Articles tagged with Drug Studies
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
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Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A study published in the journal Pain found oxycodone to be an effective treatment for acute shingles pain, with patients experiencing a significant reduction in pain levels. The medication was more than twice as effective as a placebo in reducing pain, making it a promising option for treating this debilitating condition.
A clinical study found that a combination of steroids and antihistamines can alleviate Plavix allergy symptoms in 88% of patients, enabling them to continue treatment. The study's findings have significant implications for cardiac patients with stents, who require long-term Plavix use.
The study found that administering eptifibatide in the emergency room or during procedures to open blocked arteries does not significantly affect patient outcomes for those at high risk of complications after a heart attack. Researchers also noted an association between earlier use of eptifibatide and non-life-threatening bleeding.
The Ocean State Clinical Coordinating Center at Rhode Island Hospital will oversee a Phase II study of CytoFab to treat severe sepsis. The center, led by Dr. Steven LaRosa, has been awarded $800,000 to coordinate the trial's international sites.
The study found that delivering a potent form of autologous adult stem cells into the heart muscle of patients with severe angina improved exercise tolerance and reduced episodes of chest pain. Six months after the procedure, treated patients were able to walk longer on a treadmill than those in the placebo group.
The study found that drug-eluting stents are safer and more effective than bare metal stents in preventing deaths and heart attacks. Over a two-and-a-half-year follow-up period, patients who received drug-eluting stents had a 25% reduction in death and a 24% reduction in heart attacks.
Researchers found omacetaxine killed 90% of leukemic stem cells in vitro and prolonged survival in test animals with resistant CML. The findings may open the door to developing a curative treatment strategy for some patients with CML.
Researchers track autoimmune disease development with bioluminescent imaging of NF-κB activation, revealing pathology in multiple organ systems. Early detection is critical for assessing new treatments and preventing disease progression.
Research finds that licorice can block absorption of cyclosporine, a vital immunosuppressant for transplant patients. Laboratory rats showed significant drop in cyclosporine levels after consuming licorice extract.
Researchers reviewed data on Japanese herbal medicines and found them to be effective in reducing symptoms of functional dyspepsia, constipation, and postoperative ileus. The use of standardized formulations of herbal medicines requires further examination for their health benefits.
International experts propose MEDQUARG guidelines to study counterfeit and poor-quality medicines globally. The guidelines aim to improve the effectiveness of treatment policies by providing a standard for medicine quality surveys.
A national study of over 700 patients will measure the cost and clinical effectiveness of acupressure wrist bands in reducing chemotherapy-related nausea. The device aims to provide a drug-free alternative for a debilitating symptom that affects quality of life, social life, and mental health.
A new study published in Hypertension journal recommends a simplified method of treating hypertension using low doses of single pill combinations, which has shown to be more effective and easier for patients than traditional treatment methods. The 'Simplified Treatment Intervention to Control Hypertension' (STITCH) study found that pat...
A new study published in The Lancet found that coronary artery bypass graft may be a better treatment choice than percutaneous coronary intervention (angioplasty) for patients with multi-vessel coronary artery disease who have diabetes and are older than 65. In contrast, PCI may be the best option for patients 55 years and younger.
A steroid nasal wash containing budesonide appears to reduce symptoms of chronic rhinosinusitis in patients. The medication is found to be safe and effective for short-term use, with minimal risk of systemic adverse effects.
The study found that the bioabsorbable stent was safe with only one major adverse event recorded at 2 years, a heart attack, and no new events between 6 months and 2 years. The device had been fully absorbed by 2 years, reducing the chance of restenosis.
Researchers found a new drug derived from magnolia trees to be effective in preventing blood clots without causing excessive bleeding. The Phase II study showed that the compound was generally well-tolerated and did not increase bleeding risk, even when taken with standard anti-clotting medications.
Research shows that patients discharged against medical advice are at higher risk of morbidity and mortality, with some groups facing four-times-higher risks of readmission within 30 days. Identifying these high-risk patients is crucial, and providing informed consent can help manage the issue.
A new study published in Journal of Human Hypertension demonstrates RESPeRATE's effectiveness in reducing office systolic blood pressure by -10.0 mm Hg in non-insulin dependent diabetics, with a full 88% of patients experiencing significant blood pressure reduction.
Men with higher vitamin C intake appear less likely to develop gout, a painful type of arthritis. Vitamin C may reduce levels of uric acid in the blood and affect kidney function, leading to a lower risk of gout.
A recent study found that oral quinacrine does not increase survival in patients with prion disease, but may slow progression and improve symptoms. However, the treatment was associated with increased incidence of adverse events, which were mostly mild and manageable.
A study compared two common drugs used to treat early-stage Parkinson's disease and found that their long-term impact is similar. The research showed that patients on different treatment regimens experience roughly the same level of disability and quality of life over time.
Researchers at Weill Cornell Medical College discovered that chloroquine is a highly active inhibitor of infection by Hendra and Nipah viruses. The drug blocks the action of cathepsin L, an enzyme essential for virus growth and maturation.
A recent study in Oregon found that drugs designed for severe mental illnesses are often prescribed at low doses and high expense for less serious conditions. This 'off-label' use can lead to unnecessary health risks and increased medical costs.
A study published in JAMA found that patients who receive a medication to reduce gastrointestinal bleeding alongside clopidogrel and aspirin after a heart attack have an increased risk of hospitalization for acute coronary syndrome or death. The study suggests that proton pump inhibitors may reduce the effectiveness of clopidogrel, but...
UCSF researchers found that hair samples can accurately predict treatment success in HIV patients by analyzing antiretroviral drug levels. This method may become a new standard in HIV clinical care, allowing for the monitoring of pill-taking and treatment response.
A UCLA study found that broccoli sprouts triggered an increase in antioxidant enzymes, offering protection against free radical damage and inflammation. The researchers discovered a significant increase in these enzymes after consuming 100g or higher of broccoli sprouts.
A Yale University study found varenicline significantly reduced heavy-drinking smokers' alcohol consumption and cravings. The drug also showed no adverse effects when combined with low doses of alcohol.
A new testosterone patch designed to boost female sex drive after menopause has been found ineffective, with small improvements and large placebo responses reported in clinical trials. The treatment's long-term safety is also unknown due to short trial duration and high side effect rates.
Researchers analyzed transtibial and anteromedial portal drilling techniques for ACL reconstruction, finding that anteromedial portal drilling allowed for better native ACL footprint restoration and knee stability. Re-reaming of the tibial tunnel was also a significant issue with conventional transtibial techniques.
A Phase 3 clinical trial found that fampridine improves walking ability in some individuals with multiple sclerosis, with 34.8% of participants experiencing a significant increase in walking speed. The study suggests that fampridine could represent an important new treatment for MS-related mobility issues.
Burn rehabilitation experts at UT Southwestern recommend a hierarchy of treatment strategies to alleviate chronic itching caused by burn scars. Topical creams and ointments are often effective, while oral antihistamines may be necessary for more severe cases. Other non-medicinal treatments like lasers and massage can also provide relief.
Studies found that low-income neighborhoods had a low availability of healthy foods, leading to poorer diet quality. Researchers suggest that place of residence plays a significant role in dietary health, with certain communities facing limited access to nutritious food options.
A new study suggests blocking neutrophil migration using rhAPC could eliminate bleeding risk from sepsis treatment. The results recommend existing drugs as potential new treatments against sepsis, increasing the pace of new treatments in the clinic.
A new study found that goserelin treatment reduced the risk of disease recurrence and deaths by 13.9% and 8.5% respectively in premenopausal women with early breast cancer. The benefits were comparable to those seen with tamoxifen treatment, suggesting goserelin may be a viable alternative for some patients.
A study by UCSF researchers found that cabergoline, a hormone disorder drug, decreased alcohol consumption and relapse in rodents. The drug showed specificity for alcohol, not affecting general reward or pleasure.
Bias in medical literature can be prevented through recognition and declaration of competing interests, detailed authorship policies, and mechanisms to control outcome reporting bias. The PLoS Medicine editors propose these measures to reestablish the integrity of the scientific record.
A clinical trial of laser therapy for stroke patients found that those with moderate to moderately severe strokes experienced significant improvement, with a 9.7% absolute gain in treated patients. However, the treatment did not significantly reduce overall stroke disability, missing its primary endpoint.
A study found that one-third of El Paso residents cross the US-Mexico border to purchase medication and healthcare services. The lack of health insurance in El Paso is directly associated with this phenomenon.
A multicenter study led by Johns Hopkins shows that an experimental clot-busting treatment can increase survival rates and improve function in patients with intracranial hemorrhage, a lethal form of stroke. After six months, about 10% had no lingering disability and 40% were independently caring for themselves.
Researchers found that administering losartan before, during and after radiation therapy prevents or lessens cognitive impairment in rats. The study validates a hypothesis that anti-hypertensive drugs can protect the brain from radiation-induced injury.
A study confirms that using genetic information can more accurately estimate warfarin doses, reducing the risk of overdose or underdose. The gene-based dosing algorithm was found to be more effective than traditional clinical formulas in identifying patients at high risk of bleeding or clotting.
The shift of clinical trials to developing countries raises questions about the scientific value and ethical implications for patients in the US. Researchers found that over half of study sites were outside the US borders, and companies were testing drugs in emerging markets without aligning with local health needs.
A comprehensive childhood asthma study shows that children who initially improved with steroid drugs no longer see those improvements after stopping the medications. The Childhood Asthma Management Program (CAMP) trial found that continued benefit of these medications likely requires continued use to manage symptoms.
The ATHENA trial found that dronedarone reduced the incidence of cardiovascular-related hospitalisation or death by 24% compared to placebo. The study also showed a significant reduction in cardiovascular death, with no difference in overall mortality.
Patients treated with infliximab and adalimumab, a type of rheumatoid arthritis medication, are at an increased risk for developing herpes zoster (shingles). A significant association was found between treatment with these monoclonal anti-TNF-α antibodies and the development of shingles.
A recent study found that Phase I drug trials are underreported, with only 17% published in scientific journals. The lack of transparency can compromise the safety and efficacy of new drugs, highlighting the need for increased mechanisms to ensure complete availability of trial results.
A new critical care pathway, ACSETS, was implemented at four western New York hospitals to improve treatment and outcomes for patients with acute coronary syndrome. The study found that ACSES patients had a 19% lower mortality rate one year after discharge compared to pre-ACSES patients.
Researchers analyzed MRI test results of 109 ischemic stroke patients and found that up to 9 hours after symptom onset, a diffusion-perfusion mismatch may still benefit from thrombolytic therapy. This extends the traditional treatment window, potentially saving more lives.
Researchers found that mice missing the AT1A protein lived significantly longer due to reduced oxidative damage and increased cell survival genes. The study suggests that antagonizing this receptor may also promote human longevity.
Researchers used electronic medical records to evaluate drug therapies, finding results comparable to randomized clinical trials in nine out of 17 outcomes. The study suggests enormous amounts of information within EMR databases can expand healthcare knowledge.
A new study by Queen's University Belfast emphasizes the importance of licensed medicines for children, with 86% of respondents unaware of unlicensed medicine use. The study calls for more clinical trials to ensure safe and effective treatment, highlighting a need to bridge the gap between adult and child medicine.
A new study suggests that green tea components may negate the effects of bortezomib (Velcade) in patients taking this medicine. The EGCG polyphenol in green tea bound to boronic acid-containing compounds like bortezomib cancels out their antitumor effects.
A new re-engineered hospital discharge program, RED, has been designed to reduce hospital utilization within 30 days of discharge. The study found that the intervention resulted in a 33.9% lower observed cost for patients who received the program compared to those in the usual care group.
UCSF's Positive Choice: Interactive Video Doctor and Healthy Living interventions have been selected by the CDC for their effectiveness in reducing HIV risk behaviors. These programs address crucial aspects of living with HIV, including stress and coping, transmission risk behaviors, and adherence to medication regimens.
A study published in Journal of the American Geriatrics Society suggests that certain medications may be associated with cognitive decline in older adults. The research found that chronic use of medications with anticholinergic properties can lead to memory difficulties and impaired daily functioning.
A new study found that patients starting rasagiline earlier experienced less progression of Parkinson's disease symptoms and signs, including rigidity and activities of daily living. The long-term study showed a 16% less progression in the early-start group compared to those who delayed treatment for six months.
A study published in Nature Medicine suggests that statin drugs can stabilize blood vessels and prevent leaks in people with cerebral cavernous malformation (CCM). The disease, which affects an estimated 1.5 million people in the US, has no known drug therapy and often requires brain surgery or radiation treatment.
UT Southwestern researchers found that drug-coated stents are less risky for heart bypass patients compared to bare-metal stents, with a 51% lower rate of re-narrowing and reduced need for repeat procedures.
A study by the University of Leicester found that premature babies are exposed to potentially harmful excipients in liquid medicines, including ethanol, sorbitol, and Ponceau 4R. The researchers emphasize the need for more research on these chemicals and their effects on infants.