A study by Michigan State University researchers found that people spend more time looking at brand names and less time reading warnings on over-the-counter pain-killers. The findings raise questions about the effectiveness of warning labels in conveying critical information to consumers.
A study published in Photochemistry and Photobiology explores the potential of light-sensitive drug delivery systems for targeted therapy. The research reveals that near-infrared light can trigger medication release without causing significant heating or damaging surrounding tissues.