Articles tagged with Drug Studies
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Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
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Two studies published in Health Affairs found that consumer-driven health plan (CDHP) participants are more likely to discontinue medications for serious chronic conditions. Researchers warn that this behavior may lead to higher healthcare costs and poor health outcomes.
Researchers found that barcoded technology is not fool-proof and nurses develop workarounds to compensate for its limitations. The study highlights 31 causes of problems with barcode systems, including unreadable medication-barcodes, malfunctioning scanners, and non-barcoded-medications.
A new review from the University of Cincinnati found that workplace-based weight loss programs are moderately effective at promoting weight loss among participating employees. The studies showed that face-to-face contact and high-intensity interventions were more effective than low-intensity programs in achieving significant weight loss.
A study of newborn intensive care found that many painful procedures are performed without pain medication or therapy. Neonates experience high rates of repeated and prolonged pain exposure, which can alter their subsequent pain processing and behavior.
A new study by Duke University researchers found that antipsychotic medications can reduce community violence in schizophrenia patients, but only among those with psychotic symptoms. Childhood conduct problems, substance abuse, and poverty remain significant predictors of violent behavior.
The OptiNose Phase II study demonstrated that its nasal device combination achieves rapid and efficient migraine relief without needle-stick injuries. The results show that 74.3% of patients experienced headache relief within 60 minutes and 83.8% after 120 minutes.
A portable transcranial magnetic stimulator (TMS) device has been found to be safe and effective in eliminating headaches during the onset of migraines. The device's pulses interrupt the electrical storms in the brain that lead to throbbing head pain, offering a promising new treatment option for those suffering from chronic migraines.
Dr. Thesleff is being honored for her early research work on the associations between oral clefts and drugs taken during pregnancy, as well as her studies on the development of tooth germs and teeth. She has published over 250 papers and made significant contributions to the public understanding of science in her domain.
A recent study published in The Lancet found that extended use of rivaroxaban significantly reduces the risk of venous thromboembolism after total hip arthroplasty, compared to short-term enoxaparin plus placebo. This finding has important implications for preventing blood clots in patients undergoing hip surgery.
Laquinimod, an oral treatment, shows promise in reducing multiple sclerosis disease activity and is well-tolerated. The study found a significant reduction in MRI disease activity with laquinimod 0.6mg daily, while laquinimod 0.3mg daily showed no significant effects.
A major international clinical trial has found that a simpler approach to treating atrial fibrillation in patients with congestive heart failure can significantly reduce hospitalization rates and eliminate the need for repeated cardioversions. The study, published in the New England Journal of Medicine, enrolled 1,376 patients at 123 h...
People with epilepsy who fail to take their medication regularly are three times more likely to die compared to those who adhere to treatment. Hospital visits and emergency room visits also increase during periods of non-compliance, highlighting the importance of consistent medication adherence.
A new study found that olmesartan medoxomil effectively reverses the narrowing of arteries in patients with high blood pressure. The one-year study showed significant improvements in vascular function and structure compared to a beta-blocker, providing hope for treating this common condition.
A long-term safety study on Lialda found that the medication is generally well-tolerated, with most adverse events being mild or moderate in intensity. The study also showed that a majority of patients remained in remission for 12 months.
A systematic review found short-term medical cannabinoid use linked to higher rates of non-serious adverse events, particularly dizziness. However, longer-term effects in chronic illness remain unexplored.
Research into crystal meth addiction has been limited to animal studies, but potential therapeutic agents targeting dopamine and non-dopamine systems are in clinical testing. The article highlights the need for accelerated clinical trials to address the public health importance of this issue.
A gene variation called alternative splicing may explain why some people don't respond well to cholesterol-lowering drugs. Researchers found that this variation accounted for 9% of the reduced power of statins in lowering low-density lipoprotein (LDL) levels.
A new study found that some patients with type 2 diabetes can maintain good blood sugar control for years using non-insulin oral diabetic medications. The study of 191 veterans showed that 55% of patients remained on oral drugs and achieved improved hemoglobin A1c levels.
Baminercept alfa, a dual-mechanism inhibitor of the LT-β and LIGHT pathway, has shown improved efficacy in patients with rheumatoid arthritis, including reduced swollen joint count and tender joint count. The Phase IIa trial results suggest that baminercept alfa is well-tolerated and may be effective in treating RA
A clinical trial is investigating the safety of a vaginal microbicide gel for pregnant women and their babies. The study aims to understand how pregnancy affects the body's absorption of the active drug and whether it can be transferred to the fetus.
A new study published in the New England Journal of Medicine found that coagulation factor VIIa can reduce cerebral hemorrhage size, but does not prevent long-term mortality or severe impairment. The study showed that patients with smaller hemorrhages and certain age restrictions may benefit from treatment.
A new analysis of raloxifene, a medication approved for osteoporosis prevention and treatment, found it reduces the risk of invasive, estrogen-receptor positive breast cancer in postmenopausal women by at least 50% for up to 8 years. The drug is also effective in reducing the risk of spine fractures.
A study published in JAMA found that St. John's wort did not improve ADHD symptoms in children and adolescents. The trial involved 54 participants who received either St. John's wort or a placebo for eight weeks, with no significant differences in symptom improvement.
Topiramate effectively decreases heavy drinking and associated physical and psychosocial harm, including lower blood pressure and improved liver function. The medication also shows promise in reducing the risk of heart disease and improving overall quality of life for alcohol-dependent individuals.
A new animal study found that boosting a specific brain protein quickly cuts excessive drinking and prevents relapse. The treatment does not block other pleasure-seeking behaviors, showing promise for a new strategy to combat alcohol abuse, addiction and especially relapse.
Alogliptin demonstrated significant reductions in hemoglobin A1c (HbA1c) levels in patients with type 2 diabetes, particularly when used as monotherapy or added to existing oral anti-diabetic treatments. The study results suggest alogliptin is a effective treatment option for patients with inadequate blood sugar control.
University of Illinois Chicago researchers modified the procedure for islet cell transplantation and achieved insulin independence in diabetes patients using fewer but better-functioning pancreatic islet cells. The study results are published in the American Journal of Transplantation.
The University of Southern California has been awarded $12.4 million to spearhead a rehabilitation project for stroke survivors. The study, named I-CARE, aims to optimize rehabilitation therapies to improve patient quality of life.
A new review suggests that participants' desire for transparency outweighs bioethicists' concerns about potential negative psychological consequences. Volunteers generally want access to aggregate study results and some individual results if relevant to their lives. However, individual results can be overwhelming and expensive to provide.
Recent studies on pain medicine highlight the need for personalized treatment approaches. Researchers found that opioid therapy often lacks sufficient trial duration to determine its effectiveness for chronic pain sufferers.
Researchers identified genetic variants that influence treatment outcome for smoking cessation treatments, including nicotine replacement therapy (NRT) and bupropion. These variants may help tailor treatment to individual smokers, increasing the likelihood of success.
Physician-scientists from NewYork-Presbyterian/Weill Cornell presented Phase II trial data showing a monoclonal antibody targeting prostate cancer cells effectively reduces PSA levels in patients with late-stage metastatic disease. The researchers also present results on RAD001, which slows cancer progression in recurrent endometrial c...
Recent studies have shown that rotigotine skin patches can effectively treat restless legs syndrome (RLS) symptoms even during the day and night. The trials found significant improvements in patient symptoms, with 75% of patients rating their treatment as good or very good. No notable augmentation of RLS symptoms was observed.
A pivotal Phase III clinical trial demonstrated that rivaroxaban was superior in preventing venous blood clots in patients undergoing total knee replacement surgery. Rivaroxaban provided a statistically significant 31% relative risk reduction in total venous thromboembolism events compared to enoxaparin.
A randomized clinical trial found that oral prednisolone is clinically equivalent to naproxen in reducing pain and inflammation in patients with gout. The study suggests that prednisolone could be a safer alternative for treating gout, with potential economic benefits due to reduced healthcare costs.
A study published in Nutrition Research shows Pycnogenol improves diabetes control and reduces antihypertensive medications. The extract lowered blood sugar, LDL cholesterol, and blood pressure in patients with type II diabetes, suggesting it may serve as a potent adjunct to prescription medications.
Researchers found that prucalopride significantly improved bowel movements and quality of life for patients with severe chronic constipation. The study involved 620 patients who received either prucalopride or a placebo, showing that nearly half took notice in their bowel movements per week.
The HORIZONS-AMI trial shows that bivalirudin reduces adverse clinical events by 24%, mortality by 33%, and cardiac mortality by 38% compared to heparin and GPI in heart attack patients. This is the largest study ever to focus on anticoagulant medications in STEMI patients undergoing primary PCI.
A review of 21 studies found no systematic association between 100% fruit juice consumption and overweight in children or adolescents. Health professionals are encouraged to promote moderate consumption of 100% fruit juice as a strategy to help children meet fruit recommendations.
New research from the University of Pennsylvania School of Medicine reveals drug-eluting stents outperform bare metal stents in reducing mortality and need for future cardiac procedures. The study found that patients with drug-coated stents saved an average of $1,350 worth of follow-up care during the year.
The HORIZONS AMI trial found bivalirudin significantly reduces major bleeding and cardiovascular events in STEMI patients undergoing angioplasty. The study showed a 24% reduction in net adverse clinical events and a 33% decrease in overall mortality at 30 days.
A new study analyzed SYMBICORT in children with persistent asthma, showing significant improvements in nighttime symptoms, rescue medication use, and lung function. The results indicate that SYMBICORT is effective for treating mild to moderate persistent asthma in children aged 6-15.
A post hoc analysis of a study on Lialda revealed significant improvements in time to symptom resolution for patients with mild to moderate ulcerative colitis. The study found that Lialda, an aminosalicylate medication, lowered the time to initial symptom resolution by up to 17 days compared to placebo.
The study shows that Perforomist Inhalation Solution delivers bronchodilation comparable to DPI delivery and has similar linear kinetics and excreted drug levels. This offers an effective, long-term treatment option for patients with COPD who may have difficulty coordinating other devices.
A study found that combining nebulized formoterol fumarate with tiotropium significantly improved COPD symptoms, including shortness of breath and chest tightness, in patients. The treatment also showed enhanced control of COPD symptoms, with decreased use of albuterol rescue medication.
A clinical trial found that combining nebulized formoterol fumarate with tiotropium significantly improves dyspnea, COPD symptoms, and rescue medication use. The treatment also shows promise in relieving shortness of breath, chest tightness, and nighttime awakenings.
A new study suggests that taking the antidepressant citalopram before starting treatment for head and neck cancer may help prevent depression during therapy. The study found that patients who took citalopram experienced lower rates of depression compared to those who took a placebo.
Researchers found that tracking patients' medication adherence was more accurate than CD4 test results in identifying those at risk of treatment failure. Adherence assessments could be used for early identification of high-risk patients, averting health impacts and prioritizing limited viral load testing.
Lubiprostone has been shown to significantly improve all IBS-C symptoms in women, including abdominal pain, bloating, and constipation severity. The drug is also effective in treating IBS-C for up to one year, with improved stool consistency and reduced nausea and diarrhea.
Researchers accessed the NINDS rt-PA Stroke Trial dataset to address concerns about its design, results, and ramifications. They found the process of gaining access to the information convoluted and difficult, with some crucial data missing.
Researchers at the University of Chicago Medical Center report positive results from a human trial of sorafenib, a cancer drug, as a treatment for pulmonary hypertension. Eight out of nine patients improved their exercise capacity and six experienced significant improvements in right ventricular ejection fraction.
TAK-390MR demonstrates consistently high healing rates and symptom relief for patients with erosive esophagitis, outperforming lansoprazole in phase 3 studies. The study's results showed that TAK-390MR produced significantly higher overall healing rates than lansoprazole across two studies.
The milk-derived dietary supplement AmealPeptide has been shown to significantly reduce daytime ambulatory systolic blood pressure by 3.6 mmHg and 24-hr systolic blood pressure by 6.2 mmHg in two placebo-controlled trials, confirming its safety and efficacy for patients with Stage I and Stage II hypertension.
A first-of-its-kind lung cancer chemoprevention trial found Celebrex reduces precancerous lesion proliferation and is safe for high-risk individuals. The study demonstrated the importance of COX-2 inhibition in preventing lung cancer, with potential implications for cancer prevention and treatment.
Two studies have shown that ustekinumab is effective in treating moderate-to-severe psoriasis, with dosing every 12 weeks maintaining efficacy in most patients. The PHOENIX studies found that 67-76% of patients achieved PASI 75 at week 12, with long-term response maintained in those given maintenance treatment.
A study published in New England Journal of Medicine identified efavirenz with NRTI as the most effective initial therapy for HIV-1 infection, achieving high viral suppression rates. The finding offers a valuable alternative to traditional triple-drug regimens and could lead to simpler treatment regimens.
A Canadian clinical trial has found that aprotinin increases the relative risk of death by 50% compared to other antifibrinolytics used to prevent blood loss during heart surgery. The study involved over 2,000 patients and showed that tranexamic acid or aminocaproic acid are safer choices for cardiac surgical patients.
Italian researchers found that an eight-month workplace initiative reduced headaches, neck and shoulder pain, and analgesic use. Staff reported a 41% decrease in headache days and a 54% reduction in neck and shoulder pain burden.
A review of 28 studies found that 90% of participants wanted to receive study results, citing clinical importance and respect for participants. While sharing results can cause negative emotions, the majority reported feeling it was important to receive them.
A study published in Biological Psychiatry used functional magnetic resonance imaging (fMRI) to match treatments for patients with generalized anxiety disorder. The researchers found that approximately two-thirds of patients experienced relief from their anxiety symptoms after treatment.