Articles tagged with Drug Studies
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A multi-center clinical trial is being conducted to investigate the effect of salsalate on blood glucose levels in adults with poorly controlled type 2 diabetes. The study aims to determine if targeting inflammation can lead to an inexpensive way to treat this common form of diabetes.
Patients using a retinoid cream containing tretinoin were more likely to die than those using a placebo in the study. However, evidence does not suggest that the therapy caused the excess deaths, and alternative explanations such as smoking are possible.
A new study led by Michigan Medicine suggests that older Americans are supportive of family surrogate-based research, which can aid in the development of treatments for dementia. The survey found that most respondents believed society should allow family surrogate consent and would participate in such research if needed.
A recent study published by the American Heart Association found that women are more likely to experience delays in emergency medical services (EMS) care for heart-related issues. The study analyzed data from nearly 6,000 men and women and revealed that women had a 52% higher chance of being delayed during EMS care.
A recent analysis estimates that over 44.7 million older Americans may benefit from statin therapy, highlighting a significant gap in current treatment guidelines. The study found that nearly 80% of this segment of the population could potentially be recommended statin therapy if new criteria are adopted.
Several herbal remedies commonly used for menopausal symptoms, such as black cohosh and red clover, lack strong evidence supporting their effectiveness. The study highlights the need for better-designed trials to assess the safety and efficacy of these herbal products.
Studies show that primary care physicians can safely and effectively perform colonoscopies, with quality and safety indicators comparable to those of gastroenterologist specialists. Having a personal health care provider is associated with a three times higher likelihood of colorectal cancer screening, highlighting the potential for po...
A recent study found that daily nitric oxide monitoring did not significantly improve treatment outcomes for children with mild to moderate asthma. Despite a reduction in medication dose, both groups showed an impressive overall improvement in symptoms.
A pilot trial of fenobam has shown no adverse side effects in adult patients with Fragile X syndrome, with some participants experiencing calmed behavior, reduced hyperactivity, and anxiety. Further research is needed to confirm its potential as a treatment option for the genetic disorder.
A phase III trial found that palonosetron was non-inferior to granisetron in preventing acute nausea and vomiting but more effective in the delayed phase, offering a safer alternative for chemotherapy prevention.
Patients with advanced Parkinson's disease who received deep brain stimulation treatment had significant improvements in movement skills and quality of life after six months. However, the treatment was also associated with a higher risk of serious adverse events, including surgical site infections and nervous system disorders.
Researchers at McGill University discovered that clioquinol reverses Alzheimer's disease progression and may slow down the aging process by inhibiting CLK-1. The study suggests a potential new answer to the mechanisms behind three unrelated neurodegenerative disorders.
Researchers discover novel compound F15845 that targets persistent sodium current, causing permanent excess sodium influx in heart cells. The drug has shown promising results in animal studies, with acceptable bioavailability when given orally.
A mobile phone text-messaging strategy has shown promising results in improving tuberculosis treatment adherence among patients in remote locations. The system uses SMS reminders to monitor medication intake, resulting in high treatment success rates and improved patient compliance.
A study found Transcendental Meditation (TM) significantly reduced ADHD symptoms, stress, and anxiety among middle school students. TM improved attention, working memory, organization, and behavior regulation, enabling teachers to teach more effectively.
A simple questionnaire can replace a doctor's exam to qualify for a job, providing a more accurate forecast of competency. The test is highly effective, with 98% accuracy, and can help those previously deemed unemployable find suitable work. This innovation brings excellent news for employers, reducing medical costs and litigation risks.
A trial conducted in northwest Thailand found that artemisinin combination therapy (ACT) is safe for pregnant women with malaria, but its efficacy is inferior to single-drug artesunate treatment. The study suggests that longer regimens of ACT may be more effective in treating pregnant women.
A recent clinical trial sponsored by NIH found that alfuzosin, a commonly prescribed drug for chronic prostatitis, did not significantly reduce symptoms in newly diagnosed men. The study showed no significant differences between the treatment and placebo groups in terms of symptom improvement.
Denise Galloway, a microbiologist, was honored for her work on human papillomaviruses causing anogenital malignancies. Her studies established that nearly all cervical cancers are caused by HPVs, leading to breakthroughs in Gardasil vaccine development. Gerald Smith, a geneticist and microbiologist, was recognized for his research on h...
The DIAS-2 trial found desmoteplase ineffective in treating acute ischemic stroke due to low clinical response rates and higher mortality rates. The authors attribute the failure to replicate previous findings to mild strokes and imaging limitations.
A phase III trial found sorafenib to be effective in increasing overall survival by 6.5 months compared to 4.2 months in the placebo group, and prolonged time to progression and disease control rate. Sorafenib was generally well-tolerated with some side effects.
Scientists have developed new pre-clinical tests that successfully reproduced the devastating reaction suffered by six volunteers in the 2006 Northwick Park trial. The new tests use a mixed human cell culture and drying the drug onto a plastic surface, providing a more reliable indicator of how the drug will react in humans.
A new study published in Annals of Internal Medicine finds that colonoscopy significantly reduces deaths from colorectal cancer due to left-sided cancers. However, the risk reduction is negligible for right-sided cancer. The study suggests that physicians should advise patients of the limitations of colonoscopy.
Two meta-analyses of global trials confirm aromatase inhibitors are more effective in preventing breast cancer recurrence and reducing mortality risk compared to tamoxifen. Patients using aromatase inhibitors had a 3% lower cancer recurrence rate and a 1.6% reduced risk of death from the disease, according to researchers.
A phase I clinical trial found rosiglitazone to be safe and well-tolerated in patients with FSGS, suggesting its potential as a treatment option. The study showed that serum albumin and kidney filtration rates affected the drug's activity, warranting further investigation.
Long-term use of diabetes medications like rosiglitazone and pioglitazone increases the risk of bone fractures in women with type 2 diabetes, according to a new study. The risk is doubled compared to men, highlighting the need for alternative treatment options.
Researchers at the University of Georgia have demonstrated that RNA interference can be used as a tool in vaccine development, reducing virus replication and disease pathogenesis while inducing immunity. The study shows promise for a new approach to combatting viral diseases like RSV.
Early investigational studies show anti-tumor activity in ZOLINZA (vorinostat) and bortezomib combination for relapsed or refractory multiple myeloma. Clinical trials are underway to further evaluate this combination, offering new hope for advanced multiple myeloma patients.
A review of nine clinical trials found that cholinesterase inhibitors significantly reduced behavioral symptoms like aggression, wandering, and paranoia in Alzheimer's disease patients. The medications are safe and produce no major side effects, making them a potential alternative to antipsychotic drugs.
A new combination of medications has improved or stabilized disease in 76% of patients with relapsed multiple myeloma. Pomalidomide combined with dexamethasone showed promising results, with minimal side effects.
Studies show Keppra XR reduces nervous system side effects compared to levetiracetam immediate release, and a new dosing schedule may offer improved tolerability. The once-daily formulation also demonstrates bioequivalence in healthy adults.
A subset analysis of the AZA-001 trial demonstrated that Vidaza significantly improved overall survival in patients with WHO-defined acute myeloid leukemia (AML) compared to conventional care regimens. The study also showed reduced infections, hospitalizations, and red blood cell transfusions.
A new study concludes that long-acting beta2-agonists (LABAs) offer no additional benefit to conventional preventative medications in children. LABAs, such as salmeterol and formoterol, can improve lung function but do not reduce asthma symptoms or hospital admissions.
A study found that dexamethasone effectively reduces postoperative nausea and vomiting after tonsillectomies, but also increases the risk of bleeding in children. The largest dose was associated with a nearly 7 times higher risk of bleeding.
Researchers evaluated REVLIMID's clinical benefit in relapsed/refractory diffuse large B-cell lymphoma (DLBCL) patients, demonstrating improved response durations and safety profiles. The study's results support the use of REVLIMID as a treatment option for these patients.
Researchers at M.D. Anderson Cancer Center report encouraging results from clinical trials of second-generation CML drugs nilotinib and dasatinib. These drugs have shown higher complete cytogenetic response rates compared to the frontline medication imatinib, with some patients achieving responses faster than ever seen before.
Vimpat demonstrates statistically significant efficacy as early as the first week of treatment, with consistently significant results for both primary endpoints starting at doses of 100 mg/day. The drug shows a significant reduction in seizure frequency versus placebo, with a 39.1% increase in patients experiencing a 50% or greater red...
Two REVLIMID Phase II studies showed significant activity and tolerability in previously untreated CLL patients, achieving response rates of 52% and 96% with manageable side effects. The studies also indicated that continued treatment can improve response rates.
Clinical trials involve millions of individuals, yet there's no formal requirement to inform them of study results, leaving participants confused. Researchers at the University of Rochester Medical Center proposed a novel approach to disseminate study results, which showed high levels of satisfaction among participants.
Researchers have found that preventive use of antithrombotic medication can reduce incidence of thromboembolic events in cancer patients. The PROTECHT Study shows a 47.2% reduction in risk, while also demonstrating safety with minimal major bleeding episodes.
A Mayo Clinic study found that withdrawing anti-seizure medication in children with epilepsy who have achieved seizure-freedom is generally safe and carries a low risk of developing intractable epilepsy. The study, which reviewed records of 241 children, found only 5% to develop intractable epilepsy after withdrawal.
Researchers at UT Southwestern Medical Center found no difference in liver disease progression among patients treated with interferon compared to those who did not receive it. The HALT-C Trial showed that interferon, often used as a maintenance treatment, is ineffective in slowing disease progression.
A literature review found that patients receiving coerced medication are more likely to have schizophrenia, bipolar disorder or another psychotic disorder. The practice is often used in the UK and has been linked to negative feelings among patients.
A large international study found that treatment with the medication irbesartan did not reduce the risk of death or hospitalization for cardiovascular causes among patients with diastolic heart failure, nor did it improve quality of life. The study also showed that the medication was safe for patients with the condition.
Dr. Scott Mintzer has received a $843,000 NIH grant to investigate the cardiovascular side effects of anti-seizure medications in patients with epilepsy and subarachnoid hemorrhage. The study aims to improve treatment outcomes while minimizing potential risks.
Neuropathy, a degenerative nerve disorder, has few evidence-based standards for evaluation and management. New guidelines recommend screening laboratory blood tests and genetic testing for accurate diagnosis. The guidelines also suggest considering specialized tests to evaluate neuropathies with autonomic dysfunction.
A new prostate cancer drug, degarelix, has been shown to dramatically reduce testosterone levels in patients as early as three days after treatment. Compared to other treatments, degarelix also resulted in faster declines in prostate-specific antigen (PSA) levels and fewer side effects such as urinary tract infections and joint pains.
Two pivotal Phase 3 trials evaluating HZT 501 met primary endpoints, showing a statistically significant reduction in gastrointestinal ulcers compared to ibuprofen alone. The treatment also demonstrated good tolerability and was well-received by patients.
A systematic review of 49 randomized trials found aprotinin to be slightly more effective at controlling blood loss but with a higher risk of death. Health Canada is set to decide on its use, with alternative treatments like tranexamic acid and aminocaproic being suggested as alternatives.
A meta-analysis of studies on generic vs. brand-name cardiovascular drugs found clinical equivalence in most cases, supporting the use of FDA bioequivalence ratings as a proxy for clinical efficacy. The study suggests that physicians and patients can rely on these ratings to make informed decisions about medication substitution.
A systematic review and meta-analysis found that homeless people in Western countries experience substantially higher rates of mental health problems compared to the general population. The prevalence of serious mental disorders was found to be raised, with notable increases in alcohol and drug abuse, as well as psychosis.
Researchers at VIB and NeuroNova are conducting the first trial of a potential ALS treatment, which involves administering VEGF protein directly into the cerebrospinal fluid. This innovative approach has shown promising results in animal models, with treated rats manifesting the disease later and living longer than untreated animals.
A new study from Mayo Clinic found that etanercept therapy was not effective in treating patients with moderate to severe alcoholic hepatitis, increasing six-month mortality rates due to increased infections. Abstinence is still considered the best policy for reversing liver damage and reducing disease progression.
A study found that extended-release naltrexone improves mental health, social functioning, general health, and physical functioning in alcohol-dependent patients. The medication reduces drinking and increases quality of life, making it a cost-effective treatment option.
A study published in the Journal of Consulting and Clinical Psychology shows that Mindfulness Based Cognitive Therapy (MBCT) is as effective as anti-depressant medication in preventing relapse and enhancing quality of life for people with long-term depression. The study found that MBCT provides a cost-effective alternative to prescript...
A study found that media coverage of clinical trials rarely provides readers with the necessary information to make informed decisions. The researchers compared pharmaceutical and herbal remedy trials and found that stories underreported risk and lacked disclosure of trial funding and scientists' conflicts of interest.
A study published in the Academy of General Dentistry reveals that stopping antiplatelet medications before dental procedures increases the risk of permanent disability or death. Dentists can help patients by discussing treatment risks and benefits with their physicians.
A recent study published in PLOS Medicine found that a quarter of submitted drug trials remain unpublished five years later. Trials with favorable outcomes were more likely to be published, while those without favorable outcomes often had outcomes omitted or altered to favor the test drug.
Researchers found that diuretics commonly prescribed for high blood pressure can lower serum potassium levels, increasing the risk of type 2 diabetes. The study examined data from 3,790 nondiabetic participants and found a 45% increased risk of diabetes for each 0.5 milliequivalent-per-liter decrease in potassium levels.
Researchers at NIH and Duke University Medical Center found no evidence of cytogenetic damage in children taking stimulant medications for ADHD. The study included 63 children aged 6-12 who received either methylphenidate or mixed amphetamine salts, and showed similar results with both treatments.