Articles tagged with Drug Studies
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A study found that overusing medications containing barbiturates or narcotics can lead to more frequent migraine attacks. The use of these medications was associated with an increased risk of transformed migraine headaches, a form of migraine characterized by 15 or more days of headache per month.
A University of Alberta researcher has developed guidelines to prevent genetic research from awakening racist attitudes. The study emphasizes the importance of proper group representation and justifying research focus on specific ethnic groups.
Researchers at the University of Utah are enrolling patients in a clinical trial using their own bone marrow cells to regenerate heart muscle and improve blood flow. The study aims to improve heart function and quality of life for those with congestive heart failure.
A landmark trial is underway to assess whether COLD-FX reduces infections in chronic lymphocytic leukemia patients, who are vulnerable to respiratory infections due to weakened immune systems. The study aims to evaluate the effectiveness of COLD-FX in preventing and treating viral respiratory infections.
A recent Canadian study found that asthma is being over-diagnosed in 30% of adults, with two-thirds able to safely stop taking medication. The study suggests that there may be a substantial over-diagnosis of asthma, potentially obscuring the true cause of symptoms.
A recent study published in European Urology found a significant relationship between prostate inflammation and lower urinary tract symptoms (LUTS) in men. The study, which analyzed data from the REDUCE trial, revealed that chronic inflammation was associated with higher IPSS scores and a greater degree of LUTS.
A study led by The University of Texas M. D. Anderson Cancer Center has found a four-drug regimen of carboplatin, paclitaxel, bevacizumab, and cetuximab to be safe for patients with advanced lung cancer. The regimen showed modest improvement in survival rate, with 53% of patients experiencing tumor shrinkage.
A study found that African-American patients with non-small cell lung cancer have a higher copy number of the epidermal growth factor receptor (EGFR) gene, predicting better long-term outcomes when taking erlotinib and gefitinib. Few EGFR mutations were observed, highlighting the need for more research in this patient population.
A new study found that vitamin C supplements can lower concentrations of CRP, a central biomarker of inflammation linked to heart disease and diabetes. The study also found no benefit from daily doses of vitamin E.
A Johns Hopkins cardiologist disputes the American Heart Association's recommendation to screen all heart patients for depression, citing lack of evidence and potential harm from treatment. Instead, he advocates for a more nuanced approach, such as listening to patients during examinations and asking about their overall well-being.
A major international study finds catheter ablation is superior to medication for treating irregular heartbeat. One year after treatment, 75% of patients were symptom-free, compared to 21%, highlighting the effectiveness of this procedure.
A recent study by Temple University Sociology Professor Matt Wray found that Las Vegas faces a significantly higher suicide rate than the rest of the country. Residents and visitors to the city are more likely to die by suicide, with some even experiencing an increased risk when traveling away from home.
A new stent coated with an antibody that binds endothelial progenitor cells has been found to be as effective as drug-eluting stents in keeping arteries open in patients with coronary heart disease. The study of 1,640 international patients showed low rates of stent blockage and revascularization procedures.
A randomized controlled trial found that patients who received unexpected gifts and positive messages took their medication 43% of the time over 12 months, compared to 36% in the control group. The intervention reduced negative feelings and improved patient affirmation.
Researchers at Michigan Medicine have discovered a vitamin and mineral combination that may prevent hearing loss caused by loud noises. The formula, called AuraQuell, was successful in laboratory tests and is now being tested in human clinical trials.
A diuretic has been found to reduce the risk of heart failure in women with a preserved ejection fraction, according to a study published in Circulation. The medication, chlorthalidone, was shown to be effective in reducing the occurrence of heart failure in people with a wide range of left ventricular ejection fractions.
A new study published in JAMA found that low-dose aspirin did not significantly reduce the risk of atherosclerotic events, including coronary and cerebrovascular events, in patients with type 2 diabetes. However, aspirin was effective in reducing fatal coronary and fatal cerebrovascular events.
A daily oral dose of MK-677 increased muscle mass in healthy older adults by restoring 20% of lost muscle mass associated with aging. The study shows promise for a treatment that could help prevent age-related frailty and maintain independence as seniors age.
A study found that adolescents addicted to opioids who received extended treatment with combination medication had lower rates of testing positive or reporting use of opioids compared to those in short-term detoxification programs. Patients in the extended treatment group reported less use of opioids and cocaine, as well as a lower nee...
A new study found that stimulating growth hormone release in healthy older adults increased lean muscle mass, but not thigh muscle area. Another study revealed a decrease in cardiogenic shock rates among patients with acute coronary syndromes, possibly linked to improved angioplasty treatments
A recent study by Saint Louis University reveals a significant increase in the use of type 2 diabetes medications among American tweens and teens between 2002 and 2005. The study also found increased utilization patterns for blood pressure, cholesterol, asthma, ADD/ADHD, depression, and other medications.
Medication overuse headaches (MOH) are associated with severe disability and unmet treatment needs. Recent research suggests that treatments developed to prevent migraine may be effective in patients with MOH before withdrawal, pointing to the need for clinical trials to re-evaluate current strategies.
The study found that VYVANSE controlled ADHD symptoms from the first time point measured through the last time point assessed. In addition, VYVANSE treatment was associated with significant improvement in math problems attempted and answered correctly for up to 13 hours post-dose.
A study by Yale University researchers found that elderly patients with multiple medical conditions can make more informed treatment decisions when involved in the process. By prioritizing global outcomes such as length of life and symptom relief, these patients can maximize their desired outcome and minimize potential harm from medica...
Better designed rodent trials could reduce the cost and time required for cancer drug development. A well-designed rodent study should include an appropriate animal model, correct statistical evaluation of data, proper randomization, and a sufficient number of animals.
Researchers discovered that using hydroxychloroquine reduces diabetes risk in rheumatoid arthritis patients by 53%. The study suggests HCQ improves glucose tolerance, preventing diabetes onset.
Researchers found that valproic acid improved memory and reduced brain lesions in mice with an AD-like disease. The drug also prompted damaged nerves to start repairing themselves and improved performance in memory-related tests.
A meta-analysis of 40 clinical trials found that metformin hydrochloride was associated with a decreased risk of cardiovascular mortality compared to other oral diabetes agents or placebo. However, the study did not find significant associations between other diabetes medications and beneficial or harmful cardiovascular effects.
A study published in PLoS Medicine calls for strengthened restrictions on off-label promotion by pharmaceutical companies, citing potential dangers to public health. The researchers argue that marketing of off-label uses is widespread and should be heavily fined to prioritize patient safety.
A recent study found that 87% of physicians receive less than 5 hours of training on tobacco dependence, and only 6% know Agency for Healthcare Research and Quality guidelines. This lack of knowledge may contribute to low quit rates among smokers, who are more likely to succeed with provider assistance.
Phase III trials demonstrate iclaprim's effectiveness in treating complicated skin and skin structure infections caused by Gram-positive bacteria, including MRSA. The antibiotic showed a high clinical cure rate similar to linezolid and was well-tolerated with a favorable safety profile.
A review found that off-label use of anticancer drugs ranged from 6.7% to 33.2% between 1990 and 2002, primarily used in palliative care. The study highlights the need for accurate data on off-label use to inform decision-making by health professionals.
Researchers developed a simple blood test that measures inflammatory gene expression to evaluate cystic fibrosis patients' response to therapy. The test identified genes CD36, CD64, and ADAM9 as accurate biomarkers for therapeutic response.
Preliminary trials of a new multi-kinase inhibitor, XL184, have indicated impressive tumour shrinkage activity in patients with advanced medullary thyroid cancer. The overall disease control rate was 84% in the 25 patients who have been followed for at least three months.
ANG1005, a proprietary peptide vector, transports paclitaxel across the blood-brain barrier with high efficacy. The drug has shown promising results in clinical trials for brain metastasis and malignant glioma, with increased survival rates and reduced tumor growth.
A new anti-cancer compound, BI 6727, has shown encouraging anti-tumour activity in a phase I clinical trial. The compound works by inhibiting the action of Polo-like kinase 1, leading to abnormal mitotic spindles and disrupting cell division.
Researchers at the University of Cambridge have discovered that alemtuzumab may not only stop MS from advancing but also restore lost functions in patients. The study found that alemtuzumab reduces attacks by 74% and disability accumulation by 71% compared to a current treatment.
A method of assessing phase I clinical trial abstract quality was developed and applied to two oncology conferences, revealing room for improvement. The study suggests that adopting guidelines for reporting phase I trials can enhance abstract quality.
The AGA Institute published evidence-based guidelines for the management and treatment of suspected GERD, highlighting the need for high-quality clinical trials. The guidelines recommend various treatments, including proton pump inhibitors and antireflux surgery, to improve patient outcomes.
According to a study published in JAMA, approximately one in four approved biological medicinal products had at least one safety-related regulatory action issued 10 years after their approval. The average time to a safety-related regulatory action was 3.7 years, with 70.7% of actions occurring within five years after approval.
The USPSTF recommends primary care interventions to promote breastfeeding, with coordinated interventions increasing initiation, duration, and exclusivity. Breastfeeding has substantial health benefits to babies and their mothers, including reduced infections, allergic skin rashes, and type 2 diabetes.
Researchers found strong associations between markers of inflammation and coagulation and increased risk of death from non-AIDS diseases. Biomarkers IL-6 and D-dimer levels were unchanged in patients receiving continuous ART treatment, suggesting a link to intermittent ART.
Recent studies confirm the prevalence of migraine remains stable, with aura doubling heart attack risk and increasing cardiovascular disease mortality. New treatments targeting calcitonin gene-related peptide (CGRP) show promise, with olcegepant and telcagepant demonstrating effective pain relief.
A clinical trial showed that drug-eluting stents are more effective than bare metal stents in reducing target lesion revascularization rates by 41% and binary restenosis by 56%. The use of drug-eluting stents also demonstrated comparable safety, with a reduced risk of major adverse cardiovascular events.
The HORIZONS AMI trial found that bivalirudin significantly reduces all-cause death, cardiac death, and major bleeding in heart attack patients. The use of bivalirudin also resulted in a 31% reduction in 1-year all cause mortality.
Research conducted at the University of Illinois shows that children with ADHD demonstrate greater attention after a 20-minute walk in a park compared to similar walks in downtown or residential areas. The study found that even small doses of nature exposure can improve symptoms, suggesting a potential long-term benefit.
The 12-month ATLANTA Trial data showed zero percent stent thrombosis in patients discontinuing dual anti-platelet therapy after 30 days. The CATANIA stent's Polyzene-F surface treatment promoted healthy endothelial cell growth and reduced platelet activation, leading to improved safety and economic benefits.
A study published in the journal AIDS found that HIV-infected patients taking efavirenz had higher treatment adherence and lower rates of virologic failure and death compared to those taking nevirapine. This suggests a more favorable clinical outcome for efavirenz-based therapies.
Research studies and clinical registry data suggest that triple antiplatelet therapy achieves greater platelet inhibition than conventional dual antiplatelet therapy in patients undergoing percutaneous coronary intervention (PCI) with drug-eluting stents. This leads to reduced early mortality and major adverse cardiac events without in...
A large review of 38 studies found regular NSAID use associated with reduced breast cancer risk. Aspirin and Advil showed significant protective effects, with a 13-21% relative risk reduction.
Researchers discovered that tamoxifen can reduce the median time to diagnosis of ER-negative breast cancer by a year, improving detection rates through mammography. The study suggests an unexpected link between tamoxifen use and earlier disease identification in high-risk patients.
A study published in JAMA found that using 5-α reductase inhibitors for treating an enlarged prostate does not increase the risk of hip fractures. The research included over 7,000 men who experienced a hip fracture and found no dose-response relationship between medication use and bone health.
A Johns Hopkins researcher found that early mobilization can help prevent muscle weakness and improve physical function in ICU patients, leading to shorter hospital stays and better quality of life. The study suggests that getting patients up and moving shortly after admission can help mitigate the negative effects of prolonged bed rest.
Takeda's investigational PPI TAK-390MR demonstrates higher healing rates than lansoprazole among patients with more severe grades of erosive esophagitis. The drug combines dexlansoprazole with a Dual Delayed Release formulation, designed to provide extended duration of acid suppression.
LIALDA demonstrated a steady 5-ASA release throughout the entire colon, with prolonged disintegration in the ascending colon. A post hoc analysis also found that patients could achieve complete symptom resolution after up to 16 weeks of LIALDA treatment.
Researchers discovered an electromagnetic biomarker that predicts a patient's response to ketamine, a fast-acting antidepressant. Increasing activity in the anterior cingulate cortex hub near the front of the brain while viewing flashing frightful faces correlates with improved symptoms after receiving ketamine.
The MOTIVATE trials show maraviroc significantly suppresses the virus at 48 weeks, increasing immune system T-cell counts and providing consistent clinical benefit for treatment-experienced patients with R5 HIV-virus infection. Maraviroc provides a valuable additional treatment option for a wide spectrum of treatment-experienced patients.
A study found that birth weight is associated with an increased risk of breast cancer later in life, particularly among women living in developed countries. The analysis of over 600,000 women revealed a 7% increase in risk for every 0.5 kg increment in birth weight.
A study found that news articles rarely report pharmaceutical company funding and frequently use brand medication names, potentially introducing commercial bias. Despite editors' reports of always using generic names, actual newspaper articles often failed to do so.
Researchers are conducting a new study to investigate the safety and effectiveness of airway bypass using drug-eluting stents for patients with advanced emphysema or COPD. The trial aims to provide a minimally invasive treatment option for patients who have limited treatment options, such as lung reduction surgery and inhalers.